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Glucocorticoid Receptor Agonists | Antagonists | Chemicals
Glucocorticoid Receptor Products
- All (42)
- Glucocorticoid Receptor Antagonists (3)
- Glucocorticoid Receptor Agonists (37)
- New Glucocorticoid Receptor Products
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1322 | Dexamethasone | Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. |
|
|
| S4028 | Dexamethasone Sodium Phosphate | Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
|
|
| S1696 | Hydrocortisone | Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. It is a naturally occurring substance that plays a crucial role in various physiological processes. This compound is commonly used in medical treatments to reduce inflammation and suppress the immune system. The chemical can be administered in several forms, including topical creams, oral tablets, and injections. Its anti-inflammatory properties make it effective in managing conditions such as allergies, skin disorders, and autoimmune diseases. Additionally, this hormone is essential for maintaining blood pressure and blood sugar levels. | ||
| S2606 | Mifepristone | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. This compound promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.It can be used to induce animal models of Spontaneous Abortion. |
|
|
| S1737 | Prednisolone | Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. This compound is widely used in the treatment of various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation in the body. The efficacy of this medication has been well-documented in clinical studies. Patients prescribed this drug should follow their healthcare provider's instructions carefully to minimize potential side effects. |
|
|
| S5956 | Dexamethasone phosphate disodium | Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. | ||
| S2559 | Cortisone acetate | Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. | ||
| S1622 | Prednisone | Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. | ||
| S1286 | Budesonide | Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. | ||
| S4646 | Ciclesonide | Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. | ||
| S1992 | Fluticasone propionate | Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. | ||
| S1628 | Triamcinolone Acetonide | Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. This compound is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. | ||
| S2570 | Prednisolone Acetate | Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. | ||
| S1733 | Methylprednisolone | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis. |
|
|
| S5685 | Desoximetasone | Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. | ||
| S5489 | Prednisone acetate | Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. | ||
| S4088 | Flumethasone | Flumethasone (RS-2177, NSC-54702, Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. | ||
| S1701 | Desonide | Desonide is a low potency topical corticosteroid. | ||
| S5184 | Dexamethasone palmitate | Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. This compound exhibits anti-inflammatory activity. | ||
| S1888 | Deflazacort | Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. | ||
| S1500 | Betamethasone | Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. | ||
| S2584 | Clobetasol propionate | Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. | ||
| S1933 | Triamcinolone | Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. | ||
| S6608 | AL082D06 | AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. | ||
| S5486 | Fluorometholone | Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. | ||
| E1091 | Relacorilant (CORT125134) | Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. | ||
| F0479 | Glucocorticoid Receptor Antibody [D9N22] | Glucocorticoid Receptor,Glucocorticoid Receptor alpha,Glucocorticoid Receptor beta,GR/NR3C1/Glucocorticoid Receptor | ||
| S1669 | Loteprednol etabonate | Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. | ||
| S1987 | Mometasone furoate | Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. | ||
| S1689 | Meprednisone | Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. | ||
| S2470 | Fluocinolone Acetonide | Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. | ||
| S1688 | Betamethasone Dipropionate | Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. | ||
| S1690 | Betamethasone Valerate | Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. | ||
| S2608 | Fluocinonide | Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. | ||
| S3078 | Beclomethasone dipropionate | Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. | ||
| S3617 | (20S)-Protopanaxatriol | (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER). | ||
| S5973 | Methylprednisolone Acetate | Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. | ||
| S4752 | Corticosterone | Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. | ||
| S4228 | Fluorometholone Acetate | Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. | ||
| E4918 | BecloMethasone | Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis. | ||
| S4775 | Cortodoxone | Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. | ||
| E0177 | Hydrocortisone sodium succinate | Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. This compound can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators. |
||
| S2606 | Mifepristone | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. This compound promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.It can be used to induce animal models of Spontaneous Abortion. |
|
|
| S6608 | AL082D06 | AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. | ||
| E1091 | Relacorilant (CORT125134) | Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. | ||
| S1322 | Dexamethasone | Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. |
|
|
| S4028 | Dexamethasone Sodium Phosphate | Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
|
|
| S1696 | Hydrocortisone | Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. It is a naturally occurring substance that plays a crucial role in various physiological processes. This compound is commonly used in medical treatments to reduce inflammation and suppress the immune system. The chemical can be administered in several forms, including topical creams, oral tablets, and injections. Its anti-inflammatory properties make it effective in managing conditions such as allergies, skin disorders, and autoimmune diseases. Additionally, this hormone is essential for maintaining blood pressure and blood sugar levels. | ||
| S1737 | Prednisolone | Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. This compound is widely used in the treatment of various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation in the body. The efficacy of this medication has been well-documented in clinical studies. Patients prescribed this drug should follow their healthcare provider's instructions carefully to minimize potential side effects. |
|
|
| S5956 | Dexamethasone phosphate disodium | Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. | ||
| S2559 | Cortisone acetate | Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. | ||
| S1622 | Prednisone | Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. | ||
| S1286 | Budesonide | Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. | ||
| S4646 | Ciclesonide | Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. | ||
| S1992 | Fluticasone propionate | Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. | ||
| S1628 | Triamcinolone Acetonide | Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. This compound is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. | ||
| S2570 | Prednisolone Acetate | Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. | ||
| S1733 | Methylprednisolone | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis. |
|
|
| S5685 | Desoximetasone | Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. | ||
| S5489 | Prednisone acetate | Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. | ||
| S4088 | Flumethasone | Flumethasone (RS-2177, NSC-54702, Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. | ||
| S1701 | Desonide | Desonide is a low potency topical corticosteroid. | ||
| S5184 | Dexamethasone palmitate | Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. This compound exhibits anti-inflammatory activity. | ||
| S1888 | Deflazacort | Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. | ||
| S1500 | Betamethasone | Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. | ||
| S2584 | Clobetasol propionate | Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. | ||
| S1933 | Triamcinolone | Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. | ||
| S5486 | Fluorometholone | Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. | ||
| S1669 | Loteprednol etabonate | Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. | ||
| S1987 | Mometasone furoate | Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. | ||
| S1689 | Meprednisone | Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. | ||
| S2470 | Fluocinolone Acetonide | Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. | ||
| S1688 | Betamethasone Dipropionate | Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. | ||
| S1690 | Betamethasone Valerate | Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. | ||
| S2608 | Fluocinonide | Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. | ||
| S3078 | Beclomethasone dipropionate | Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. | ||
| S3617 | (20S)-Protopanaxatriol | (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER). | ||
| S5973 | Methylprednisolone Acetate | Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. | ||
| S4752 | Corticosterone | Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. | ||
| S4228 | Fluorometholone Acetate | Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. | ||
| E4918 | BecloMethasone | Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis. | ||
| S4775 | Cortodoxone | Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
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