Chloride Channel

Inhibitory Selectivity

Chloride Channel Products

Catalog No. Information Product Use Citations Product Validations
S8279

Shikonin

Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay.

S3807

Dehydroandrographolide

Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.

S1675

Lubiprostone

Lubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.

S1351

Ivermectin

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

Catalog No. Information Product Use Citations Product Validations
S8279

Shikonin

Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay.

S3807

Dehydroandrographolide

Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.

Catalog No. Information Product Use Citations Product Validations
S1675

Lubiprostone

Lubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.

S1351

Ivermectin

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

Tags: Chloride Channel inhibitor | Chloride Channel activator | Chloride Channel blocker