Dasatinib Monohydrate

Catalog No.S7782 Synonyms: BMS-354825 Monohydrate

For research use only.

Dasatinib Monohydrate (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

Dasatinib Monohydrate Chemical Structure

CAS No. 863127-77-9

Selleck's Dasatinib Monohydrate has been cited by 232 publications

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Biological Activity

Description Dasatinib Monohydrate (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
Targets
Abl [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
c-Kit (D816V) [2]
(Cell-free assay)
c-Kit (wt) [2]
(Cell-free assay)
0.6 nM 0.8 nM 37 nM 79 nM
In vitro

Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (∼325-fold) increased potency relative to imatinib. Dasatinib potently inhibits wild-type Abl kinase and all mutants except T315I over a narrow range. Dasatinib directly targets wild-type and mutant Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. [1] The percent of colonies of TgE bone marrow cells are decreased from 100% in untreated wells to 4.12% in Dasatinib treated wells. In the presence of Dasatinib, the difference in the percentage of colonies formed by WT and TgE bone marrow cells is statistically significant. Expression of LMP2A is able to promote B lymphocyte survival and proliferation, which can be inhibited by targeting Lyn and/or c-Abl kinases through Dasatinib. [3] Dasatinib treatment inhibits Src signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells. Treatment with increasing doses of Dasatinib (0.019 μM to 1.25 μM) for 3 days inhibits the growth of the C643, TPC1, BCPAP, and SW1736 cell lines by about 50% at low nanomolar concentrations, while higher concentrations are required to inhibit the growth of the K1 cell line. Treatment with 10 nM or 50 nM Dasatinib results in a 9-22% increase of cells in the G1 population among BCPAP and SW1736 and K1 cells, and a corresponding 7-18% decrease in the percentage of cells in the S phase. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 cell MlzQVJJwdGmoZYLheIlwdiCjc4PhfS=> M2fJNVczKGh? NXTTWY17SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0xNjByMTFOwG0> NWLZWIZTOTV4MUW1NVI>
WiDr cell NFnUVIZRem:uaX\ldoF1cW:wIHHzd4F6 M3noXlczKGh? MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFerRIKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUCuNFUzKM7:TR?= MnfiNVU3OTV3MUK=
PC3 cell MVzQdo9tcW[ncnH0bY9vKGG|c3H5 MYC3NkBp MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MD6wNFk1KM7:TR?= MX:xOVYyPTVzMh?=
MDA-MB-231 cell MmHPVJJwdGmoZYLheIlwdiCjc4PhfS=> MmL3O|IhcA>? NGPHSoRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUCuNFEzKM7:TR?= NFzUV5IyPTZzNUWxNi=>
M07ep210 cell NGn4U4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV;mUZJbPDhiaB?= NXPNVoVuT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTB5ZYCyNVAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGuzTH11cHmvaXTpcoUhfXC2YXvlJIF{e2G7LDDJR|UxRTBwMEegcm0> NYPrcmt4OTd7NU[wPFA>
K562 cell NWOxOZRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2Ww[FQ5KGh? MljRS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgX|NJZXSqeX3p[Ilv\SC3cIThb4Uh[XO|YYmsJGlEPTB;MD6wNFEh|ryP M4C2Z|E4QTV4MEiw
M07e cell MoTJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX:0PEBp M3\NWmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG0xP2ViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHs{UF22aIntbYRqdmVidYD0ZYtmKGG|c3H5MEBKSzVyPUCuNFAyOiEQvF2= MkTiNVc6PTZyOEC=
K562 cell M1P0ZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYrmOmFrPzJiaB?= M2LybWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXC16IILlZYdmdnRiYnHz[YQhVVSWIHHzd4F6NCCLQ{WwQVEzNjh|IN88US=> NUPkRYxbOjJ{MUe4O|c>
U937 cell MmTrR5l1d3SxeHnjbZR6KGG|c3H5 MUm3NkBp NFrmd|lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RvODDy[YFo\W62IHLhd4VlKE2WVDDhd5NigSxiSVO1NF0yOy54MzFOwG0> MnKyNlIzOTd6N{e=
K562 cell NYm3RWV2WHKxbHnm[ZJifGmxbjDhd5NigQ>? MmSyO|IhcA>? MmiwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxRTBwNzDuUS=> MlzLNlM2OjFyMkC=
MDA-MB-435S cell MVvQdo9tcW[ncnH0bY9vKGG|c3H5 MkT5O|IhcA>? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01OzWVIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9N{46KM7:TR?= M1jwUFI{PTJzMEKw
NCI-H460 cell MorEVJJwdGmoZYLheIlwdiCjc4PhfS=> MU[3NkBp M2\Qd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME24Mlk6KM7:TR?= MUSyN|UzOTB{MB?=
NCI-H23 cell MXnQdo9tcW[ncnH0bY9vKGG|c3H5 MXW3NkBp M4e1SGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuNlch|ryP MmXuNlM2OjFyMkC=
A549 cell M1\aNnBzd2yrZnXyZZRqd25iYYPzZZk> MYq3NkBp M2LHOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF{Lk[2JO69VQ>? MXeyN|UzOTB{MB?=
T47D cell NGTMR45Rem:uaX\ldoF1cW:wIHHzd4F6 MV:3NkBp M4j1eGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwOTFOwG0> MXWyN|UzOTB{MB?=
HCT116 cell MojpVJJwdGmoZYLheIlwdiCjc4PhfS=> NE\CZ3k4OiCq NVSzNI91SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yMlMh|ryP MYeyN|UzOTB{MB?=
MCF7 cells MWPQdo9tcW[ncnH0bY9vKGG|c3H5 NGD5b4Y4OiCq NHj2XmJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{LkW3JO69VQ>? MomzNlM2OjFyMkC=
RXF 393NL cell M37mXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NY\QbVJPPCCmYYnz MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGYhOzl|TlygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoctKEmFNUC9NlEvPyCwTR?= NXO0[5VnOjN{NUOwO|Q>
PRXF DU145 cell MWfDfZRwfG:6aXPpeJkh[XO|YYm= M1r6dFQh\GG7cx?= M1nHcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBTYEZiRGWxOFUh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmduIFnDOVA:OC5yNkKzJO69VQ>? NG\1XogzOzJ3M{C3OC=>
LXFA 983L cell M3zFVWN6fG:2b4jpZ4l1gSCjc4PhfS=> M37LW|Qh\GG7cx?= M2Phb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxZTkFiOUizUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF02Pi53IH7N Ml3xNlMzPTNyN{S=
GXF251L cell MYrDfZRwfG:6aXPpeJkh[XO|YYm= NHjpV3E1KGSjeYO= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHXGYzPTGOIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMEBKSzVyPUKuNlUh|ryP MViyN|I2OzB5NB?=
CXF 1103L cell MXPDfZRwfG:6aXPpeJkh[XO|YYm= M{XLR|Qh\GG7cx?= M{D5dWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNZTiBzMUCzUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF01NjN4IN88US=> NYDsOVFiOjN{NUOwO|Q>
PAXF 1657L cell MVLDfZRwfG:6aXPpeJkh[XO|YYm= MV60JIRigXN? NE\veYNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSViIIEG2OVdNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLDDJR|UxRTBwMUKxJO69VQ>? NEXCZ3MzOzJ3M{C3OC=>
NCI-H1648 cell M{S3Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFn1TYdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEKwNVEh|ryP Ml\YV2FPT0WU
NCI-H1838 cell NWDIOmJjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUizPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzB5M{Og{txO NGfH[oVUSU6JRWK=
NCI-H2126 cell MmTnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLwTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh5NUWyJO69VQ>? NXXlSmZLW0GQR1XS
NCI-H2141 cell M1TMdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFrIVJRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE1OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lke3OVQh|ryP M2TrdXNCVkeHUh?=
NCI-H2107 cell NX3oTGlzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{fWdGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVA4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDNwNEi0O{DPxE1? M2nzbnNCVkeHUh?=
NCI-H747 cell Moe2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\mW2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3OFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB6M{[yJO69VQ>? NFfrXplUSU6JRWK=
NCI-H720 cell NInGO29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIDoNGtKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwMkezN{DPxE1? M{XKdXNCVkeHUh?=
NKM-1 cell NWfWSlJZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnRdZF5UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU4{ODh3OTFOwG0> MXPTRW5ITVJ?
NMC-G1 cell NVzISoNFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGjDWllKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yOTZyNjFOwG0> M2Ltd3NCVkeHUh?=
NTERA-S-cl-D1 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH;BWJJKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVIzQDNizszN NHXSXGdUSU6JRWK=
OCI-AML2 cell MnOzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX32T3FKUW6qaXLpeIlwdiCxZjDoeY1idiCRQ1mtRW1NOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PS56NkG1OEDPxE1? M3H6bXNCVkeHUh?=
OCUB-M cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6wOFQyOiEQvF2= NXvtWYV5W0GQR1XS
OPM-2 cell MniwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3XNTWlvcGmkaYTpc44hd2ZiaIXtZY4hV1CPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUSuNlc3QDVizszN MVHTRW5ITVJ?
OS-RC-2 cell M4P0fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFIxOyEQvF2= M{DFVnNCVkeHUh?=
ONS-76 cell NGfL[49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVKwd|VnUW6qaXLpeIlwdiCxZjDoeY1idiCRTmOtO|Yh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPDJ7NUGg{txO NWGzR|duW0GQR1XS
OVCAR-4 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVi3cZZoUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjN5NEOzJO69VQ>? M4XNZnNCVkeHUh?=
NCI-H446 cell NWP1c5U1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX31ZZNpUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ1PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC54Mke2JO69VQ>? NYD4TZJRW0GQR1XS
NCI-H510A cell NV3wTmp6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmX6TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVE6NjN7N{Og{txO MVvTRW5ITVJ?
PF-382 cell NXTMeWxVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUDqZmhWUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTd4N{ig{txO NVHHOo1iW0GQR1XS
NCI-H64 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUK5MlYzPTNizszN M2e0XHNCVkeHUh?=
PSN1 cell NE\KWmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7xcXJKdmirYnn0bY9vKG:oIHj1cYFvKFCVTkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFQ1PzRizszN NIHqVmlUSU6JRWK=
QIMR-WIL cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDLTY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE44ODZ{OTFOwG0> MVnTRW5ITVJ?
RL95-2 cell MmTZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX32[4hRUW6qaXLpeIlwdiCxZjDoeY1idiCUTEm1MVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTB|ODFOwG0> MYnTRW5ITVJ?
RCC10RGB cell M3q3Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUXvXZBvUW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC52OUGxJO69VQ>? M3vvVHNCVkeHUh?=
RKO cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3rMZ2lvcGmkaYTpc44hd2ZiaIXtZY4hWkuRIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkWyPVY3KM7:TR?= M3LPTHNCVkeHUh?=
NCI-SNU-16 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLqepFuUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD16LkW2NVI5KM7:TR?= MYDTRW5ITVJ?
RPMI-6666 cell MkDlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDNSZlKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Py5{N{C2O{DPxE1? MWXTRW5ITVJ?
NEC8 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHrRcFNKdmirYnn0bY9vKG:oIHj1cYFvKE6HQ{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUS0MlM{PiEQvF2= MnfEV2FPT0WU
RS4-11 cell M4jubWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEnEcGRKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9O{43PTd6NzFOwG0> MYjTRW5ITVJ?
RXF393 cell MkTtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml\3TY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFI{PTdizszN MmrJV2FPT0WU
Raji cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzPR3U4UW6qaXLpeIlwdiCxZjDoeY1idiCUYXrpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xN{44PDl5IN88US=> MX;TRW5ITVJ?
NOS-1 cell NGTyRY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEXpe3hKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxPjF{OTFOwG0> MkDGV2FPT0WU
SBC-1 cell M4nGd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkfVTY5pcWKrdHnvckBw\iCqdX3hckBUSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT61O|k5PCEQvF2= M4LkNXNCVkeHUh?=
SF126 cell Mn;PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHjqW2lKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM2PDFizszN M2Cx[XNCVkeHUh?=
SF539 cell M1HpPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJHNHPTN7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zMz64OVU4KM7:TR?= MmTqV2FPT0WU
SH-4 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37oU2lvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xPFQyOyEQvF2= MXTTRW5ITVJ?
OMC-1 cell NUnDb|lkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJG9OSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{Nz6xOFIzKM7:TR?= NUnSTmxkW0GQR1XS
SIG-M5 cell M3TYZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIPoeYFKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9PU4xOjR7MzFOwG0> MY\TRW5ITVJ?
SJSA-1 cell NXrzUIdwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fWbWlvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME24MlczQDB3IN88US=> MV3TRW5ITVJ?
SK-LMS-1 cell M2OxVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNUyPUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlEyQDh4IN88US=> M2jtTHNCVkeHUh?=
SK-NEP-1 cell NWLSbmw2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jRUmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvQDlzNUWg{txO NUmwUm9rW0GQR1XS
SKM-1 cell NEmyUXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MknUTY5pcWKrdHnvckBw\iCqdX3hckBUU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;OT6wNVc{PCEQvF2= NYq2OIFXW0GQR1XS
SK-PN-DW cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfpPFh4UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OzZwMUm0N{DPxE1? NFKye2ZUSU6JRWK=
SK-UT-1 cell NETpU29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUKuNVY3QTNizszN NEjCRXRUSU6JRWK=
SNB75 cell NFPJXVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfISItKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1PDN3IN88US=> MnfqV2FPT0WU
REH cell NWrMZpM5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OjBwNkO1O{DPxE1? NFjCVoZUSU6JRWK=
SNU-C2B cell M3\5XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkD6TY5pcWKrdHnvckBw\iCqdX3hckBUVlVvQ{LCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlMxPTh7IN88US=> M{HJdXNCVkeHUh?=
RPMI-8866 cell MnXoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmLjTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi4OlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVE4NjR2NUWg{txO M13KbXNCVkeHUh?=
SW872 cell NHjQ[2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHv6d3FKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1OTZzIN88US=> NICxOmlUSU6JRWK=
SW962 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGi0[lVKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlEyOjl{IN88US=> MULTRW5ITVJ?
SF268 cell NFnzN3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFq2V4ZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMk[4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE4PDB2IN88US=> M{C5[3NCVkeHUh?=
TE-1 cell NGnSOHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUC1OEDPxE1? MoOzV2FPT0WU
8-MG-BA cell NGX1dFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[3cWlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yPTR3ODFOwG0> M1K5dHNCVkeHUh?=
A101D cell NXL4W3NpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn:zTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6wN|A1OyEQvF2= M4HRNnNCVkeHUh?=
A253 cell NGrC[FFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrOdnVXUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlc{OjR4IN88US=> M1zmVHNCVkeHUh?=
A3-KAW cell MkjJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn3qTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuPVg1PTJizszN MomzV2FPT0WU
A4-Fuk cell NHXyNFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2TyUGlvcGmkaYTpc44hd2ZiaIXtZY4hSTRvRoXrJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zPE4yODB7IN88US=> MkHHV2FPT0WU
A388 cell NYXvfFBLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEW2SldKdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFUxQTVizszN MnHHV2FPT0WU
ACN cell M4OyNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPvPIJCUW6qaXLpeIlwdiCxZjDoeY1idiCDQ16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuPFIzPTJizszN NILG[mJUSU6JRWK=
A704 cell NEnRc3RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3mwVGlvcGmkaYTpc44hd2ZiaIXtZY4hSTdyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNVQ6OSEQvF2= NX\PfY1yW0GQR1XS
ALL-PO cell NYHEdGhpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTONFlKdmirYnn0bY9vKG:oIHj1cYFvKEGOTD3QU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVAvPzl|ODFOwG0> NVvmXJhMW0GQR1XS
ARH-77 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjmRllKdmirYnn0bY9vKG:oIHj1cYFvKEGUSD23O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N{41PjlzNTFOwG0> NUXOfVU6W0GQR1XS
SR cell NEfQRnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILwfG1KdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD12LkS5PVU1KM7:TR?= NV\vN2JkW0GQR1XS
BB65-RCC cell NFq0cndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\0SmlvcGmkaYTpc44hd2ZiaIXtZY4hSkJ4NT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh{Mkeg{txO NWXQeZQ1W0GQR1XS
BB49-HNC cell NGm0bZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlvmTY5pcWKrdHnvckBw\iCqdX3hckBDSjR7LVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{QDV7OTFOwG0> NUH5N4dYW0GQR1XS
BC-1 cell NUH2bG5zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4PLOWlvcGmkaYTpc44hd2ZiaIXtZY4hSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MkiuOlUyKM7:TR?= MXvTRW5ITVJ?
BC-3 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGPORnJKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGyMlEyOzhizszN NHm5PW9USU6JRWK=
BL-41 cell M2\1VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1XYWGlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNlkyOjNizszN NVnDWHg{W0GQR1XS
BL-70 cell Mm\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIr0dWFKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxODByMEiyNVgh|ryP NITxVmJUSU6JRWK=
SW684 cell NYC1NGVkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1vIXWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|Q6QCEQvF2= NXTVO|N6W0GQR1XS
BOKU cell NIHKbnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\WVmJKdmirYnn0bY9vKG:oIHj1cYFvKEKRS2WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOFkyOzNizszN MVrTRW5ITVJ?
