Dasatinib Monohydrate

For research use only.

Catalog No.S7782 Synonyms: BMS-354825 Monohydrate

117 publications

Dasatinib Monohydrate Chemical Structure

CAS No. 863127-77-9

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

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Selleck's Dasatinib Monohydrate has been cited by 117 publications

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Choose Selective Src Inhibitors

Biological Activity

Description Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
Targets
Abl [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
c-Kit (D816V) [2]
(Cell-free assay)
c-Kit (wt) [2]
(Cell-free assay)
0.6 nM 0.8 nM 37 nM 79 nM
In vitro

Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (∼325-fold) increased potency relative to imatinib. Dasatinib potently inhibits wild-type Abl kinase and all mutants except T315I over a narrow range. Dasatinib directly targets wild-type and mutant Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. [1] The percent of colonies of TgE bone marrow cells are decreased from 100% in untreated wells to 4.12% in Dasatinib treated wells. In the presence of Dasatinib, the difference in the percentage of colonies formed by WT and TgE bone marrow cells is statistically significant. Expression of LMP2A is able to promote B lymphocyte survival and proliferation, which can be inhibited by targeting Lyn and/or c-Abl kinases through Dasatinib. [3] Dasatinib treatment inhibits Src signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells. Treatment with increasing doses of Dasatinib (0.019 μM to 1.25 μM) for 3 days inhibits the growth of the C643, TPC1, BCPAP, and SW1736 cell lines by about 50% at low nanomolar concentrations, while higher concentrations are required to inhibit the growth of the K1 cell line. Treatment with 10 nM or 50 nM Dasatinib results in a 9-22% increase of cells in the G1 population among BCPAP and SW1736 and K1 cells, and a corresponding 7-18% decrease in the percentage of cells in the S phase. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 cell NGDq[2NRem:uaX\ldoF1cW:wIHHzd4F6 NHuxd5o4OiCq NWf3eZFWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0xNjByMTFOwG0> MWexOVYyPTVzMh?=
WiDr cell M4LhUXBzd2yrZnXyZZRqd25iYYPzZZk> NHzmN|g4OiCq Ml73RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZaVTyJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2wMlA2OiEQvF2= NYjhTGplOTV4MUW1NVI>
PC3 cell NYPNW|ltWHKxbHnm[ZJifGmxbjDhd5NigQ>? MVG3NkBp NEfhcHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9NE4xODl2IN88US=> M4frVVE2PjF3NUGy
MDA-MB-231 cell MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 NVvsPFBJPzJiaB?= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwMEGyJO69VQ>? MkPFNVU3OTV3MUK=
M07ep210 cell NYTVO|RnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWm0PEBp MXXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNNFdmeDJzMDDj[YxteyCjZoTldkA1QCCqcoOgZpkhYzOKXYTofY1q\GmwZTD1dJRic2ViYYPzZZktKEmFNUC9NE4xPyCwTR?= MYOxO|k2PjB6MB?=
K562 cell M4e3O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYO0PEBp MoXtS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgX|NJZXSqeX3p[Ilv\SC3cIThb4Uh[XO|YYmsJGlEPTB;MD6wNFEh|ryP NFLhclQyPzl3NkC4NC=>
M07e cell NHztR5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvQdohmPDhiaB?= MULHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNNFdmKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDbN2hefGi7bXnkbY5mKHWydHHr[UBie3OjeTygTWM2OD1yLkCwNVIh|ryP MlPINVc6PTZyOEC=
K562 cell NWL4c2w6S3m2b4TvfIlkcXS7IHHzd4F6 M4ruRlczKGh? M1fNXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXC16IILlZYdmdnRiYnHz[YQhVVSWIHHzd4F6NCCLQ{WwQVEzNjh|IN88US=> NVftXJliOjJ{MUe4O|c>
U937 cell NFrPU5hEgXSxdH;4bYNqfHliYYPzZZk> NFHNTGM4OiCq MoPBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVNThicnXh[4VvfCCkYYPl[EBOXFRiYYPzZZktKEmFNUC9NVMvPjNizszN NIPSOHYzOjJzN{i3Oy=>
K562 cell Ml\LVJJwdGmoZYLheIlwdiCjc4PhfS=> M1mzfVczKGh? MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC55IH7N MW[yN|UzOTB{MB?=
MDA-MB-435S cell NV31SWxLWHKxbHnm[ZJifGmxbjDhd5NigQ>? M2rDVVczKGh? MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01OzWVIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9N{46KM7:TR?= NV3UTIJpOjN3MkGwNlA>
NCI-H460 cell MlPNVJJwdGmoZYLheIlwdiCjc4PhfS=> M4Hhc|czKGh? NFPDVmdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9PE46QSEQvF2= MmfNNlM2OjFyMkC=
NCI-H23 cell M4KwNnBzd2yrZnXyZZRqd25iYYPzZZk> M4LwXFczKGh? MlnxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFI{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mj6yO{DPxE1? M2TMeFI{PTJzMEKw
A549 cell M4XVWHBzd2yrZnXyZZRqd25iYYPzZZk> MmfaO|IhcA>? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOi54NjFOwG0> MmfyNlM2OjFyMkC=
T47D cell MmLpVJJwdGmoZYLheIlwdiCjc4PhfS=> MVS3NkBp MoLzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWNEfEJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC57IN88US=> NWrROY9bOjN3MkGwNlA>
HCT116 cell MkLNVJJwdGmoZYLheIlwdiCjc4PhfS=> MlfXO|IhcA>? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJwMzFOwG0> MlW5NlM2OjFyMkC=
MCF7 cells NYHuT4JCWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mmm0O|IhcA>? NUDjPHJnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mj61O{DPxE1? MVqyN|UzOTB{MB?=
RXF 393NL cell NVniWmt3S3m2b4TvfIlkcXS7IHHzd4F6 MV60JIRigXN? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGYhOzl|TlygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoctKEmFNUC9NlEvPyCwTR?= M3v0XVI{OjV|MEe0
PRXF DU145 cell M3zxb2N6fG:2b4jpZ4l1gSCjc4PhfS=> NY[5S|hPPCCmYYnz NYTOfY1vS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWFK[RjDEWVE1PSClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzygTWM2OD1yLkC2NlMh|ryP MmXlNlMzPTNyN{S=
LXFA 983L cell NX;QV4hxS3m2b4TvfIlkcXS7IHHzd4F6 MWS0JIRigXN? NHfGZolEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNYE[DIEm4N2wh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmduIFnDOVA:PTZwNTDuUS=> MlHQNlMzPTNyN{S=
GXF251L cell NWTVVJVES3m2b4TvfIlkcXS7IHHzd4F6 M3XkVlQh\GG7cx?= M2TrdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdZTjJ3MVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoctKEmFNUC9Nk4zPSEQvF2= MorRNlMzPTNyN{S=
CXF 1103L cell MXjDfZRwfG:6aXPpeJkh[XO|YYm= M1jBWVQh\GG7cx?= MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDXGYhOTFyM1ygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoctKEmFNUC9OE4{PiEQvF2= MmD6NlMzPTNyN{S=
PAXF 1657L cell MUDDfZRwfG:6aXPpeJkh[XO|YYm= MVK0JIRigXN? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRXhHKDF4NUfMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNCCLQ{WwQVAvOTJzIN88US=> MYKyN|I2OzB5NB?=
NCI-H1648 cell NHPNNnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DsS2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMkCxNUDPxE1? NIfvNJpUSU6JRWK=
NCI-H1838 cell NVzZPHBjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfvW4VKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVg{QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwM{C3N|Mh|ryP NHXzNllUSU6JRWK=
