Chloride Channel

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8279 Shikonin <1 mg/mL 57 mg/mL 23 mg/mL
S3807 Dehydroandrographolide -1 mg/mL 66 mg/mL -1 mg/mL
S1675 Lubiprostone <1 mg/mL 78 mg/mL 78 mg/mL
S1351 Ivermectin <1 mg/mL 100 mg/mL 28 mg/mL
Catalog No. Information Product Use Citations Product Validations


Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay.



Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.



Lubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.



Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

Tags: Chloride Channel inhibitor | Chloride Channel activator | Chloride Channel blocker