SW954 cell NI\yOGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTV2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyPVI4KM7:TR?= M4nYd3NCVkeHUh?=
C2BBe1 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXfZOHdYUW6qaXLpeIlwdiCxZjDoeY1idiCFMlLC[VEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh|MEig{txO Ml7qV2FPT0WU
BV-173 cell M{LCOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoO0TY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODByMUC5JO69VQ>? NFLReI5USU6JRWK=
Becker cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoGxTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFMxODNizszN MUfTRW5ITVJ?
SW982 cell NYrsOlFwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4HrZ2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFEyOTVizszN NH7GW2tUSU6JRWK=
697 cell NEjwUI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYnJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zOUm4O{DPxE1? NWrvbGdRW0GQR1XS
TE-15 cell NX:1fmxmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1T2OWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFA2QDlzIN88US=> NUP2V3JVW0GQR1XS
TE-11 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC3PFU5KM7:TR?= M3ryfHNCVkeHUh?=
TE-5 cell MoT2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIrRcGtKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuO|kyOzlizszN MUDTRW5ITVJ?
TE-6 cell M3ztcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlTiTY5pcWKrdHnvckBw\iCqdX3hckBVTS14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkKxNlI3KM7:TR?= MWTTRW5ITVJ?
TE-9 cell NVjjTZA{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fwZ2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD64O|U{OiEQvF2= M2PkbXNCVkeHUh?=
TGBC24TKB cell NF7GPXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGHMeINKdmirYnn0bY9vKG:oIHj1cYFvKFSJQlOyOHRMSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yNEe2NUDPxE1? NV\ZW21vW0GQR1XS
TGW cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJHRIXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OTFwMkiyPEDPxE1? MYHTRW5ITVJ?
TK10 cell NEPvNYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfjTY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxNVc1KM7:TR?= M2G4OHNCVkeHUh?=
TGBC1TKB cell MofWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUnJcohq[mm2aX;uJI9nKGi3bXHuJHRISkNzVFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA3OTZ2IN88US=> NYjuUop[W0GQR1XS
A498 cell NYTsNWc4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmXyTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC3Nlg1KM7:TR?= NGrwNoRUSU6JRWK=
UACC-257 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlzDTY5pcWKrdHnvckBw\iCqdX3hckBWSUOFLUK1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVIvQTF7ODFOwG0> MVnTRW5ITVJ?
U-87-MG cell NFvVOHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml;wTY5pcWKrdHnvckBw\iCqdX3hckBWNTh5LV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zNE44PjZizszN MlL1V2FPT0WU
BB30-HNC cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoDVTY5pcWKrdHnvckBw\iCqdX3hckBDSjNyLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPTR|NzFOwG0> MnTSV2FPT0WU
no-10 cell NX[3WXlqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnSdHBtUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{OTl|MTFOwG0> MXjTRW5ITVJ?
CAS-1 cell NEDzRnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LG[GlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuOFA6QTJizszN M17rSHNCVkeHUh?=
CGTH-W-1 cell NVu2T5F1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\NTY5pcWKrdHnvckBw\iCqdX3hckBET1SKLWetNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOzV2ODFOwG0> MmfkV2FPT0WU
TE-10 cell NWnjdotRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vJbGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFY{PTdizszN MnvuV2FPT0WU
COLO-684 cell NGW0fZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHLGNpNKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tOlg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF01Pi5{MkW4JO69VQ>? NGHIXJNUSU6JRWK=
TE-12 cell NFfPUFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2DLbGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFE5PjFizszN NF;KXWtUSU6JRWK=
COR-L279 cell M4Du[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzmTGhKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNlc6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF01OC5{OEWyJO69VQ>? NIHvfoZUSU6JRWK=
TE-8 cell M4f1W2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3PNmM3UW6qaXLpeIlwdiCxZjDoeY1idiCWRT24JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyPTd4IN88US=> NV\rbm95W0GQR1XS
CP66-MEL cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULjRZRTUW6qaXLpeIlwdiCxZjDoeY1idiCFUE[2MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zOUWzNUDPxE1? MmO2V2FPT0WU
CTV-1 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2POT2lvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODRyM{[g{txO M4DkcnNCVkeHUh?=
VA-ES-BJ cell M{jHNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NILiUXRKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB|OUCyJO69VQ>? NEfPWJFUSU6JRWK=
D-263MG cell M2HaRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXmwXIZqUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjN4MkK0JO69VQ>? MWPTRW5ITVJ?
D-336MG cell NIP1NFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFA3Ojl6IN88US=> NYP6XpQzW0GQR1XS
D-502MG cell M4LCcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3nBdGlvcGmkaYTpc44hd2ZiaIXtZY4hTC13MELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU4zOzN5NjFOwG0> M2jvVnNCVkeHUh?=
DJM-1 cell MkfVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGRLVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD14LkS4OVU5KM7:TR?= MmjNV2FPT0WU
no-11 cell Mn3SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjiR5pkUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE42ODJ{ODFOwG0> MlmyV2FPT0WU
DMS-153 cell MmPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXmwfVg1UW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVU{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yPC5yMEK4JO69VQ>? MYTTRW5ITVJ?