NCI-H2126 cell MkDCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NE\FSIZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlEzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOEe1OVIh|ryP M33SfnNCVkeHUh?=
NCI-H2141 cell NF\SXHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M37tUGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVQyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjRwN{e1OEDPxE1? NXPzfnZOW0GQR1XS
NCI-H2107 cell NGfiVHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGwO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ{NjR6NEeg{txO NIW3fWZUSU6JRWK=
NCI-H747 cell M1HZO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGHwUW5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|Q4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yOEO2NkDPxE1? NETTdIRUSU6JRWK=
NCI-H720 cell M3TJXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mmm2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEeyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjJ5M{Og{txO Ml2xV2FPT0WU
NKM-1 cell NYX5[2lvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkOwPFU6KM7:TR?= NEjROoNUSU6JRWK=
NMC-G1 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5OSy2JMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNVYxPiEQvF2= NUPiXoRpW0GQR1XS
NTERA-S-cl-D1 cell MkPZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWH0SZRjUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlEzOjh|IN88US=> Mm\RV2FPT0WU
OCI-AML2 cell NX3PVVRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVzJcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME21Mlg3OTV2IN88US=> MV3TRW5ITVJ?
OCUB-M cell MoX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlfvTY5pcWKrdHnvckBw\iCqdX3hckBQS1WELV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNFQ1OTJizszN MV7TRW5ITVJ?
OPM-2 cell M1LrfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV7kO|JvUW6qaXLpeIlwdiCxZjDoeY1idiCRUF2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OE4zPzZ6NTFOwG0> MUTTRW5ITVJ?
OS-RC-2 cell NV7QbWNxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFIxOyEQvF2= M4rrVXNCVkeHUh?=
ONS-76 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVLJcohq[mm2aX;uJI9nKGi3bXHuJG9PWy15NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD60Nlk2OSEQvF2= MX3TRW5ITVJ?
OVCAR-4 cell NUKzcWtuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|c1OzNizszN MkKyV2FPT0WU
NCI-H446 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNES2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlYzPzZizszN NUn4OWFoW0GQR1XS
NCI-H510A cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPsPXNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OTlwM{m3N{DPxE1? MVHTRW5ITVJ?
PF-382 cell MmnYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xO|Y4QCEQvF2= MUjTRW5ITVJ?
NCI-H64 cell MoTYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUK5MlYzPTNizszN MYDTRW5ITVJ?
PSN1 cell MkniS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;rSGlvcGmkaYTpc44hd2ZiaIXtZY4hWFOQMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wOFQ4PCEQvF2= MXnTRW5ITVJ?
QIMR-WIL cell NYj5bldXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jHTmlvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPzB4Mkmg{txO Mn\LV2FPT0WU
RL95-2 cell M3;GXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNFM5KM7:TR?= M130O3NCVkeHUh?=
RCC10RGB cell MkHLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWfpT21wUW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC52OUGxJO69VQ>? M3\EenNCVkeHUh?=
RKO cell NE[5V21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC53Mkm2OkDPxE1? MVfTRW5ITVJ?
NCI-SNU-16 cell NXTpdFF1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn;5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvU17VMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjV4MUK4JO69VQ>? NIXZPZBUSU6JRWK=
RPMI-6666 cell NHHidpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLnZWtKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Py5{N{C2O{DPxE1? MXvTRW5ITVJ?
NEC8 cell NFL6O4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmnCTY5pcWKrdHnvckBw\iCqdX3hckBPTUN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD12ND6zN|Yh|ryP NUnpcJpqW0GQR1XS
RS4-11 cell M3rCUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2HPZWlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME23MlY2Pzh5IN88US=> NH\vOJBUSU6JRWK=
RXF393 cell Ml3mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkPQTY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFI{PTdizszN NUPPPZJqW0GQR1XS
Raji cell NGDhSIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4H6ZWlvcGmkaYTpc44hd2ZiaIXtZY4hWmGsaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUOuO|Q6PyEQvF2= NYLzTJBIW0GQR1XS
NOS-1 cell MojRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmqxTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFYyOjlizszN M3PRRnNCVkeHUh?=
SBC-1 cell NWTEUlluT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHHWZ3NKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlU4QTh2IN88US=> M3zRVHNCVkeHUh?=
SF126 cell NX32e2IxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGS2b25KdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM2PDFizszN MXLTRW5ITVJ?
SF539 cell Mn\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33RNmlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z3M{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGzMlg2PTdizszN NX;kVFhQW0GQR1XS
SH-4 cell NXm2TmxRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXf6Ro1xUW6qaXLpeIlwdiCxZjDoeY1idiCVSD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE5PDF|IN88US=> NVi4XFNsW0GQR1XS
OMC-1 cell M3HGR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXWTWpKdmirYnn0bY9vKG:oIHj1cYFvKE:PQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2yO{4yPDJ{IN88US=> MUHTRW5ITVJ?
SIG-M5 cell M{LNb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkP0TY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUmuNFI1QTNizszN MkTFV2FPT0WU
SJSA-1 cell M4ns[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37GSmlvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME24MlczQDB3IN88US=> M4jaTnNCVkeHUh?=
SK-LMS-1 cell MmjYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHnKenNKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzNV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{NjFzOEi2JO69VQ>? NIXqN5VUSU6JRWK=
SK-NEP-1 cell NFfGPW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DMNWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvQDlzNUWg{txO NX7x[FdVW0GQR1XS
SKM-1 cell MmLCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHW1W|RKdmirYnn0bY9vKG:oIHj1cYFvKFONTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME25MlAyPzN2IN88US=> M3OyRXNCVkeHUh?=
SK-PN-DW cell NFHVW4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zlfmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvUF6tSHch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVM3NjF7NEOg{txO NXTOV4tnW0GQR1XS
SK-UT-1 cell NHLn[ldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjoZ2VKdmirYnn0bY9vKG:oIHj1cYFvKFONLWXUMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVIvOTZ4OUOg{txO M3vMO3NCVkeHUh?=
