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Glucocorticoid Receptor

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Glucocorticoid Receptor Products

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Glucocorticoid Receptor Inhibitors (2)
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Glucocorticoid Receptor Agonists (34)
New Glucocorticoid Receptor Products

Catalog No.	Product Name	Information	Product Use Citations
E0177^New	Hydrocortisone sodium succinate	Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
S1322	Dexamethasone (MK-125)	Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.	Cell Stem Cell, 2022, 29(4):545-558.e13 Blood, 2022, blood.2022016241 Hepatology, 2022, 10.1002/hep.32436
E1091^New	Relacorilant	Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
S2606	Mifepristone (RU486)	Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.	Nat Commun, 2021, 12(1):7041 Exp Eye Res, 2021, S0014-4835(21)00331-6 Oncol Rep, 2021, 46(3)202
S6608	AL082D06	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1286	Budesonide	Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.	Front Immunol, 2022, 13:882277 Int J Mol Sci, 2021, 22(14)7540 Sci Rep, 2020, 24;10(1):5363
S1500	Betamethasone	Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1622	Prednisone (NSC-10023)	Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	Blood Cancer J, 2022, 12(3):36 Int J Mol Sci, 2022, 23(7)3834 Front Immunol, 2021, 12:739605
S1628	Triamcinolone Acetonide	Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.	J Inflamm Res, 2021, 14:843-858 Theranostics, 2020, 10(1):247-264 Drug Test Anal, 2020, 10.1002/dta.2917
S1669	Loteprednol etabonate	Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1688	Betamethasone Dipropionate	Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1689	Meprednisone	Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690	Betamethasone Valerate	Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1696	Hydrocortisone (NSC 10483)	Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Stem Cells Transl Med, 2022, 11(5):552-565 Reprod Toxicol, 2022, 111:68-80 Reprod Toxicol, 2022, S0890-6238(22)00068-5
S1701	Desonide	Desonide is a low potency topical corticosteroid.	Drug Test Anal, 2020, 10.1002/dta.2917
S1733	Methylprednisolone (NSC-19987)	Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.	Drug Test Anal, 2020, 10.1002/dta.2917 Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59
S1737	Prednisolone (NSC-9900)	Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054 Ther Adv Hematol, 2020, 11:2040620719898373
S1888	Deflazacort	Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.	Drug Test Anal, 2020, 10.1002/dta.2917
S1933	Triamcinolone	Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.	Drug Test Anal, 2020, 10.1002/dta.2917
S1987	Mometasone furoate	Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate	Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S2470	Fluocinolone Acetonide	Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S2559	Cortisone acetate	Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S2570	Prednisolone Acetate	Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054 Int J Biol Sci, 2020, 16(13):2382-2391
S2584	Clobetasol propionate	Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S2608	Fluocinonide	Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078	Beclomethasone dipropionate	Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S4088	Flumethasone	Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.	Drug Test Anal, 2020, 10.1002/dta.2917
S4228	Fluorometholone Acetate	Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4646	Ciclesonide	Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.	mBio, 2022, 13(1):e0304421 Pharmaceutics, 2022, 14(7)1511 J Cell Biochem, 2022, 10.1002/jcb.30213
S4752	Corticosterone (NSC-9705)	Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Proc Biol Sci, 2022, 289(1976):20220592 Behav Brain Res, 2021, 418:113647 Neuroscience, 2019, 411:11-22
S4775	Cortodoxone	Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S5184	Dexamethasone palmitate	Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S5486	Fluorometholone	Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.	Drug Test Anal, 2020, 10.1002/dta.2917
S5489	Prednisone acetate	Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.	Blood Cancer J, 2022, 12(3):36 Front Immunol, 2021, 12:739605 J Immunotoxicol, 2021, 18(1):154-162
S5685	Desoximetasone	Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.	Cell Death Dis, 2022, 13(6):521 Autophagy, 2021, 10.1080/15548627.2021.2008692
S5956	Dexamethasone phosphate disodium	Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.	Cancers (Basel), 2022, 14(4)983 Pharmaceutics, 2022, 14(2)400 Dis Model Mech, 2022, dmm.049109
