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Formula | C6H9NO5 |
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Molecular Weight | 175.14 | CAS No. | 89464-63-1 | |
Solubility (25°C)* | In vitro | DMSO | 35 mg/mL (199.84 mM) | |
Water | 35 mg/mL (199.84 mM) | |||
Ethanol | 35 mg/mL (199.84 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy. | |||||
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Targets |
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In vitro | DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3] |
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In vivo | DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4] |
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Density | 1.246 g/mL |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Hepatology, 2018, 68(6):2359-2375]
Data from [Data independently produced by , , Theranostics, 2017, 7(13): 3293-3305]
Data from [Data independently produced by , , Theranostics, 2017, 7(13):3293-3305]
Data from [Data independently produced by , , Clin Exp Immunol, 2018, doi:10.1111/cei.13227]
Hypoxia stabilizes SETDB1 to maintain genome stability [ Nucleic Acids Res, 2023, gkad796] | PubMed: 37850636 |
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology [ Redox Biol, 2023, 66:102858] | PubMed: 37633048 |
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress [ EMBO J, 2023, 42(20):e113743] | PubMed: 37661833 |
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology [ Redox Biol, 2023, 66:102858] | PubMed: 37633048 |
Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1α/NLRP3 signaling following thalamic hemorrhagic stroke [ J Neuroinflammation, 2023, 20(1):82] | PubMed: 36944982 |
Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor [ Elife, 2023, 12RP85597] | PubMed: 37610425 |
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity [ Cell Mol Gastroenterol Hepatol, 2023, 10.1016/j.jcmgh.2023.07.012] | PubMed: 37562653 |
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity [ Cell Mol Gastroenterol Hepatol, 2023, 16(5):823-846] | PubMed: 37562653 |
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α [ Research Square, 2023, 10.21203/rs.3.rs-3493586/v1] | PubMed: none |
Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA [ Mol Cancer, 2022, 21(1):168] | PubMed: 35986274 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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