SNB75 cell M3HteGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3SxUGlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFQ1OzVizszN MlvzV2FPT0WU
REH cell Mly5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OjBwNkO1O{DPxE1? NXnVd3BLW0GQR1XS
SNU-C2B cell Moq0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\tRmlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLVOyRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU4{ODV6OTFOwG0> M1TVXnNCVkeHUh?=
RPMI-8866 cell NV7HdXVkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MljrTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi4OlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVE4NjR2NUWg{txO MVLTRW5ITVJ?
SW872 cell M4GxRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC0NVYyKM7:TR?= NF7RdZBUSU6JRWK=
SW962 cell NG[5UnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkGxNlkzKM7:TR?= M2jGW3NCVkeHUh?=
SF268 cell M3vGZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX7iXXJDUW6qaXLpeIlwdiCxZjDoeY1idiCVRkK2PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yPzRyNDFOwG0> M4jORnNCVkeHUh?=
TE-1 cell Mlj1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mkj1TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkGwOVQh|ryP NYnsZolQW0GQR1XS
8-MG-BA cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVHSXnBpUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF3NEW4JO69VQ>? M1zZXHNCVkeHUh?=
A101D cell Mk\OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlzaTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6wN|A1OyEQvF2= M3vXUnNCVkeHUh?=
A253 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{DMb2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJ3MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Mz63N|I1PiEQvF2= MWjTRW5ITVJ?
A3-KAW cell MnjnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml\mTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuPVg1PTJizszN Mki3V2FPT0WU
A4-Fuk cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml:xTY5pcWKrdHnvckBw\iCqdX3hckBCPC2IdXugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUO4MlExODlizszN MmXGV2FPT0WU
A388 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEWwPVUh|ryP MW\TRW5ITVJ?
ACN cell NVfqW3EzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1H2RmlvcGmkaYTpc44hd2ZiaIXtZY4hSUOQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkiyNlUzKM7:TR?= M{fqd3NCVkeHUh?=
A704 cell NVLycZg1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlzTTY5pcWKrdHnvckBw\iCqdX3hckBCPzB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxOFkyKM7:TR?= NYLLdIFEW0GQR1XS
ALL-PO cell NH7aSlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MojNTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGwMlc6OzhizszN NGjwdmJUSU6JRWK=
ARH-77 cell M2L3TGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJGFTUC15NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Mz60OlkyPSEQvF2= M331b3NCVkeHUh?=
SR cell Mm\1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml7HTY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PC52OUm1OEDPxE1? M3nYUHNCVkeHUh?=
BB65-RCC cell M{nteGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmHUTY5pcWKrdHnvckBw\iCqdX3hckBDSjZ3LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xQDJ{NzFOwG0> MUDTRW5ITVJ?
BB49-HNC cell NIf1do9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MknUTY5pcWKrdHnvckBw\iCqdX3hckBDSjR7LVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{QDV7OTFOwG0> MmHoV2FPT0WU
BC-1 cell MoXjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnTUTY5pcWKrdHnvckBw\iCqdX3hckBDSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{OD62OVEh|ryP NEPUbJZUSU6JRWK=
BC-3 cell NVHENGIzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGJENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTF{LkGxN|gh|ryP MYDTRW5ITVJ?
BL-41 cell NUDQbmdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7RT5N5UW6qaXLpeIlwdiCxZjDoeY1idiCETD20NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4zQTF{MzFOwG0> MnrsV2FPT0WU
BL-70 cell NESzcmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTdyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwNFAxODh{MUig{txO NUP2UHVZW0GQR1XS
SW684 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XX[WlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|Q6QCEQvF2= MmPDV2FPT0WU
BOKU cell M{i4eWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKGi3bXHuJGJQU1ViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwNEmxN|Mh|ryP NV;HdHc1W0GQR1XS
SW954 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlzvTY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNlkzPyEQvF2= NEiwfJRUSU6JRWK=
C2BBe1 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7PNZJKdmirYnn0bY9vKG:oIHj1cYFvKEN{QlLlNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xQDNyODFOwG0> M4fjU3NCVkeHUh?=
BV-173 cell NVf3SWpLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\pTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODByMUC5JO69VQ>? M4fEVXNCVkeHUh?=
Becker cell Mn7nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH;zPYJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOzByMzFOwG0> NEnEV3hUSU6JRWK=
SW982 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NETMdIpKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyOTF3IN88US=> NVnSV2gzW0GQR1XS
697 cell NULnbVJqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPlTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUm5PFch|ryP MmrNV2FPT0WU
TE-15 cell M1TtcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVPJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwOVg6OSEQvF2= NEj5eJBUSU6JRWK=
TE-11 cell NYLIRY16T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3OzXmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFc5PThizszN NWHofHFZW0GQR1XS
TE-5 cell NXHNe|J2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHRGNTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwN{mxN|kh|ryP MnjkV2FPT0WU
TE-6 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4[2XmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6yNVIzPiEQvF2= NELufldUSU6JRWK=
TE-9 cell NWXXVZllT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXK3Xmh2UW6qaXLpeIlwdiCxZjDoeY1idiCWRT25JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlg4PTN{IN88US=> M{\IVXNCVkeHUh?=
TGBC24TKB cell Mkm5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYrwV2EyUW6qaXLpeIlwdiCxZjDoeY1idiCWR1LDNlRVU0JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMES3OlEh|ryP MWHTRW5ITVJ?
TGW cell M{DSPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfmWpVKdmirYnn0bY9vKG:oIHj1cYFvKFSJVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUGuNlgzQCEQvF2= MkjRV2FPT0WU
TK10 cell M{G4dGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJHRMOTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEGxO|Qh|ryP MYjTRW5ITVJ?
TGBC1TKB cell M1fN[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWj0OIdwUW6qaXLpeIlwdiCxZjDoeY1idiCWR1LDNXRMSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yNkG2OEDPxE1? M1XhXnNCVkeHUh?=
