E0177New |
Hydrocortisone sodium succinate
|
Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
|
|
|
S1322 |
Dexamethasone (MK-125)
|
Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. |
-
Cell Stem Cell, 2022, 29(4):545-558.e13
-
Blood, 2022, blood.2022016241
-
Hepatology, 2022, 10.1002/hep.32436
|
|
E1091New |
Relacorilant
|
Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. |
|
|
S2606 |
Mifepristone (RU486)
|
Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. |
-
Nat Commun, 2021, 12(1):7041
-
Exp Eye Res, 2021, S0014-4835(21)00331-6
-
Oncol Rep, 2021, 46(3)202
|
|
S6608 |
AL082D06
|
AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. |
|
|
S1286 |
Budesonide
|
Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. |
-
Front Immunol, 2022, 13:882277
-
Int J Mol Sci, 2021, 22(14)7540
-
Sci Rep, 2020, 24;10(1):5363
|
|
S1500 |
Betamethasone
|
Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S1622 |
Prednisone (NSC-10023)
|
Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. |
-
Blood Cancer J, 2022, 12(3):36
-
Int J Mol Sci, 2022, 23(7)3834
-
Front Immunol, 2021, 12:739605
|
|
S1628 |
Triamcinolone Acetonide
|
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. |
-
J Inflamm Res, 2021, 14:843-858
-
Theranostics, 2020, 10(1):247-264
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1669 |
Loteprednol etabonate
|
Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. |
|
|
S1688 |
Betamethasone Dipropionate
|
Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. |
|
|
S1689 |
Meprednisone
|
Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
|
|
S1690 |
Betamethasone Valerate
|
Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S1696 |
Hydrocortisone (NSC 10483)
|
Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland. |
-
Stem Cells Transl Med, 2022, 11(5):552-565
-
Reprod Toxicol, 2022, 111:68-80
-
Reprod Toxicol, 2022, S0890-6238(22)00068-5
|
|
S1701 |
Desonide
|
Desonide is a low potency topical corticosteroid. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1733 |
Methylprednisolone (NSC-19987)
|
Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
-
Nat Med, 2017, 23(4):424-428
-
Trop J Pharm Res, 2014, 13 (1): 53-59
|
|
S1737 |
Prednisolone (NSC-9900)
|
Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
-
J Immunotoxicol, 2021, 18(1):154-162
-
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
-
Ther Adv Hematol, 2020, 11:2040620719898373
|
|
S1888 |
Deflazacort
|
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1933 |
Triamcinolone
|
Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1987 |
Mometasone furoate
|
Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
|
|
S1992 |
Fluticasone propionate
|
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
-
Nat Med, 2017, 23(4):424-428
|
|
S2470 |
Fluocinolone Acetonide
|
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
|
|
S2559 |
Cortisone acetate
|
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
-
Hum Cell, 2021, 10.1007/s13577-021-00579-z
|
|
S2570 |
Prednisolone Acetate
|
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. |
-
J Immunotoxicol, 2021, 18(1):154-162
-
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
-
Int J Biol Sci, 2020, 16(13):2382-2391
|
|
S2584 |
Clobetasol propionate
|
Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. |
-
Exp Ther Med, 2019, 18(2):1258-1266
|
|
S2608 |
Fluocinonide
|
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
|
|
S3078 |
Beclomethasone dipropionate
|
Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. |
|
|
S3617 |
(20S)-Protopanaxatriol
|
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER). |
|
|
S4088 |
Flumethasone
|
Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S4228 |
Fluorometholone Acetate
|
Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
|
|
S4646 |
Ciclesonide
|
Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. |
-
mBio, 2022, 13(1):e0304421
-
Pharmaceutics, 2022, 14(7)1511
-
J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S4752 |
Corticosterone (NSC-9705)
|
Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. |
-
Proc Biol Sci, 2022, 289(1976):20220592
-
Behav Brain Res, 2021, 418:113647
-
Neuroscience, 2019, 411:11-22
|
|
S4775 |
Cortodoxone
|
Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
|
|
S5184 |
Dexamethasone palmitate
|
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
-
Dis Model Mech, 2022, dmm.049109
-
Hematology, 2022, 27(1):32-42
|
|
S5486 |
Fluorometholone
|
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5489 |
Prednisone acetate
|
Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. |
-
Blood Cancer J, 2022, 12(3):36
-
Front Immunol, 2021, 12:739605
-
J Immunotoxicol, 2021, 18(1):154-162
|
|
S5685 |
Desoximetasone
|
Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
-
Cell Death Dis, 2022, 13(6):521
-
Autophagy, 2021, 10.1080/15548627.2021.2008692
|
|
S5956 |
