For research use only.

Catalog No.S8134 Synonyms: IY-5511

1 publication

Radotinib Chemical Structure

Molecular Weight(MW): 530.50

Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.

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Selleck's Radotinib has been cited by 1 publication

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Biological Activity

Description Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.
BCR-ABL1 [1]
34 nM
In vitro

In vitro, Radotinib binds BCR-ABL1 and reduces phosphorylation of CrkL, a BCR-ABL1 target protein. Radotinib also effectively inhibits the proliferation of common mutant clones of BCR-ABL1, with the exception of T315I. [1] In AML cells, radotinib significantly decreases the cell viability, promotes differentiation, and induces CD11b expression and apoptosis. In NB4, THP-1, and Kasumi-1 cells, radotinib also induces CD11b expression, and decreases the viability. [2]


Cell Research:[2]
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  • Cell lines: BMCs of AML and CML patients, NB4, HL60, KASUMI-1, and THP-1 cells
  • Concentrations: ~100 μM
  • Incubation Time: 72 h
  • Method: Cells are seeded in 96-well plates at a density of 2×104 cells/ml with 100 μL of medium per well and then incubated with various concentrations of radotinib (0, 1, 10, and 100 μM) for 72 h at 37°C. The CellTiter 96 solution (20 μL) is added directly to each well and plates are incubated for 4 h in a humidified 5% CO2 atmosphere at 37°C. Absorbance is measured with a PowerWave XS2 Microplate Spectrophotometer at 490 nm and the results are expressed as percentage changes from the basal condition using four to five culture wells for each experimental treatment. In some experiments, HL60 cells are cultured with 100 nM ATRA and 1 μM dasatinib for 4 days, and 10 μM radotinib is added to each group according to the planned schedule
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (188.5 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 530.50


CAS No. 926037-48-1
Storage powder
in solvent
Synonyms IY-5511
Smiles CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=NC=CN=C5

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID