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Catalog No.S1988 Synonyms: NSC 6498, NSC 70461

2 publications

Propylthiouracil Chemical Structure

CAS No. 51-52-5

Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.

Selleck's Propylthiouracil has been cited by 2 publications

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Biological Activity

Description Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
thyroperoxidase [1]
5'-deiodinase [1]
In vivo Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. [1] Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. [2] Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. [3]Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. [4] Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. [5] Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. [6]


Solubility (25°C)

In vitro DMSO 34 mg/mL (199.72 mM)
Ethanol 19 mg/mL (111.61 mM)
Water Insoluble

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Chemical Information

Molecular Weight 170.23


CAS No. 51-52-5
Storage powder
in solvent
Synonyms NSC 6498, NSC 70461
Smiles CCCC1=CC(=O)NC(=S)N1

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02390180 Completed Other: Tasting solutions Taste Qualities|Primary Tastes Purdue University October 2014 --
NCT01097915 Completed -- Dysgeusia University of Cagliari October 2009 --
NCT00570466 Completed Behavioral: Video Games|Behavioral: Web and DVD knowledge Type 2 Diabetes National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Baylor College of Medicine January 2008 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID