Home Hippo TEAD

TEAD

Other Hippo Related Inhibitors

YAP MST MAP4K LATS

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
E6486New VT3989 VT3989 (YAP/TAZ inhibitor-3) is a potent and selective oral inhibitor of TEAD auto-palmitoylation, blocking its interaction with yes-associated protein (YAP). It exhibits antitumor activity and shows potential for treating mesothelioma and solid tumors with NF2 mutations.
S1786 Verteporfin Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Theranostics, 2026 Jan 1, 2372-2387
Theranostics, 2026, 2372-2387
Pharmaceutics, 2025 Mar 28, 434
Verified customer review of Verteporfin
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Gastric Cancer, 2025, 10.1007/s10120-025-01630-w
Viruses, 2025, 17(3)400
Sci Rep, 2025, 15(1):26968
S9735 MGH-CP1 MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. This compound exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
bioRxiv, October 21, 2025, 2025.10.21.683728
bioRxiv, October 21, 2025, nan
Clinical Cancer Research, July 05, 2023, 2480-2493
E1329 K-975 K-975 is a potent, selective and orally active TEAD inhibitor that directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma.
A Dissertation Submitted for the Degree of Doctor of Philosophy, Osaka University, July 2024, 3
Nat Commun, 2024, 15(1):8159
iScience, 2024, 27(3):109247
S8950 MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
Exp Dermatol, 2022, 31(10):1477-1499
E1599 VT107 VT107 is an enantiomer analogous to VT10 and is a potent inhibitor of pan-TEAD auto-palmitoylation with IC50 of 4.93 nM that blocks TEAD-mediated gene transcription by preventing its association with YAP/TAZ.
Mol Oncol, 2024, 10.1002/1878-0261.13749
E1483 IK-930 IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. This compound demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.
E6434New BPI-460372 BPI‑460372 is an orally available, covalent, irreversible inhibitor of TEAD 1/3/4 that binds to the cysteine residue in the TEAD palmitoylation pocket, preventing palmitoylation and inhibiting TEAD’s transcriptional activity.
E4655 VT104 VT104 is an inhibitor of TEAD auto-palmitoylation that effectively blocks the palmitoylation of TEAD1 and TEAD3 proteins. It selectively inhibits YAP/TAZ-TEAD-promoted gene transcription and exhibits strong antitumor and anti-proliferative effects.