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Chloride Channel

Other Transmembrane Transporters Related Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
S1351 Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. This compound is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). It is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. This chemical induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
JHEP Rep, 2026, S2589-5559(26)00116-3
Nat Commun, 2025, 16(1):7156
J Adv Res, 2025, S2090-1232(25)00874-4
S1698 Torsemide Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
J Immunother Cancer, 2024, 12(11)e009805
Cell Chem Biol, 2021, S2451-9456(21)00442-6
S0454 Adjudin Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. This compound exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
Brain Res Bull, 2022, 182:80-89
Brain Research Bulletin, 2022, 80-89
S1203 T16Ainh-A01

T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of 1.8 μM.
Adipocyte, 2026, 15(1):2649662
S1675 Lubiprostone Lububiprostone (RU 0211,SPI-0211) is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.
E4665 NMD670 NMD670 is a first-in-class small molecule inhibitor of skeletal muscle-specific chloride channel (ClC-1) with an EC50 of 1.6 μM. It improves muscle weakness and fatigue in neuromuscular diseases and may serve as a potential therapeutic approach for Myasthenia Gravis (MG).
E7830 R(+)-Methylindazone R(+)-Methylindazone (R(+)-IAA-94) is a potentand specific indanyloxyacetic inhibitor of the renal epithelial chloride channel and exacerbates myocardial infarction by impairing mitochondrial calcium retention capacity (CRC), leading to mitochondrial permeability transition pore (mPTP) opening and increased cell death during ischemia-reperfusion injury.
S3264 Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. This compound inhibits chloride channels from mitochondrial membranes of rat heart.
S0125 CaCCinh-A01 CaCCinh-A01 (TMEM16 Blocker I) is a blocker of TMEM16A with IC50 of 2.1 μM. This compound is also an inhibitor of calcium-activated chloride channel (CaCC) with IC50 of ~ 10 μM.
S3807 Dehydroandrographolide Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.