Lapatinib (GW-572016) Ditosylate

Name: Lapatinib (GW-572016) Ditosylate
Brand: Selleck Chemicals
SKU: S1028
Rating: 5 (98 reviews)

For research use only.

Catalog No.S1028

98 publications

Lapatinib (GW-572016) Ditosylate Chemical Structure

CAS No. 388082-77-7

Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Selleck's Lapatinib (GW-572016) Ditosylate has been cited by 98 publications

Nat Cell Biol, 2021, 23(4):377-390

PubMed: 33795873 ( click the link to review the publication )

Cell Metab, 2018, 28(6):817-832

PubMed: 30244971 ( click the link to review the publication )

Cancer Cell, 2016, 29(4):563-573

PubMed: 27070703 ( click the link to review the publication )

Cancer Cell, 2012, 21(4):488-503

PubMed: 22516258 ( click the link to review the publication )

Breast Cancer Res, 2021, 23(1):81

PubMed: 34344439 ( click the link to review the publication )

Cancers (Basel), 2021, 13(14)3635

PubMed: 34298852 ( click the link to review the publication )

Cell Death Dis, 2021, 12(6):588

PubMed: 34099636 ( click the link to review the publication )

Oncogenesis, 2021, 10(9):61

PubMed: 34535639 ( click the link to review the publication )

J Transl Med, 2021, 19(1):184

PubMed: 33933113 ( click the link to review the publication )

Sci Rep, 2021, 11(1):10893

PubMed: 34035375 ( click the link to review the publication )

BMC Cancer, 2021, 21(1):923

PubMed: 34399705 ( click the link to review the publication )

Cancer Med, 2021, 10(7):2370-2379

PubMed: 33665980 ( click the link to review the publication )

Environ Toxicol, 2021, 10.1002/tox.23125

PubMed: 33734566 ( click the link to review the publication )

Biochem Biophys Res Commun, 2021, 567:154-160

PubMed: 34157442 ( click the link to review the publication )

Hum Cell, 2021, 10.1007/s13577-021-00579-z

PubMed: 34304386 ( click the link to review the publication )

NPJ Breast Cancer, 2021, 7(1):51

PubMed: 33980863 ( click the link to review the publication )

NPJ Breast Cancer, 2021, 7(1):79

PubMed: 34145270 ( click the link to review the publication )

Nat Commun, 2020, 11(1):4591

PubMed: 32929084 ( click the link to review the publication )

Cancer Discov, 2020, 10(5):674-687

PubMed: 32213539 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Front Pharmacol, 2020, 11:601572

PubMed: 33362556 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Oncol Rep, 2020, 44(3):1127-1135

PubMed: 32582968 ( click the link to review the publication )
Cell Rep, 2019, 28(9):2331-2344

PubMed: 31461650 ( click the link to review the publication )

J Clin Med, 2019, 8(12)

PubMed: 31847378 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(18):4566-4578

PubMed: 29895705 ( click the link to review the publication )

Cell Syst, 2018, 6(3):329-342

PubMed: 29550255 ( click the link to review the publication )

Mol Cancer Res, 2018, 16(5):894-908

PubMed: 29453318 ( click the link to review the publication )

Ann Thorac Surg, 2018, 105(2):363-370

PubMed: 29223420 ( click the link to review the publication )

Cancer Biol Ther, 2018, 19(10):921-933

PubMed: 29856687 ( click the link to review the publication )

Methods Mol Biol, 2018, 1788:251-268

PubMed: 29243084 ( click the link to review the publication )

Oncotarget, 2018, 9(9):8560-8572

PubMed: 29492217 ( click the link to review the publication )

Cancer Res, 2017, 77(20):5554-5563

PubMed: 28923853 ( click the link to review the publication )

Cell Syst, 2017, 5(2):105-118

PubMed: 28837809 ( click the link to review the publication )

Proteomics, 2017, 10.1002/pmic.201600335

PubMed: 28127872 ( click the link to review the publication )

Tumour Biol, 2017, 39(3):1010428317695028

PubMed: 28349782 ( click the link to review the publication )

Cancer Res, 2016, 76(20):6095-6106

PubMed: 27569217 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2486-2497

PubMed: 27507850 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

BMC Cancer, 2016, 16(1):813

PubMed: 27756261 ( click the link to review the publication )

BMC Cancer, 2016, 16:678

PubMed: 27558154 ( click the link to review the publication )

Cancer Invest, 2016, 34(9):424-430

PubMed: 27657189 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26551-66

PubMed: 27034169 ( click the link to review the publication )

Gut, 2015, 10.1136/gutjnl-2014-309026

PubMed: ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Cancer Res, 2015, 10.1158/0008-5472.CAN-15-0370

PubMed: 25952648 ( click the link to review the publication )

Mol Cancer, 2015, 10.1186/s12943-015-0345-x

PubMed: ( click the link to review the publication )
Oncogene, 2015, 34(9):1160-73

PubMed: ( click the link to review the publication )

Cell Death Dis, 2015, 6:e1699

PubMed: 25789974 ( click the link to review the publication )

Mol Oncol, 2015, 9(3):586-600

PubMed: 25435280 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2015, 10.1016/j.taap.2015.05.001

PubMed: 25981168 ( click the link to review the publication )

Cell Cycle, 2015, 14(7):1059-69

PubMed: 25602630 ( click the link to review the publication )

Org Biomol Chem, 2015, 13(17):5006-11

PubMed: 25820099 ( click the link to review the publication )

Mol Cancer, 2015, 14:72

PubMed: 25889650 ( click the link to review the publication )

Nat Commun, 2014, 5:3384

PubMed: 24594970 ( click the link to review the publication )

Neuro Oncol, 2014, 16(1):72-80

PubMed: 24366975 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 109(17):6584-9

PubMed: 22492965 ( click the link to review the publication )

Cancer Res, 2014, 10.1158/0008-5472.CAN-14-0844

PubMed: 25377473 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.153.

PubMed: 24909179 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.161.

PubMed: 24909170 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.106.

PubMed: 24747966 ( click the link to review the publication )

Cancer Lett, 2014, 342(1):82-91

PubMed: 24001610 ( click the link to review the publication )

Breast Cancer Res, 2014, 16(3):R45

PubMed: 24887236 ( click the link to review the publication )

Antimicrob Agents Chemother, 2014, 10.1128/AAC.02393-14

PubMed: 24663025 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(20):3843-54

PubMed: 25113560 ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

J Mol Endocrinol, 2014, 52(2):223-34

PubMed: 24463098 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )

PLoS One, 2014, 9(9):e106349

PubMed: 25238247 ( click the link to review the publication )

Genes Cancer, 2014, 5(7-8):261-72

PubMed: 25221644 ( click the link to review the publication )

Biores Open Access, 2014,

PubMed: ( click the link to review the publication )
J Clin Invest, 2013, 123(2):682-99

PubMed: 23348745 ( click the link to review the publication )

Neuro Oncol, 2013, 10.1093/neuonc/not152

PubMed: 24343111 ( click the link to review the publication )

Cancer Lett, 2013, 340(1):43-50

PubMed: 23811285 ( click the link to review the publication )

Mol Pharmacol, 2013, 83(4):882-93

PubMed: 23371912 ( click the link to review the publication )

Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

PubMed: 24335466 ( click the link to review the publication )

Invest New Drugs, 2013, 31(6):1458-65

PubMed: 24068620 ( click the link to review the publication )

Virginia Commonwealth University, 2013, 2013

PubMed: ( click the link to review the publication )

Cell Cycle, 2013, 12(18):2978-91

PubMed: 23974111 ( click the link to review the publication )

ACS Nano, 2012, 6(10):8525-35

PubMed: 22947044 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2012, 109(17):6584-9

PubMed: 22492965 ( click the link to review the publication )

Oncogene, 2012, 32(37):4331-42

PubMed: 23085751 ( click the link to review the publication )

Cancer Lett, 2012, 316(1):77-84

PubMed: 22082529 ( click the link to review the publication )

Cancer Lett, 2012, 324(1):98-108

PubMed: 22579651 ( click the link to review the publication )

Mol Oncol, 2012, 7(3):392-401

PubMed: 23253899 ( click the link to review the publication )

Mol Carcinog, 2012, 52(12):959-69

PubMed: 22693070 ( click the link to review the publication )

Prostate, 2012, 72(10):1140-9

PubMed: 22127954 ( click the link to review the publication )

Anal Bioanal Chem, 2012, 403(6):1685-95

PubMed: 22526649 ( click the link to review the publication )

PLoS One, 2012, 7(5):e36691

PubMed: 22615792 ( click the link to review the publication )

Br J Cancer, 2011, 105(6):796-806

PubMed: 21847123 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(10):1846-56

PubMed: 21768330 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(4):697-707

PubMed: 21447712 ( click the link to review the publication )

Biochem Pharmacol, 2011, 82(10):1457-66

PubMed: 21664897 ( click the link to review the publication )

Anticancer Res, 2011, 31(11):3767-73

PubMed: 22110198 ( click the link to review the publication )

Int J Proteomics, 2011, 2011:215496

PubMed: 22091388 ( click the link to review the publication )
Carcinogenesis, 2010, 31(11):1948-55

PubMed: 20837598 ( click the link to review the publication )

Methods Mol Biol, 2010, 661:107-22

PubMed: 20811979 ( click the link to review the publication )

