YAP-TEAD Inhibitor 1 (Peptide 17)

Catalog No.S8164

For research use only.

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.

YAP-TEAD Inhibitor 1 (Peptide 17) Chemical Structure

CAS No. 1659305-78-8

Selleck's YAP-TEAD Inhibitor 1 (Peptide 17) has been cited by 11 Publications

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Biological Activity

Description YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Targets
YAP/TEAD interaction [1]
(Cell-free assay)
25 nM
In vitro

The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Bel-7404 cells M2POWWZ2dmO2aX;uJIF{e2G7 MoDITY5pcWKrdHnvckBw\iC\QWCvJGdUXC2WRVHENUBqdnSncnHjeIlwdiCrbjDoeY1idiCEZXytO|QxPCClZXzsd{BjgSCJU2SgdJVtdC2mb4fuJIF{e2G7LDDL[F0xNjBzNTFOwG0> MoPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MkG2OVUoRjJ3MkKxOlU2RC:jPh?=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 2019.86
Formula

C93H144ClN23O21S2

CAS No. 1659305-78-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCC1NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCSSCC(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(C)NC(=O)C3CCCN3C1=O)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCC(O)=O)C(N)=O)NC(=O)C(C

In vivo Formulation Calculator (Clear solution)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Frequently Asked Questions

Question 1:
Is this inhibitor cell permeable?

Answer:
The following paper states that the cyclic YAP petide at N terminus may improve the cell permeability: “Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides”

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