TEAD

Choose Selective TEAD Inhibitors
Isoform-selective Inhibitors

TEAD Products

  • All (7)
  • TEAD Inhibitors (7)
  • New TEAD Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1786 Verteporfin (CL 318952) Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Nat Commun, 2022, 13(1):50
Hum Mol Genet, 2022, ddab374
Exp Cell Res, 2022, 411(1):113000
S8164 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Cancer Res, 2021, 81(22):5652-5665
Mol Cell Endocrinol, 2021, 541:111524
Clin Cancer Res, 2020, clincanres.0018.2020
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
J Exp Clin Cancer Res, 2021, 40(1):23
Front Cell Dev Biol, 2021, 9:741060
Front Cell Dev Biol, 2021, 9:741060
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Sci Rep, 2022, 12(1):45
Cancers (Basel), 2021, 13(21)5474
Mol Carcinog, 2021, 60(7):497-507
S8950 MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
S8951 TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
S9735New MGH-CP1 MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
S1786 Verteporfin (CL 318952) Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Nat Commun, 2022, 13(1):50
Hum Mol Genet, 2022, ddab374
Exp Cell Res, 2022, 411(1):113000
S8164 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Cancer Res, 2021, 81(22):5652-5665
Mol Cell Endocrinol, 2021, 541:111524
Clin Cancer Res, 2020, clincanres.0018.2020
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
J Exp Clin Cancer Res, 2021, 40(1):23
Front Cell Dev Biol, 2021, 9:741060
Front Cell Dev Biol, 2021, 9:741060
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Sci Rep, 2022, 12(1):45
Cancers (Basel), 2021, 13(21)5474
Mol Carcinog, 2021, 60(7):497-507
S8950 MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
S8951 TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
S9735New MGH-CP1 MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
S9735New MGH-CP1 MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.