Purity & Quality Control

Choose Selective HER2 Inhibitors

Biological Activity

Description

Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Targets

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

In vitro

Lapatinib Ditosylate weakly inhibits the activity of ErbB4 with IC50 of 367 nM, and displays >300-fold selectivity for EGFR and ErbB2 over other kinases such as c-Src, c-Raf, MEK, ERK, c-Fms, CDK1, CDK2, p38, Tie-2, and VEGFR2. Lapatinib Ditosylate significantly inhibits receptor autophosphorylation of EGFR and ErbB2 in a dose-dependent manner with IC50 of 170 nM and 80 nM, respectively in HN5 cells; as well as 210 nM and 60 nM, respectively in BT474 cells. Unlike OSI-774 and Iressa (ZD1839) which preferentially inhibit the growth of the EGFR-overexpressing cells, Lapatinib Ditosylate inhibits the growth of both EGFR- and ErbB2-overexpressing cells. Lapatinib Ditosylate displays higher inhibitory activity against EGFR- or ErbB2-overexpressing cells with IC50 of 0.09-0.21 μM, compared with cells expressing low levels of EGFR or ErbB2 with IC50 of 3-12 μM, and exhibits ~100-fold selectivity over the normal fibroblast cells. Lapatinib Ditosylate potently inhibits the outgrowth of EGFR-overexpressing HN5 and A-431 cells, as well as ErbB2-overexpressing BT474 and N87 cells, and significantly induces G1 arrest of HN5 cells and apoptosis of BT474 cells, which are associated with inhibition of AKT phosphorylation. ^[1]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HN5 cell line	MonQVJJwdGmoZYLheIlwdiCjc4PhfS=>			NEfVV2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjOOUBk\WyuIHzpcoUtKEmFNUC9NE4xOjVizszN	NYLSd4F5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
BT474 cell line	MYDQdo9tcW[ncnH0bY9vKGG\|c3H5			NWfXXGlCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsJIxqdmVuIFnDOVA:OC5yMkWg{txO	NXuzc2F2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
HN5 cell	MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M2Lk[GlvcGmkaYTpc44hd2ZiSF61JINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czygTWM2OD1yLkGyJO69VQ>?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd5N{SxNEc,OTZ5N{e0NVA9N2F-
BT474 cell	NIfFT\|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NHPQepdKdmirYnn0bY9vKG:oIFLUOFc1KGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{whUUN3ME2wMlA5KM7:TR?=	NX6wVWx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3O\|c1OTBpPkG2O\|c4PDFyPD;hQi=>
N87 cell	NWO0UpI5T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			Mm\xTY5pcWKrdHnvckBw\iCQOEegZ4VtdCCpcn;3eIgh[W[2ZYKgO\|IhcHK\|LDDJR\|UxRTBwMEig{txO	Mor2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5N{e0NVAoRjF4N{e3OFExRC:jPh?=
HFF cell	MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MojPTY5pcWKrdHnvckBw\iCKRl[gZ4VtdCCpcn;3eIgtKEmFNUC9PU46KM7:TR?=	NYPU[VBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3O\|c1OTBpPkG2O\|c4PDFyPD;hQi=>
BT474	M{nwXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NH;ER5RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXyRlItKEmFNUC9NE4xOjYQvF2=	NGCxNWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[1N\|M{Oyd-MUi2OVM{OzN:L3G+
SKBR3	NFL4NGhEgXSxdH;4bYNqfHliYYPzZZk>		NX:2Tmg5PzJiaILz	M{\vOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ\|IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOTgQvF2=	MnLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMki0NlUoRjF7MEK4OFI2RC:jPh?=
SKBR3	MUDDfZRwfG:6aXPpeJkh[XO\|YYm=		NXLFNFd{PzJiaILz	NFe3XVdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ7zszN	NX\1[lRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PFg4PjFpPkG5PFg5PzZzPD;hQi=>
A431	MnzuR5l1d3SxeHnjbZR6KGG\|c3H5		M1z0V\|czKGi{cx?=	MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MD6xNFTPxE1?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh6OEe2NUc,OTl6OEi3OlE9N2F-
SK-BR-3	M37YeWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NV3NTldESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT{1DWi1\|IHPlcIx{KGGodHXyJIhzeyCkeTDBWHAh[2:wdHXueEBie3OjeTygTWM2OD1yLkC0{txO	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
SKHEP1	MkXwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONSFXQNUBk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUC9OU4{\|ryP	Mn7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
MDA-MB-231	NEnqVVJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NUS5OYNiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKGi{czDifUBCXFBiY3;ueIVvfCCjc4PhfUwhUUN3ME21MlTPxE1?	NWHtZWNwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
Hep3B2	MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NFuz[YhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldFNDOiClZXzsd{Bi\nSncjDodpMh[nliQWTQJINwdnSnboSgZZN{[XluIFnDOVA:PS52Od88US=>	Mnv2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
HepG2	NXi1OGVVSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M2DXcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS\|Ih[2WubIOgZYZ1\XJiaILzJIJ6KEGWUDDjc451\W62IHHzd4F6NCCLQ{WwQVYvOjgQvF2=	NVPaWJRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
MCF7	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			Ml7uRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKGi{czDifUBCXFBiY3;ueIVvfCCjc4PhfUwhUUN3ME22MlbPxE1?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
A431	M1H4[WZ2dmO2aX;uJIF{e2G7			NVPmfIszUW6qaXLpeIlwdiCxZjDFS2ZTKGmwdILhZ4VtdHWuYYKgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFG0N\|Eh[2WubIOgZpkhTUyLU1GsJGlEPTB;MD6wOVLPxE1?	NXvJ[Id6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOFY3PTVpPkKwN\|Q3PjV3PD;hQi=>
N87	NXTDVJF4TnWwY4Tpc44h[XO\|YYm=			M1LGNWlvcGmkaYTpc44hd2ZiRYLiRlIhcW62cnHj[YxtfWyjcjDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTki3JINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMd88US=>	M4[xZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{S2OlU2Lz5{MEO0OlY2PTxxYU6=
MIAPaCa	M1myeGZ2dmO2aX;uJIF{e2G7			NHzVWopKdmirYnn0bY9vKG:oIFXSRoIzKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBOUUGSYVPhJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMUVOwG0>	NX:zcWRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OjNpPkKwPFE4PTJ\|PD;hQi=>
MIAPaCa	MmfxSpVv[3Srb36gZZN{[Xl?			NXu2W3oxUW6qaXLpeIlwdiCxZjDFS2ZTKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBOUUGSYVPhJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwNEOz{txO	NGDZSZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|UzOyd-MkC4NVc2OjN:L3G+
SKBR3	M2jXOWN6fG:2b4jpZ4l1gSCjc4PhfS=>			MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKGK7IILld4F7fXKrbjDkfYUhemWmdXP0bY9vKGG\|c3H5MEBKSzVyPUCuNFAz\|ryP	MnzzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
SKOV3	NGH1UZhEgXSxdH;4bYNqfHliYYPzZZk>			Mme2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlAxO87:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
CAL27	NUjn[VRRS3m2b4TvfIlkcXS7IHHzd4F6			NX7DWnU4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDifUBz\XOjeoXybY4h\HmnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0xNjByN988US=>	MorGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
CAL27	NFX3NGpHfW6ldHnvckBie3OjeR?=		M1HpTFE3KGi{cx?=	M4jKcmlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgSWdHWiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDh[pRmeiBzNjDodpMh[nliV3XzeIVzdiCkbH;0MEBKSzVyPECuNFMz\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
A431	MY\DfZRwfG:6aXPpeJkh[XO\|YYm=			NVHDXZNHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR\|MTDj[YxteyCxdnXy[ZhxemW\|c3nu[{BGT0[UIHL5JJJme2G8dYLpckBlgWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVAvQTgQvF2=	M17C[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
HeLa	MUHDfZRwfG:6aXPpeJkh[XO\|YYm=			NUX3cmdUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW\|c3nu[{BJTEGFIHL5JJJme2G8dYLpckBlgWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVUvQc7:TR?=	MlnCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
A549	M4\xWWN6fG:2b4jpZ4l1gSCjc4PhfS=>			NIHROXBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhFSUNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9PE42\|ryP	M13mfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
SK-BR-3	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M3\XdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSZJjSjJib4\ldoV5eHKnc4PpcochcHWvYX6gV2suSlJvMzDj[YxteyCkeTDNWHQh[XO\|YYmsJGlEPTB;ND6zOe69VQ>?	MlTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3N{C4OFMoRjJzNUewPFQ{RC:jPh?=
MDA-MB-468	NFLk[WFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MnfuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDFS2ZTKG:4ZYLlfJBz\XO\|aX7nJIh2dWGwIF3ERU1OSi12NkigZ4VtdHNiYomgUXRVKGG\|c3H5MEBKSzVyPUKzMlQ3\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV5MEi0N{c,OjF3N{C4OFM9N2F-
HCT116	NH7jclZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9OFIvOzcQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV5MEi0N{c,OjF3N{C4OFM9N2F-
BT474	M3LtXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGHCeJc4OiCqcoO=	NVLrSnBOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{Bi\nSncjC3NkBpenNiYomgcYV1cHmuZX7lJIJtfWVic4ThbY5qdmdvYnHz[YQhdWW2aH;kMEBKSzVyPUCuNFI2\|ryP	NITFcok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi4O\|QxOyd-MkG4PFc1ODN:L3G+
NCI-N87	Ml[1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NID2[Zk{KGSjeYO=	Ml7wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtUlg4KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDt[ZRpgWynbnWgZox2\SC\|dHHpcolv\yxiSVO1NF0xNjB7zszN	NFXqUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNVE{Oid-MkKxNFEyOzJ:L3G+
BT474	NWDMUXUzSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mn\jN{Bl[Xm\|	MmPPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEVES3OEBk\WyuczDh[pRmeiB\|IHThfZMh[nlibXX0bJlt\W6nIHLseYUhe3SjaX7pcoctKEmFNUC9NE4y\|ryP	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyMUGzNkc,OjJzMEGxN\|I9N2F-
NCI-N87	M2S3XGFvfGm2dX3vdkBie3OjeR?=	NF;DbYszOCCvZz;r[y=>	NWrVfHNmOTRiZHH5dy=>	MWPBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtUlg4KGOnbHzzJJhmdm:pcnHmeIVlKGmwIHH0bJlucWNibX;1d4Uh[XO\|ZYPz[YQh[XNidIXtc5Ih\3Kxd4ToJIlvcGmkaYTpc44h[XRiMkCgcYcwc2duIIDvJHFFKG[xcjCxOEBl[Xm\|IH3lZZN2emWmIHHmeIVzKDF7IHThfZM>	Mo\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMEGxN\|IoRjJ{MUCxNVMzRC:jPh?=
DIFI	NWWyS49JS3m2b4TvfIlkcXS7IHHzd4F6		NF;BbVk1KGSjeYO=	NYLMNYpmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEmISTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9NE4zOzYQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
CAL27	MkXFR5l1d3SxeHnjbZR6KGG\|c3H5		M3X4RVQh\GG7cx?=	M1[0SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3ME2wMlU{\|ryP	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
GXF251L	M2LMcGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M33GNVQh\GG7cx?=	NEHBPYhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIYEZ{NUHMJINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yNjR6zszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
LXFA 629L	NYLhcmRUS3m2b4TvfIlkcXS7IHHzd4F6		M4[2O\|Qh\GG7cx?=	NHvnVoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNYE[DIE[yPWwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m\|LDDJR\|UxRTJwOEhOwG0>	MlnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
DU145	M3vHPGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NWXjcmVwPCCmYYnz	NGGyNFBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9Nk46Qc7:TR?=	NGrac\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
OVXF 899L	NFHuW5BEgXSxdH;4bYNqfHliYYPzZZk>		MX[0JIRigXN?	M1LXcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XYEZiOEm5UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:Oy5\|Nd88US=>	NIfSNVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
LXFL 529L	Mn;0R5l1d3SxeHnjbZR6KGG\|c3H5		MV:0JIRigXN?	MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMXGZNKDV{OVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVMvPTIQvF2=	MkLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
LNCAP	NVjBOFMxS3m2b4TvfIlkcXS7IHHzd4F6		NU\NOYtbPCCmYYnz	MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;Mz62PO69VQ>?	Mnj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
LXFA 526L	MX\DfZRwfG:6aXPpeJkh[XO\|YYm=		M{DHOlQh\GG7cx?=	NWfxeZhNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFiIQTC1NlZNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD12LkKx{txO	NYrXS2gxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
UXF 1138L	MlnkR5l1d3SxeHnjbZR6KGG\|c3H5		NIjCfYE1KGSjeYO=	NYGwNpBLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXViIIEGxN\|hNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD12LkVOwG0>	NYizN29zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
PC3M	MVnDfZRwfG:6aXPpeJkh[XO\|YYm=		NX;WeVFSPCCmYYnz	M3zw[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEO01iY3XscJMh[W[2ZYKgOEBl[Xm\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyPUSuOVXPxE1?	NF;3NZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
HT-29	MoPNR5l1d3SxeHnjbZR6KGG\|c3H5		NYXIRnZrPCCmYYnz	M1nhNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3ME20MlYz\|ryP	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MCF7	M3LrWGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MUS0JIRigXN?	MnvpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;ND64N:69VQ>?	NUi4elJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
MEXF 1341L	MmXpR5l1d3SxeHnjbZR6KGG\|c3H5		M2jCNVQh\GG7cx?=	NF35RmVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTViIIEGzOFFNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD12Lki1{txO	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
RKO	MV7DfZRwfG:6aXPpeJkh[XO\|YYm=		M2XTNFQh\GG7cx?=	M3rDN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJMVyClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;NT6zOe69VQ>?	NGjQPYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
LXFA 289L	MlvrR5l1d3SxeHnjbZR6KGG\|c3H5		NULWSXZKPCCmYYnz	MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMXGZCKDJ6OVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVUvPzoQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MAXF 401NL	M3zZ[mN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3zqVFQh\GG7cx?=	M13kXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1CYEZiNECxUmwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m\|LDDJR\|UxRTVwON88US=>	Ml\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
22Rv1	MVzDfZRwfG:6aXPpeJkh[XO\|YYm=		MUW0JIRigXN?	NInLcmNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAzOlK4MTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9Ok4xPs7:TR?=	NUC3eHhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
PAXF 546L	NEL4TGFEgXSxdH;4bYNqfHliYYPzZZk>		M{DTWVQh\GG7cx?=	MnfzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFZTiB3NE\MJINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF03NjF{zszN	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
PXF 1118L	MU\DfZRwfG:6aXPpeJkh[XO\|YYm=		NGnXV2E1KGSjeYO=	MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQXGYhOTFzOFygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVYvQDcQvF2=	NYjOUWdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
LIXF 575L	NV7ObWdMS3m2b4TvfIlkcXS7IHHzd4F6		NHjtXJg1KGSjeYO=	MlzIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUGlZTiB3N{XMJINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF04NjF6zszN	NFH5NIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
RXF 1781L	NYP6dVRyS3m2b4TvfIlkcXS7IHHzd4F6		M2S0bVQh\GG7cx?=	NFfE[GtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTYEZiMUe4NWwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m\|LDDJR\|UxRTdwNkhOwG0>	NIrpRlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
MDA231	M3XIUmN6fG:2b4jpZ4l1gSCjc4PhfS=>		Ml3LOEBl[Xm\|	M1fjUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSTJ\|MTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9O{44\|ryP	NH\BTGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
LXFL 1121L	M1K2XmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NFX2Xng1KGSjeYO=	NHzBV3dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNYE[OIEGxNlFNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD15Lkez{txO	NIX4XGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
RXF 393NL	MWXDfZRwfG:6aXPpeJkh[XO\|YYm=		M2nXUFQh\GG7cx?=	NV7VSYJuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWliIIEO5N25NKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD15Lke3{txO	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
PANC1	MWPDfZRwfG:6aXPpeJkh[XO\|YYm=		M2PQNlQh\GG7cx?=	NUPyOVluS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVgvOTMQvF2=	NVnZe4J6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
CXF 269L	MXfDfZRwfG:6aXPpeJkh[XO\|YYm=		NIToSVU1KGSjeYO=	MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDXGYhOjZ7TDDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9PE4{Ps7:TR?=	NYq0NFN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
RXF 486L	NUO3TVhnS3m2b4TvfIlkcXS7IHHzd4F6		MlzUOEBl[Xm\|	M{KzW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTiB2OE\MJINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF06NjIQvF2=	M2GxS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
Saos2	M4Dp[mN6fG:2b4jpZ4l1gSCjc4PhfS=>		MV:0JIRigXN?	NUHMT\|FbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVkvOzkQvF2=	NYTO[FlbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
PXF 1752L	NVPK[npCS3m2b4TvfIlkcXS7IHHzd4F6		Mm\4OEBl[Xm\|	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQXGYhOTd3MlygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVkvPDcQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
PXF 698L	MoD3R5l1d3SxeHnjbZR6KGG\|c3H5		M{\POlQh\GG7cx?=	NYO0VVdoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWFiIIE[5PGwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m\|LDDJR\|UxRTlwNEpOwG0>	M1ixSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
BXF T24	MX\DfZRwfG:6aXPpeJkh[XO\|YYm=		NWixV452PCCmYYnz	NYLSV2FFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSliIIGSyOEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:QS54Nd88US=>	M1r6[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
MEXF 462NL	NHLhV2xEgXSxdH;4bYNqfHliYYPzZZk>		NHPMUlM1KGSjeYO=	NWPNVYdkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUW[RjC0OlJPVCClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;MUCuNVPPxE1?	M4LIVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
TE671	M3:5UGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NX7Ib5dNPCCmYYnz	Mne1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGU3PzFiY3XscJMh[W[2ZYKgOEBl[Xm\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyPUGwMlk2\|ryP	NULxU29ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
PAXF 1657L	NGi0W\|VEgXSxdH;4bYNqfHliYYPzZZk>		MXW0JIRigXN?	NX3GSldqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEG[RjCxOlU4VCClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;MUGuNVHPxE1?	M2Lt[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
MEXF 276L	MoXBR5l1d3SxeHnjbZR6KGG\|c3H5		Mkn4OEBl[Xm\|	NYX2VWV1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUW[RjCyO\|ZNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD1zMT6zO:69VQ>?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MKN45	M{DwW2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NFXsZ\|E1KGSjeYO=	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm\|aYOsJGlEPTB;MUGuOFjPxE1?	M1PB[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
BXF 1352L	M1ThR2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MmfmOEBl[Xm\|	M2HOdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJZTiBzM{WyUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:OTFwNUROwG0>	NHjLVnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
BXF 1218L	MkXxR5l1d3SxeHnjbZR6KGG\|c3H5		NIrTdJk1KGSjeYO=	MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCXGYhOTJzOFygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVEyNjd5zszN	NHzm[IY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
HCT116	M33ZfWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MXu0JIRigXN?	NWLjfVF7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yOy5zNN88US=>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
OVCAR3	Mnz6R5l1d3SxeHnjbZR6KGG\|c3H5		NWnTd5diPCCmYYnz	MlLiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ\|IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3ME2xN{41PM7:TR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
H460	MmXaR5l1d3SxeHnjbZR6KGG\|c3H5		MWK0JIRigXN?	MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD1zMz60Ou69VQ>?	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
A431	MVHDfZRwfG:6aXPpeJkh[XO\|YYm=		NVnLUVQ1PzJiaILz	MnjkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk43Os7:TR?=	MkHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOEK1PFEoRjJ{MUiyOVgyRC:jPh?=
SKOV3	NI\xVYdEgXSxdH;4bYNqfHliYYPzZZk>		NHPaWIs4OiCqcoO=	M{fEd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGVz[kJ{IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi57Od88US=>	NI[yNIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG4NlU5OSd-MkKxPFI2QDF:L3G+
SKBR3	NGf5bHpEgXSxdH;4bYNqfHliYYPzZZk>		NGnET3E4OiCqcoO=	MkjFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTNTJiZ3Xu[UBi\nSncjC3NkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUCuNFI6\|ryP	MoTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|N{K4OlQoRjJ{M{eyPFY1RC:jPh?=
NCI-N87	MULDfZRwfG:6aXPpeJkh[XO\|YYm=		M4Tue\|czKGi{cx?=	NHmwPXhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvTki3JINmdGy\|IHX4dJJme3OrbnegTGVTNTJiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjB\|Nt88US=>	M{P4eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{eyPFY1Lz5{MkO3Nlg3PDxxYU6=
MDA-MB-175	MlvDR5l1d3SxeHnjbZR6KGG\|c3H5		MV[3NkBpenN?	NWrxNmRlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVE4PSClZXzsd{BmgHC{ZYPzbY5oKFO{YzygVoV1KGGwZDDsc5chUEWULUKgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkC0OFTPxE1?	M17XOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{eyPFY1Lz5{MkO3Nlg3PDxxYU6=
A431	NF;oeVBEgXSxdH;4bYNqfHliYYPzZZk>		NFPocXg4OiCqcoO=	Mn\6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIuOSCpZX7lJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MD6xNFTPxE1?	NYHiVFN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzO\|I5PjRpPkKyN\|czQDZ2PD;hQi=>
MDA-MB-453	Mk[5R5l1d3SxeHnjbZR6KGG\|c3H5		NYLSN\|d3PzJiaILz	M3jjNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFCWRV6t[IVncWOrZX70JIh2dWGwIF3ERU1OSi12NUOgZ4VtdHNiZYjwdoV{e2mwZzDISXIuOixiYX7kJHBKUzOFQTDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjV3Nd88US=>	M3;wSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{eyPFY1Lz5{MkO3Nlg3PDxxYU6=
MDA-MB-361	MWjDfZRwfG:6aXPpeJkh[XO\|YYm=		NWKwbmg{PzJiaILz	Mlz3R5l1d3SxeHnjbZR6KGGpYXnud5QhTVJiYXP0bZZifGWmIHj1cYFvKE2GQT3NRk0{PjFiY3XscJMh\XiycnXzd4lv\yCKZYKtNkwhW3KlIHHu[EBRUUt\|Q1GgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OS5yMkpOwG0>	M4GwW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{eyPFY1Lz5{MkO3Nlg3PDxxYU6=
NCI-H1781	NYrrV\|ROS3m2b4TvfIlkcXS7IHHzd4F6		NYrCNXV[PzJiaILz	NV63bWZQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixO\|gyKGOnbHzzJIV5eHKnc4PpcochUEWULUKgS\|c4Pmmwc2\fS{9EKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9N{4xPDgQvF2=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ\|N{K4OlQ9N2F-
A431	NWXXZYJwSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoDlO\|IhcHK\|	M1zvOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Mj62{txO	Ml2yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OUWxO\|coRjJ{NUm1NVc4RC:jPh?=
NIH/3T3	MlPrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M2Xpd\|czKGi{cx?=	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKE6LSD:zWFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12LkROwG0>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7NUG3O{c,OjJ3OUWxO\|c9N2F-
SKBR3	NXjHRY94SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M{fseFczKGi{cx?=	M{PFPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iZYP0do9o\W5icnXj[ZB1d3JiYX7kJJBzd2enc4Tldo9v\SC{ZXPldJRweiCmZX\pZ4lmdnRiU1vCVlMh[2WubIOg[ZhxemW\|c3nu[{BJTVJ{IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS5yNd88US=>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl{N{m3Nkc,OjN7Mke5O\|I9N2F-
MCF7	MmqxR5l1d3SxeHnjbZR6KGG\|c3H5		MnPYOFghcHK\|	M{DZNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh\XiycnXzd4lv\yCyY1TORVMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BE\WyuVHn0[ZIuT2yxIHHzd4F6NCCLQ{WwQVE2NjdzzszN	NF\JT4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7	MmHqR5l1d3SxeHnjbZR6KGG\|c3H5		NVTFNocxPDhiaILz	MnfXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BmgHC{ZYPzbY5oKEiHUkKgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDD[YxtXGm2ZYKtS4xwKGG\|c3H5MEBKSzVyPUG1Mlc6\|ryP	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	NHvKVoNEgXSxdH;4bYNqfHliYYPzZZk>		MVm0PEBpenN?	M2\YU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh\XiycnXzd4lv\yCKRWKy[IVtfGFzNjDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IFPlcIxVcXSncj3HcI8h[XO\|YYmsJGlEPTB;MUmuNlLPxE1?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	MXvGeY5kfGmxbjDhd5NigQ>?	NX3yS2RvOTBidV2=	NHjScmozKGi{cx?=	NUTqR293UW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVExPjhiaX6gbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO\|aX7nJGhGWjKmZXz0ZVE3KGG2IEGwJJVOKGGodHXyJFIhcHK\|IHL5JHdme3Sncn6gZoxwfHSrbne=	NYHheI9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVUyOzBpPkK0N\|U2OTNyPD;hQi=>
MCF7	NXHrTlAzTnWwY4Tpc44h[XO\|YYm=	M4DXd\|ExKHWP	MnXqNkBpenN?	MVjJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvckBifCC\MUC2PEBqdiCqdX3hckBOS0Z5IHPlcIx{KGW6cILld5NqdmdiSFXSNkBifCBzMDD1UUBi\nSncjCyJIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6p	NF7pTI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7	MlXlSpVv[3Srb36gZZN{[Xl?	NUHJcnVXOTBidV2=	NF\xZYczKGi{cx?=	MXjJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvckBifCC\MUC2PEBqdiCqdX3hckBOS0Z5IHPlcIx{KGW6cILld5NqdmdicHPEUmE{KGG2IEGwJJVOKGGodHXyJFIhcHK\|IHL5JHdme3Sncn6gZoxwfHSrbne=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	NXTsN4NWTnWwY4Tpc44h[XO\|YYm=	NF7sO5AyOCC3TR?=	NH65N3ozKGi{cx?=	NX3iPGkyUW6qaXLpeIlwdiCxZjDISXIzKGSnbIThNVYhdXW2YX70JIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUGyOFghcW5iaIXtZY4hVUOINzDj[YxteyCjdDCxNEB2VSCjZoTldkAzKGi{czDifUBY\XO2ZYLuJIJtd3S2aX7n	NVP6cnQzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVUyOzBpPkK0N\|U2OTNyPD;hQi=>
MCF7	NVyzbJlXTnWwY4Tpc44h[XO\|YYm=	NET3eJQyOCC3TR?=	M2TtTVIhcHK\|	NWDH[IpWUW6qaXLpeIlwdiCxZjDISXIzKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVEzPDhiaX6gbJVu[W5iTVPGO{Bk\WyuczDheEAyOCC3TTDh[pRmeiB{IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5o	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	NV7QdZV6TnWwY4Tpc44h[XO\|YYm=	M4XHc\|ExKHWP	NVjGeFdCOiCqcoO=	MUjJcohq[mm2aX;uJI9nKEiHUkKgZZV1d3Cqb4PwbI9zgWyjdHnvckBifCC\MUK0PEBqdiCqdX3hckBOS0Z5IHPlcIx{KGW6cILld5NqdmdicHPEUmE{KGG2IEGwJJVOKGGodHXyJFIhcHK\|IHL5JHdme3Sncn6gZoxwfHSrbne=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
4T1	NGX3PHhEgXSxdH;4bYNqfHliYYPzZZk>			NED3bVlEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UB1emmybHWgcoVo[XSrdnWgOHQyKGOnbHzzMEBKSzVyPUCuNFExOzgQvF2=	M{O5RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MDA-MB-231	NFHlOXZEgXSxdH;4bYNqfHliYYPzZZk>			MlztR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6geJJqeGynIH7l[4F1cX[nIF3ERU1OSi1{M{GgZ4VtdHNuIFnDOVA:OC5yMt88US=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-435	Moq2R5l1d3SxeHnjbZR6KGG\|c3H5			M1izZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N\|Uh[2WubIOsJGlEPTB;MD6wNlk4\|ryP	NF;CWm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7	NEjZNXdEgXSxdH;4bYNqfHliYYPzZZk>			MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFVk1xd3OrdHn2[UBOS0Z5IHPlcIx{NCCLQ{WwQVAvODZ2Od88US=>	NFG5VHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-468	NYXQNY9iS3m2b4TvfIlkcXS7IHHzd4F6			M4fB[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJRzcXCuZTDu[YdifGm4ZTDNSGEuVUJvNE[4JINmdGy\|LDDJR\|UxRTBwMEizNu69VQ>?	M4HjZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MCF7	MW\DfZRwfG:6aXPpeJkh[XO\|YYm=		M3XMU\|Q5KGi{cx?=	NI\JNJpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOTIQvF2=	M1\zdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUWxOVgzLz5{NUG1NVU5OjxxYU6=
SKBR3	MnT4R5l1d3SxeHnjbZR6KGG\|c3H5		MoXZO\|IhcHK\|	MoHuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OD1yLkCzNFHPxE1?	NX7ufpdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
BT474	M{LEdmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NXnwPYVsPzJiaILz	NWW0TlJRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSlR2N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2wMlA3OzoQvF2=	NGXYRm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
MDA-MB-453	MkLYR5l1d3SxeHnjbZR6KGG\|c3H5		MWi3NkBpenN?	M{nlS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20OVMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0xNjF7zszN	NETzPHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
Calu3	MYjDfZRwfG:6aXPpeJkh[XO\|YYm=		NVTle\|dYPzJiaILz	NFGzUmhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[Wy3MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5MEBKSzVyPUCuNlPPxE1?	NYjHZVN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
SKOV3	MoG0R5l1d3SxeHnjbZR6KGG\|c3H5		MVu3NkBpenN?	M{nz[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO\|YYmsJGlEPTB;MD61Pe69VQ>?	NEXuWHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
A431	NWTsWmJKS3m2b4TvfIlkcXS7IHHzd4F6		MnPvO\|IhcHK\|	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIgh[W[2ZYKgO\|IhcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:OC54NEOx{txO	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNyNUOzNEc,OjV\|MEWzN\|A9N2F-
MCF7	MUjDfZRwfG:6aXPpeJkh[XO\|YYm=		NGf5O4Y4OiCqcoO=	MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIgh[W[2ZYKgO\|IhcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:QC52NklOwG0>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNyNUOzNEc,OjV\|MEWzN\|A9N2F-
A431	MXvGeY5kfGmxbjDhd5NigQ>?	NYSybZEyOC5yMEGgeI8hOTBidV2=	NILYSIgzKGi{cx?=	M1jEXmlvcGmkaYTpc44hd2ZiSFXSNUBxcG:\|cHjvdplt[XSrb36gLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hcHWvYX6gRVQ{OSClZXzsd{BifCByLkCwNUB1dyBzMDD1UUBqdmO3YnH0[YQh\m:{IEKgbJJ{KGK7IGfld5Rmem5iYnzveEBu\XSqb3S=	M3;oSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N\|MxLz5{NUOwOVM{ODxxYU6=
BT474	MnvTSpVv[3Srb36gZZN{[Xl?	NU[3XZk2OC5yMEGgeI8hOTBidV2=	MWWyJIhzew>?	MV7Jcohq[mm2aX;uJI9nKEiHUkKgdIhwe3Cqb4L5cIF1cW:wIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFLUOFc1KGOnbHzzJIF1KDBwMECxJJRwKDFyIIXNJIlv[3WkYYTl[EBnd3JiMjDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?=	M1X5S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N\|MxLz5{NUOwOVM{ODxxYU6=
A431	NEnRbpBHfW6ldHnvckBie3OjeR?=	MXmwMlAxOSC2bzCxNEB2VQ>?	Mn7iNkBpenN?	MmPCTY5pcWKrdHnvckBw\iCKRWKxJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGi3bXHuJGE1OzFiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVTUzFxMjDwbI9{eGixconsZZRqd25iYYSgNE4xODFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAzKGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l	M375XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N\|MxLz5{NUOwOVM{ODxxYU6=
A431	M1vjOGZ2dmO2aX;uJIF{e2G7	NX7DOY1yOC5yMEGgeI8hOTBidV2=	MlLSNkBpenN?	NH\BPZpKdmirYnn0bY9vKG:oIFjFVlEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaIXtZY4hSTR\|MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hSUuWIIDoc5NxcG:{eXzheIlwdiCjdDCwMlAxOSC2bzCxNEB2VSCrbnP1ZoF1\WRiZn;yJFIhcHK\|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q>	NUfzR3R[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
BT474	MmnuSpVv[3Srb36gZZN{[Xl?	MlrVNE4xODFidH:gNVAhfU1?	MV6yJIhzew>?	NE\Jbm5KdmirYnn0bY9vKG:oIFjFVlIhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaIXtZY4hSlR2N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEWUS{GvNkBxcG:\|cHjvdplt[XSrb36gZZQhOC5yMEGgeI8hOTBidV2gbY5kfWKjdHXkJIZweiB{IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m	NUnNTZhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
BT474	NWmyNJZlTnWwY4Tpc44h[XO\|YYm=	NW[4S3d5OC5yMEGgeI8hOTBidV2=	NELxSnMzKGi{cx?=	NXPoUlVKUW6qaXLpeIlwdiCxZjDISXIzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEKWNEe0JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JFAvODBzIITvJFExKHWPIHnuZ5Vj[XSnZDDmc5IhOiCqcoOgZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	NU[5fHJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
BT474	NIrwNW1EgXSxdH;4bYNqfHliYYPzZZk>		MlvXO\|IhcHK\|	MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BmgHC{ZYPzbY5oKEiHUkKgZYZ1\XJiN{KgbJJ{KGK7IFPlcIwhXGm2ZYKgS4xwKGG\|c3H5MEBIUTVyPUCuPVPPxE1?	NUTScpdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O\|U2OjBpPkK2OFc2PTJyPD;hQi=>
HeLa	NFm2UHNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4jzNFEzKGi{cx?=	MlmxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDF{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5zMt88US=>	MmXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK0PFIoRjJ4NkWyOFgzRC:jPh?=
B16F10	M1\rOWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{LU[\|EzKGi{cx?=	NVfR[m16SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCNVZHOTBiY3XscJMh[W[2ZYKgNVIhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlIy\|ryP	NHzud3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[1NlQ5Oid-Mk[2OVI1QDJ:L3G+
HepG2	MlXORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1ToVVEzKGi{cx?=	NVi1cIhuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCxNkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNlfPxE1?	Mn\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK0PFIoRjJ4NkWyOFgzRC:jPh?=
MCF7	MkDwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFKzemsyOiCqcoO=	NEjuRoFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMUKgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkS3{txO	NYnYXXdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI1QDJpPkK2OlUzPDh{PD;hQi=>
SKBR3	MnizRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHv5RZg1QCCqcoO=	NFzwN4NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLRnI{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD60Pe69VQ>?	M2\mWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUi3PFU3Lz5{N{G4O\|g2PjxxYU6=
A549	M2nROWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MkLkOFghcHK\|	MnLJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNUS5JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi55NN88US=>	Ml3SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEe4OVYoRjJ5MUi3PFU3RC:jPh?=
LLC	MYPBcpRqfHWvb4KgZZN{[Xl?	NIDmNVUyODBibXevb4c>	M1rjTVE1KGSjeYO=	M3LFNWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFzMR{Bk\WyuczDpcZBt[W62ZXSgbY4hcW5iQ{W3RmwwPiCvb4Xz[UBie3Onc4Pl[EBieyC2dX3vdkBoem:5dHigbY5pcWKrdHnvckBifCBzMECgcYcwc2duIIDvJJFlKG[xcjCxOEBl[Xm\|	NHSxOmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4O\|g2Pid-MkexPFc5PTZ:L3G+
BT474	NGjye3BEgXSxdH;4bYNqfHliYYPzZZk>		M{H1OlczKGi{cx?=	MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BmgHC{ZYPzbY5oKEinckKgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyuIITpeIVzNWeubzDseY1qdmW\|Y3XuZ4Uh[XO\|YYmsJGlEPTB;MD6wN\|HPxE1?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ6OEG4NEc,Ojd{OEixPFA9N2F-
SK-BR-3	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MYW0PEBpenN?	NHWxUmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMWJTNTNiY3XscJMh\XiycnXzd4lv\yCKRWKyJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODcQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OU[3NUc,Ojd5Nkm2O\|E9N2F-
BT474	NH3EeZFEgXSxdH;4bYNqfHliYYPzZZk>		NFnLfok1QCCqcoO=	NVTyPFRRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSlR2N{SgZ4VtdHNiZYjwdoV{e2mwZzDISXIzKGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwMd88US=>	MkfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5Nkm2O\|EoRjJ5N{[5OlcyRC:jPh?=
A431	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NWDxSlM6PDhiaILz	M{CzZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDlfJBz\XO\|aX7nJGVITlJxSFXSNkBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHlibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjF3zszN	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OU[3NUc,Ojd5Nkm2O\|E9N2F-
A549	Ml22R5l1d3SxeHnjbZR6KGG\|c3H5		NH75OIQ1QCCqcoO=	NWi3OHhpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCneIDy[ZN{cW6pIFXHSnIh[W6mIFvSRXMhdXW2YX70JIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTIQvF2=	M1voXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{[5OlcyLz5{N{e2PVY4OTxxYU6=
Calu3	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVTjcVEyPzJiaILz	M371cWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ3HseVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkJOwG0>	M12wblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEmyPFYxLz5{OEC5Nlg3ODxxYU6=
A431NS	NVT4S2x5SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1;ldFczKGi{cx?=	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{HOV{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwNt88US=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB7Mki2NEc,OjhyOUK4OlA9N2F-
Bel7402	M4LSeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXW0cG9TPzJiaILz	M1nJdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO\|QxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUOuO:69VQ>?	MmDPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
SK-BR-3	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFvve3M4OiCqcoO=	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLVLSMVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12LkVOwG0>	MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
COLO205	MkCxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1XQZlczKGi{cx?=	NFTq[HpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPPUG8zODViY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlbPxE1?	MlLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
HCT116	M33yWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1TvblczKGi{cx?=	NGDUd3FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPU[uNu69VQ>?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB7Mki2NEc,OjhyOUK4OlA9N2F-
NCI-H522	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NWOzVpZxPzJiaILz	MnPuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtTFUzOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPU[uOO69VQ>?	MlnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
NCI-H460	MoHRRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYK3NkBpenN?	MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;OD60{txO	Ml\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
MDA-MB-468	NEXuXoZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MmrnO\|IhcHK\|	M{HSeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTR4ODDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIx\|ryP	MoHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
NCI-H522	MmTKRY51cXS3bX;yJIF{e2G7	NXTT[\|RtOTByIH3nM4to	NWe2e2NvOjhiZHH5dy=>	MnvjRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg2OjJiY3XscJMhgGWwb3fyZYZ1\WRiaX6gRoFt[i:lIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhfHWvb4Kg[5Jwf3SqIHnubIljcXSrb36gZZQhOTByIH3nM4toNCCrZzDh[I1qdmm\|dHXy[YQhd26lZTDkZYltgSCob4KgNlgh\GG7czDy[YxifGm4ZTD0c{Bkd262cn;s	NUXaTXZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPVI5PjBpPkK4NFkzQDZyPD;hQi=>
A431	MnHxR5l1d3SxeHnjbZR6KGG\|c3H5		MVu3NkBpenN?	M3HLNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVe1NF01NjkQvF2=	M4TD[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkO4OlE1Lz5{OEKzPFYyPDxxYU6=
NCI-H1975	NUfq[JB3S3m2b4TvfIlkcXS7IHHzd4F6		NIfBZVU4OiCqcoO=	NGLzXVREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG5O\|Uh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUd3ME25MlA5\|ryP	NETLRlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKzPFYyPCd-MkiyN\|g3OTR:L3G+
SW480	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=		NETVU404OiCqcoO=	MlvMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c1QDBiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVe1NF0yOi53ON88US=>	Mo\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{M{i2NVQoRjJ6MkO4OlE1RC:jPh?=
A549	NFHpNXpEgXSxdH;4bYNqfHliYYPzZZk>		MX63NkBpenN?	NVK4OplOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJS\|UxRTF2LkpOwG0>	NU\JflJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyN\|g3OTRpPkK4NlM5PjF2PD;hQi=>
A549	M3zxRmZ2dmO2aX;uJIF{e2G7	M4fTSVUxKHWP	NV3SZZB{OiCqcoO=	NH;DcoVKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIF1KFS7cjDy[ZNq\HWnIHnuJIh2dWGwIFG1OFkh[2WubIOgZZQhPTBidV2gdJJmcW6ldXLheIVlKG[xcjCyJIhzeyCob3zsc5dm\CCkeTDFS2YhcW6mdXP0bY9vKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ\|OE[xOEc,Ojh{M{i2NVQ9N2F-
A549	NGfuZ2dHfW6ldHnvckBie3OjeR?=	Ml\mOVAhfU1?	MontNkBpenN?	M17FZmlvcGmkaYTpc44hd2ZiRVfGVkBxcG:\|cHjvdplt[XSrb36gZZQhYTFyNkigbY4hcHWvYX6gRVU1QSClZXzsd{BifCB3MDD1UUBxemWrbnP1ZoF1\WRiZn;yJFIhcHK\|IH\vcIxwf2WmIHL5JGVITiCrbnT1Z5Rqd25ibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m	M3G1SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkO4OlE1Lz5{OEKzPFYyPDxxYU6=
RAW264.7	M4S1NmFvfGmuZXnzbI1idmmjbDDhd5NigQ>?		MmDKPVYhcHK\|	NHXWUVZCdnSrbHXpd4hu[W6rYXygZYN1cX[rdImgZYdicW6\|dDDseYNq\mW{YYPlMYV5eHKnc4PpcochVGWrc3jtZY5q[SCvYXrvdkBidWG\|dHnnc5RmeyCrbn\lZ5Rm\CCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjC5OkBpenNiYomgcJVucW6nc3PlcoNmKGG\|c3H5MEBGSzVyPUGx{txO	M2\aXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O3N\|I6Lz5{OEOzO\|MzQTxxYU6=
3T3	NIDJXoRCdnSrdIL5dIFvd3OxbXHsJIF{e2G7		NXvjeWk{PDhiaILz	MkLPRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTDh[4FqdnO2IGTyfZBidm:\|b33hJINzfXqrIGT1cIFpfWWwIHHtZZN1cWexdHXzJIlv\mWldHXkJIlvKHKjdDCzWFMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPocI9zd3CqZX7vcEBz\WRvYnX0ZU1FNWejbHHjeI9xgXKjbn;zbYRmKGKjc3XkJIF{e2G7LDDFR\|UxRTF\|zszN	M3Hxb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O3N\|I6Lz5{OEOzO\|MzQTxxYU6=
HEK293	MXHGeY5kfGmxbjDhd5NigQ>?			NYHGV2lUUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDDMZRmem2rbnHsJGhqey22YXfn[YQhTUeIUjCoNUB1dyB4NEWgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkhTUyLU1GsJGlEPTB;MD6wNlcxPs7:TR?=	M{fs[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{GxO\|A{Lz5{OEexNVcxOzxxYU6=
A431	NWPNUFRtSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NWX4XWVHPzJiaILz	NWnie5BnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhTUeIUjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwON88US=>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdzMUewN{c,Ojh5MUG3NFM9N2F-
NCI-H1975	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MY[3NkBpenN?	NIKwXoVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTl5NTDj[YxteyCqYYLic5JqdmdiRVfGVkBNQDV6Uj;UO\|kxVSCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME25MlA5\|ryP	MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MUG3NFMoRjJ6N{GxO\|A{RC:jPh?=
SW480	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFPoR\|k4OiCqcoO=	NHPpXm9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhTUeIUjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF{LkW4{txO	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdzMUewN{c,Ojh5MUG3NFM9N2F-
A549	MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NWXB[XBqPzJiaILz	NELKO5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgbIFz[m:{aX7nJJdqdGRidInw[UBGT0[UL1utVoF{KG23dHHueEBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUG0MlnPxE1?	NHHPXmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEexNVcxOyd-Mki3NVE4ODN:L3G+
HepG2	M2PZeGN6fG:2b4jpZ4l1gSCjc4PhfS=>			NHW3XlBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJHREPTB;Nj6yO:69VQ>?	MnntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNEm5OlMoRjJ7MES5PVY{RC:jPh?=
BT474	NXjlc45US3m2b4TvfIlkcXS7IHHzd4F6		M2GzSVczKGi{cx?=	MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCmeXWgZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDHTVUxRTBwMt88US=>	MoX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyOVkoRjJ7MEi5NlU6RC:jPh?=
EOL-1	M2fIXmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MUe3NkBpenN?	NHW0PYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGV0xvMTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3HsZ4Vqdi2DTTDkfYUh[mG\|ZXSg[ox2d3Knc3PlcoNmKGG\|c3H5MEBIUTVyPUCuOFHPxE1?	M2C5NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi5NlU6Lz5{OUC4PVI2QTxxYU6=
K562	NYrXfGFKS3m2b4TvfIlkcXS7IHHzd4F6		NFH3eJc4OiCqcoO=	NYDHZ3ZpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3HsZ4Vqdi2DTTDkfYUh[mG\|ZXSg[ox2d3Knc3PlcoNmKGG\|c3H5MEBIUTVyPUWuO:69VQ>?	NETJPVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4PVI2QSd-MkmwPFkzPTl:L3G+
MCF7	NEXOR5FEgXSxdH;4bYNqfHliYYPzZZk>		M3GzOlczKGi{cx?=	M32yTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOjbHPlbY4uSU1iZInlJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygS2k2OD16LkJOwG0>	M1HXWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi5NlU6Lz5{OUC4PVI2QTxxYU6=
HCC827	NUH4TZBOS3m2b4TvfIlkcXS7IHHzd4F6		M1nkZlczKGi{cx?=	MlrRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNEQDJ5IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClYXzj[YlvNUGPIHT5[UBj[XOnZDDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGdKPTB;MkKuN:69VQ>?	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6OUK1PUc,OjlyOEmyOVk9N2F-
HEK293	M3;VRWZ2dmO2aX;uJIF{e2G7			MmnDTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFjpd{11[WepZXSgSWdHWiBqMTD0c{A3PDVicnXzbYR2\XNrIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5yMkex{txO	NFG5Z3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyNVU4Oyd-Mkm0NlE2PzN:L3G+
HCC827	NYnYfZg6SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYW3NkBpenN?	NYnuPYlCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2M5OjdiY3XscJMhcGG{Yn;ybY5oKEWJRmKgSVc1Pi2DN{WwJIRmdCCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlbPxE1?	M4jKV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVc{Lz5{OUSyNVU4OzxxYU6=
A431	M1f0dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NUjibFhOPzJiaILz	NXT1VZpNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhTUeIUjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwON88US=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{MUW3N{c,Ojl2MkG1O\|M9N2F-
SW480	NIfKOpdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVfKNGRCPzJiaILz	NVz5fZJOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW\|Q5OCClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEWJRmKgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMj61PO69VQ>?	MkWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkG1O\|MoRjJ7NEKxOVc{RC:jPh?=
NCI-H1975	MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NEjhWXA4OiCqcoO=	MlnYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtTFE6PzViY3XscJMhcGG{Yn;ybY5oKEWJRmKgUFg2QFJxVEe5NG0h\G:3YnzlJI12fGGwdDDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF{Lk[4{txO	NVuzV4FyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlE2PzNpPkK5OFIyPTd\|PD;hQi=>
A549	NU[z[FU2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NH7GbYU4OiCqcoO=	NVjvT3F5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhTUeIUj;LMZJieyCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xOE46\|ryP	NIXFelA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyNVU4Oyd-Mkm0NlE2PzN:L3G+
DAOY	M3voVpFJXFNiYYPzZZk>			MWDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>?	NGrQfok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SJ-GBM2	MlW3dWhVWyCjc4PhfS=>			NULJcJljeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
A673	M1TFOZFJXFNiYYPzZZk>			NWrIZWp4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	NF3GTlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	NWHKPGFzeUiWUzDhd5NigQ>?			MlfQdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	MnLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
BT-37	MV;xTHRUKGG\|c3H5			NVXwfnJWeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFLUMVM4KGOnbHzz	NWfqOXh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB-EBc1	NUXuO21EeUiWUzDhd5NigQ>?			MWXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	NFXoT4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
U-2 OS	MUTxTHRUKGG\|c3H5			NYLsVnRneUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGWtNkBQWyClZXzsdy=>	NWW5ZYxsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2	M1rNZZFJXFNiYYPzZZk>			NVf6N\|IzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	MkTYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	MVzxTHRUKGG\|c3H5			M4TOTpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMXNJKGOnbHzz	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	NGrJVVJyUFSVIHHzd4F6			MkTzdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEyDTj21JINmdGy\|	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	MorIdWhVWyCjc4PhfS=>			MoDrdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqMUigZ4VtdHN?	MmTGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	NIDEfWRyUFSVIHHzd4F6			Mk\NdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{	M{jDVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R)	MmH0dWhVWyCjc4PhfS=>			MXXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	M{HVeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
