Home Angiogenesis -Protein Tyrosine Kinase Src Fgr Inhibitors

Fgr Inhibitors

  • Lck
  • Fyn
  • Lyn
  • Yes
  • Fgr
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1006 Saracatinib (AZD0530) Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. Pan FGR, IC50: 10 nM
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70. Pan FGR, IC50: 81 nM