Proton Pump

Signaling Pathway Map

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Inhibitory Selectivity

Proton Pump Products

All (16) Proton Pump Inhibitors (16)

Catalog No.	Information	Product Use Citations	Product Validations
S1354	Lansoprazole Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.	Front Microbiol, 2019, 10:2790
S1389	Omeprazole Omeprazole is a proton pump inhibitor, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.	Redox Biol, 2020, 32:101464 Int J Oncol, 2019, 54(3):1061-1070
S1413	Bafilomycin A1(Baf-A1) Bafilomycin A1 is a vacuolar H⁺-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.	Sci Adv, 2020, 29;6(18):eaax7881 Autophagy, 2020, 10.1080/15548627.2020.1740529 Autophagy, 2020, 16(6):1061-1076	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion.
S4075	Zinc Pyrithione Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.	Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S2222	PF-3716556 PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
S4099	Dexlansoprazole Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.	Front Microbiol, 2019, 10:2790
S4845	Rabeprazole Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	Front Microbiol, 2019, 10:2790
S5658	Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion.
S5502	Ilaprazole sodium Ilaprazole sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor.
S3666	Ilaprazole Ilaprazole is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.
S4212	Tenatoprazole Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM.
S4665	Rabeprazole sodium Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
S4538	Pantoprazole sodium Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
S2105	Pantoprazole Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.	Front Microbiol, 2019, 10:2790
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.

Catalog No.	Information	Product Use Citations	Product Validations
S1354	Lansoprazole Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.	Front Microbiol, 2019, 10:2790
S1389	Omeprazole Omeprazole is a proton pump inhibitor, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.	Redox Biol, 2020, 32:101464 Int J Oncol, 2019, 54(3):1061-1070
S1413	Bafilomycin A1(Baf-A1) Bafilomycin A1 is a vacuolar H⁺-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.	Sci Adv, 2020, 29;6(18):eaax7881 Autophagy, 2020, 10.1080/15548627.2020.1740529 Autophagy, 2020, 16(6):1061-1076	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion.
S4075	Zinc Pyrithione Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.	Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S2222	PF-3716556 PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
S4099	Dexlansoprazole Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.	Front Microbiol, 2019, 10:2790
S4845	Rabeprazole Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	Front Microbiol, 2019, 10:2790
S5658	Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion.
S5502	Ilaprazole sodium Ilaprazole sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor.
S3666	Ilaprazole Ilaprazole is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.
S4212	Tenatoprazole Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM.
S4665	Rabeprazole sodium Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
S4538	Pantoprazole sodium Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
S2105	Pantoprazole Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.	Front Microbiol, 2019, 10:2790
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.

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