A673	M2XuVpFJXFNiYYPzZZk>			NWX5dVR{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSTZ5MzDj[Yxteyl?	M2rhZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-12	M{PKbZFJXFNiYYPzZZk>			NF3ONVNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1zMjDj[Yxtew>?	MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
U-2 OS	NIi4OYRyUFSVIHHzd4F6			Mln4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWU0zKE:VIHPlcIx{	NHXQSJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh41	M1TQeZFJXFNiYYPzZZk>			M4XhTZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJpPDFiY3XscJM>	MoGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	MYHxTHRUKGG\|c3H5			M1[1O5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJpOThiY3XscJM>	NVnqbXIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh30	MXLxTHRUKGG\|c3H5			MXXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSbFMxKGOnbHzz	MlP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	MnzIdWhVWyCjc4PhfS=>			MkHldWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2VSDDj[Yxtew>?	NVu4emZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
MCF7	Ml7aRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MlXkO\|IhcHK\|	NUP0TY1XSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Nj64{txO	M1rs[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nki0O\|A5Lz5{OU[4OFcxQDxxYU6=
HCT116	NFSy[m5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NGWzVm84OiCqcoO=	Mnq5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMD6xNu69VQ>?	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
A2780	NGO4dlhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVntPGlnPzJiaILz	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTBwNN88US=>	M4DUSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nki0O\|A5Lz5{OU[4OFcxQDxxYU6=
SKBR3	MW\DfZRwfG:6aXPpeJkh[XO\|YYm=		NH\LeIw4OiCqcoO=	MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{IHX4dJJme3OrbnegTGVTOiCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUC9NE4yP87:TR?=	MlO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MEK3NVkoRjJ7OUCyO\|E6RC:jPh?=
A431	NF22SY9EgXSxdH;4bYNqfHliYYPzZZk>		MlLaO\|IhcHK\|	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XJiZYjwdoV{e2mwZzDFS2ZTKGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2xMlY6\|ryP	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyMkexPUc,Ojl7MEK3NVk9N2F-
NCI-H1975	M4n5fGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MYW3NkBpenN?	MknnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzOUe1JINmdGy\|IHjhdoJwemmwZzDFS2ZTKFR5OUDNJI12fGGwdDDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:OTFwNEdOwG0>	NXXOc5B7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFI4OTlpPkK5PVAzPzF7PD;hQi=>
MDA-MB-361	M1zLNWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NXrhcGtvPzJiaILz	NInLcoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtN\|YyKGOnbHzzJI93\XJiZYjwdoV{e2mwZzDISXIzKGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2xN{44O87:TR?=	NX;ONWJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFI4OTlpPkK5PVAzPzF7PD;hQi=>
HepG2	NWSwdG96TnWwY4Tpc44h[XO\|YYm=			MXzJcohq[mm2aX;uJI9nKEWJRmKgbY4hcHWvYX6gTIVxTzJiY3XscJMtKEmFNUC9NE4xOjdzzszN	MnnRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
insect cells	NYrkZVFWTnWwY4Tpc44h[XO\|YYm=		M1fFdFUhdWmwcx?=	NXHUTHJpUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDFS2ZTKEx6NUjSJI12fGGwdDDlfJBz\XO\|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KGOnbHzzJJBz\WmwY4XiZZRm\CCob4KgOUBucW6\|IH\vcIxwf2WmIHL5JGFVWCCjZHTpeIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiM{CgcYlveyCkeTDIWHJHKGG\|c3H5MEBKSzVyPUCuNFM4PTYQvF2=	NFy5fGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
Sf21	NGfYNVRHfW6ldHnvckBie3OjeR?=		MXu1JI1qdnN?	M1rseWlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDHV3QufGGpZ3XkJJJm[2:vYnnuZY51KGi3bXHuJGVITlJiVEe5NG0hdXW2YX70JIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lIyKGmwc3XjeEBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEWgcYlveyCob3zsc5dm\CCkeTDBWHAh[WSmaYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliSGTSSkBie3OjeTygTWM2OD1yLkKyOFg6\|ryP	Mn;5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
MCF7	NF\FN3NEgXSxdH;4bYNqfHliYYPzZZk>		NIjkZ\|kzPCCqcoO=	MojvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUWuNFLPxE1?	NV3tcHRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVY2QDBpPkOwNFk3PThyPD;hQi=>
HCT116	MV7DfZRwfG:6aXPpeJkh[XO\|YYm=		MUmyOEBpenN?	MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME21Mlkz\|ryP	M1;KZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
HepG2	NWn1epZCS3m2b4TvfIlkcXS7IHHzd4F6		MVyyOEBpenN?	NGrRVZpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEyNjdzzszN	NVXOVJliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVY2QDBpPkOwNFk3PThyPD;hQi=>
Caco	M1uyN2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M3G2PFI1KGi{cx?=	MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYNwKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MUKuNVHPxE1?	M3;mOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
HepG2	MVvDfZRwfG:6aXPpeJkh[XO\|YYm=			NFm5TodEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiVFO1NF03NjQQvF2=	NV;PbGFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFQ6ODZpPkOwN\|Q1QTB4PD;hQi=>
L929	MkjtR5l1d3SxeHnjbZR6KGG\|c3H5		MnvmO\|IhcHK\|	MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDMPVI6KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{LkC1{txO	NH\5RYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwPFM4QSd-M{C1NFg{Pzl:L3G+
A431	MlfKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVi3NkBpenN?	NFruU4FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N\|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Lk[2{txO	M3\GWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNUC4N\|c6Lz5\|MEWwPFM4QTxxYU6=
A549	NHnTR3NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWrlNHU{PzJiaILz	M13iTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTNwNkVOwG0>	NHflNWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwPFM4QSd-M{C1NFg{Pzl:L3G+
A549	M2HpeGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NFnqS3g3KHWP	M37rWlI1KGi{cx?=	M{C2e2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO\|ZYPz[YQh[XNiZX\m[YN1KG:wIHnueJJi[2WubIXsZZIhSVSSIHzleoVteyCjdDC2JJVOKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmNWy3Y3nm[ZJqdiCkYYPl[EBie3OjeR?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODVyOEO3PUc,OzB3MEizO\|k9N2F-
HN5	NEOwVWFHfW6ldHnvckBie3OjeR?=		M{Wy[\|I1KGi{cx?=	MX\Jcohq[mm2aX;uJI9nKEWJRj3pcoR2[2WmIFXHSnIheGixc4Doc5J6dGG2aX;uJIF1KFS7cj3y[ZNq\HWnIHnuJIh2dWGwIFjOOUBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEK0JIhzeyCob3zsc5dm\CCkeTDFS2Yue3SrbYXsZZRqd25iYX7kJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{NCCLQ{WwQVAvODIQvF2=	M4Ttc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkCwNVQ6Lz5\|ME[wNFE1QTxxYU6=
MCF7	MlPkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mk\3O\|IhcHK\|	M2TJc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwNkmx{txO	NYXNU2ExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3PVIyODFpPkOwO\|kzOTBzPD;hQi=>
MDA231	M4XuPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MX23NkBpenN?	NHrNd5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUSuOlky\|ryP	NGLmNHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEe5NlExOSd-M{C3PVIyODF:L3G+
SK-MEL-19	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M4rublczKGi{cx?=	M3TvWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utUWVNNTF7IHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTYQvF2=	Mm\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
JeKo1	MnnWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYW3NkBpenN?	M4G2UGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSnXLc\|Eh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9Oe69VQ>?	NXPBZoxyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C4NFI4OzBpPkOwPFAzPzNyPD;hQi=>
MIAPaCa2	NE\DfI9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MUG3NkBpenN?	NH\KNJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTFyzszN	M2nKVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
U87MG	NWD6NI9jSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MkD4O\|IhcHK\|	NIjMZppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW4O21IKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdmOnIHHzd4F6NCCJSUWwQVEx\|ryP	NFr0SZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
MV4-11	MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYCzOmU1PzJiaILz	NWnD[ZRoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFfJOVA:OTEQvF2=	NHjQTYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
DU145	MmHwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHjZU\|U4OiCqcoO=	NYT2d3hCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiR1m1NF0zOM7:TR?=	M3LsSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
HCT116	NITmcmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NETXSXQ4OiCqcoO=	MmfmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9NlDPxE1?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
MDA-MB-231	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NInXOmY4OiCqcoO=	MoPSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTJyzszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
T47D	NF22W2lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MljCO\|IhcHK\|	NIG3OZpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS0O2Qh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9OFDPxE1?	M2no[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
A431	NH\sN\|NHfW6ldHnvckBie3OjeR?=		MUK5NEBucW6\|	MoPVTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVITi2\|dHnteYxifGWmIFXHSnIh[XW2b4Doc5NxcG:{eXzheIlwdiCycnXpcoN2[WK2ZXSg[o9zKDlyIH3pcpMh\m:ubH;3[YQh[nliRVfGMZN1cW23bHH0bY9vKGK7IIPhcoR4cWOqLVXMTXNCNCCLQ{WwQVAvODJzzszN	NV[5U4JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UCH1	MojrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIT5S5U4OiCqcoO=	MnjZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXQ1ixJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0{NjMQvF2=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl5M{ezOUc,OzB7N{O3N\|U9N2F-
WS1	M1fWcGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NI\kRoc4OiCqcoO=	MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXV\|Eh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7LDDJR\|UxRTF\|zszN	NXPVb4lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UMCHOR1	NUnwWYF2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlLoO\|IhcHK\|	NIr1XolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGXNR2hQWjFiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcjDicJVmKGG\|c3H5MEBKSzVyPUK1{txO	M3nYfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUezO\|M2Lz5\|MEm3N\|c{PTxxYU6=
CH22	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MnvIO\|IhcHK\|	M3jUfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1iyNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:OjYQvF2=	MnPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7N{O3N\|UoRjNyOUezO\|M2RC:jPh?=
UCH7	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MYq3NkBpenN?	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFWFSEegZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwQVI3\|ryP	NXrVTYNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UCH12	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NH\rdlg4OiCqcoO=	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFWFSEGyJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0{O87:TR?=	NUntTlVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
A549	MWPGeY5kfGmxbjDhd5NigQ>?	M1vVblg3KG2PL3vn	NFHSRXUzPyCmYYnz	M1P5RmRzfWdiY3;uZ4VvfHKjdHnvckBqdiCQT1SvV2NKTCCvb4Xz[UBjdG:xZDD4[Y5w\3KjZoTl[EB4cXSqIHj1cYFvKEF3NEmgZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDheEA5PiCvaXPyc41wdC:tZzygdI8h[WSvaX7pd5RmemWmIH;uZ4Uh\GGrbImg[o9zKDJ5IHThfZMh[W6mIH3lZZN2emWmIHH0JIRigSB{NzDheEAzKGi{czDh[pRmeiCuYYP0JIFldWmwaYP0[ZJm\CCmb4PlJIJ6KEyFLV3TM21UKGGwYXz5d4l{NCCFdE2yMlgy\|ryP	NFW4R2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyOVg6PCd-M{GxNlU5QTR:L3G+
HCC1954	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NGrLPWc4OiCqcoO=	NWOxSXF3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2MyQTV2IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhGWjJiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13zszN	NWLTW\|VzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlU5QTRpPkOxNVI2QDl2PD;hQi=>
