YAP

Choose Selective YAP Inhibitors

YAP Products

  • All (7)
  • YAP Inhibitors (5)
  • YAP Activator (1)
  • New YAP Products
Catalog No. Product Name Information Product Use Citations Product Validations
E1145New GA-017 GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
S8164 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
PLoS One, 2022, 17(4):e0266143
Research (Wash D C), 2022, 2022:9825916
Cancer Res, 2021, 81(22):5652-5665
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
Nat Commun, 2022, 13(1):3117
Int J Mol Med, 2022, 49(6)84
J Exp Clin Cancer Res, 2021, 40(1):23
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Cell Rep, 2022, 38(7):110390
Sci Rep, 2022, 12(1):45
Int J Ophthalmol, 2022, 15(5):701-710
S8951 TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
Pediatr Blood Cancer, 2022, e29705
S0881 Mitochonic acid 5 Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
Neural Regen Res, 2021, 16(9):1813-1820
Neural Regen Res, 2021, 16(9):1813-1820
Cell Mol Biol Lett, 2018, 23:14
S1786 Verteporfin (CL 318952) Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Nat Commun, 2022, 13(1):3117
Nat Commun, 2022, 13(1):50
J Pathol, 2022, 10.1002/path.5910
E1145New GA-017 GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
S8164 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
PLoS One, 2022, 17(4):e0266143
Research (Wash D C), 2022, 2022:9825916
Cancer Res, 2021, 81(22):5652-5665
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
Nat Commun, 2022, 13(1):3117
Int J Mol Med, 2022, 49(6)84
J Exp Clin Cancer Res, 2021, 40(1):23
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Cell Rep, 2022, 38(7):110390
Sci Rep, 2022, 12(1):45
Int J Ophthalmol, 2022, 15(5):701-710
S8951 TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
Pediatr Blood Cancer, 2022, e29705
S0881 Mitochonic acid 5 Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
Neural Regen Res, 2021, 16(9):1813-1820
Neural Regen Res, 2021, 16(9):1813-1820
Cell Mol Biol Lett, 2018, 23:14
E1145New GA-017 GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
Tags: YAP antagonist | YAP inhibitor | YAP agonist | YAP activator