DSH1 cell NYPK[4M2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnP0TY5pcWKrdHnvckBw\iCqdX3hckBFW0hzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkK0NFAyKM7:TR?= MWfTRW5ITVJ?
DU-4475 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWT2UIVkUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJzNkWyJO69VQ>? MoLqV2FPT0WU
EB-3 cell NVLWU4dKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJGVDNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTN2LkOxNVgh|ryP MULTRW5ITVJ?
EHEB cell MlrBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGVJTUJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFyLkC2OVYh|ryP Mni1V2FPT0WU
COLO-829 cell M2DCeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vOEK5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlEzOjF|IN88US=> MVnTRW5ITVJ?
CP67-MEL cell NHv4SGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGD1UmxKdmirYnn0bY9vKG:oIHj1cYFvKEOSNketUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjJyNEi4JO69VQ>? NXPaSXpkW0GQR1XS
ES8 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPTVGRXUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUOyMlEzPTJizszN MkLDV2FPT0WU
EVSA-T cell NFv5dJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGVXW0FvVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;OT6yO|c6OyEQvF2= NHvL[pFUSU6JRWK=
ES4 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVfSfWdZUW6qaXLpeIlwdiCxZjDoeY1idiCHU{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNFUyPDVizszN MVHTRW5ITVJ?
ETK-1 cell NVGyTZVTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknETY5pcWKrdHnvckBw\iCqdX3hckBGXEtvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNlg{OiEQvF2= NFHxcVJUSU6JRWK=
ES6 cell NGDHW2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTnTY5pcWKrdHnvckBw\iCqdX3hckBGWzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEOxPVMh|ryP NXnPbZFsW0GQR1XS
EW-24 cell Ml7TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rYUWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuO|gyPjVizszN M4LtcXNCVkeHUh?=
EoL-1-cell cell NITr[2VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXyzVI5GUW6qaXLpeIlwdiCxZjDoeY1idiCHb1ytNU1k\WyuIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwNFAyOzB7IN88US=> MnnrV2FPT0WU
Calu-6 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LubWlvcGmkaYTpc44hd2ZiaIXtZY4hS2GudT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlA2PzRzIN88US=> NH;4V4dUSU6JRWK=
GAK cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1\XUmlvcGmkaYTpc44hd2ZiaIXtZY4hT0GNIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1|MT6yOlg3KM7:TR?= NEj1N|dUSU6JRWK=
D-247MG cell NUL6NWZGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1HDd2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NEfNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Ok4yOjVzOTFOwG0> MVvTRW5ITVJ?
GB-1 cell Mn;CS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJGdDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEKxOVch|ryP NHTHZ4lUSU6JRWK=
GI-ME-N cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVv1VZJZUW6qaXLpeIlwdiCxZjDoeY1idiCJST3NSU1PKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB4MUG4JO69VQ>? NWDES4tQW0GQR1XS
GCIY cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3r0R2lvcGmkaYTpc44hd2ZiaIXtZY4hT0OLWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wPVY2PiEQvF2= MVHTRW5ITVJ?
GT3TKB cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MULJcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;OT6zOVU1PiEQvF2= M2jGSXNCVkeHUh?=
HC-1 cell NXz6Z|JoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\ZTY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{ND61OVUyKM7:TR?= M1rkSXNCVkeHUh?=
HAL-01 cell M1HSZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFTUPIxKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVkvPzV2MzFOwG0> NF3SbmVUSU6JRWK=
HCC1187 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV\wXYtoUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxNVg4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{PS56MEWyJO69VQ>? MlvyV2FPT0WU
DEL cell NWH6O41PT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PDFwOUC4OkDPxE1? M3jXe3NCVkeHUh?=
HCC1599 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWTKZ2F7UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxOVk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{Oi5|M{K1JO69VQ>? NFX5S|dUSU6JRWK=
DOHH-2 cell NUTrPZI6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4HFcmlvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyPzF7IN88US=> M4SzPXNCVkeHUh?=
HCC2157 cell NWfrbFdDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYC5bJF5UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNVU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{Py57OUS2JO69VQ>? NX3Bc41TW0GQR1XS
HCE-4 cell NYjvc29VT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX3zbY1tUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1WtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4zPjR|OTFOwG0> MWjTRW5ITVJ?
HCE-T cell NFHINpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILEOJNKdmirYnn0bY9vKG:oIHj1cYFvKEiFRT3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlU3PzF2IN88US=> NHf6fW1USU6JRWK=
HEL cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3iTY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFyLkS3O|Yh|ryP NH6xO|dUSU6JRWK=
EM-2 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXSRYVKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODBzMEe4JO69VQ>? NVfEco46W0GQR1XS
HT-144 cell NUH2R2tmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVrud2V4UW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPTN4MEmg{txO MmfqV2FPT0WU
EW-16 cell NGTHSFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3X3NGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuO|YyPzhizszN NILKS25USU6JRWK=
IA-LM cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWK3VIE2UW6qaXLpeIlwdiCxZjDoeY1idiCLQT3MUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVIvPDR2NTFOwG0> Mn[4V2FPT0WU
IST-MEL1 cell NX\xNJhwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH[zbotKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3NSWwyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF|NEWg{txO Mnu3V2FPT0WU