NCI-H1975	M4OwTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFXldm44OiCqcoO=	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVk4PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVnPxE1?	NF64cWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyOVg6PCd-M{GxNlU5QTR:L3G+
A549	NXn4TYR6SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4XlVVczKGi{cx?=	M33EXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVHPxE1?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{NUi5OEc,OzFzMkW4PVQ9N2F-
Sf9	NF3jZ\|JHfW6ldHnvckBie3OjeR?=	NUixeldkOSC2bzCxNEB2VQ>?	MnP0OlAhdWmwcx?=	M4fudmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiR2PUMZRi\2enZDDFS2ZTKCilYYThcJl1cWNiZH;tZYlvKDZ7NTD0c{BmdmRicnXzbYR2\XNrIHH1eI9xcG:\|cHjvdplt[XSrb36g[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIGPmPUBk\WyuczD1d4lv\yCyb3z5LEBIdHVuVInyLUA1QjFiYYOgd5Vje3S{YYTlJIF1KDFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkA3OCCvaX7zJIJ6KEWOSWPB	M4jablxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
HCC1954	MkXNSpVv[3Srb36gZZN{[Xl?	NX7rPZZmOC5yMjD0c{AzKHWP	NIHm[mUyKGi{	NFfQZmxKdmirYnn0bY9vKG:oIFjFVlIh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCKQ1OxPVU1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjFVlIh[XRiMD6wNkB1dyB{IIXNJIlv[3WkYYTl[EBnd3JiMTDodkBjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	NEHSU2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyOVg6PCd-M{GxNlU5QTR:L3G+
HCC827	MnjIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1u0clczKGi{cx?=	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ{iyO{Bk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC54zszN	M3zXT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
A431	M{PPO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MonKO\|IhcHK\|	Mnf4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNEOxJINmdGy\|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01NjkQvF2=	NFrVVFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUKwNlk6OCd-M{GyNFI6QTB:L3G+
SW480	M2\LRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MoC3O\|IhcHK\|	MkHxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVV{S4NEBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTJwNUlOwG0>	M4f0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
NCI-H1975	NYDxO4s2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEH3OZU4OiCqcoO=	NH3rN5dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTl5NTDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVIvPjkQvF2=	M4HLXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
A549	M4XlbGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NIDUflg4OiCqcoO=	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE1NjoQvF2=	MkK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{MEK5PVAoRjNzMkCyPVkxRC:jPh?=
A549	MVXGeY5kfGmxbjDhd5NigQ>?	M3\pcFE2KHWP	M3vPOVQ5KGi{cx?=	MVzJcohq[mm2aX;uJI9nKGOnbHygcYloemG2aX;uJIlvKEOPLXTpcE1t[WKnbHzl[EBpfW2jbjDBOVQ6KGOnbHzzJJhmdm:pcnHmeIVlKGmwIES4JIhzeyCyb4P0MYZmenSrbHn6ZZRqd25ienXidoFncXOqIHXtZpJ6d3NiYYSgNVUhfU1iaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkh[2:wZn;jZYwhdWmlcn;zZ49xcWNibXX0bI9l	NX3Vd3pqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTBpPkOxNlAzQTlyPD;hQi=>
WS1	MlfKR5l1d3SxeHnjbZR6KGG\|c3H5			MX\DfZRwfG:6aXPpeJkhcW5iaIXtZY4hX1NzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[pJwKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDkfYUh[mG\|ZXSgZZN{[XluIFnDOVA:OTQQvF2=	Mn3KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF\|N{i1O\|EoRjNzM{e4OVcyRC:jPh?=
SKBR3	M2O3VWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXq3NkBpenN?	MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONQmKzJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUmuO\|bPxE1?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV2NkG5O{c,OzF3NE[xPVc9N2F-
SUM159	NXLaeYl{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NHrrNpo4OiCqcoO=	MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOXTUG1PUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME25Mlc3\|ryP	MnXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3NE[xPVcoRjNzNUS2NVk4RC:jPh?=
KG1a	NETuV4lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MoL3O\|IhcHK\|	NV7jeGVYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLS\|FiKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPzcQvF2=	NF:wN\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUW0OlE6Pyd-M{G1OFYyQTd:L3G+
MCF7	NH7JUWxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHPrSWc4OiCqcoO=	NHT1cnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14LklOwG0>	NGTOZ4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
A2780	NV7LWFFuSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGHU[nQ4OiCqcoO=	Mn3zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDMke4NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFyLkVOwG0>	NF3xd5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
HT-29	NX3ONW9lSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIOxXmM4OiCqcoO=	NFL3WJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUKuOlfPxE1?	M1SwcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNkW1OFI6Lz5\|MU[1OVQzQTxxYU6=
MRC5	MUnDfZRwfG:6aXPpeJkh[XO\|YYm=		MWW3NkBpenN?	MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUOuOlbPxE1?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ3NUSyPUc,OzF4NUW0Nlk9N2F-
NCI-H1648 cell	NHnRSoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MoDhTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{NUS0JO69VQ>?	NWLyUog1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
NMC-G1 cell	NXPCTG1XT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M{fWUmlvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PDVyMTFOwG0>	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
NTERA-S-cl-D1 cell	M2r5XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M1\TRmlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPU[uNlY2PjFizszN	M1rBTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
OCUB-M cell	MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M{PZN2lvcGmkaYTpc44hd2ZiaIXtZY4hV0OXQj3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPTd2IN88US=>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OS-RC-2 cell	M3z3VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NIi1S2lKdmirYnn0bY9vKG:oIHj1cYFvKE:VLWLDMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7MUm5JO69VQ>?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OVCAR-4 cell	NUjZcVB3T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M3X1XWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOTF4N{Wg{txO	MlfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
RL95-2 cell	MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUOuNVU3PyEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
SW954 cell	MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MYfJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTV2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;NT6zPVI1PSEQvF2=	NEi0d4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SW962 cell	M2LnZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MnLFTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWuN\|kzPDVizszN	Mn\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-1 cell	MmfzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXvRS4V{UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4xOjF3OTFOwG0>	M4r0R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A253 cell	M1rrcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MkDRTY5pcWKrdHnvckBw\iCqdX3hckBCOjV\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mj6wOFg{KM7:TR?=	M3SzPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A388 cell	MoTrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MWLJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC0PFMh\|ryP	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
BB30-HNC cell	M4faN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NEG4RlRKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{OzOUDPxE1?	MnLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-12 cell	MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M1HmemlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczOjV6IN88US=>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-5 cell	NFy3V5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWnJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkK0OlU1KM7:TR?=	M{HXU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
TE-6 cell	MoPYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3HOd2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuOFkxPTdizszN	NHXJXpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-8 cell	NYm2bWFlT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MVfJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkCzO\|Mh\|ryP	NX;LV3hlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-9 cell	NEfZbFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4PnOWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuOVUzODFizszN	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TK10 cell	M2OwNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NE\oXVdKdmirYnn0bY9vKG:oIHj1cYFvKFSNMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE3PTJ{IN88US=>	NYDmZ2N2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
DSH1 cell	MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MnWzTY5pcWKrdHnvckBw\iCqdX3hckBFW0hzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD6wPVM6PiEQvF2=	NXjmd2drRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
ECC12 cell	NHzXWZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4fGZWlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA6OjNzIN88US=>	MnjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
EKVX cell	MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NHz4eWhKdmirYnn0bY9vKG:oIHj1cYFvKEWNVmigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlQ1QDd2IN88US=>	NEnEWmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
HCC2218 cell	NGPpfolIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NXjt[IVvUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNUOyOkDPxE1?	NIfqOlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LB2241-RCC cell	MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVjJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF3NECzJO69VQ>?	MkLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LB996-RCC cell	NX;oXFMzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NVfQTolGUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkO2NlI5KM7:TR?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LC-1F cell	NVixc5JQT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGXHUYFKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUHGJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{QDJ2NDFOwG0>	NV6yblJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
LS-513 cell	MlXHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			Mli1TY5pcWKrdHnvckBw\iCqdX3hckBNWy13MUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxODRzIN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ErbB2 / t-ErbB2 / p-Akt / t-Akt / p-Erk / t-Erk; PubMed: 25238247 PLoS One Dose response of lapatinib and PD168393 on phosphorylation of ErbB2, AKT and ERK in Calu3 and SkBr3 cells in response to EGF treatment. p-ErbB2: phosphorylated ErbB2; t-ErbB2: total-ErbB2; p-AKT: phosphorylated AKT; t-AKT: total AKT; p-ERK: phosphorylated ERK; t-ERK: total ERK. pEGFR / EGFR / p-mTOR / mTOR / PARP / c-PARP ; PubMed: 28938602 Oncotarget SKBR3 and 78617 cells were treated with lapatinib as in panel A, then the expression of phospho-ErbB2 (Tyr1221/1222), ErbB2, phospho-EGFR (Tyr1068), EGFR, phospho-Akt (Ser473), Akt, phospho-Erk1/2 (Thr202/Tyr204), Erk2, phospho-mTOR (Ser2448), and mTOR were analyzed using Western blotting. All values are presented as the mean ± standard error (S.E.) (**p < 0.01).	25238247 28938602
Growth inhibition assay	Cell viability ; PubMed: 24947784 Oncotarget Huh7 (A), HepG2 (B), or HA22T (C) HCC cells were left untreated or treated with 0.1% DMSO (vehicle, D) or with DMSO containing various concentrations of lapatinib (1.25, 2.5, 5, or 10 μM) for 3 days. Relative amounts of viable cells were detected by MTS assay. O.D. values from DMSO-treated control cells were designated 100%.	24947784