S5973	Methylprednisolone Acetate	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
E0177^New	Hydrocortisone sodium succinate	Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
S1322	Dexamethasone (MK-125)	Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.	Cell Stem Cell, 2022, 29(4):545-558.e13 Blood, 2022, blood.2022016241 Hepatology, 2022, 10.1002/hep.32436
E1091^New	Relacorilant	Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
S2606	Mifepristone (RU486)	Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.	Nat Commun, 2021, 12(1):7041 Exp Eye Res, 2021, S0014-4835(21)00331-6 Oncol Rep, 2021, 46(3)202
S6608	AL082D06	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1286	Budesonide	Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.	Front Immunol, 2022, 13:882277 Int J Mol Sci, 2021, 22(14)7540 Sci Rep, 2020, 24;10(1):5363
S1500	Betamethasone	Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1622	Prednisone (NSC-10023)	Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	Blood Cancer J, 2022, 12(3):36 Int J Mol Sci, 2022, 23(7)3834 Front Immunol, 2021, 12:739605
S1628	Triamcinolone Acetonide	Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.	J Inflamm Res, 2021, 14:843-858 Theranostics, 2020, 10(1):247-264 Drug Test Anal, 2020, 10.1002/dta.2917
S1669	Loteprednol etabonate	Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1688	Betamethasone Dipropionate	Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1689	Meprednisone	Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690	Betamethasone Valerate	Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S1696	Hydrocortisone (NSC 10483)	Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Stem Cells Transl Med, 2022, 11(5):552-565 Reprod Toxicol, 2022, 111:68-80 Reprod Toxicol, 2022, S0890-6238(22)00068-5
S1701	Desonide	Desonide is a low potency topical corticosteroid.	Drug Test Anal, 2020, 10.1002/dta.2917
S1733	Methylprednisolone (NSC-19987)	Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.	Drug Test Anal, 2020, 10.1002/dta.2917 Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59
S1737	Prednisolone (NSC-9900)	Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054 Ther Adv Hematol, 2020, 11:2040620719898373
S1888	Deflazacort	Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.	Drug Test Anal, 2020, 10.1002/dta.2917
S1933	Triamcinolone	Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.	Drug Test Anal, 2020, 10.1002/dta.2917
S1987	Mometasone furoate	Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate	Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S2470	Fluocinolone Acetonide	Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S2559	Cortisone acetate	Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S2570	Prednisolone Acetate	Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054 Int J Biol Sci, 2020, 16(13):2382-2391
S2584	Clobetasol propionate	Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S2608	Fluocinonide	Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078	Beclomethasone dipropionate	Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S4088	Flumethasone	Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.	Drug Test Anal, 2020, 10.1002/dta.2917
S4228	Fluorometholone Acetate	Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4646	Ciclesonide	Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.	mBio, 2022, 13(1):e0304421 Pharmaceutics, 2022, 14(7)1511 J Cell Biochem, 2022, 10.1002/jcb.30213
S4752	Corticosterone (NSC-9705)	Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Proc Biol Sci, 2022, 289(1976):20220592 Behav Brain Res, 2021, 418:113647 Neuroscience, 2019, 411:11-22
S4775	Cortodoxone	Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S5184	Dexamethasone palmitate	Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S5486	Fluorometholone	Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.	Drug Test Anal, 2020, 10.1002/dta.2917
S5489	Prednisone acetate	Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.	Blood Cancer J, 2022, 12(3):36 Front Immunol, 2021, 12:739605 J Immunotoxicol, 2021, 18(1):154-162
S5685	Desoximetasone	Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.	Cell Death Dis, 2022, 13(6):521 Autophagy, 2021, 10.1080/15548627.2021.2008692
S5956	Dexamethasone phosphate disodium	Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.	Cancers (Basel), 2022, 14(4)983 Pharmaceutics, 2022, 14(2)400 Dis Model Mech, 2022, dmm.049109
S5973	Methylprednisolone Acetate	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
E0177^New	Hydrocortisone sodium succinate	Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
E1091^New	Relacorilant	Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.