IST-MES1 cell NWDkSYF6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PEUGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FV|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh3NUKg{txO NXXvXVJXW0GQR1XS
GI-1 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDBTY5pcWKrdHnvckBw\iCqdX3hckBIUS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkO2NlIh|ryP M1HKe3NCVkeHUh?=
IST-SL2 cell M3jydmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVA{ODJizszN M2P1[3NCVkeHUh?=
JVM-2 cell M1fFVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYC5V2dRUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk4{PjJ6NDFOwG0> MXzTRW5ITVJ?
JVM-3 cell M1XtdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVLJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1|Nz6yN|M5KM7:TR?= MUnTRW5ITVJ?
KALS-1 cell NWq4T4tKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnLXTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFk1QSEQvF2= M1LONXNCVkeHUh?=
KARPAS-422 cell NFS3emRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmjmTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjN|OUm3JO69VQ>? NUC4c21qW0GQR1XS
JiyoyeP-2003 cell NUnUU5NiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3ITY5pcWKrdHnvckBw\iCqdX3hckBLcXmxeXXQMVIxODNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwN{O0OlYh|ryP NIXsdlNUSU6JRWK=
KARPAS-45 cell NVvIbXRDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYHJcohq[mm2aX;uJI9nKGi3bXHuJGtCWlCDUz20OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9O{42OTZ5MTFOwG0> NVuxW416W0GQR1XS
KGN cell NH3Re3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yMUm0NkDPxE1? NHvme2xUSU6JRWK=
KLE cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MljJTY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUGzNVch|ryP MVjTRW5ITVJ?
KNS-42 cell NXPH[oxFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH;HRZlKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU4zPDRzMjFOwG0> NVXmRWRRW0GQR1XS
KNS-81-FD cell NGDkPVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVnleXFWUW6qaXLpeIlwdiCxZjDoeY1idiCNTmOtPFEuTkRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ|LkG0OkDPxE1? MW\TRW5ITVJ?
KP-N-YS cell M1\CZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHSeJk{UW6qaXLpeIlwdiCxZjDoeY1idiCNUD3OMXlUKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yOi57MkizJO69VQ>? M3zsSXNCVkeHUh?=
HOP-62 cell NGP3N2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NITQUotKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOTh|NDFOwG0> M{TFd3NCVkeHUh?=
KURAMOCHI cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\5cYJKdmirYnn0bY9vKG:oIHj1cYFvKEuXUlHNU2NJUSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yM{S4O{DPxE1? NF3OZXZUSU6JRWK=
HUTU-80 cell M13EXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoTaTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlMyPDJizszN NGfSWZBUSU6JRWK=
LAMA-84 cell NHrLPJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3\FdWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xODByMEOyNFch|ryP MnWxV2FPT0WU
LB1047-RCC cell NXP4Z|Z[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4ftb2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yMEm4PFch|ryP M1vVSHNCVkeHUh?=
LB2518-MEL cell M{HlSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\FdFJKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUSxOlIh|ryP MoLKV2FPT0WU
LB373-MEL-D cell Mn[2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3zKV2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ|N{OtUWVNNURiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwOEK1NFgh|ryP NX\xVWY2W0GQR1XS
LB771-HNC cell MlTmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGxDPzdzLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk42PzV3MTFOwG0> NELnTJdUSU6JRWK=
LB996-RCC cell NGfCZoVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1\UeGlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByOUmxNkDPxE1? M4ntZnNCVkeHUh?=
LC-2-ad cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInnN4JKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODJ3OE[g{txO NVHpfnRmW0GQR1XS
J-RT3-T3-5 cell NH\USFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlrFTY5pcWKrdHnvckBw\iCqdX3hckBLNVKWMz3UN{02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05Njl4NUK5JO69VQ>? NEDqWYtUSU6JRWK=
LP-1 cell M4rjcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfDcokzUW6qaXLpeIlwdiCxZjDoeY1idiCOUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME23MlU1Pzh{IN88US=> NXq3VY5JW0GQR1XS
K-562 cell NV7hU5o2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWDJcohq[mm2aX;uJI9nKGi3bXHuJGsuPTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwNFAxODJ4NU[g{txO NIfqR|hUSU6JRWK=
LS-123 cell Ml3JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrP[YdOUW6qaXLpeIlwdiCxZjDoeY1idiCOUz2xNlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTRyNkSg{txO M4K1NXNCVkeHUh?=
K5 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDITY5pcWKrdHnvckBw\iCqdX3hckBMPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zNkS4PUDPxE1? MXzTRW5ITVJ?
LS-411N cell M13vd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfpO2FKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUSxNW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVQ5NjR5NEig{txO MXjTRW5ITVJ?
KG-1 cell M1\nc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3LiU2lvcGmkaYTpc44hd2ZiaIXtZY4hU0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;ND62NFg1PSEQvF2= M4LkOnNCVkeHUh?=
KINGS-1 cell Mof5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\0RopUUW6qaXLpeIlwdiCxZjDoeY1idiCNSV7HV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjF4Nk[2JO69VQ>? MYPTRW5ITVJ?
LXF-289 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFM6PTZizszN M1\jenNCVkeHUh?=
MC116 cell MoLIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\JdnNKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlEyPDFizszN MWHTRW5ITVJ?
KS-1 cell NF\POIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MonJTY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyO|Mh|ryP M37Be3NCVkeHUh?=
KU812 cell NGPUe|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmLQTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNVg5OyEQvF2= MYrTRW5ITVJ?
