Home Apoptosis MDM2/MDMX antagonist YH239-EE

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YH239-EE MDM2/MDMX antagonist

Cat.No.S7489

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
YH239-EE MDM2/MDMX antagonist Chemical Structure

Chemical Structure

Molecular Weight: 504.41

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Quality Control

Batch: S748901 DMSO]100 mg/mL]false]Ethanol]18 mg/mL]false]Water]Insoluble]false Purity: 99.88%
99.88

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (198.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 504.41 Formula

C25H27Cl2N3O4

 Storage (From the date of receipt)
CAS No. 1364488-67-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O

Mechanism of Action

Targets/IC50/Ki
p53-MDM2 interaction
In vitro
YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. This compound induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
References

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