Phloretin (RJC 02792)

Catalog No.S2342 Batch:S234205

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Technical Data

Formula

C15H14O5
Molecular Weight 274.27 CAS No. 60-82-2
Solubility (25°C)* In vitro DMSO 55 mg/mL (200.53 mM)
Ethanol 55 mg/mL (200.53 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
Targets
SGLT1 [1] SGLT2 [1]
In vitro Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , J Transl Med, 2017, 15:158]

Selleck's Phloretin (RJC 02792) has been cited by 6 publications

Novel luciferase-based glucagon-like peptide 1 reporter assay reveals naturally occurring secretagogues [ Br J Pharmacol, 2022, 10.1111/bph.15896] PubMed: 35736785
The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy [ Food Funct, 2020, 10.1039/d0fo02362k] PubMed: 33291138
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Intramelanocytic Acidification Plays a Role in the Antimelanogenic and Antioxidative Properties of Vitamin C and Its Derivatives. [ Oxid Med Cell Longev, 2019, 2019:2084805] PubMed: 31214276
Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability. [ J Transl Med, 2017, 15(1):158] PubMed: 28724379
NOX2-Mediated TFEB Activation and Vacuolization Regulate Lysosome-Associated Cell Death Induced by Gypenoside L, a Saponin Isolated from Gynostemma pentaphyllum. [ J Agric Food Chem, 2017, 65(31):6625-6637] PubMed: 28697598

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.