MEG-01 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnH3TY5pcWKrdHnvckBw\iCqdX3hckBOTUdvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODB7OEC1JO69VQ>? MYPTRW5ITVJ?
MFH-ino cell NYfGZmhzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofyTY5pcWKrdHnvckBw\iCqdX3hckBOTkhvaX7vJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1PzJ2IN88US=> NF75codUSU6JRWK=
L-540 cell NHrOSI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkjCTY5pcWKrdHnvckBw\iCqdX3hckBNNTV2MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUWuNFY4OSEQvF2= Ml;kV2FPT0WU
MHH-NB-11 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2QQj2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OFMvODhzODFOwG0> MkKxV2FPT0WU
MMAC-SF cell M{n0SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFq5XoxKdmirYnn0bY9vKG:oIHj1cYFvKE2PQVOtV2Yh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvPzl|MEeg{txO M1\LZ3NCVkeHUh?=
LB2241-RCC cell Ml32S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojyTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF06NjB{MEGyJO69VQ>? NFHEWJdUSU6JRWK=
LB831-BLC cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MofBTY5pcWKrdHnvckBw\iCqdX3hckBNSjh|MT3CUGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODR4MEmg{txO MXHTRW5ITVJ?
MOLT-16 cell Mo\VS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH\vcnRKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVI6NjZ{OUKg{txO NVjnWGxTW0GQR1XS
LC-1F cell Mo\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGxENTGIIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{Nz6zNlQ2KM7:TR?= NYD5WHZPW0GQR1XS
MOLT-4 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Mk[uOlc2OyEQvF2= M{\vV3NCVkeHUh?=
MZ1-PC cell NEnQUmZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYHJcohq[mm2aX;uJI9nKGi3bXHuJG1bOS2SQzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wN|EyQSEQvF2= MkG0V2FPT0WU
MONO-MAC-6 cell MmnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrvTY5pcWKrdHnvckBw\iCqdX3hckBOV06RLV3BR{03KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05NjJ5ME[2JO69VQ>? MYjTRW5ITVJ?
MZ2-MEL cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MorDTY5pcWKrdHnvckBw\iCqdX3hckBOYjJvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlI5PTN5IN88US=> MWDTRW5ITVJ?
MPP-89 cell NI\4NGRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wOFA1QSEQvF2= MYLTRW5ITVJ?
MZ7-mel cell MkP0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33NeWlvcGmkaYTpc44hd2ZiaIXtZY4hVVp5LX3lcEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE41PzlzMTFOwG0> M1f3V3NCVkeHUh?=
LOXIMVI cell M4j6ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjScoZKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOzF3MEOg{txO MVnTRW5ITVJ?
NALM-6 cell NWLa[mdlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;kVGlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE6Ojl3IN88US=> NUHVW45xW0GQR1XS
NB13 cell M3\jfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWfaSYZ4UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xPU41QDd5IN88US=> M{\WSHNCVkeHUh?=
NB5 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3r1[2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJ3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkO5PFI4KM7:TR?= MYrTRW5ITVJ?
NB17 cell MnvOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTNwNkO4OFch|ryP NHPR[2FUSU6JRWK=
NCCIT cell NWLMPJAxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYO5Znd[UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk45PjZzNjFOwG0> NVnVWVhiW0GQR1XS
NB69 cell MljSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEToOodKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVQ1OzZizszN NF;WUGVUSU6JRWK=
NCI-H1304 cell M33jPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfNcoZUUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ6LkG2Nlgh|ryP MXLTRW5ITVJ?
NCI-H1395 cell NH3kbnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVzWdmxsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{QTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTR{LkCxOlMh|ryP M3[xR3NCVkeHUh?=
MHH-PREB-1 cell Ml\qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1HCbmlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLWDSSWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC55NES2PUDPxE1? MUTTRW5ITVJ?
MLMA cell M2HBO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37iRWlvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xOFA{OiEQvF2= NEWzb|ZUSU6JRWK=
MN-60 cell MoK5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlW1TY5pcWKrdHnvckBw\iCqdX3hckBOVi14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUWuNVk4QSEQvF2= NVfYe|diW0GQR1XS
MV-4-11 cell M{eyc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PSXGlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OE4{PjR3NDFOwG0> M{nSUnNCVkeHUh?=
NB6 cell NYnhRopMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4e1OWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD17LkmyNlU6KM7:TR?= MmHaV2FPT0WU
NCI-H1355 cell NV;zWoVNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLxfFI6UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{PTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUGwNlgh|ryP M1fDc3NCVkeHUh?=
Assay
Methods Test Index PMID
Western blot phospho-c-Abl(Tyr245) / phospho-c-Src(Tyr416) ; p27 / p21 ; cleaved caspase 3 ; p-FAK/p-STAT3 23049975 20145167 23721490
Growth inhibition assay Cell viability 23721490
Immunofluorescence SRC / Met ; α-tubulin ; F-actin / Actinin-4 / Paxillin 26517812 31053734
ELISA TNF-α ; E-selectin ; VCAM-1 17684099 31110200
In vivo Dasatinib reverses splenomegaly in LMP2A/MYC double transgenic mice. Dasatinib specifically prevents colony formation by LMP2A expressing bone marrow B cells and decreased spleen size in the TgE mice. Spleen mass is significantly decreased among Dasatinib treated Tg6/λ-MYC mice when compared to the control group. Dasatinib inhibits lymphadenopathy in LMP2A/MYC double transgenic mice. Dasatinib reverses splenomegaly in Rag1KO mice engrafted with tumor cells from LMP2A/MYC double transgenic mice. Dasatinib therapy inhibits Lyn phosphorylation in B lymphocyte tumors expressing LMP2A. [3]

Protocol (from reference)

Kinase Assay:

[1]

  • Kinase autophosphorylation assays:

    Kinase assays using wild-type and mutant glutathione S-transferase (GST)-Abl fusion proteins (c-Abl amino acids 220-498) are done. GST-Abl fusion proteins are released from glutathione-Sepharose beads before use; the concentration of ATP is 5 μM. Immediately before use in kinase autophosphorylation and in vitro peptide substrate phosphorylation assays, GST-Abl kinase domain fusion proteins are treated with LAR tyrosine phosphatase. After 1-hour incubation at 30 °C, LAR phosphatase is inactivated by addition of sodium vanadate (1 mM). Immunoblot analysis comparing untreated GST-Abl kinase to dephosphorylated GST-Abl kinase is routinely done using phosphotyrosine-specific antibody 4G10 to confirm complete (>95%) dephosphorylation of tyrosine residues and c-Abl antibody CST 2862 to confirm equal loading of GST-Abl kinase. The Dasatinib concentration range is extended to 1,000 nM for mutant T315I. These same inhibitor concentrations are used for the in vitro peptide substrate phosphorylation assays. The three inhibitors are tested over these same concentration ranges against GST-Src kinase and GST-Lyn kinase.

Cell Research:

[1]

  • Cell lines: Ba/F3 cell lines
  • Concentrations: ~32 nM
  • Incubation Time: 72 hours
  • Method:

    Ba/F3 cell lines are seeded in triplicate and incubated with escalating concentrations of Dasatinib for 72 hours. Proliferation is measured using a methanethiosulfonate-based viability assay. IC50 and IC90 values are reported as the mean of three independent experiments done in quadruplicate. The inhibitor concentration ranges are 0 nM to 32 nM (Dasatinib). The Dasatinib concentration range is extended to 200 nM for mutant T315I.

Animal Research:

[3]

  • Animal Models: EμLMP2A (TgE and Tg6 strains), MYC (λ-MYC), and LMP2A/λ-MYC double transgenic mice (Tg6/λ-MYC)
  • Dosages: 30 mg/kg
  • Administration: Administered via i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+dd H2O
For best results, use promptly after mixing.

5mg/mL

Chemical Information

Molecular Weight 506.02
Formula

C22H28ClN7O3S

CAS No. 863127-77-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04925648 Recruiting Drug: Dasatinib|Drug: Darolutamide Metastatic Prostate Cancer St Vincent''s Hospital Sydney October 18 2021 Phase 2
NCT04933526 Not yet recruiting Drug: Flumatinib|Drug: Dasatinib Chronic Myeloid Leukemia in Chronic Phase Shenzhen Second People''s Hospital July 1 2021 Phase 4
NCT04063124 Recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT04155411 Recruiting Drug: Dasatinib Dasatinib|BCR-ABL|Chronic Myeloid Leukemia Shenzhen Second People''s Hospital December 1 2019 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
What’s the difference between S1021 and S7782?

Answer:
Usually, hydrate will be more stable and dissolve better than free base. But this compound (S1021) dissolves better in DMSO than hydrate one (S7782).

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