Torsemide

For research use only.

Catalog No.S1698 Synonyms: AC-4464, JDL-464

Torsemide  Chemical Structure

CAS No. 56211-40-6

Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.

Purity & Quality Control

Choose Selective Chloride Channel Inhibitors

Biological Activity

Description Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
Targets
Cl- channel [1]
In vitro

Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. [1] Torsemide's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. Torsemide interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. [2]

In vivo Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only. [2] Torsemide increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. Torsemide immediately increases urine volume significantly. [3]

Protocol

Solubility (25°C)

In vitro DMSO 3 mg/mL warmed (8.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.42
Formula

C16H20N4O3S

CAS No. 56211-40-6
Storage powder
in solvent
Synonyms AC-4464, JDL-464
Smiles CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID