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Technical Data
| Formula | C19H11ClN3NaO2 |
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| Molecular Weight | 371.75 | CAS No. | 1309357-15-0 | |
| Solubility (25°C)* | In vitro | DMSO | 74 mg/mL (199.05 mM) | |
| Water | 74 mg/mL (199.05 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'. | ||||
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Protocol (from reference)
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Selleck's Silmitasertib (CX-4945) sodium salt has been cited by 63 publications
| CK2 activity is crucial for proper glucagon expression [ Diabetologia, 2024, 10.1007/s00125-024-06128-1] | PubMed: 38503901 |
| AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity [ Proc Natl Acad Sci U S A, 2022, 119(12):e2114336119] | PubMed: 35290121 |
| Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation [ Haematologica, 2022, 10.3324/haematol.2022.281668] | PubMed: 36226498 |
| CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway [ Br J Pharmacol, 2022, 10.1111/bph.15945] | PubMed: 36070072 |
| Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00003-0] | PubMed: 35031518 |
| Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2 [ Int J Mol Sci, 2022, 23(13)7274] | PubMed: 35806278 |
| Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines [ Int J Mol Sci, 2022, 23(8)4409] | PubMed: 35457227 |
| Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma [ CNS Neurosci Ther, 2022, 10.1111/cns.13835] | PubMed: 35419951 |
| CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells [ Viruses, 2022, 14(8)1681] | PubMed: 36016303 |
| Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection [ Viruses, 2022, 14(3)552] | PubMed: 35336959 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.