Glucocorticoid Receptor

Inhibitory Selectivity

Glucocorticoid Receptor Products

All (31) Glucocorticoid Receptor Antagonists (1) Glucocorticoid Receptor Agonists (30) New Glucocorticoid Receptor Products

Catalog No.	Information	Product Use Citations	Product Validations
S6608^New	AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1696	Hydrocortisone (cortisol) Hydrocortisone (cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Biochem Pharmacol, 2020, 175:113865 Cell Oncol (Dordr), 2019, 42(4):459-475 J Virol, 2019, 93(7)
S1737	Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	Ther Adv Hematol, 2020, 11:2040620719898373 Elife, 2019, 8 Int J Mol Sci, 2019, 20(23)	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987	Mometasone furoate Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.	Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
S1628	Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
S1689	Meprednisone Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
S1888	Deflazacort Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
S2470	Fluocinolone Acetonide Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688	Betamethasone Dipropionate Betamethasone Dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690	Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2570	Prednisolone Acetate Prednisolone Acetate is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S4088	Flumethasone Flumethasone is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
S1701	Desonide Desonide is a low potency topical corticosteroid.
S2608	Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S2584	Clobetasol propionate Clobetasol propionate is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
S3078	Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S2559	Cortisone acetate Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
S5685	Desoximetasone Desoximetasone is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
S4752	Corticosterone Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.
S5486	Fluorometholone Fluorometholone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
S4228	Fluorometholone Acetate Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775	Cortodoxone Cortodoxone, also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

Catalog No.

Information

Product Use Citations

Product Validations

S6608^New

AL082D06

AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

Catalog No.	Information	Product Use Citations	Product Validations
S1696	Hydrocortisone (cortisol) Hydrocortisone (cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Biochem Pharmacol, 2020, 175:113865 Cell Oncol (Dordr), 2019, 42(4):459-475 J Virol, 2019, 93(7)
S1737	Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	Ther Adv Hematol, 2020, 11:2040620719898373 Elife, 2019, 8 Int J Mol Sci, 2019, 20(23)	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987	Mometasone furoate Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.	Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
S1628	Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
S1689	Meprednisone Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
S1888	Deflazacort Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
S2470	Fluocinolone Acetonide Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688	Betamethasone Dipropionate Betamethasone Dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690	Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2570	Prednisolone Acetate Prednisolone Acetate is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S4088	Flumethasone Flumethasone is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
S1701	Desonide Desonide is a low potency topical corticosteroid.
S2608	Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S2584	Clobetasol propionate Clobetasol propionate is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
S3078	Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S2559	Cortisone acetate Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
S5685	Desoximetasone Desoximetasone is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
S4752	Corticosterone Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.
S5486	Fluorometholone Fluorometholone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
S4228	Fluorometholone Acetate Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775	Cortodoxone Cortodoxone, also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

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Glucocorticoid Receptor

Inhibitory Selectivity

Glucocorticoid Receptor Products