Dexamethasone phosphate disodium
|
Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
-
Cancers (Basel), 2022, 14(4)983
-
Pharmaceutics, 2022, 14(2)400
-
Dis Model Mech, 2022, dmm.049109
|
|
S5973 |
Methylprednisolone Acetate
|
Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
|
|
S1286 |
Budesonide
|
Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. |
- Front Immunol, 2022, 13:882277
- Int J Mol Sci, 2021, 22(14)7540
- Sci Rep, 2020, 24;10(1):5363
|
|
S1500 |
Betamethasone
|
Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S1622 |
Prednisone (NSC-10023)
|
Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. |
- Blood Cancer J, 2022, 12(3):36
- Int J Mol Sci, 2022, 23(7)3834
- Front Immunol, 2021, 12:739605
|
|
S1628 |
Triamcinolone Acetonide
|
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. |
- J Inflamm Res, 2021, 14:843-858
- Theranostics, 2020, 10(1):247-264
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1669 |
Loteprednol etabonate
|
Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. |
|
|
S1688 |
Betamethasone Dipropionate
|
Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. |
|
|
S1689 |
Meprednisone
|
Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
|
|
S1690 |
Betamethasone Valerate
|
Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S1696 |
Hydrocortisone (NSC 10483)
|
Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland. |
- Stem Cells Transl Med, 2022, 11(5):552-565
- Reprod Toxicol, 2022, 111:68-80
- Reprod Toxicol, 2022, S0890-6238(22)00068-5
|
|
S1701 |
Desonide
|
Desonide is a low potency topical corticosteroid. |
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1733 |
Methylprednisolone (NSC-19987)
|
Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
- Drug Test Anal, 2020, 10.1002/dta.2917
- Nat Med, 2017, 23(4):424-428
- Trop J Pharm Res, 2014, 13 (1): 53-59
|
|
S1737 |
Prednisolone (NSC-9900)
|
Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
- J Immunotoxicol, 2021, 18(1):154-162
- Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
- Ther Adv Hematol, 2020, 11:2040620719898373
|
|
S1888 |
Deflazacort
|
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1933 |
Triamcinolone
|
Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. |
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1987 |
Mometasone furoate
|
Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
|
|
S1992 |
Fluticasone propionate
|
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
- Nat Med, 2017, 23(4):424-428
|
|
S2470 |
Fluocinolone Acetonide
|
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
|
|
S2559 |
Cortisone acetate
|
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 34(6):1911-1918
- Hum Cell, 2021, 10.1007/s13577-021-00579-z
|
|
S2570 |
Prednisolone Acetate
|
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. |
- J Immunotoxicol, 2021, 18(1):154-162
- Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
- Int J Biol Sci, 2020, 16(13):2382-2391
|
|
S2584 |
Clobetasol propionate
|
Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. |
- Exp Ther Med, 2019, 18(2):1258-1266
|
|
S2608 |
Fluocinonide
|
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
|
|
S3078 |
Beclomethasone dipropionate
|
Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. |
|
|
S3617 |
(20S)-Protopanaxatriol
|
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER). |
|
|
S4088 |
Flumethasone
|
Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S4228 |
Fluorometholone Acetate
|
Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
|
|
S4646 |
Ciclesonide
|
Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. |
- mBio, 2022, 13(1):e0304421
- Pharmaceutics, 2022, 14(7)1511
- J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S4752 |
Corticosterone (NSC-9705)
|
Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. |
- Proc Biol Sci, 2022, 289(1976):20220592
- Behav Brain Res, 2021, 418:113647
- Neuroscience, 2019, 411:11-22
|
|
S4775 |
Cortodoxone
|
Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
|
|
S5184 |
Dexamethasone palmitate
|
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
- Dis Model Mech, 2022, dmm.049109
- Hematology, 2022, 27(1):32-42
|
|
S5486 |
Fluorometholone
|
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5489 |
Prednisone acetate
|
Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. |
- Blood Cancer J, 2022, 12(3):36
- Front Immunol, 2021, 12:739605
- J Immunotoxicol, 2021, 18(1):154-162
|
|
S5685 |
Desoximetasone
|
Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
- Cell Death Dis, 2022, 13(6):521
- Autophagy, 2021, 10.1080/15548627.2021.2008692
|
|
S5956 |
Dexamethasone phosphate disodium
|
Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
- Cancers (Basel), 2022, 14(4)983
- Pharmaceutics, 2022, 14(2)400
- Dis Model Mech, 2022, dmm.049109
|
|
S5973 |
Methylprednisolone Acetate
|
Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
|
|