A498 cell NGHnWZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LBZWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wO|I5PCEQvF2= NUf0NndUW0GQR1XS
UACC-257 cell MkXLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPEcZhKdmirYnn0bY9vKG:oIHj1cYFvKFWDQ1OtNlU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yOi57MUm4JO69VQ>? M1Lv[3NCVkeHUh?=
U-87-MG cell NGX5eWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4HYO2lvcGmkaYTpc44hd2ZiaIXtZY4hXS16Nz3NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N|AvPzZ4IN88US=> NEjrSm9USU6JRWK=
BB30-HNC cell NXTLfoJXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA2PDN5IN88US=> NIXFPWdUSU6JRWK=
no-10 cell M3r1Nmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXjxc2NXUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{OTl|MTFOwG0> MlXiV2FPT0WU
CAS-1 cell M2fROWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\rSIZKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlQxQTl{IN88US=> MnHsV2FPT0WU
CGTH-W-1 cell NV\RcFE3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJGNIXEhvVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA{PTR6IN88US=> MV7TRW5ITVJ?
TE-10 cell NUTvcFBQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXNVWJ6UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPjN3NzFOwG0> NYjBT3cxW0GQR1XS
COLO-684 cell MlO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20Ok4zOjV6IN88US=> NI\PTVhUSU6JRWK=
TE-12 cell NHv4R29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxPFYyKM7:TR?= NGr6SYNUSU6JRWK=
COR-L279 cell M4Tk[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OMke5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20NE4zQDV{IN88US=> Mm\TV2FPT0WU
TE-8 cell NVO0N3BiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jDSWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNVU4PiEQvF2= NH7JRWRUSU6JRWK=
CP66-MEL cell M1fieWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mmf2TY5pcWKrdHnvckBw\iCqdX3hckBEWDZ4LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yQTV|MTFOwG0> MXPTRW5ITVJ?
CTV-1 cell MofUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwNFA1ODN4IN88US=> NWjXbmlPW0GQR1XS
VA-ES-BJ cell NFrqS|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2XJVWlvcGmkaYTpc44hd2ZiaIXtZY4hXkFvRWOtRmoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODN7MEKg{txO MXPTRW5ITVJ?
D-263MG cell MmjFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTnTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ4M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM3OjJ2IN88US=> MY\TRW5ITVJ?
D-336MG cell MnnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHHVIVnUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByNkK5PEDPxE1? NVixfHJMW0GQR1XS
D-502MG cell NYLkRnVKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTB{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNlM{PzZizszN NYH0cYN5W0GQR1XS
DJM-1 cell NU[0WpV3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGRLVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD14LkS4OVU5KM7:TR?= MkCzV2FPT0WU
no-11 cell NFnHUo5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInoVm9KdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlUxOjJ6IN88US=> NHXhW3NUSU6JRWK=
DMS-153 cell NIn1c|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoD6TY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xOE4xODJ6IN88US=> NGPpdpFUSU6JRWK=
DSH1 cell NXuwUGF1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMkSwNFEh|ryP MlXoV2FPT0WU
DU-4475 cell M33sUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVTSWHVWUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJzNkWyJO69VQ>? MoqxV2FPT0WU
EB-3 cell MmnaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGf3R4xKdmirYnn0bY9vKG:oIHj1cYFvKEWELUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUO0MlMyOThizszN MlL0V2FPT0WU
EHEB cell NE[1dJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXP5cHhoUW6qaXLpeIlwdiCxZjDoeY1idiCHSFXCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xNE4xPjV4IN88US=> NYDFS3F3W0GQR1XS
COLO-829 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjlTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiyPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yOjJzMzFOwG0> M{Dae3NCVkeHUh?=
CP67-MEL cell NHLQcFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\lTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ5LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4zODR6ODFOwG0> NFrhNpVUSU6JRWK=
ES8 cell NV23XmFkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoG3TY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTN{LkGyOVIh|ryP NW\KWVNSW0GQR1XS
EVSA-T cell Mn7aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVvCRlJKUW6qaXLpeIlwdiCxZjDoeY1idiCHVmPBMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVkvOjd5OUOg{txO NVvvZnN{W0GQR1XS
ES4 cell Ml;LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;kRZkyUW6qaXLpeIlwdiCxZjDoeY1idiCHU{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNFUyPDVizszN NF7PdYtUSU6JRWK=
ETK-1 cell NIPUbGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGVVUy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyPFMzKM7:TR?= MYjTRW5ITVJ?
ES6 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXH6R25vUW6qaXLpeIlwdiCxZjDoeY1idiCHU{[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFMyQTNizszN NXvDcmdTW0GQR1XS
EW-24 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTJ2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLke4NVY2KM7:TR?= MYrTRW5ITVJ?
EoL-1-cell cell NI[yemtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnS1TY5pcWKrdHnvckBw\iCqdX3hckBGd0xvMT3j[YxtKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByMECxN|A6KM7:TR?= M2PxV3NCVkeHUh?=
Calu-6 cell Mo\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGi3bXHuJGNidHVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Mz6wOVc1OSEQvF2= NXHMOVhQW0GQR1XS
GAK cell NF3DNpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXL2ZnpIUW6qaXLpeIlwdiCxZjDoeY1idiCJQVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUOxMlI3QDZizszN Mo[5V2FPT0WU
D-247MG cell M4r4cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1HBXGlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NEfNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Ok4yOjVzOTFOwG0> NGniUHBUSU6JRWK=
GB-1 cell NVvXV5R4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmTBTY5pcWKrdHnvckBw\iCqdX3hckBISi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyNVU4KM7:TR?= NGfEeZJUSU6JRWK=
GI-ME-N cell MkW4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{j3NGlvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPjFzODFOwG0> M4iweHNCVkeHUh?=
GCIY cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn\XTY5pcWKrdHnvckBw\iCqdX3hckBIS0m\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC5OlU3KM7:TR?= NGjDeVNUSU6JRWK=
GT3TKB cell NYjnSoxTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\sTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUmuN|U2PDZizszN MUjTRW5ITVJ?
