Dasatinib Monohydrate

Catalog No.S7782 Synonyms: BMS-354825 Monohydrate

Dasatinib Monohydrate Chemical Structure

Molecular Weight(MW): 506.02

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

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Cited by 62 Publications

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
Targets
Abl [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
c-Kit (D816V) [2]
(Cell-free assay)
c-Kit (wt) [2]
(Cell-free assay)
0.6 nM 0.8 nM 37 nM 79 nM
In vitro

Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (∼325-fold) increased potency relative to imatinib. Dasatinib potently inhibits wild-type Abl kinase and all mutants except T315I over a narrow range. Dasatinib directly targets wild-type and mutant Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. [1] The percent of colonies of TgE bone marrow cells are decreased from 100% in untreated wells to 4.12% in Dasatinib treated wells. In the presence of Dasatinib, the difference in the percentage of colonies formed by WT and TgE bone marrow cells is statistically significant. Expression of LMP2A is able to promote B lymphocyte survival and proliferation, which can be inhibited by targeting Lyn and/or c-Abl kinases through Dasatinib. [3] Dasatinib treatment inhibits Src signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells. Treatment with increasing doses of Dasatinib (0.019 μM to 1.25 μM) for 3 days inhibits the growth of the C643, TPC1, BCPAP, and SW1736 cell lines by about 50% at low nanomolar concentrations, while higher concentrations are required to inhibit the growth of the K1 cell line. Treatment with 10 nM or 50 nM Dasatinib results in a 9-22% increase of cells in the G1 population among BCPAP and SW1736 and K1 cells, and a corresponding 7-18% decrease in the percentage of cells in the S phase. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 cell NGW2ZYFRem:uaX\ldoF1cW:wIHHzd4F6 NVT5XW94PzJiaB?= NVS3[nBuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0xNjByMTFOwG0> MYCxOVYyPTVzMh?=
WiDr cell MlXFVJJwdGmoZYLheIlwdiCjc4PhfS=> MnG1O|IhcA>? MoXlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZaVTyJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2wMlA2OiEQvF2= M1nY[|E2PjF3NUGy
PC3 cell NG\3c2JRem:uaX\ldoF1cW:wIHHzd4F6 MlLZO|IhcA>? NYPGOot5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwQVAvODB7NDFOwG0> Mn7wNVU3OTV3MUK=
MDA-MB-231 cell MlrMVJJwdGmoZYLheIlwdiCjc4PhfS=> M{Lud|czKGh? NHjnSY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUCuNFEzKM7:TR?= MnLlNVU3OTV3MUK=
M07ep210 cell NHfrO3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnTyOFghcA>? MUjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNNFdmeDJzMDDj[YxteyCjZoTldkA1QCCqcoOgZpkhYzOKXYTofY1q\GmwZTD1dJRic2ViYYPzZZktKEmFNUC9NE4xPyCwTR?= MX6xO|k2PjB6MB?=
K562 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmTaOFghcA>? NUHZcFdsT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhYzOKXYTofY1q\GmwZTD1dJRic2ViYYPzZZktKEmFNUC9NE4xODFizszN MoK0NVc6PTZyOEC=
M07e cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;4cIVIPDhiaB?= M4W0Wmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG0xP2ViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHs{UF22aIntbYRqdmVidYD0ZYtmKGG|c3H5MEBKSzVyPUCuNFAyOiEQvF2= Mlz2NVc6PTZyOEC=
K562 cell NVjR[2dGS3m2b4TvfIlkcXS7IHHzd4F6 MYW3NkBp MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3QuQCC{ZXHn[Y51KGKjc3XkJG1VXCCjc4PhfUwhUUN3ME2xNk45OyEQvF2= NIHlToQzOjJzN{i3Oy=>
U937 cell M{nLOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVzwd|dKPzJiaB?= NH;iW3lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RvODDy[YFo\W62IHLhd4VlKE2WVDDhd5NigSxiSVO1NF0yOy54MzFOwG0> M4nlcFIzOjF5OEe3
K562 cell NV3SPZNlWHKxbHnm[ZJifGmxbjDhd5NigQ>? MWS3NkBp M17RV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkegcm0> M{TWN|I{PTJzMEKw
MDA-MB-435S cell M{LnUHBzd2yrZnXyZZRqd25iYYPzZZk> NXrUeVJoPzJiaB?= NGi3eVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oy57IN88US=> MmD4NlM2OjFyMkC=
NCI-H460 cell MoXVVJJwdGmoZYLheIlwdiCjc4PhfS=> MUC3NkBp MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;OD65PUDPxE1? M{ThOFI{PTJzMEKw
NCI-H23 cell NVrKcmQxWHKxbHnm[ZJifGmxbjDhd5NigQ>? NHLnVpo4OiCq MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INlMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{LkK3JO69VQ>? Mn3ONlM2OjFyMkC=
A549 cell MXnQdo9tcW[ncnH0bY9vKGG|c3H5 MX[3NkBp Mn7oRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTJwNk[g{txO MmLKNlM2OjFyMkC=
T47D cell NVTYTlVIWHKxbHnm[ZJifGmxbjDhd5NigQ>? MYK3NkBp M4fPT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwOTFOwG0> NITSR|QzOzV{MUCyNC=>
HCT116 cell Mn\lVJJwdGmoZYLheIlwdiCjc4PhfS=> NVTnN2tHPzJiaB?= M3vjeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mj6zJO69VQ>? MXGyN|UzOTB{MB?=
MCF7 cells M3:zT3Bzd2yrZnXyZZRqd25iYYPzZZk> MY[3NkBp MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0zNjV5IN88US=> NUPFe2JTOjN3MkGwNlA>
RXF 393NL cell MoizR5l1d3SxeHnjbZR6KGG|c3H5 NHHHb201KGSjeYO= M1zR[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTiB|OUPOUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF0zOS55IH7N MWeyN|I2OzB5NB?=
PRXF DU145 cell MV3DfZRwfG:6aXPpeJkh[XO|YYm= M{PTd|Qh\GG7cx?= NXvEdIJGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWFK[RjDEWVE1PSClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzygTWM2OD1yLkC2NlMh|ryP MnzUNlMzPTNyN{S=
LXFA 983L cell NFjpSFZEgXSxdH;4bYNqfHliYYPzZZk> M1fSPFQh\GG7cx?= MnjvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHhHSSB7OEPMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNCCLQ{WwQVU3NjVibl2= M2K4d|I{OjV|MEe0
GXF251L cell MVzDfZRwfG:6aXPpeJkh[XO|YYm= M1PQd|Qh\GG7cx?= MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHXGYzPTGOIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMEBKSzVyPUKuNlUh|ryP NWewc2hvOjN{NUOwO|Q>
CXF 1103L cell MnPqR5l1d3SxeHnjbZR6KGG|c3H5 MmHFOEBl[Xm| MnfwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR3hHKDFzMEPMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNCCLQ{WwQVQvOzZizszN MWmyN|I2OzB5NB?=
PAXF 1657L cell NELiUlFEgXSxdH;4bYNqfHliYYPzZZk> Ml30OEBl[Xm| MknZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFZTiBzNkW3UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF0xNjF{MTFOwG0> MlvYNlMzPTNyN{S=
NCI-H1648 cell NGG5TpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODJyMUGg{txO MYfTRW5ITVJ?
NCI-H1838 cell NXK2cnF6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV36d4QxUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE5OzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkOwO|M{KM7:TR?= NHjCUJBUSU6JRWK=
NCI-H2126 cell NXfI[oR[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfpNJdXUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lki3OVUzKM7:TR?= NVnzOWx7W0GQR1XS
NCI-H2141 cell NF;2RZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTCTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxOFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC55N{W0JO69VQ>? Mk\lV2FPT0WU
NCI-H2107 cell NFLScW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2TXZ2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVA4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDNwNEi0O{DPxE1? MVXTRW5ITVJ?
NCI-H747 cell MlO5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQDN4MjFOwG0> NHnheW1USU6JRWK=
NCI-H720 cell M2LkXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFXIbnlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwMkezN{DPxE1? MmOwV2FPT0WU
NKM-1 cell MkiyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXZNYNKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlMxQDV7IN88US=> M4LB[XNCVkeHUh?=
NMC-G1 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnwSYhwUW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTF4ME[g{txO MY\TRW5ITVJ?
NTERA-S-cl-D1 cell NVnHWI5sT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHKVopWUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlEzOjh|IN88US=> MW\TRW5ITVJ?
OCI-AML2 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnrXTY5pcWKrdHnvckBw\iCqdX3hckBQS0lvQV3MNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OU45PjF3NDFOwG0> MU\TRW5ITVJ?
OCUB-M cell NYTFXpNbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmHYTY5pcWKrdHnvckBw\iCqdX3hckBQS1WELV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNFQ1OTJizszN NYW1TGg1W0GQR1XS
OPM-2 cell MmjuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLyUY5xUW6qaXLpeIlwdiCxZjDoeY1idiCRUF2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OE4zPzZ6NTFOwG0> MX3TRW5ITVJ?
OS-RC-2 cell NUXGW2VJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PTSmlvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOjB|IN88US=> MXjTRW5ITVJ?
ONS-76 cell NIDmSWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG9PWy15NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD60Nlk2OSEQvF2= NXLVOoNuW0GQR1XS
OVCAR-4 cell MnfrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnFTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM4PDN|IN88US=> NIixWIZUSU6JRWK=
NCI-H446 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1j0WGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OFYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPjJ5NjFOwG0> MnHEV2FPT0WU
NCI-H510A cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEXzZWRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OTlwM{m3N{DPxE1? NWTifJVKW0GQR1XS
PF-382 cell NEjzVmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmPZTY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVc3PzhizszN M1H2XHNCVkeHUh?=
NCI-H64 cell NXHKXo54T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWD2SYJjUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0zQS54MkWzJO69VQ>? MXfTRW5ITVJ?
PSN1 cell M4X1Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoH2TY5pcWKrdHnvckBw\iCqdX3hckBRW05zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC0OFc1KM7:TR?= NFu1NIZUSU6JRWK=
QIMR-WIL cell MoS5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nwb2lvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPzB4Mkmg{txO M2XzcnNCVkeHUh?=
RL95-2 cell MoLVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNFM5KM7:TR?= NHWxe5hUSU6JRWK=
RCC10RGB cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJHJESzFyUlfCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlQ6OTFizszN MVHTRW5ITVJ?
RKO cell NWn5cIZXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEDx[lFKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD61Nlk3PiEQvF2= NYfvTXdSW0GQR1XS
NCI-SNU-16 cell MnzHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWrLW|UxUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD16LkW2NVI5KM7:TR?= MU\TRW5ITVJ?
RPMI-6666 cell NILve2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XKcWlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST22OlY3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF04NjJ5ME[3JO69VQ>? M2ftTnNCVkeHUh?=
NEC8 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmnjTY5pcWKrdHnvckBw\iCqdX3hckBPTUN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD12ND6zN|Yh|ryP MofzV2FPT0WU
RS4-11 cell NX:5b5ZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnTQTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUeuOlU4QDdizszN NEGzOW1USU6JRWK=
RXF393 cell NYPwOpd[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUnJcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNlM2PyEQvF2= NVH1[4ZvW0GQR1XS
Raji cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmmzTY5pcWKrdHnvckBw\iCqdX3hckBT[WqrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zMz63OFk4KM7:TR?= NXzofpp4W0GQR1XS
NOS-1 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3vRWpKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxPjF{OTFOwG0> NVj1V2xTW0GQR1XS
SBC-1 cell M2nUb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M135emlvcGmkaYTpc44hd2ZiaIXtZY4hW0KFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuOVc6QDRizszN NI\tOohUSU6JRWK=
SF126 cell MmHuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\MdmxMUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{PTRzIN88US=> NYLucWQ6W0GQR1XS
SF539 cell MlrPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{nFNGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z3M{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGzMlg2PTdizszN NXvveVhSW0GQR1XS
SH-4 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLTVZZKdmirYnn0bY9vKG:oIHj1cYFvKFOKLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVg1OTNizszN MlPTV2FPT0WU
OMC-1 cell NEO0bZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJG9OSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{Nz6xOFIzKM7:TR?= MWLTRW5ITVJ?
SIG-M5 cell M1jwZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWK3b3d3UW6qaXLpeIlwdiCxZjDoeY1idiCVSVetUVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVkvODJ2OUOg{txO NFXHUHlUSU6JRWK=
SJSA-1 cell MlzXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHWNpBlUW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvPzJ6MEWg{txO MmK1V2FPT0WU
SK-LMS-1 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXv2N3NKUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MUXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Oy5zMUi4OkDPxE1? NHL6bGpUSU6JRWK=
SK-NEP-1 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGmz[IhKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05Njh7MUW1JO69VQ>? MWXTRW5ITVJ?
SKM-1 cell NISyeGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX3ZeXZEUW6qaXLpeIlwdiCxZjDoeY1idiCVS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9PU4xOTd|NDFOwG0> MmXSV2FPT0WU
SK-PN-DW cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWG2bYNGUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OzZwMUm0N{DPxE1? M3e0PHNCVkeHUh?=
SK-UT-1 cell NUTFfJVsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUKuNVY3QTNizszN NVvYWYRzW0GQR1XS
SNB75 cell M1niXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\L[4dKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1PDN3IN88US=> Mkj4V2FPT0WU