In vivo

Oral administration of Lapatinib Ditosylate (~100 mg/kg) twice daily significantly inhibits the growth of BT474 and HN5 xenografts in a dose-dependent manner. ^[1]

Protocol

Kinase Assay:^[1]	- Collapse In vitro kinase assays: The IC50 values for inhibition of enzyme activity are generated by measuring inhibition of phosphorylation of a peptide substrate. The intracellular kinase domains of EGFR and ErbB2 are purified from a baculovirus expression system. EGFR and ErbB2 reactions are performed in 96-well polystyrene round-bottomed plates in a final volume of 45 μL. Reaction mixtures contain 50 mM 4-morpholinepropanesulfonic acid (pH 7.5), 2 mM MnCl₂, 10 μM ATP, 1 μCi of [γ³³P] ATP/reaction, 50 μM Peptide A [Biotin-(amino hexonoic acid)-EEEEYFELVAKKK-CONH2], 1 mM dithiothreitol, and 1 μL of DMSO containing serial dilutions of Lapatinib beginning at 10 μM. The reaction is initiated by adding the indicated purified type-1 receptor intracellular domain. The amount of enzyme added is 1 pmol/reaction (20 nM). Reactions are terminated after 10 minutes at 23°C by adding 45 μL of 0.5% phosphoric acid in water. The terminated reaction mix (75 μL) is transferred to phosphocellulose filter plates. The plates are filtered and washed three times with 200 μL of 0.5% phosphoric acid. Scintillation cocktail (50 μL) is added to each well, and the assay is quantified by counting in a Packard Topcount. IC50 values are generated from 10-point dose-response curves.
Cell Research:^[1]	- Collapse Cell lines: HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, and HB4a c5.2 Concentrations: Dissolved in DMSO, final concentrations ~100 μM Incubation Time: 72 hours Method: Cells are exposed to various concentrations of Lapatinib for 72 hours. Relative cell number is estimated using methylene blue staining. The absorbance at 620 nm is read in a Spectra microplate reader. Cell death and cell cycle analysis are assessed by propidium iodide staining and antibody detection of incorporated BrdUrd and staining with propidium iodide. (Only for Reference)
Animal Research:^[1]	- Collapse Animal Models: CD-1 nude female mice implanted s.c. with HN5 cells, and C.B-17 SCID female mice implanted s.c. with BT474 cells Dosages: ~100 mg/kg Administration: Orally twice daily (Only for Reference)

References

[1] Rusnak DW, et al. Mol Cancer Ther, 2001, 1(2), 85-94.

Solubility (25°C)

In vitro	DMSO	100 mg/mL (108.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+40% PEG 300+5% Tween 80+53% ddH2O For best results, use promptly after mixing.	1.25 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Lapatinib (GW-572016) Ditosylate SDF

Molecular Weight	925.46
Formula	C₂₉H₂₆ClFN₄O₄S.2C₇H₈O₃S
CAS No.	388082-77-7
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04608409	Recruiting	Drug: Lapatinib and Paclitaxel	Ovarian Cancer	Frederick R. Ueland M.D.\|University of Kentucky	November 16 2020	Phase 1
NCT03075995	Unknown status	Other: hight-fat breakfast	Breast Cancer	Sun Yat-sen University	April 12 2017	Not Applicable
NCT02338245	Completed	Drug: ASLAN001\|Drug: Lapatinib\|Drug: Capecitabine	Metastatic Breast Cancer	Aslan Pharmaceuticals	December 29 2014	Phase 2
NCT02294786	Terminated	Drug: Lapatinib\|Drug: Capecitabine\|Drug: Octreotide	Cancer	Novartis Pharmaceuticals\|Novartis	December 17 2014	Phase 2
NCT02213042	Completed	Drug: Lapatinib\|Biological: Trastuzumab	Neoplasms Breast	Novartis Pharmaceuticals\|Novartis	October 24 2014	Phase 2
NCT02158507	Active not recruiting	Drug: Combination of Veliparib + Lapatinib	Metastatic Triple Negative Breast Cancer	University of Alabama at Birmingham\|Scariot Foundation\|GlaxoSmithKline\|AbbVie	September 2014	Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
If I need to use S1028 for treating tumor-bearing mice with injection, how could I prepare the solution?
Answer:
S1028 Lapatinib Ditosylate can be dissolved in 2% DMSO/30% PEG 300/ddH2O at 10 mg/ml as clear solution.

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

Selective EGFR Inhibitor

Erlotinib HCl (OSI-744) : EGFR-selective, IC50=2 nM.
Most Potent EGFR Inhibitor

Afatinib (BIBW2992) : EGFR(wt), IC50=0.5 nM; EGFR(L858R), IC50=0.4 nM; EGFR(L858R/T790M), IC50=10 nM; HER2, IC50=14 nM.
FDA-approved EGFR Inhibitor

Lapatinib : Approved by FDA for breast cancer.
Newest EGFR Inhibitor

CO-1686 (AVL-301) ^New : Irreversible, mutant-selective EGFR inhibitor with K_i of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively.

Related HER2 Products

Erlotinib (OSI-774) ^New

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
Bemcentinib (R428) ^New

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
Pexidartinib (PLX3397) ^New

Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.
AC480 (BMS-599626)

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
CP-724714

CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.
Neratinib (HKI-272)

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
Sapitinib (AZD8931)

Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
Mubritinib (TAK 165)

Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1.
Tyrphostin AG 879

Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

Choose Your Country or Region

By Signaling Pathways

By product type

Lapatinib (GW-572016) Ditosylate