Choose Your Country or Region

Proton Pump

Proton Pump Products

All (22)
Proton Pump Inhibitors (22)
New Proton Pump Products

Catalog No.	Product Name	Information	Product Use Citations
S1413	Bafilomycin A1 (Baf-A1)	Bafilomycin A1(Baf-A1) is a vacuolar H⁺-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.	Cell Res, 2025, 10.1038/s41422-025-01085-9 Signal Transduct Target Ther, 2025, 10(1):81 Nat Genet, 2025, 57(3):680-693
S1389	Omeprazole	Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.	Drug Metab Dispos, 2025, 53(4):100049 J Extracell Vesicles, 2024, 13(4):e12426 J Extracell Vesicles, 2024, 13(4):e12426
S4845	Rabeprazole	Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	J Extracell Vesicles, 2024, 13(4):e12426 Sci Rep, 2024, 14(1):28163 Med Oncol, 2024, 41(8):188
S5658	Omeprazole Sodium	Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.	Theranostics, 2021, 11(5):2364-2380 Theranostics, 2021, 11(5):2364-2380 J Virol, 2021, JVI.00190-21
S2105	Pantoprazole	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Med Oncol, 2024, 41(8):188 Int J Mol Sci, 2022, 23-158572 Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
S1354	Lansoprazole	Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.	Front Cell Dev Biol, 2021, 9:655559 J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S4075	Zinc Pyrithione	Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.	Cell Chem Biol, 2021, S2451-9456(21)00213-0 Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S4099	Dexlansoprazole	Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.	J Immunother Cancer, 2024, 12(11)e009805 J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S5608	Pantoprazole sodium hydrate	Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.	Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x J Virol, 2021, JVI.00190-21
S4538	Pantoprazole sodium	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x J Virol, 2021, JVI.00190-21
S5885	Rabeprazole Related Compound E	Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.	Stem Cells Int, 2022, 2022:1396735
S5502	Ilaprazole sodium	Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.	J Virol, 2021, JVI.00190-21
S3666	Ilaprazole	Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.	Med Oncol, 2024, 41(8):188 J Virol, 2021, JVI.00190-21
S4212	Tenatoprazole	Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Tenatoprazole labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.	Viruses, 2024, 16(10)1566 J Virol, 2021, JVI.00190-21
S4665	Rabeprazole sodium	Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.	J Virol, 2021, JVI.00190-21
S5058	Revaprazan Hydrochloride	Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
S1743	Esomeprazole magnesium	Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.
S2222	PF-3716556	PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
E4878^New	Lansoprazole sodium	Lansoprazole Sodium, a sodium salt form of Lansoprazole, is an orally active inhibitor of proton pump, preventing the stomach from producing acid. Lansoprazole enhances the expression and transcriptional effectiveness of runt-related transcription factor 2 (Runx2), stimulating osteoprogenitor cell's commitment and differentiation toward their lineage.
E6009^New	Esomeprazole	Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.
S5847	Ethacrynate Sodium	Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.
S6438	Ufiprazole	Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
S1413	Bafilomycin A1 (Baf-A1)	Bafilomycin A1(Baf-A1) is a vacuolar H⁺-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.	Cell Res, 2025, 10.1038/s41422-025-01085-9 Signal Transduct Target Ther, 2025, 10(1):81 Nat Genet, 2025, 57(3):680-693
S1389	Omeprazole	Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.	Drug Metab Dispos, 2025, 53(4):100049 J Extracell Vesicles, 2024, 13(4):e12426 J Extracell Vesicles, 2024, 13(4):e12426
S4845	Rabeprazole	Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	J Extracell Vesicles, 2024, 13(4):e12426 Sci Rep, 2024, 14(1):28163 Med Oncol, 2024, 41(8):188
S5658	Omeprazole Sodium	Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.	Theranostics, 2021, 11(5):2364-2380 Theranostics, 2021, 11(5):2364-2380 J Virol, 2021, JVI.00190-21
S2105	Pantoprazole	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Med Oncol, 2024, 41(8):188 Int J Mol Sci, 2022, 23-158572 Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
S1354	Lansoprazole	Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.	Front Cell Dev Biol, 2021, 9:655559 J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S4075	Zinc Pyrithione	Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.	Cell Chem Biol, 2021, S2451-9456(21)00213-0 Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S4099	Dexlansoprazole	Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.	J Immunother Cancer, 2024, 12(11)e009805 J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S5608	Pantoprazole sodium hydrate	Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.	Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x J Virol, 2021, JVI.00190-21
S4538	Pantoprazole sodium	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x J Virol, 2021, JVI.00190-21
S5885	Rabeprazole Related Compound E	Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.	Stem Cells Int, 2022, 2022:1396735
S5502	Ilaprazole sodium	Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.	J Virol, 2021, JVI.00190-21
S3666	Ilaprazole	Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.	Med Oncol, 2024, 41(8):188 J Virol, 2021, JVI.00190-21
S4212	Tenatoprazole	Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Tenatoprazole labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.	Viruses, 2024, 16(10)1566 J Virol, 2021, JVI.00190-21
S4665	Rabeprazole sodium	Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.	J Virol, 2021, JVI.00190-21
S5058	Revaprazan Hydrochloride	Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
S1743	Esomeprazole magnesium	Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.
S2222	PF-3716556	PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
E4878^New	Lansoprazole sodium	Lansoprazole Sodium, a sodium salt form of Lansoprazole, is an orally active inhibitor of proton pump, preventing the stomach from producing acid. Lansoprazole enhances the expression and transcriptional effectiveness of runt-related transcription factor 2 (Runx2), stimulating osteoprogenitor cell's commitment and differentiation toward their lineage.
E6009^New	Esomeprazole	Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.
S5847	Ethacrynate Sodium	Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.
S6438	Ufiprazole	Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
E4878^New	Lansoprazole sodium	Lansoprazole Sodium, a sodium salt form of Lansoprazole, is an orally active inhibitor of proton pump, preventing the stomach from producing acid. Lansoprazole enhances the expression and transcriptional effectiveness of runt-related transcription factor 2 (Runx2), stimulating osteoprogenitor cell's commitment and differentiation toward their lineage.
E6009^New	Esomeprazole	Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.

Choose Selective Proton Pump Inhibitors

Proton PumpSignaling Pathway