Home Apoptosis -DNA Damage/DNA Repair MDM2/MDMX p53-MDM2-interaction Inhibitors | Antagonists

p53-MDM2-interaction Inhibitors | Antagonists

  • MDM2
  • MDMX
  • p53-MDM2 interaction
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8606 Siremadlin (HDM201) Siremadlin (HDM201) is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. Pan
S7205 Idasanutlin (RG7388) Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity. Pan p53-MDM2 interaction, IC50: 6 nM
S7030 RG-7112 RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM. Pan p53-MDM2 interaction, IC50: 18 nM
S8059 Nutlin-3a Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner. Pan p53-MDM2 interaction, IC50: 90 nM
S7489 YH239-EE YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. Pan