REH cell NH22V3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XZSGlvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{MD62N|U4KM7:TR?= NV3MWmE{W0GQR1XS
SNU-C2B cell NYnJR5dmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInK[FJKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNmIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVEvOzB3OEmg{txO NICzfYVUSU6JRWK=
RPMI-8866 cell NIriRVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHL[|YxUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVg5PjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTF5LkS0OVUh|ryP NESyU5pUSU6JRWK=
SW872 cell NICzcXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF;3UolKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1OTZzIN88US=> NYPYW21yW0GQR1XS
SW962 cell Ml\sS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkGxNlkzKM7:TR?= Mnz4V2FPT0WU
SF268 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3Z[nRKdmirYnn0bY9vKG:oIHj1cYFvKFOIMk[4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE4PDB2IN88US=> NXy3fVdEW0GQR1XS
TE-1 cell M3GwSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYXObYZFUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlExPTRizszN Mkn4V2FPT0WU
8-MG-BA cell M{HhNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVU1PThizszN MYfTRW5ITVJ?
A101D cell M17pZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnuTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6wN|A1OyEQvF2= M3y4PXNCVkeHUh?=
A253 cell MnjkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGEzPTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTNwN{OyOFYh|ryP NX7CR|BOW0GQR1XS
A3-KAW cell MofiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4jiU2lvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlk5PDV{IN88US=> NH;ZRpFUSU6JRWK=
A4-Fuk cell NHT2RXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGE1NU[3azDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;M{iuNVAxQSEQvF2= MlzYV2FPT0WU
A388 cell NGjiUItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEWwPVUh|ryP MoXKV2FPT0WU
ACN cell NVOxdIFST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGFEViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OS56MkK1NkDPxE1? MXnTRW5ITVJ?
A704 cell NX7CWFZRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIP4XYdKdmirYnn0bY9vKG:oIHj1cYFvKEF5MESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFE1QTFizszN NIizfHlUSU6JRWK=
ALL-PO cell M3PrSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmrXTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGwMlc6OzhizszN NHnzUFhUSU6JRWK=
ARH-77 cell NX7t[3ZxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M122WGlvcGmkaYTpc44hd2ZiaIXtZY4hSVKKLUe3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlQ3QTF3IN88US=> Mn;yV2FPT0WU
SR cell Moi0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjCXpk5UW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;ND60PVk2PCEQvF2= NITCT|NUSU6JRWK=
BB65-RCC cell NV3HOlc3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TqPWlvcGmkaYTpc44hd2ZiaIXtZY4hSkJ4NT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh{Mkeg{txO MontV2FPT0WU
BB49-HNC cell M3jLZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJGJDPDlvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM5PTl7IN88US=> M4G0R3NCVkeHUh?=
BC-1 cell NHvOcm9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ6Lk[1NUDPxE1? NFK5eohUSU6JRWK=
BC-3 cell NHXoVGpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmfCTY5pcWKrdHnvckBw\iCqdX3hckBDSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zMj6xNVM5KM7:TR?= NX7jb|BzW0GQR1XS
BL-41 cell NEPPPYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XXTGlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNlkyOjNizszN NXO4b4dSW0GQR1XS
BL-70 cell MknJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4m1XWlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODByOEKxPEDPxE1? NEX6[XVUSU6JRWK=
SW684 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVviVGI6UW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{PDl6IN88US=> MkniV2FPT0WU
BOKU cell MmroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHrdWFMUW6qaXLpeIlwdiCxZjDoeY1idiCET1vVJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlQ6OTN|IN88US=> M{LjcHNCVkeHUh?=
SW954 cell M3q4Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnrKTY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNlkzPyEQvF2= Mo\NV2FPT0WU
C2BBe1 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvkVFVKdmirYnn0bY9vKG:oIHj1cYFvKEN{QlLlNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xQDNyODFOwG0> MUXTRW5ITVJ?
BV-173 cell NVnrdHQxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2C4WWlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxODByMEGwPUDPxE1? MXnTRW5ITVJ?
Becker cell MorMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2nMU2lvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA{ODB|IN88US=> NHHT[5RUSU6JRWK=
SW982 cell NUXqXGJiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxNVE2KM7:TR?= MWDTRW5ITVJ?
697 cell NXTQVIVIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTxS5dKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xPVk5PyEQvF2= M1PVbnNCVkeHUh?=
TE-15 cell M2jnT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mlm1TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFU5QTFizszN NGHOOXlUSU6JRWK=
TE-11 cell NX31TlhGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4PoSmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFc5PThizszN MWfTRW5ITVJ?
TE-5 cell NWrvTnBCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHvwbW5KdmirYnn0bY9vKG:oIHj1cYFvKFSHLUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuO|kyOzlizszN MWnTRW5ITVJ?
TE-6 cell Moe4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkmxTY5pcWKrdHnvckBw\iCqdX3hckBVTS14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkKxNlI3KM7:TR?= NF7MdYlUSU6JRWK=
TE-9 cell NWnHSHhXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnfFTY5pcWKrdHnvckBw\iCqdX3hckBVTS17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLki3OVMzKM7:TR?= Mo[4V2FPT0WU
TGBC24TKB cell NILsPZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fi[WlvcGmkaYTpc44hd2ZiaIXtZY4hXEeEQ{K0WGtDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB2N{[xJO69VQ>? MYHTRW5ITVJ?
TGW cell NHnFVHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXv6ZVdEUW6qaXLpeIlwdiCxZjDoeY1idiCWR2egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGxMlI5OjhizszN NYPsNFFRW0GQR1XS
TK10 cell NHm4VFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHHCU5FKdmirYnn0bY9vKG:oIHj1cYFvKFSNMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFEyPzRizszN M2XudnNCVkeHUh?=
TGBC1TKB cell NUjYWGJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2PZeWlvcGmkaYTpc44hd2ZiaIXtZY4hXEeEQ{HUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODZzNkSg{txO NEjLdG1USU6JRWK=
A498 cell NFmzTFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEeyPFQh|ryP NHfBdIFUSU6JRWK=