HC-1 cell NF3TbXZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3z4WGlvcGmkaYTpc44hd2ZiaIXtZY4hUENvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MkSuOVU2OSEQvF2= MVPTRW5ITVJ?
HAL-01 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGP5OIZKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVkvPzV2MzFOwG0> NITCcZZUSU6JRWK=
HCC1187 cell NHPPZphIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MofFTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zOU45ODV{IN88US=> MnnoV2FPT0WU
DEL cell NFvDWW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYW1dWdvUW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUSxMlkxQDZizszN MmHjV2FPT0WU
HCC1599 cell M4jTV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7wTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzNUm5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zNk4{OzJ3IN88US=> MmLjV2FPT0WU
DOHH-2 cell NWDI[ZZwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH;xeWxKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOTdzOTFOwG0> NGT6blNUSU6JRWK=
HCC2157 cell M2XST2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGhESzJzNUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUO3Mlk6PDZizszN MmrYV2FPT0WU
HCE-4 cell M1f1V2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVXJcohq[mm2aX;uJI9nKGi3bXHuJGhETS12IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkK2OFM6KM7:TR?= NWjYUnM2W0GQR1XS
HCE-T cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGhETS2WIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkW2O|E1KM7:TR?= MXXTRW5ITVJ?
HEL cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJGhGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OTBwNEe3OkDPxE1? M3G3NnNCVkeHUh?=
EM-2 cell MmO4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInJSJlKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODBzMEe4JO69VQ>? M12wXXNCVkeHUh?=
HT-144 cell NXHIOW5ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoToTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVM3ODlizszN MUPTRW5ITVJ?
EW-16 cell NWHK[45ZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGXhZWhKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlc3OTd6IN88US=> MV;TRW5ITVJ?
IA-LM cell NWDQV5E{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2mySGlvcGmkaYTpc44hd2ZiaIXtZY4hUUFvTF2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGyMlQ1PDVizszN M4r5WXNCVkeHUh?=
IST-MEL1 cell NIe0RoJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlzWTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvTVXMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yOzR3IN88US=> MX7TRW5ITVJ?
IST-MES1 cell NHfrR|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1;sbmlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FV|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh3NUKg{txO M4D1PXNCVkeHUh?=
GI-1 cell NFe0WJdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rNd2lvcGmkaYTpc44hd2ZiaIXtZY4hT0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6zOlIzKM7:TR?= NEnMSVRUSU6JRWK=
IST-SL2 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVA{ODJizszN M1zvcHNCVkeHUh?=
JVM-2 cell NYXvblI6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;vUWlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUKuN|YzQDRizszN NXztNXlHW0GQR1XS
JVM-3 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFW5RWZKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zO{4zOzN6IN88US=> NWCwVWlrW0GQR1XS
KALS-1 cell NGnaW2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTnTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFk1QSEQvF2= NG\SPJhUSU6JRWK=
KARPAS-422 cell M1nTb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWjVOJNFUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDJ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkOzPVk4KM7:TR?= NHnUVWJUSU6JRWK=
JiyoyeP-2003 cell NVfVOFBHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTPOYFKdmirYnn0bY9vKG:oIHj1cYFvKEqreX;5[XAuOjByMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT63N|Q3PiEQvF2= NXy0dI46W0GQR1XS
KARPAS-45 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NI[4N|hKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Py53MU[3NUDPxE1? NHrzbmtUSU6JRWK=
KGN cell NX;PZ5lPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yMUm0NkDPxE1? NVnZUJpXW0GQR1XS
KLE cell NVqycnhiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVLtfY5XUW6qaXLpeIlwdiCxZjDoeY1idiCNTFWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVE{OTdizszN MmW3V2FPT0WU
KNS-42 cell NUSyTGdVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtPWy12MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6yOFQyOiEQvF2= NWfhSlBrW0GQR1XS
KNS-81-FD cell NGPwR5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHWwW3JKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz24NU1HTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OjNwMUS2JO69VQ>? MYPTRW5ITVJ?
KP-N-YS cell NEPtPHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWnheIZUUW6qaXLpeIlwdiCxZjDoeY1idiCNUD3OMXlUKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yOi57MkizJO69VQ>? NX7YSZBJW0GQR1XS
HOP-62 cell MnftS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI[3cWxKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOTh|NDFOwG0> NXfXZXBJW0GQR1XS
KURAMOCHI cell M{fRTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37QOmlvcGmkaYTpc44hd2ZiaIXtZY4hU1WUQV3PR2hKKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB|NEi3JO69VQ>? NEnqZXZUSU6JRWK=
HUTU-80 cell NHTUSY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVT3d5NYUW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjNzNEKg{txO NXfHZXZ6W0GQR1XS
LAMA-84 cell M1rJOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWO2XHcyUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByMECwN|IxPyEQvF2= NIHLUWtUSU6JRWK=
LB1047-RCC cell NGrVUIRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3ETY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByOUi4O{DPxE1? MoDLV2FPT0WU
LB2518-MEL cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInS[nJKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUSxOlIh|ryP NV3GR49[W0GQR1XS
LB373-MEL-D cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKGi3bXHuJGxDOzd|LV3FUE1FKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjh{NUC4JO69VQ>? NGDkeFBUSU6JRWK=
LB771-HNC cell NYHOdXh4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGxDPzdzLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk42PzV3MTFOwG0> NEDTdGxUSU6JRWK=
LB996-RCC cell MlzuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1i3XmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByOUmxNkDPxE1? NXWyV4xiW0GQR1XS
LC-2-ad cell MmK4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXhXnVGUW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB{NUi2JO69VQ>? NUK4OnV3W0GQR1XS
J-RT3-T3-5 cell MlT2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4LkcWlvcGmkaYTpc44hd2ZiaIXtZY4hUi2UVEOtWFMuPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:QC57NkWyPUDPxE1? MXXTRW5ITVJ?
LP-1 cell NXLY[GRWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PrXmlvcGmkaYTpc44hd2ZiaIXtZY4hVFBvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Nz61OFc5OiEQvF2= M2fPUnNCVkeHUh?=
K-562 cell NHr6SmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJGsuPTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwNFAxODJ4NU[g{txO M4[0NnNCVkeHUh?=
LS-123 cell M4fqeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYLJcohq[mm2aX;uJI9nKGi3bXHuJGxUNTF{MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xOFA3PCEQvF2= Mn;oV2FPT0WU
K5 cell NYnKT4tST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJGs2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF4NEi5JO69VQ>? NGH3O2dUSU6JRWK=
LS-411N cell M3ThXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NILSV5JKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUSxNW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVQ5NjR5NEig{txO NXLX[2JvW0GQR1XS
KG-1 cell M{Hpd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWXRRY1JUW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20MlYxQDR3IN88US=> MoPpV2FPT0WU
KINGS-1 cell MnuyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGtKVkeVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVY3PjZizszN NHvNfGRUSU6JRWK=
LXF-289 cell NHj6[mhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkn1TY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA{QTV4IN88US=> MlTCV2FPT0WU
MC116 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4rzZmlvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVE1OSEQvF2= MVjTRW5ITVJ?
KS-1 cell M3\6[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEK3N{DPxE1? M2HHdnNCVkeHUh?=
KU812 cell M4HRfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXKTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNVg5OyEQvF2= NF;adoVUSU6JRWK=
MEG-01 cell NIfLPHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmfmTY5pcWKrdHnvckBw\iCqdX3hckBOTUdvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODB7OEC1JO69VQ>? MVHTRW5ITVJ?
MFH-ino cell M3vYZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1:w[WlvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPDd{NDFOwG0> Ml7VV2FPT0WU
L-540 cell NInEN4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHr[WZCUW6qaXLpeIlwdiCxZjDoeY1idiCOLUW0NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVUvODZ5MTFOwG0> MXzTRW5ITVJ?
MHH-NB-11 cell MmeyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHGdllKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3ORk0yOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PDNwMEixPEDPxE1? NWjxc3hlW0GQR1XS
MMAC-SF cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmnFTY5pcWKrdHnvckBw\iCqdX3hckBOVUGFLWPGJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME24Mlc6OzB5IN88US=> NX32PYVuW0GQR1XS
LB2241-RCC cell NH7UdlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkDFTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF06NjB{MEGyJO69VQ>? NWLp[ZhSW0GQR1XS
LB831-BLC cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPDZyOTFOwG0> NEW4W21USU6JRWK=
MOLT-16 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MofUTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2yPU43Ojl{IN88US=> M4\VT3NCVkeHUh?=
LC-1F cell NFOzVVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLDTY5pcWKrdHnvckBw\iCqdX3hckBNSy1zRjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MkeuN|I1PSEQvF2= M2LWTXNCVkeHUh?=
MOLT-4 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\adYlKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NlYvPjd3MzFOwG0> NHvkemFUSU6JRWK=
MZ1-PC cell M1jL[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmPFTY5pcWKrdHnvckBw\iCqdX3hckBOYjFvUFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFMyOTlizszN M2L0ZnNCVkeHUh?=
MONO-MAC-6 cell M4PS[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn;ITY5pcWKrdHnvckBw\iCqdX3hckBOV06RLV3BR{03KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJ5ME[2JO69VQ>? NYfLfWtuW0GQR1XS
MZ2-MEL cell NIrEO|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG1bOi2PRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNlg2OzdizszN NWnDRZhlW0GQR1XS
MPP-89 cell NEfZVIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PQdGlvcGmkaYTpc44hd2ZiaIXtZY4hVVCSLUi5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1ODR7IN88US=> MUDTRW5ITVJ?
MZ7-mel cell M{fZXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mki5TY5pcWKrdHnvckBw\iCqdX3hckBOYjdvbXXsJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlQ4QTFzIN88US=> MYDTRW5ITVJ?
LOXIMVI cell NWTTOG92T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|E2ODNizszN M3XFdXNCVkeHUh?=
NALM-6 cell NXGxUItZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF;zPINKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yQTJ7NTFOwG0> MkjTV2FPT0WU
NB13 cell M3rsbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEDDOYlKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUG5MlQ5PzdizszN MoHiV2FPT0WU
NB5 cell NVi3cXd2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjyTmNKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6zPVgzPyEQvF2= MnW4V2FPT0WU
NB17 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVTHVYNbUW6qaXLpeIlwdiCxZjDoeY1idiCQQkG3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlY{QDR5IN88US=> NH30cJpUSU6JRWK=
NCCIT cell NV65bXY5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3fCVmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOFSWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUKuPFY3OTZizszN MUnTRW5ITVJ?
NB69 cell NVH6WXI{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELDUoFKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVQ1OzZizszN MWDTRW5ITVJ?
NCI-H1304 cell M3T1WWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPmb|V7UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ6LkG2Nlgh|ryP NHPFTZJUSU6JRWK=
NCI-H1395 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWLrO2hwUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{QTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTR{LkCxOlMh|ryP M{jMOHNCVkeHUh?=
MHH-PREB-1 cell MkGzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlewTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjd2NE[5JO69VQ>? NXzlWHZJW0GQR1XS
MLMA cell NYPtUopYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG1NVUFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUSwN|Ih|ryP NGHWcHRUSU6JRWK=
MN-60 cell M3XMcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYDTWpZHUW6qaXLpeIlwdiCxZjDoeY1idiCPTj22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVUvOTl5OTFOwG0> NE\pO3RUSU6JRWK=
MV-4-11 cell M1X4emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fJOGlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OE4{PjR3NDFOwG0> Mk\nV2FPT0WU
NB6 cell MkLGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLqTY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTlwOUKyOVkh|ryP NVrwfndxW0GQR1XS
NCI-H1355 cell NYW1fIZuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEi2UHRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVM2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zMUCyPEDPxE1? Mmr0V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
phospho-c-Abl(Tyr245) / phospho-c-Src(Tyr416) ; 

