A-205804

Catalog No.S2885 Batch:S288501

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Technical Data

Formula

C15H12N2OS2
Molecular Weight 300.4 CAS No. 251992-66-2
Solubility (25°C)* In vitro DMSO 60 mg/mL (199.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
3.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Targets
E-selectin [1] ICAM-1 [1]
20 nM 25 nM
In vitro A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. [2]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Cancer Lett, 2018, 438:105-115]

Data from [Data independently produced by , , Acta Pharmacologica Sinica, 2018, 39: 1-12 ]

Selleck's A-205804 has been cited by 5 publications

Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway [ Stem Cell Res Ther, 2022, 13(1):218] PubMed: 35619172
Adhesion Promotes Allergic Rhinitis CD4+IL4+ T Cell Differentiation via ICAM1 and E-Selectin [ Am J Rhinol Allergy, 2022, 19458924221086061] PubMed: 35296145
Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation [Zhang C, et al. Cancer Lett, 2018, 438:105-115] PubMed: 30227221
CTC clusters induced by heparanase enhance breast cancer metastasis [Wei RR, et al. Acta Pharmacol Sin, 2018, 39(8):1326-1337] PubMed: 29417941
Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells [Zimmermann-Geller B, et al. Immunol Cell Biol, 2018, 10.1111/imcb.12208] PubMed: 30252968

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.