UACC-257 cell NHfWeXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3fHd2lvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVEzNjlzOUig{txO M3vFbHNCVkeHUh?=
U-87-MG cell M{\X[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJHUuQDdvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUOwMlc3PiEQvF2= M{TKU3NCVkeHUh?=
BB30-HNC cell NVT2WVZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA2PDN5IN88US=> M33wWXNCVkeHUh?=
no-10 cell NHXWfo5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJI5wNTFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkOxPVMyKM7:TR?= MmrPV2FPT0WU
CAS-1 cell M{LxWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkSwPVkzKM7:TR?= NXrZcYZsW0GQR1XS
CGTH-W-1 cell NX7Gc|FVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;Ke2lvcGmkaYTpc44hd2ZiaIXtZY4hS0eWSD3XMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODN3NEig{txO NYm2RYVqW0GQR1XS
TE-10 cell NVLoPGVYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkG3TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wOlM2PyEQvF2= MYTTRW5ITVJ?
COLO-684 cell NGS3OIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPEcoF3UW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVY5PCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PDZwMkK1PEDPxE1? M4PUd3NCVkeHUh?=
TE-12 cell NX32VpJVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2jPPGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFE5PjFizszN MkHZV2FPT0WU
COR-L279 cell M4PveGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1vKdWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVyyO|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVQxNjJ6NUKg{txO NF3LfYRUSU6JRWK=
TE-8 cell M1\mfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{GxUmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNVU4PiEQvF2= MnPVV2FPT0WU
CP66-MEL cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGXUZ2hKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF7NUOxJO69VQ>? MkP2V2FPT0WU
CTV-1 cell NF;xXlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3vqNGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODRyM{[g{txO M2faTnNCVkeHUh?=
VA-ES-BJ cell NGfjOI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA{QTB{IN88US=> NHLsRZZUSU6JRWK=
D-263MG cell MnzIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;CTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ4M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM3OjJ2IN88US=> NVe3eZI{W0GQR1XS
D-336MG cell NY[x[4x2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYC4OZlNUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByNkK5PEDPxE1? MWLTRW5ITVJ?
D-502MG cell M3jsO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHKxO4hKdmirYnn0bY9vKG:oIHj1cYFvKERvNUCyUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVEvOjN|N{[g{txO MXLTRW5ITVJ?
DJM-1 cell M4rW[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXS3dFNtUW6qaXLpeIlwdiCxZjDoeY1idiCGSl2tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Ok41QDV3ODFOwG0> Ml33V2FPT0WU
no-11 cell M1HWNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk[5TY5pcWKrdHnvckBw\iCqdX3hckBvdy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD61NFIzQCEQvF2= NHz4NXRUSU6JRWK=
DMS-153 cell NGHaOXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYS4ZWZ6UW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVU{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yPC5yMEK4JO69VQ>? NHr2VpFUSU6JRWK=
DSH1 cell NXroWppmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvIbWxqUW6qaXLpeIlwdiCxZjDoeY1idiCGU1ixJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlI1ODBzIN88US=> MUPTRW5ITVJ?
DU-4475 cell NVjPZpFOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV3ic4c1UW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJzNkWyJO69VQ>? NFLRR4pUSU6JRWK=
EB-3 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXjncINPUW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zOE4{OTF6IN88US=> NEnoS3pUSU6JRWK=
EHEB cell NIrm[GxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKGi3bXHuJGVJTUJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFyLkC2OVYh|ryP MmnvV2FPT0WU
COLO-829 cell NEDqUXZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPLdlZKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFI6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF{MkGzJO69VQ>? NWH2Omc1W0GQR1XS
CP67-MEL cell NUHWflB5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrmTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ5LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4zODR6ODFOwG0> MYfTRW5ITVJ?
ES8 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OzJwMUK1NkDPxE1? Ml7UV2FPT0WU
EVSA-T cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPqW2M3UW6qaXLpeIlwdiCxZjDoeY1idiCHVmPBMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVkvOjd5OUOg{txO MnS3V2FPT0WU
ES4 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mlf2TY5pcWKrdHnvckBw\iCqdX3hckBGWzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwMEWxOFUh|ryP NXnxfXRZW0GQR1XS
ETK-1 cell NF;ETlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGVVUy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyPFMzKM7:TR?= NH\5[lNUSU6JRWK=
ES6 cell NETlU2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWnJcohq[mm2aX;uJI9nKGi3bXHuJGVUPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yM{G5N{DPxE1? NGO2UGRUSU6JRWK=
EW-24 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1vMRmlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuO|gyPjVizszN NHS5VGdUSU6JRWK=
EoL-1-cell cell MlrES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvYbllKdmirYnn0bY9vKG:oIHj1cYFvKEWxTD2xMYNmdGxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMECwNFE{ODlizszN MnntV2FPT0WU
Calu-6 cell M1fy[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3vwOGlvcGmkaYTpc44hd2ZiaIXtZY4hS2GudT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlA2PzRzIN88US=> MVzTRW5ITVJ?
GAK cell MojOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\Kd2tKdmirYnn0bY9vKG:oIHj1cYFvKEeDSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;M{GuNlY5PiEQvF2= NF\KOYZUSU6JRWK=
D-247MG cell M1TTeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDqTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ2N13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME22MlEzPTF7IN88US=> NH\6cGpUSU6JRWK=
GB-1 cell NIjFNYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYLJcohq[mm2aX;uJI9nKGi3bXHuJGdDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEKxOVch|ryP Ml;wV2FPT0WU
GI-ME-N cell M{\Pcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFYyOThizszN MYHTRW5ITVJ?
GCIY cell NIDvdWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXvJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEm2OVYh|ryP NXfVO256W0GQR1XS
GT3TKB cell M{jVdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnThTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUmuN|U2PDZizszN MX;TRW5ITVJ?
HC-1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWL1S3ZFUW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2yOE42PTVzIN88US=> NXfWe2lbW0GQR1XS