PubMed: 23049975     


Protein levels of phosphorylated c-Abl (Tyr245), c-Abl, phosphorylated c-Src (Tyr416), c-Src, and GAPDH in NSC-34 cells overexpressing human wild-type or mutant SOD1s treated with various concentrations of dasatinib were measured by western blot. Cells were cultured in serum-free culture medium with doxycycline (Dox, 2 µg/ml), and western blot was performed at 24 h after dasatinib addition.

p27 / p21; 

PubMed: 20145167     


Dasatnib induced cell cycle arrest. Dasatinib induced growth arrest, shown as a cell cycle distribution graph in the lower panel, correlated with increased p27 and p21 levels. Western blotting for levels of p27 and p21 was performed on protein lysates of THP-1 cells treated for 48 hours with indicated doses of dasatinib or DMSO. Detection of actin served as control for comparable protein loading.

cleaved caspase 3 ; 

PubMed: 20145167     


Dasatinib induced apoptosis. Dasatinib causes apoptosis in Mo7e-KitD816H cells as detected by cleavage of caspase 3. Whole cell lysates were prepared after 24 hour treatment with dasatinib. Caspase 3 and cleaved capase 3 were analyzed by western blotting. Actin serves as loading control.

p-FAK/p-STAT3; 

PubMed: 23721490     


The effect of dasatinib in cell signalling. Western blot analysis with phosphorylated Src, FAK, Stat3, Akt and MAPK in HCC cell lines after 24 hours treatment of dasatinib. The cell lines were arranged according to their IC50 to dasatinib. The top three were most sensitive, the bottom 3 were least sensitive.

23049975 20145167 23721490
Growth inhibition assay
Cell viability; 

PubMed: 23721490     


9 HCC cell lines were exposed to the dedicated concentrations of dasatinib for 72 hours, and IC50 was tested by MTS. Results represent the mean (± SD) of three experiments.

23721490
Immunofluorescence
SRC / Met; 

PubMed: 26517812     


Immunocytochemistry of SRC and Met localization. Cellular localization of SRC and Met following treatment for 48 h with dasatinib, crizotinib or combination in A. LN-18 and B. U373 cells. Scale bar denotes 10 μm. Nuclei were visualized by DAPI while SRC and Met were labeled with a fluorescein and Texas-red conjugated secondary antibodies, respectively.

α-tubulin; 

PubMed: 26517812     


Combination of dasatinib and crizotinib impedes the formation of the α-tubulin-labeled mitotic spindle. LN-18 cells were treated with dasatinib 0.2 μM, crizotinib 4 μM or their combination for 48 h. Mitotic spindle were visualized using α-tubulin antibody conjugated to a fluorescein-labeled secondary antibody. Nuclei were stained by DAPI. The scale bar denotes 10 μm.

F-actin / Actinin-4 / Paxillin; 

PubMed: 31053734     


Conditionally immortalized differentiated podocytes treated for one-hour with 2 µM kinase inhibitor were stained for F-actin (phalloidin), α-actinin-4, paxillin, and nuclei (Hoechst 33342) to assess cytoskeletal and focal adhesion architecture (scale bars = 50 µm). Podocytes treated with dasatinib showed a marked decrease in cell-to-cell contacts, cell size and number of focal adhesions.

26517812 31053734
ELISA
TNF-α; 

PubMed: 17684099     


U937 cells were differentiated with vitamin D3, pretreated with the indicated concentrations of drugs for 1 h and stimulated with LPS for 6 h. TNF-α secretion was measured by ELISA. The graph shows the mean of two experiments done in duplicate.

E-selectin; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of E-selectin was determined using ELISA (n = 3, ±SEM).

VCAM-1; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of VCAM-1 was determined using ELISA (n = 3, ±SEM).

17684099 31110200
In vivo Dasatinib reverses splenomegaly in LMP2A/MYC double transgenic mice. Dasatinib specifically prevents colony formation by LMP2A expressing bone marrow B cells and decreased spleen size in the TgE mice. Spleen mass is significantly decreased among Dasatinib treated Tg6/λ-MYC mice when compared to the control group. Dasatinib inhibits lymphadenopathy in LMP2A/MYC double transgenic mice. Dasatinib reverses splenomegaly in Rag1KO mice engrafted with tumor cells from LMP2A/MYC double transgenic mice. Dasatinib therapy inhibits Lyn phosphorylation in B lymphocyte tumors expressing LMP2A. [3]

Protocol

Kinase Assay:

[1]

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Kinase autophosphorylation assays:

Kinase assays using wild-type and mutant glutathione S-transferase (GST)-Abl fusion proteins (c-Abl amino acids 220-498) are done. GST-Abl fusion proteins are released from glutathione-Sepharose beads before use; the concentration of ATP is 5 μM. Immediately before use in kinase autophosphorylation and in vitro peptide substrate phosphorylation assays, GST-Abl kinase domain fusion proteins are treated with LAR tyrosine phosphatase. After 1-hour incubation at 30 °C, LAR phosphatase is inactivated by addition of sodium vanadate (1 mM). Immunoblot analysis comparing untreated GST-Abl kinase to dephosphorylated GST-Abl kinase is routinely done using phosphotyrosine-specific antibody 4G10 to confirm complete (>95%) dephosphorylation of tyrosine residues and c-Abl antibody CST 2862 to confirm equal loading of GST-Abl kinase. The Dasatinib concentration range is extended to 1,000 nM for mutant T315I. These same inhibitor concentrations are used for the in vitro peptide substrate phosphorylation assays. The three inhibitors are tested over these same concentration ranges against GST-Src kinase and GST-Lyn kinase.
Cell Research:

[1]

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  • Cell lines: Ba/F3 cell lines
  • Concentrations: ~32 nM
  • Incubation Time: 72 hours
  • Method:

    Ba/F3 cell lines are seeded in triplicate and incubated with escalating concentrations of Dasatinib for 72 hours. Proliferation is measured using a methanethiosulfonate-based viability assay. IC50 and IC90 values are reported as the mean of three independent experiments done in quadruplicate. The inhibitor concentration ranges are 0 nM to 32 nM (Dasatinib). The Dasatinib concentration range is extended to 200 nM for mutant T315I.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: EμLMP2A (TgE and Tg6 strains), MYC (λ-MYC), and LMP2A/λ-MYC double transgenic mice (Tg6/λ-MYC)
  • Dosages: 30 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL warmed (41.5 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+dd H2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 506.02
Formula

C22H28ClN7O3S

CAS No. 863127-77-9
Storage powder
in solvent
Synonyms BMS-354825 Monohydrate
Smiles CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT04155411 Recruiting Drug: Dasatinib Dasatinib|BCR-ABL|Chronic Myeloid Leukemia Shenzhen Second People''s Hospital December 1 2019 Phase 4
NCT04115059 Recruiting Drug: Dasatinib Waldenstrom Macroglobulinemia|DASATINIB Jorge J. Castillo MD|Bristol-Myers Squibb|Dana-Farber Cancer Institute November 4 2019 Phase 1
NCT03318770 Not yet recruiting Drug: Dasatinib and blinatumomab Acute Lymphoblastic Leukemia Gruppo Italiano Malattie EMatologiche dell''Adulto December 2018 --
NCT03625388 Recruiting Drug: Dasatinib Chronic Myelogenous Leukemia Hikma Pharmaceuticals LLC November 5 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What’s the difference between S1021 and S7782?

  • Answer:

    Usually, hydrate will be more stable and dissolve better than free base. But this compound (S1021) dissolves better in DMSO than hydrate one (S7782).

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID