Glucocorticoid Receptor

Glucocorticoid Receptor Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1322 Dexamethasone Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Cell Host Microbe, 2024, S1931-3128(24)00005-2
Oncogene, 2024, 43(4):235-247
bioRxiv, 2024, 2024.01.29.577409
S4028 Dexamethasone Sodium Phosphate Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Pharmaceutics, 2022, 14(2)400
Front Oncol, 2022, 12:888695
Sci Rep, 2022, 12(1):10616
S1696 Hydrocortisone Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
Neurobiol Stress, 2024, 28:100593
Nature, 2023, 620(7974):607-614
Cell Rep, 2023, 10.1016/j.celrep.2023.113343
S2606 Mifepristone Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.
Cell Death Dis, 2024, 15(1):70
Oncogene, 2024, 43(4):235-247
Neurobiol Stress, 2024, 28:100593
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Life Sci Alliance, 2023, 6(10)e202302009
Life Sci Alliance, 2023, 6(10)e202302009
Front Oncol, 2022, 12:905665
S5956 Dexamethasone phosphate disodium Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.
Cell Rep, 2023, 42(6):112566
Blood Adv, 2023, 7(4):469-481
Heliyon, 2023, 9(3):e14006
S2559 Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S1622 Prednisone Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S1286 Budesonide Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Front Immunol, 2023, 14:1097383
Front Immunol, 2023, 14:1097383
Front Immunol, 2022, 13:882277
S4646 Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736
mBio, 2022, 13(1):e0304421
Pharmaceutics, 2022, 14(7)1511
S1992 Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Cell Rep Methods, 2023, 3(4):100440
Cell Reports Methods, 2023, 10.1016/j.crmeth.2023.100440
Arch Immunol Ther Exp (Warsz), 2022, 71(1):1
S1628 Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
J Transl Med, 2022, 20(1):561
J Inflamm Res, 2021, 14:843-858
Theranostics, 2020, 10(1):247-264
S2570 Prednisolone Acetate Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
Oncogene, 2024, 43(4):235-247
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S1733 Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S5685 Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
Free Radic Biol Med, 2023, 203:1-10
Cell Death Dis, 2022, 13(6):521
Autophagy, 2021, 10.1080/15548627.2021.2008692
S5489 Prednisone acetate Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
Blood Cancer J, 2022, 12(3):36
Front Immunol, 2021, 12:739605
J Immunotoxicol, 2021, 18(1):154-162
S4088 Flumethasone Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Elife, 2023, 12e82249
Drug Test Anal, 2020, 10.1002/dta.2917
S1701 Desonide Desonide is a low potency topical corticosteroid.
Nat Commun, 2022, 13(1):4109
Drug Test Anal, 2020, 10.1002/dta.2917
S5184 Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.
Dis Model Mech, 2022, dmm.049109
Hematology, 2022, 27(1):32-42
S1888 Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Drug Test Anal, 2020, 10.1002/dta.2917
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S2584 Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Exp Ther Med, 2019, 18(2):1258-1266
S1933 Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
Gastroenterology, 2024, S0016-5085(24)00062-3
Drug Test Anal, 2020, 10.1002/dta.2917
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
Int J Mol Sci, 2023, 24(14)11700
S5486 Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
Drug Test Anal, 2020, 10.1002/dta.2917
E1091 Relacorilant (CORT125134) Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3
S1669 Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987 Mometasone furoate Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1689 Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S2470 Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2608 Fluocinonide Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S4752 Corticosterone Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Gen Psychiatr, 2024, 37(1):e101291
Front Endocrinol -Lausanne), 2022, 13:951928
Proc Biol Sci, 2022, 289(1976):20220592
S4228 Fluorometholone Acetate Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775 Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
E0177 Hydrocortisone sodium succinate

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

S1322 Dexamethasone Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Cell Host Microbe, 2024, S1931-3128(24)00005-2
Oncogene, 2024, 43(4):235-247
bioRxiv, 2024, 2024.01.29.577409
S2606 Mifepristone Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.
Cell Death Dis, 2024, 15(1):70
Oncogene, 2024, 43(4):235-247
Neurobiol Stress, 2024, 28:100593
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
Int J Mol Sci, 2023, 24(14)11700
E1091 Relacorilant (CORT125134) Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3
S4028 Dexamethasone Sodium Phosphate Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Pharmaceutics, 2022, 14(2)400
Front Oncol, 2022, 12:888695
Sci Rep, 2022, 12(1):10616
S1696 Hydrocortisone Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
Neurobiol Stress, 2024, 28:100593
Nature, 2023, 620(7974):607-614
Cell Rep, 2023, 10.1016/j.celrep.2023.113343
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Life Sci Alliance, 2023, 6(10)e202302009
Life Sci Alliance, 2023, 6(10)e202302009
Front Oncol, 2022, 12:905665
S5956 Dexamethasone phosphate disodium Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.
Cell Rep, 2023, 42(6):112566
Blood Adv, 2023, 7(4):469-481
Heliyon, 2023, 9(3):e14006
S2559 Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S1622 Prednisone Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S1286 Budesonide Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Front Immunol, 2023, 14:1097383
Front Immunol, 2023, 14:1097383
Front Immunol, 2022, 13:882277
S4646 Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736
mBio, 2022, 13(1):e0304421
Pharmaceutics, 2022, 14(7)1511
S1992 Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Cell Rep Methods, 2023, 3(4):100440
Cell Reports Methods, 2023, 10.1016/j.crmeth.2023.100440
Arch Immunol Ther Exp (Warsz), 2022, 71(1):1
S1628 Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
J Transl Med, 2022, 20(1):561
J Inflamm Res, 2021, 14:843-858
Theranostics, 2020, 10(1):247-264
S2570 Prednisolone Acetate Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
Oncogene, 2024, 43(4):235-247
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S1733 Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S5685 Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
Free Radic Biol Med, 2023, 203:1-10
Cell Death Dis, 2022, 13(6):521
Autophagy, 2021, 10.1080/15548627.2021.2008692
S5489 Prednisone acetate Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
Blood Cancer J, 2022, 12(3):36
Front Immunol, 2021, 12:739605
J Immunotoxicol, 2021, 18(1):154-162
S4088 Flumethasone Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Elife, 2023, 12e82249
Drug Test Anal, 2020, 10.1002/dta.2917
S1701 Desonide Desonide is a low potency topical corticosteroid.
Nat Commun, 2022, 13(1):4109
Drug Test Anal, 2020, 10.1002/dta.2917
S5184 Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.
Dis Model Mech, 2022, dmm.049109
Hematology, 2022, 27(1):32-42
S1888 Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Drug Test Anal, 2020, 10.1002/dta.2917
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S2584 Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Exp Ther Med, 2019, 18(2):1258-1266
S1933 Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
Gastroenterology, 2024, S0016-5085(24)00062-3
Drug Test Anal, 2020, 10.1002/dta.2917
S5486 Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
Drug Test Anal, 2020, 10.1002/dta.2917
S1669 Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987 Mometasone furoate Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1689 Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S2470 Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2608 Fluocinonide Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S4752 Corticosterone Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Gen Psychiatr, 2024, 37(1):e101291
Front Endocrinol -Lausanne), 2022, 13:951928
Proc Biol Sci, 2022, 289(1976):20220592
S4228 Fluorometholone Acetate Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775 Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

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