HAL-01 cell NVvKO5k3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnm4TY5pcWKrdHnvckBw\iCqdX3hckBJSUxvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUG5Mlc2PDNizszN MWPTRW5ITVJ?
HCC1187 cell MorGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlu2TY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zOU45ODV{IN88US=> M3vsbHNCVkeHUh?=
DEL cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDYOGhWUW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUSxMlkxQDZizszN MVHTRW5ITVJ?
HCC1599 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{W3d2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUW5PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N|IvOzN{NTFOwG0> NEfkVmdUSU6JRWK=
DOHH-2 cell NVXvOIVFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1XFe2lvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyPzF7IN88US=> M1zWTnNCVkeHUh?=
HCC2157 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2S5[2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMkG1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N|cvQTl2NjFOwG0> MXPTRW5ITVJ?
HCE-4 cell NYXHV5NqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGhETS12IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkK2OFM6KM7:TR?= NFf5NHZUSU6JRWK=
HCE-T cell NHrXbWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zpPGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOHLWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuOVY4OTRizszN MV\TRW5ITVJ?
HEL cell NVzTbWY{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\uOGlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zMD60O|c3KM7:TR?= Mkn6V2FPT0WU
EM-2 cell NFXPeZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYOzdWR[UW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxODByMUC3PEDPxE1? M4nIPXNCVkeHUh?=
HT-144 cell NX\xVIs2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoD5TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVM3ODlizszN MXnTRW5ITVJ?
EW-16 cell NX33VpFHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4HFTGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuO|YyPzhizszN M3mzNnNCVkeHUh?=
IA-LM cell NGnpcYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3PHTGlvcGmkaYTpc44hd2ZiaIXtZY4hUUFvTF2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGyMlQ1PDVizszN MorWV2FPT0WU
IST-MEL1 cell M3XlXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRVyxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE{PDVizszN MnT5V2FPT0WU
IST-MES1 cell M4H4[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHrmfIhKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3NSXMyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB6NUWyJO69VQ>? Mm[1V2FPT0WU
GI-1 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3LEemlvcGmkaYTpc44hd2ZiaIXtZY4hT0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6zOlIzKM7:TR?= NW\uOnRFW0GQR1XS
IST-SL2 cell NGS0b2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfvTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlUxOzB{IN88US=> NXfIUXJ3W0GQR1XS
JVM-2 cell M{LEXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4TETWlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUKuN|YzQDRizszN MlHKV2FPT0WU
JVM-3 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1|Nz6yN|M5KM7:TR?= MXnTRW5ITVJ?
KALS-1 cell M3nwWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13VR2lvcGmkaYTpc44hd2ZiaIXtZY4hU0GOUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA6PDlizszN M4TpTXNCVkeHUh?=
KARPAS-422 cell NITGempIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGrPV|dKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01OjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwM{O5PVch|ryP M3zpWXNCVkeHUh?=
JiyoyeP-2003 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkWxTY5pcWKrdHnvckBw\iCqdX3hckBLcXmxeXXQMVIxODNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwN{O0OlYh|ryP MoP5V2FPT0WU
KARPAS-45 cell MnvYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jFXGlvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQ2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF04NjVzNkexJO69VQ>? MnrFV2FPT0WU
KGN cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yMUm0NkDPxE1? NGTENIFUSU6JRWK=
KLE cell M2T1NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4r5WGlvcGmkaYTpc44hd2ZiaIXtZY4hU0yHIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkGxN|E4KM7:TR?= MkixV2FPT0WU
KNS-42 cell M37kdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfJVXVKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU4zPDRzMjFOwG0> MV\TRW5ITVJ?
KNS-81-FD cell NWTuR|dMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;ZW2lvcGmkaYTpc44hd2ZiaIXtZY4hU06VLUixMWZFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0zOy5zNE[g{txO MUfTRW5ITVJ?
KP-N-YS cell M1i4T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtRNU5vWWOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGyMlkzQDNizszN MkDGV2FPT0WU
HOP-62 cell M1fTc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nJfWlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyQDN2IN88US=> NFHrd2pUSU6JRWK=
KURAMOCHI cell NXfIelZ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnniTY5pcWKrdHnvckBw\iCqdX3hckBMXVKDTV;DTGkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODN2OEeg{txO MmLIV2FPT0WU
HUTU-80 cell M4DrN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\FTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlMyPDJizszN MknBV2FPT0WU
LAMA-84 cell M2H5NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHFTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxODByM{KwO{DPxE1? NYDlPFhEW0GQR1XS
LB1047-RCC cell NV3vco9kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX;2do1mUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwPVg5PyEQvF2= NHf3[Y5USU6JRWK=
LB2518-MEL cell M4OxWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVX6WGJjUW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkG0NVYzKM7:TR?= M4ixXXNCVkeHUh?=
LB373-MEL-D cell NVXYcXNST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGr6[GFKdmirYnn0bY9vKG:oIHj1cYFvKEyEM{ezMW1GVC2GIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkiyOVA5KM7:TR?= M4H3R3NCVkeHUh?=
LB771-HNC cell MmTtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFXqbGJKdmirYnn0bY9vKG:oIHj1cYFvKEyEN{exMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Oi53N{W1NUDPxE1? M4X6enNCVkeHUh?=
LB996-RCC cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MULJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xODl7MUKg{txO NHfmSppUSU6JRWK=
LC-2-ad cell NWHDbJhOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFI2QDZizszN Mlz6V2FPT0WU
J-RT3-T3-5 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGouWlR|LWSzMVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvQTZ3Mkmg{txO M4HibnNCVkeHUh?=
LP-1 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFXvRohKdmirYnn0bY9vKG:oIHj1cYFvKEySLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUeuOVQ4QDJizszN Mmm0V2FPT0WU
K-562 cell M4HKS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3X6OGlvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODByMk[1OkDPxE1? NVzqeo02W0GQR1XS
LS-123 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGxUNTF{MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xOFA3PCEQvF2= M1nZbHNCVkeHUh?=
K5 cell NHu2emNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn3TTY5pcWKrdHnvckBw\iCqdX3hckBMPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zNkS4PUDPxE1? MkHqV2FPT0WU
LS-411N cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1rEcmlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvNEGxUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OFgvPDd2ODFOwG0> NGPRTXZUSU6JRWK=
KG-1 cell M33JXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXmzd2gzUW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20MlYxQDR3IN88US=> MoLzV2FPT0WU
KINGS-1 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnHVY9wUW6qaXLpeIlwdiCxZjDoeY1idiCNSV7HV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF4Nk[2JO69VQ>? M3POTnNCVkeHUh?=
LXF-289 cell NImyPXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{e0cGlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOzl3NjFOwG0> NVfldHVGW0GQR1XS
MC116 cell MoTIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGi3bXHuJG1EOTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkGxOFEh|ryP M4WzdHNCVkeHUh?=
KS-1 cell M2HFT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEK3N{DPxE1? MmG2V2FPT0WU
KU812 cell NUjUXlc4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYW0Sop3UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yOTh6MzFOwG0> NITvSGtUSU6JRWK=
MEG-01 cell NWjtT3JWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVnJcohq[mm2aX;uJI9nKGi3bXHuJG1GTy1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFAxODl6MEWg{txO NETl[mhUSU6JRWK=
MFH-ino cell NGDadHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPj[IRKdmirYnn0bY9vKG:oIHj1cYFvKE2ISD3pco8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODR5MkSg{txO MkjWV2FPT0WU
L-540 cell NX[1WJZjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{jhXGlvcGmkaYTpc44hd2ZiaIXtZY4hVC13NECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUG1MlA3PzFizszN NF7INlVUSU6JRWK=
MHH-NB-11 cell M{C4PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13LcWlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLV7CMVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF01Oy5yOEG4JO69VQ>? M{n4dXNCVkeHUh?=
MMAC-SF cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{H6TWlvcGmkaYTpc44hd2ZiaIXtZY4hVU2DQz3TSkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9PE44QTNyNzFOwG0> Ml:0V2FPT0WU
LB2241-RCC cell NGfNTJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NITlSIZKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTlwMEKwNVIh|ryP MVfTRW5ITVJ?
LB831-BLC cell NXv4Vm5kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIX6e4dKdmirYnn0bY9vKG:oIHj1cYFvKEyEOEOxMWJNSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yNE[wPUDPxE1? MWPTRW5ITVJ?
MOLT-16 cell NHnVO21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIn2dWtKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVI6NjZ{OUKg{txO NVLQZVZTW0GQR1XS
LC-1F cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{jUdGlvcGmkaYTpc44hd2ZiaIXtZY4hVENvMV[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUK3MlMzPDVizszN MVXTRW5ITVJ?
MOLT-4 cell M13pSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXid4FFUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVI3NjZ5NUOg{txO MmLvV2FPT0WU
MZ1-PC cell M4G3cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPL[2JUUW6qaXLpeIlwdiCxZjDoeY1idiCPWkGtVGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODNzMUmg{txO MV3TRW5ITVJ?
MONO-MAC-6 cell NV;jb25IT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnXBTY5pcWKrdHnvckBw\iCqdX3hckBOV06RLV3BR{03KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJ5ME[2JO69VQ>? MVrTRW5ITVJ?
MZ2-MEL cell NXHEPI81T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEjhc3dKdmirYnn0bY9vKG:oIHj1cYFvKE2cMj3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOjh3M{eg{txO MknxV2FPT0WU
MPP-89 cell NXvYfVViT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wOFA1QSEQvF2= MmqwV2FPT0WU
MZ7-mel cell NXuw[pZTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmfXTY5pcWKrdHnvckBw\iCqdX3hckBOYjdvbXXsJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlQ4QTFzIN88US=> NXrCRZNZW0GQR1XS
LOXIMVI cell Mn3iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{DhW2lvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{OTVyMzFOwG0> MXjTRW5ITVJ?
NALM-6 cell MnPOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xPVI6PSEQvF2= MYPTRW5ITVJ?
NB13 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\uTY5pcWKrdHnvckBw\iCqdX3hckBPSjF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zOT60PFc4KM7:TR?= NHjhUGZUSU6JRWK=
NB5 cell NYPZ[IFlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXm5[WJRUW6qaXLpeIlwdiCxZjDoeY1idiCQQkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuN|k5OjdizszN NVGzTm5WW0GQR1XS
NB17 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MljZTY5pcWKrdHnvckBw\iCqdX3hckBPSjF5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1|Lk[zPFQ4KM7:TR?= NInle2ZUSU6JRWK=
NCCIT cell NULSdndUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWnJcohq[mm2aX;uJI9nKGi3bXHuJG5ES0mWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{Lki2OlE3KM7:TR?= MmS4V2FPT0WU
NB69 cell NFLEfYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M37Kc2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xOFQ{PiEQvF2= MYDTRW5ITVJ?
NCI-H1304 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7IWHB[UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ6LkG2Nlgh|ryP NYn3TXcxW0GQR1XS
NCI-H1395 cell M2[weGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3K5c2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|k2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF01Oi5yMU[zJO69VQ>? MVTTRW5ITVJ?
MHH-PREB-1 cell NWnMUWE2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPzR2Nkmg{txO NVzXeox7W0GQR1XS
MLMA cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDT[mVKdmirYnn0bY9vKG:oIHj1cYFvKE2OTVGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVQxOzJizszN NXyyVZlMW0GQR1XS
MN-60 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJG1PNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zNT6xPVc6KM7:TR?= NXPDSnBjW0GQR1XS
MV-4-11 cell NWfZTWVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoTDTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20MlM3PDV2IN88US=> NXzlepFlW0GQR1XS
NB6 cell NUG2VGMxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rUXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD17LkmyNlU6KM7:TR?= NXfMeohKW0GQR1XS
NCI-H1355 cell MoO2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yOTB{ODFOwG0> NF;xSJBUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
phospho-c-Abl(Tyr245) / phospho-c-Src(Tyr416) ; 

