Chloride Channel
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S8279 | Shikonin | <1 mg/mL | 57 mg/mL | 23 mg/mL |
| S3807 | Dehydroandrographolide | -1 mg/mL | 66 mg/mL | -1 mg/mL |
| S1675 | Lubiprostone | <1 mg/mL | 78 mg/mL | 78 mg/mL |
| S1351 | Ivermectin | <1 mg/mL | 100 mg/mL | 28 mg/mL |
Chloride Channel Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8279 |
ShikoninShikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. |
||
| S3807 |
DehydroandrographolideDehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. |
||
| S1675 |
LubiprostoneLubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation. |
||
| S1351 |
IvermectinIvermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8279 |
ShikoninShikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. |
||
| S3807 |
DehydroandrographolideDehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1675 |
LubiprostoneLubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation. |
||
| S1351 |
IvermectinIvermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. |
2019, 10(2):118 |
