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Fenretinide Retinoid Receptor inhibitor

Name: Fenretinide
Brand: Selleck Chemicals
SKU: S5233
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S5233

Fenretinide is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). This compound (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, and it can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.

Chemical Structure

Molecular Weight: 391.55

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Quality Control

Batch: Purity: 99.82%

99.82

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Retinoid Receptor Inhibitors	TTNPB (Arotinoid acid) Tamibarotene AM580 BMS493 SR 11237 UVI 3003 AR7 Palovarotene CD1530 YCT529

Solubility

In vitro
Batch:

DMSO : 78 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.900mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 78 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.480mg/ml (1.23mM)	Taking the 1 mL working solution as an example, add 50 μL of 9.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	391.55	Formula	C₂₆H₃₃NO₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	65646-68-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC 374551, 4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016			SMILES	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-19)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06922539	RECRUITING	Small Cell Lung Cancer	SciTech Development, Inc.	2025-12-11	PHASE1
NCT04234048	RECRUITING	T-cell Lymphoma; Cutaneous/Peripheral T-Cell Lymphoma; Peripheral T-cell Lymphoma; Peripheral T-Cell Lymphoma, Not Classified; Primary Cutaneous T-cell Lymphoma; Cutaneous T-Cell Lymphoma, Unspecified; Cutaneous T-cell Lymphoma; Follicular T-Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Sézary's Disease; Mycosis Fungoides	SciTech Development, Inc.	2023-12-18	PHASE1
NCT07149220	ACTIVE_NOT_RECRUITING	Oral Leukoplakia; Oral Dysplasia	Ohio State University Comprehensive Cancer Center	2025-10-14	PHASE1
NCT06528457	COMPLETED	Dengue	Island Pharmaceuticals	2024-09-05	PHASE2
NCT06181760	COMPLETED	Safety and Tolerability	Island Pharmaceuticals	2023-11-22	PHASE1
NCT04234048	Recruiting	T-cell Lymphoma\|Cutaneous/Peripheral T-Cell Lymphoma\|Peripheral T-cell Lymphoma\|Peripheral T-Cell Lymphoma Not Classified\|Primary Cutaneous T-cell Lymphoma\|Cutaneous T-Cell Lymphoma Unspecified\|Cutaneous T-cell Lymphoma\|Follicular T-Cell Lymphoma\|Angioimmunoblastic T-cell Lymphoma\|Sézary''s Disease\|Mycosis Fungoides	SciTech Development LLC	2023-12-18	Phase 1

Tech Support

Handling Instructions

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