PubMed: 23049975     


Protein levels of phosphorylated c-Abl (Tyr245), c-Abl, phosphorylated c-Src (Tyr416), c-Src, and GAPDH in NSC-34 cells overexpressing human wild-type or mutant SOD1s treated with various concentrations of dasatinib were measured by western blot. Cells were cultured in serum-free culture medium with doxycycline (Dox, 2 µg/ml), and western blot was performed at 24 h after dasatinib addition.

p27 / p21; 

PubMed: 20145167     


Dasatnib induced cell cycle arrest. Dasatinib induced growth arrest, shown as a cell cycle distribution graph in the lower panel, correlated with increased p27 and p21 levels. Western blotting for levels of p27 and p21 was performed on protein lysates of THP-1 cells treated for 48 hours with indicated doses of dasatinib or DMSO. Detection of actin served as control for comparable protein loading.

cleaved caspase 3 ; 

PubMed: 20145167     


Dasatinib induced apoptosis. Dasatinib causes apoptosis in Mo7e-KitD816H cells as detected by cleavage of caspase 3. Whole cell lysates were prepared after 24 hour treatment with dasatinib. Caspase 3 and cleaved capase 3 were analyzed by western blotting. Actin serves as loading control.

p-FAK/p-STAT3; 

PubMed: 23721490     


The effect of dasatinib in cell signalling. Western blot analysis with phosphorylated Src, FAK, Stat3, Akt and MAPK in HCC cell lines after 24 hours treatment of dasatinib. The cell lines were arranged according to their IC50 to dasatinib. The top three were most sensitive, the bottom 3 were least sensitive.

23049975 20145167 23721490
Growth inhibition assay
Cell viability; 

PubMed: 23721490     


9 HCC cell lines were exposed to the dedicated concentrations of dasatinib for 72 hours, and IC50 was tested by MTS. Results represent the mean (± SD) of three experiments.

23721490
Immunofluorescence
SRC / Met; 

PubMed: 26517812     


Immunocytochemistry of SRC and Met localization. Cellular localization of SRC and Met following treatment for 48 h with dasatinib, crizotinib or combination in A. LN-18 and B. U373 cells. Scale bar denotes 10 μm. Nuclei were visualized by DAPI while SRC and Met were labeled with a fluorescein and Texas-red conjugated secondary antibodies, respectively.

