Glucocorticoid Receptor

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Glucocorticoid Receptor Products

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  • New Glucocorticoid Receptor Products
Catalog No. Product Name Information Product Use Citations Product Validations
E0177New Hydrocortisone sodium succinate

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

S1322 Dexamethasone (MK-125) Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Cell Stem Cell, 2022, 29(4):545-558.e13
Blood, 2022, blood.2022016241
Hepatology, 2022, 10.1002/hep.32436
E1091New Relacorilant Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
S2606 Mifepristone (RU486) Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.
Nat Commun, 2021, 12(1):7041
Exp Eye Res, 2021, S0014-4835(21)00331-6
Oncol Rep, 2021, 46(3)202
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1286 Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Front Immunol, 2022, 13:882277
Int J Mol Sci, 2021, 22(14)7540
Sci Rep, 2020, 24;10(1):5363
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1622 Prednisone (NSC-10023) Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S1628 Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
J Inflamm Res, 2021, 14:843-858
Theranostics, 2020, 10(1):247-264
Drug Test Anal, 2020, 10.1002/dta.2917
S1669 Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1689 Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1696 Hydrocortisone (NSC 10483) Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.
Stem Cells Transl Med, 2022, 11(5):552-565
Reprod Toxicol, 2022, 111:68-80
Reprod Toxicol, 2022, S0890-6238(22)00068-5
S1701 Desonide Desonide is a low potency topical corticosteroid.
Drug Test Anal, 2020, 10.1002/dta.2917
S1733 Methylprednisolone (NSC-19987) Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S1737 Prednisolone (NSC-9900) Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
Ther Adv Hematol, 2020, 11:2040620719898373
S1888 Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Drug Test Anal, 2020, 10.1002/dta.2917
S1933 Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
Drug Test Anal, 2020, 10.1002/dta.2917
S1987 Mometasone furoate Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992 Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Nat Med, 2017, 23(4):424-428
S2470 Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S2559 Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S2570 Prednisolone Acetate Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
Int J Biol Sci, 2020, 16(13):2382-2391
S2584 Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Exp Ther Med, 2019, 18(2):1258-1266
S2608 Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S4088 Flumethasone Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Drug Test Anal, 2020, 10.1002/dta.2917
S4228 Fluorometholone Acetate Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4646 Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
mBio, 2022, 13(1):e0304421
Pharmaceutics, 2022, 14(7)1511
J Cell Biochem, 2022, 10.1002/jcb.30213
S4752 Corticosterone (NSC-9705) Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Proc Biol Sci, 2022, 289(1976):20220592
Behav Brain Res, 2021, 418:113647
Neuroscience, 2019, 411:11-22
S4775 Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S5184 Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.
Dis Model Mech, 2022, dmm.049109
Hematology, 2022, 27(1):32-42
S5486 Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
Drug Test Anal, 2020, 10.1002/dta.2917
S5489 Prednisone acetate Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
Blood Cancer J, 2022, 12(3):36
Front Immunol, 2021, 12:739605
J Immunotoxicol, 2021, 18(1):154-162
S5685 Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
Cell Death Dis, 2022, 13(6):521
Autophagy, 2021, 10.1080/15548627.2021.2008692
S5956 Dexamethasone phosphate disodium Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.
Cancers (Basel), 2022, 14(4)983
Pharmaceutics, 2022, 14(2)400
Dis Model Mech, 2022, dmm.049109
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
E0177New Hydrocortisone sodium succinate

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

S1322 Dexamethasone (MK-125) Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Cell Stem Cell, 2022, 29(4):545-558.e13
Blood, 2022, blood.2022016241
Hepatology, 2022, 10.1002/hep.32436
E1091New Relacorilant Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
S2606 Mifepristone (RU486) Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.
Nat Commun, 2021, 12(1):7041
Exp Eye Res, 2021, S0014-4835(21)00331-6
Oncol Rep, 2021, 46(3)202
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1286 Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Front Immunol, 2022, 13:882277
Int J Mol Sci, 2021, 22(14)7540
Sci Rep, 2020, 24;10(1):5363
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1622 Prednisone (NSC-10023) Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S1628 Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
J Inflamm Res, 2021, 14:843-858
Theranostics, 2020, 10(1):247-264
Drug Test Anal, 2020, 10.1002/dta.2917
S1669 Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1689 Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1696 Hydrocortisone (NSC 10483) Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.
Stem Cells Transl Med, 2022, 11(5):552-565
Reprod Toxicol, 2022, 111:68-80
Reprod Toxicol, 2022, S0890-6238(22)00068-5
S1701 Desonide Desonide is a low potency topical corticosteroid.
Drug Test Anal, 2020, 10.1002/dta.2917
S1733 Methylprednisolone (NSC-19987) Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S1737 Prednisolone (NSC-9900) Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
Ther Adv Hematol, 2020, 11:2040620719898373
S1888 Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Drug Test Anal, 2020, 10.1002/dta.2917
S1933 Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
Drug Test Anal, 2020, 10.1002/dta.2917
S1987 Mometasone furoate Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992 Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Nat Med, 2017, 23(4):424-428
S2470 Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S2559 Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S2570 Prednisolone Acetate Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
Int J Biol Sci, 2020, 16(13):2382-2391
S2584 Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Exp Ther Med, 2019, 18(2):1258-1266
S2608 Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S4088 Flumethasone Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Drug Test Anal, 2020, 10.1002/dta.2917
S4228 Fluorometholone Acetate Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4646 Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
mBio, 2022, 13(1):e0304421
Pharmaceutics, 2022, 14(7)1511
J Cell Biochem, 2022, 10.1002/jcb.30213
S4752 Corticosterone (NSC-9705) Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Proc Biol Sci, 2022, 289(1976):20220592
Behav Brain Res, 2021, 418:113647
Neuroscience, 2019, 411:11-22
S4775 Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S5184 Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.
Dis Model Mech, 2022, dmm.049109
Hematology, 2022, 27(1):32-42
S5486 Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
Drug Test Anal, 2020, 10.1002/dta.2917
S5489 Prednisone acetate Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
Blood Cancer J, 2022, 12(3):36
Front Immunol, 2021, 12:739605
J Immunotoxicol, 2021, 18(1):154-162
S5685 Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
Cell Death Dis, 2022, 13(6):521
Autophagy, 2021, 10.1080/15548627.2021.2008692
S5956 Dexamethasone phosphate disodium Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.
Cancers (Basel), 2022, 14(4)983
Pharmaceutics, 2022, 14(2)400
Dis Model Mech, 2022, dmm.049109
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
E0177New Hydrocortisone sodium succinate

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

E1091New Relacorilant Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
Tags: Glucocorticoid Receptor inhibitor|Glucocorticoid Receptor agonist|Glucocorticoid Receptor activator|Glucocorticoid Receptor inducer|Glucocorticoid Receptor antagonist|Glucocorticoid Receptor signaling pathway|Glucocorticoid Receptor assay kit