α-tubulin; 

PubMed: 26517812     


Combination of dasatinib and crizotinib impedes the formation of the α-tubulin-labeled mitotic spindle. LN-18 cells were treated with dasatinib 0.2 μM, crizotinib 4 μM or their combination for 48 h. Mitotic spindle were visualized using α-tubulin antibody conjugated to a fluorescein-labeled secondary antibody. Nuclei were stained by DAPI. The scale bar denotes 10 μm.

F-actin / Actinin-4 / Paxillin; 

PubMed: 31053734     


Conditionally immortalized differentiated podocytes treated for one-hour with 2 µM kinase inhibitor were stained for F-actin (phalloidin), α-actinin-4, paxillin, and nuclei (Hoechst 33342) to assess cytoskeletal and focal adhesion architecture (scale bars = 50 µm). Podocytes treated with dasatinib showed a marked decrease in cell-to-cell contacts, cell size and number of focal adhesions.

26517812 31053734
ELISA
TNF-α; 

PubMed: 17684099     


U937 cells were differentiated with vitamin D3, pretreated with the indicated concentrations of drugs for 1 h and stimulated with LPS for 6 h. TNF-α secretion was measured by ELISA. The graph shows the mean of two experiments done in duplicate.

E-selectin; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of E-selectin was determined using ELISA (n = 3, ±SEM).

VCAM-1; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of VCAM-1 was determined using ELISA (n = 3, ±SEM).

17684099 31110200
In vivo Dasatinib reverses splenomegaly in LMP2A/MYC double transgenic mice. Dasatinib specifically prevents colony formation by LMP2A expressing bone marrow B cells and decreased spleen size in the TgE mice. Spleen mass is significantly decreased among Dasatinib treated Tg6/λ-MYC mice when compared to the control group. Dasatinib inhibits lymphadenopathy in LMP2A/MYC double transgenic mice. Dasatinib reverses splenomegaly in Rag1KO mice engrafted with tumor cells from LMP2A/MYC double transgenic mice. Dasatinib therapy inhibits Lyn phosphorylation in B lymphocyte tumors expressing LMP2A. [3]

Protocol

Kinase Assay:

[1]

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Kinase autophosphorylation assays:

Kinase assays using wild-type and mutant glutathione S-transferase (GST)-Abl fusion proteins (c-Abl amino acids 220-498) are done. GST-Abl fusion proteins are released from glutathione-Sepharose beads before use; the concentration of ATP is 5 μM. Immediately before use in kinase autophosphorylation and in vitro peptide substrate phosphorylation assays, GST-Abl kinase domain fusion proteins are treated with LAR tyrosine phosphatase. After 1-hour incubation at 30 °C, LAR phosphatase is inactivated by addition of sodium vanadate (1 mM). Immunoblot analysis comparing untreated GST-Abl kinase to dephosphorylated GST-Abl kinase is routinely done using phosphotyrosine-specific antibody 4G10 to confirm complete (>95%) dephosphorylation of tyrosine residues and c-Abl antibody CST 2862 to confirm equal loading of GST-Abl kinase. The Dasatinib concentration range is extended to 1,000 nM for mutant T315I. These same inhibitor concentrations are used for the in vitro peptide substrate phosphorylation assays. The three inhibitors are tested over these same concentration ranges against GST-Src kinase and GST-Lyn kinase.
Cell Research:

[1]

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  • Cell lines: Ba/F3 cell lines
  • Concentrations: ~32 nM
  • Incubation Time: 72 hours
  • Method:

    Ba/F3 cell lines are seeded in triplicate and incubated with escalating concentrations of Dasatinib for 72 hours. Proliferation is measured using a methanethiosulfonate-based viability assay. IC50 and IC90 values are reported as the mean of three independent experiments done in quadruplicate. The inhibitor concentration ranges are 0 nM to 32 nM (Dasatinib). The Dasatinib concentration range is extended to 200 nM for mutant T315I.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: EμLMP2A (TgE and Tg6 strains), MYC (λ-MYC), and LMP2A/λ-MYC double transgenic mice (Tg6/λ-MYC)
  • Formulation: DMSO
  • Dosages: 30 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL warmed (41.5 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+dd H2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 506.02
Formula

C22H28ClN7O3S

CAS No. 863127-77-9
Storage powder
in solvent
Synonyms BMS-354825 Monohydrate

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Not yet recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic December 2019 Phase 1|Phase 2
NCT04115059 Not yet recruiting Drug: Dasatinib Waldenstrom Macroglobulinemia|DASATINIB Jorge J. Castillo MD|Bristol-Myers Squibb|Dana-Farber Cancer Institute November 2019 Phase 1
NCT03318770 Not yet recruiting Drug: Dasatinib and blinatumomab Acute Lymphoblastic Leukemia Gruppo Italiano Malattie EMatologiche dell''Adulto December 2018 --
NCT03625388 Recruiting Drug: Dasatinib Chronic Myelogenous Leukemia Hikma Pharmaceuticals LLC November 5 2018 Phase 2
NCT03193281 Recruiting Drug: Dasatinib|Drug: Imatinib Chronic Myeloid Leukemia University of Auckland New Zealand|Leukaemia & Blood Cancer New Zealand July 17 2017 Phase 2
NCT03041701 Recruiting Drug: Dasatinib|Drug: Ganitumab Rhabdomyosarcoma|Rhabdomyosarcoma- Alveolar|Rhabdomyosarcoma-Embryonal National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 7 2017 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What’s the difference between S1021 and S7782?

  • Answer:

    Usually, hydrate will be more stable and dissolve better than free base. But this compound (S1021) dissolves better in DMSO than hydrate one (S7782).

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID