Lapatinib (GW-572016) Ditosylate

Name: Lapatinib (GW-572016) Ditosylate
Brand: Selleck Chemicals
SKU: S1028
Rating: 5 (92 reviews)

For research use only.

Catalog No.S1028

92 publications

Lapatinib (GW-572016) Ditosylate Chemical Structure

CAS No. 388082-77-7

Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Selleck's Lapatinib (GW-572016) Ditosylate has been cited by 92 publications

Nat Cell Biol, 2021, 23(4):377-390

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Cell Metab, 2018, 28(6):817-832

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Cancer Cell, 2016, 29(4):563-573

PubMed: 27070703 ( click the link to review the publication )

Cancer Cell, 2012, 21(4):488-503

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Cell Death Dis, 2021, 12(6):588

PubMed: 34099636 ( click the link to review the publication )

J Transl Med, 2021, 19(1):184

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Sci Rep, 2021, 11(1):10893

PubMed: 34035375 ( click the link to review the publication )

Cancer Med, 2021, 10(7):2370-2379

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Environ Toxicol, 2021, 10.1002/tox.23125

PubMed: 33734566 ( click the link to review the publication )

Biochem Biophys Res Commun, 2021, 567:154-160

PubMed: 34157442 ( click the link to review the publication )

NPJ Breast Cancer, 2021, 7(1):51

PubMed: 33980863 ( click the link to review the publication )

NPJ Breast Cancer, 2021, 7(1):79

PubMed: 34145270 ( click the link to review the publication )

Nat Commun, 2020, 11(1):4591

PubMed: 32929084 ( click the link to review the publication )

Cancer Discov, 2020, 10(5):674-687

PubMed: 32213539 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Front Pharmacol, 2020, 11:601572

PubMed: 33362556 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Oncol Rep, 2020, 44(3):1127-1135

PubMed: 32582968 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2331-2344

PubMed: 31461650 ( click the link to review the publication )

J Clin Med, 2019, 8(12)

PubMed: 31847378 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(18):4566-4578

PubMed: 29895705 ( click the link to review the publication )

Cell Syst, 2018, 6(3):329-342

PubMed: 29550255 ( click the link to review the publication )

Mol Cancer Res, 2018, 16(5):894-908

PubMed: 29453318 ( click the link to review the publication )
Cancer Biol Ther, 2018, 19(10):921-933

PubMed: 29856687 ( click the link to review the publication )

Methods Mol Biol, 2018, 1788:251-268

PubMed: 29243084 ( click the link to review the publication )

Oncotarget, 2018, 9(9):8560-8572

PubMed: 29492217 ( click the link to review the publication )

Cancer Res, 2017, 77(20):5554-5563

PubMed: 28923853 ( click the link to review the publication )

Cell Syst, 2017, 5(2):105-118

PubMed: 28837809 ( click the link to review the publication )

Proteomics, 2017, 10.1002/pmic.201600335

PubMed: 28127872 ( click the link to review the publication )

Tumour Biol, 2017, 39(3):1010428317695028

PubMed: 28349782 ( click the link to review the publication )

Cancer Res, 2016, 76(20):6095-6106

PubMed: 27569217 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2486-2497

PubMed: 27507850 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

BMC Cancer, 2016, 16(1):813

PubMed: 27756261 ( click the link to review the publication )

BMC Cancer, 2016, 16:678

PubMed: 27558154 ( click the link to review the publication )

Cancer Invest, 2016, 34(9):424-430

PubMed: 27657189 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26551-66

PubMed: 27034169 ( click the link to review the publication )

Gut, 2015, 10.1136/gutjnl-2014-309026

PubMed: ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Cancer Res, 2015, 10.1158/0008-5472.CAN-15-0370

PubMed: 25952648 ( click the link to review the publication )

Mol Cancer, 2015, 10.1186/s12943-015-0345-x

PubMed: ( click the link to review the publication )

Oncogene, 2015, 34(9):1160-73

PubMed: ( click the link to review the publication )

Cell Death Dis, 2015, 6:e1699

PubMed: 25789974 ( click the link to review the publication )

Mol Oncol, 2015, 9(3):586-600

PubMed: 25435280 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2015, 10.1016/j.taap.2015.05.001

PubMed: 25981168 ( click the link to review the publication )

Cell Cycle, 2015, 14(7):1059-69

PubMed: 25602630 ( click the link to review the publication )

Org Biomol Chem, 2015, 13(17):5006-11

PubMed: 25820099 ( click the link to review the publication )
Mol Cancer, 2015, 14:72

PubMed: 25889650 ( click the link to review the publication )

Nat Commun, 2014, 5:3384

PubMed: 24594970 ( click the link to review the publication )

Neuro Oncol, 2014, 16(1):72-80

PubMed: 24366975 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 109(17):6584-9

PubMed: 22492965 ( click the link to review the publication )

Cancer Res, 2014, 10.1158/0008-5472.CAN-14-0844

PubMed: 25377473 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.153.

PubMed: 24909179 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.161.

PubMed: 24909170 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.106.

PubMed: 24747966 ( click the link to review the publication )

Cancer Lett, 2014, 342(1):82-91

PubMed: 24001610 ( click the link to review the publication )

Breast Cancer Res, 2014, 16(3):R45

PubMed: 24887236 ( click the link to review the publication )

Antimicrob Agents Chemother, 2014, 10.1128/AAC.02393-14

PubMed: 24663025 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(20):3843-54

PubMed: 25113560 ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

J Mol Endocrinol, 2014, 52(2):223-34

PubMed: 24463098 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )

PLoS One, 2014, 9(9):e106349

PubMed: 25238247 ( click the link to review the publication )

Genes Cancer, 2014, 5(7-8):261-72

PubMed: 25221644 ( click the link to review the publication )

Biores Open Access, 2014,

PubMed: ( click the link to review the publication )

J Clin Invest, 2013, 123(2):682-99

PubMed: 23348745 ( click the link to review the publication )

Neuro Oncol, 2013, 10.1093/neuonc/not152

PubMed: 24343111 ( click the link to review the publication )

Cancer Lett, 2013, 340(1):43-50

PubMed: 23811285 ( click the link to review the publication )

Mol Pharmacol, 2013, 83(4):882-93

PubMed: 23371912 ( click the link to review the publication )

Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

PubMed: 24335466 ( click the link to review the publication )

Invest New Drugs, 2013, 31(6):1458-65

PubMed: 24068620 ( click the link to review the publication )
Virginia Commonwealth University, 2013, 2013

PubMed: ( click the link to review the publication )

Cell Cycle, 2013, 12(18):2978-91

PubMed: 23974111 ( click the link to review the publication )

ACS Nano, 2012, 6(10):8525-35

PubMed: 22947044 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2012, 109(17):6584-9

PubMed: 22492965 ( click the link to review the publication )

Oncogene, 2012, 32(37):4331-42

PubMed: 23085751 ( click the link to review the publication )

Cancer Lett, 2012, 316(1):77-84

PubMed: 22082529 ( click the link to review the publication )

Cancer Lett, 2012, 324(1):98-108

PubMed: 22579651 ( click the link to review the publication )

Mol Oncol, 2012, 7(3):392-401

PubMed: 23253899 ( click the link to review the publication )

Mol Carcinog, 2012, 52(12):959-69

PubMed: 22693070 ( click the link to review the publication )

Prostate, 2012, 72(10):1140-9

PubMed: 22127954 ( click the link to review the publication )

Anal Bioanal Chem, 2012, 403(6):1685-95

PubMed: 22526649 ( click the link to review the publication )

PLoS One, 2012, 7(5):e36691

PubMed: 22615792 ( click the link to review the publication )

Br J Cancer, 2011, 105(6):796-806

PubMed: 21847123 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(10):1846-56

PubMed: 21768330 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(4):697-707

PubMed: 21447712 ( click the link to review the publication )

Biochem Pharmacol, 2011, 82(10):1457-66

PubMed: 21664897 ( click the link to review the publication )

Anticancer Res, 2011, 31(11):3767-73

PubMed: 22110198 ( click the link to review the publication )

Int J Proteomics, 2011, 2011:215496

PubMed: 22091388 ( click the link to review the publication )

Carcinogenesis, 2010, 31(11):1948-55

PubMed: 20837598 ( click the link to review the publication )

Methods Mol Biol, 2010, 661:107-22

PubMed: 20811979 ( click the link to review the publication )

Purity & Quality Control

Choose Selective HER2 Inhibitors

Biological Activity

Description

Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Targets

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

In vitro

Lapatinib Ditosylate weakly inhibits the activity of ErbB4 with IC50 of 367 nM, and displays >300-fold selectivity for EGFR and ErbB2 over other kinases such as c-Src, c-Raf, MEK, ERK, c-Fms, CDK1, CDK2, p38, Tie-2, and VEGFR2. Lapatinib Ditosylate significantly inhibits receptor autophosphorylation of EGFR and ErbB2 in a dose-dependent manner with IC50 of 170 nM and 80 nM, respectively in HN5 cells; as well as 210 nM and 60 nM, respectively in BT474 cells. Unlike OSI-774 and Iressa (ZD1839) which preferentially inhibit the growth of the EGFR-overexpressing cells, Lapatinib Ditosylate inhibits the growth of both EGFR- and ErbB2-overexpressing cells. Lapatinib Ditosylate displays higher inhibitory activity against EGFR- or ErbB2-overexpressing cells with IC50 of 0.09-0.21 μM, compared with cells expressing low levels of EGFR or ErbB2 with IC50 of 3-12 μM, and exhibits ~100-fold selectivity over the normal fibroblast cells. Lapatinib Ditosylate potently inhibits the outgrowth of EGFR-overexpressing HN5 and A-431 cells, as well as ErbB2-overexpressing BT474 and N87 cells, and significantly induces G1 arrest of HN5 cells and apoptosis of BT474 cells, which are associated with inhibition of AKT phosphorylation. ^[1]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HN5 cell line	MWHQdo9tcW[ncnH0bY9vKGG\|c3H5			NE\2epVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjOOUBk\WyuIHzpcoUtKEmFNUC9NE4xOjVizszN	NVXUSYRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
BT474 cell line	NVzlSGh3WHKxbHnm[ZJifGmxbjDhd5NigQ>?			NFjlRYxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHygcIlv\SxiSVO1NF0xNjB{NTFOwG0>	MkDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OEO3O\|IoRjF4NEizO\|czRC:jPh?=
HN5 cell	NVyxc\|FQT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGr5S4hKdmirYnn0bY9vKG:oIFjOOUBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOsJGlEPTB;MD6xNkDPxE1?	MkTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5N{e0NVAoRjF4N{e3OFExRC:jPh?=
BT474 cell	M3G3c2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NVjCdnZ1UW6qaXLpeIlwdiCxZjDCWFQ4PCClZXzsJIdzd3e2aDDh[pRmeiB5MjDodpMtKEmFNUC9NE4xQCEQvF2=	M4jRb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{e3OFExLz5zNke3O\|QyODxxYU6=
N87 cell	Mkj6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NE\vVWJKdmirYnn0bY9vKG:oIF64O{Bk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOsJGlEPTB;MD6wPEDPxE1?	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd5N{SxNEc,OTZ5N{e0NVA9N2F-
HFF cell	NWnNcmRWT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M3jvRmlvcGmkaYTpc44hd2ZiSF\GJINmdGxiZ4Lve5RpNCCLQ{WwQVkvQSEQvF2=	M3PKblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{e3OFExLz5zNke3O\|QyODxxYU6=
BT474	NIS3[WZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NWjpVlRjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFdmIzNCCLQ{WwQVAvODJ3zszN	NWTNT3BCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2OVM{OzNpPkG4OlU{OzN\|PD;hQi=>
SKBR3	M{nMSmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MVm3NkBpenN?	NGDWSGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODF5zszN	M1rZPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEK4OFI2Lz5zOUCyPFQzPTxxYU6=
SKBR3	NYT0OmlwS3m2b4TvfIlkcXS7IHHzd4F6		MkPmO\|IhcHK\|	M4frUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ\|IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjoQvF2=	NIPnUGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi4PFc3OSd-MUm4PFg4PjF:L3G+
A431	M3HHW2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MYW3NkBpenN?	MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MD6xNFTPxE1?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh6OEe2NUc,OTl6OEi3OlE9N2F-
SK-BR-3	MlPzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLVLSMVMh[2WubIOgZYZ1\XJiaILzJIJ6KEGWUDDjc451\W62IHHzd4F6NCCLQ{WwQVAvODUQvF2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
SKHEP1	MoXTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MmPORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVS1jFVFEh[2WubIOgZYZ1\XJiaILzJIJ6KEGWUDDjc451\W62IHHzd4F6NCCLQ{WwQVUvO87:TR?=	M2e1[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO\|c5Lz5{MEG0N\|c4QDxxYU6=
MDA-MB-231	M3rpXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgbJJ{KGK7IFHUVEBkd262ZX70JIF{e2G7LDDJR\|UxRTVwNN88US=>	NF63eGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
Hep3B2	NWPnemlLSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M4CweWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwN2IzKGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NF02NjR7zszN	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
HepG2	M2fze2FvfGmycn;sbYZmemG2aY\lJIF{e2G7			NF\xNodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NF03NjJ5zszN	NV;FUVFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
MCF7	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NHnnS4pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiaILzJIJ6KEGWUDDjc451\W62IHHzd4F6NCCLQ{WwQVYvPs7:TR?=	M2DDOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO\|c5Lz5{MEG0N\|c4QDxxYU6=
A431	NXv4Umk5TnWwY4Tpc44h[XO\|YYm=			MV;Jcohq[mm2aX;uJI9nKEWJRmKgbY51emGlZXzseYxieiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hSTR\|MTDj[YxteyCkeTDFUGlUSSxiSVO1NF0xNjB3Mt88US=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2Nk[1OUc,OjB\|NE[2OVU9N2F-
N87	MWTGeY5kfGmxbjDhd5NigQ>?			NVradoR7UW6qaXLpeIlwdiCxZjDFdoJDOiCrboTyZYNmdGy3bHHyJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDOPFch[2WubIOgZpkhTUyLU1GsJGlEPTB;MD6x{txO	MojxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB\|NE[2OVUoRjJyM{S2OlU2RC:jPh?=
MIAPaCa	NIG3ZWFHfW6ldHnvckBie3OjeR?=			NX\qUoFTUW6qaXLpeIlwdiCxZjDFVmJjOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVUmDUHHDZUBk\WyuczDifUBGVEmVQTygTWM2OD1yLkG0{txO	MoDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1NlMoRjJyOEG3OVI{RC:jPh?=
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MDA-MB-175	M3vuOmN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{\sO\|czKGi{cx?=	MlnLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUG3OUBk\WyuczDlfJBz\XO\|aX7nJHNz[yxiUnX0JIFv\CCub4egTGVTNTJiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjB2NEVOwG0>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ\|N{K4OlQ9N2F-
A431	M4jTRWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGnGW\|Q4OiCqcoO=	NGjNWpZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhGWi1zIHflcoUh[W[2ZYKgO\|IhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlExPM7:TR?=	NVrpSZBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzO\|I5PjRpPkKyN\|czQDZ2PD;hQi=>
MDA-MB-453	NFjYfGtEgXSxdH;4bYNqfHliYYPzZZk>		NW\lNlJsPzJiaILz	MmGzR5l1d3SxeHnjbZR6KGGpYXnud5QhWFSHTj3k[YZq[2mnboSgbJVu[W5iTVTBMW1DNTR3MzDj[YxteyCneIDy[ZN{cW6pIFjFVk0zNCCjbnSgVGlMO0ODIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvPTV3zszN	MnHYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|N{K4OlQoRjJ{M{eyPFY1RC:jPh?=
MDA-MB-361	M1rTcGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NHTVT3g4OiCqcoO=	MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCjY4TpeoF1\WRiaIXtZY4hVUSDLV3CMVM3OSClZXzsd{BmgHC{ZYPzbY5oKEincj2yMEBUemNiYX7kJHBKUzOFQTDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0yNjB{Od88US=>	M4O0SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{eyPFY1Lz5{MkO3Nlg3PDxxYU6=
NCI-H1781	MV7DfZRwfG:6aXPpeJkh[XO\|YYm=		Mn3sO\|IhcHK\|	NV3veXA5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixO\|gyKGOnbHzzJIV5eHKnc4PpcochUEWULUKgS\|c4Pmmwc2\fS{9EKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9N{4xPDgQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ\|N{K4OlQ9N2F-
A431	MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkDuO\|IhcHK\|	M3PUfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Mj62{txO	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7NUG3O{c,OjJ3OUWxO\|c9N2F-
NIH/3T3	NE\3TY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWeyWVBRPzJiaILz	NXrSbI0zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDOTWgwO1R\|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OE4{\|ryP	NFrFXFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW5OVE4Pyd-MkK1PVUyPzd:L3G+
SKBR3	MmDyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mn6xO\|IhcHK\|	NFTONolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHXzeJJw\2WwIILlZ4VxfG:{IHHu[EBxem:pZYP0[ZJwdmVicnXj[ZB1d3JiZHXmbYNq\W62IGPLRnI{KGOnbHzzJIV5eHKnc4PpcochUEWUMjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTVwMEZOwG0>	M2nPd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUK3PVczLz5{M{myO\|k4OjxxYU6=
MCF7	M{\oRWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NIXzOXY1QCCqcoO=	MoXpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BmgHC{ZYPzbY5oKHClRF7BN{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NVUvPzIQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	MV7DfZRwfG:6aXPpeJkh[XO\|YYm=		MnPjOFghcHK\|	M2PBU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh\XiycnXzd4lv\yCKRWKyJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3ME2xOU44Qc7:TR?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR\|NUWxN\|A9N2F-
MCF7	Ml63R5l1d3SxeHnjbZR6KGG\|c3H5		NGHkeJU1QCCqcoO=	MmPVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BmgHC{ZYPzbY5oKEiHUkLk[Yx1[TF4IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiQ3XscHRqfGW{LVfsc{Bie3OjeTygTWM2OD1zOT6yNu69VQ>?	M1zqOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W1NVMxLz5{NEO1OVE{ODxxYU6=
MCF7	M1vK[WZ2dmO2aX;uJIF{e2G7	MoG0NVAhfU1?	M371UlIhcHK\|	MVvJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvckBifCC\MUC2PEBqdiCqdX3hckBOS0Z5IHPlcIx{KGW6cILld5NqdmdiSFXSNoRmdHSjMU[gZZQhOTBidV2gZYZ1\XJiMjDodpMh[nliV3XzeIVzdiCkbH;0eIlv\w>?	M3O1O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W1NVMxLz5{NEO1OVE{ODxxYU6=
MCF7	NVro[o5ETnWwY4Tpc44h[XO\|YYm=	MU[xNEB2VQ>?	NEmzNWYzKGi{cx?=	MnvTTY5pcWKrdHnvckBw\iCHR1\SJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUGwOlghcW5iaIXtZY4hVUOINzDj[YxteyCneIDy[ZN{cW6pIFjFVlIh[XRiMUCgeW0h[W[2ZYKgNkBpenNiYomgW4V{fGW{bjDicI91fGmwZx?=	NEL3NVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7	M4niVWZ2dmO2aX;uJIF{e2G7	M17OdVExKHWP	Mmq4NkBpenN?	NYj0d2xIUW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVExPjhiaX6gbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO\|aX7nJJBkTE6DMzDheEAyOCC3TTDh[pRmeiB{IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5o	NIH0c2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7	M4izWmZ2dmO2aX;uJIF{e2G7	NFz3fHIyOCC3TR?=	NX\WRXlSOiCqcoO=	M4TKeGlvcGmkaYTpc44hd2ZiSFXSNkBl\Wy2YUG2JI12fGGwdDDheZRweGixc4Doc5J6dGG2aX;uJIF1KFlzMkS4JIlvKGi3bXHuJG1ETjdiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNkBpenNiYomgW4V{fGW{bjDicI91fGmwZx?=	NHfHeJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7	M1LnfGZ2dmO2aX;uJIF{e2G7	NGC0WIMyOCC3TR?=	NXT4XngxOiCqcoO=	MoX3TY5pcWKrdHnvckBw\iCKRWKyJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUGyOFghcW5iaIXtZY4hVUOINzDj[YxteyCjdDCxNEB2VSCjZoTldkAzKGi{czDifUBY\XO2ZYLuJIJtd3S2aX7n	MnzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NUWxN\|AoRjJ2M{W1NVMxRC:jPh?=
MCF7	NWXEdWp5TnWwY4Tpc44h[XO\|YYm=	MVexNEB2VQ>?	NHPafHgzKGi{cx?=	M3TJcGlvcGmkaYTpc44hd2ZiSFXSNkBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGmxNlQ5KGmwIHj1cYFvKE2FRkegZ4VtdHNiZYjwdoV{e2mwZzDwZ2RPSTNiYYSgNVAhfU1iYX\0[ZIhOiCqcoOgZpkhX2W\|dHXyckBjdG:2dHnu[y=>	NHKwcIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
4T1	NH;V[plEgXSxdH;4bYNqfHliYYPzZZk>			NXy2PFJYS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhfHKrcHzlJI5m\2G2aY\lJFRVOSClZXzsd{whUUN3ME2wMlAyODN5zszN	NISwPHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-231	NVTKNWRPS3m2b4TvfIlkcXS7IHHzd4F6			MlLER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6geJJqeGynIH7l[4F1cX[nIF3ERU1OSi1{M{GgZ4VtdHNuIFnDOVA:OC5yMt88US=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-435	NYjlRodPS3m2b4TvfIlkcXS7IHHzd4F6			M4\1cGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N\|Uh[2WubIOsJGlEPTB;MD6wNlk4\|ryP	MoTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MCF7	NYLDNYhHS3m2b4TvfIlkcXS7IHHzd4F6			M3SwRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVTNXCxc3n0bZZmKE2FRkegZ4VtdHNuIFnDOVA:OC5yNkS5{txO	NWHtRVJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MDA-MB-468	MlfQR5l1d3SxeHnjbZR6KGG\|c3H5			MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjD0dolxdGVibnXnZZRqfmViTVTBMW1DNTR4ODDj[YxteyxiSVO1NF0xNjB6M{NOwG0>	NUjwNlhFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MCF7	NX;wdolCS3m2b4TvfIlkcXS7IHHzd4F6		NYL0WFRUPDhiaILz	NX;mS\|lPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODFzzszN	M1vQXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUWxOVgzLz5{NUG1NVU5OjxxYU6=
SKBR3	Mn3NR5l1d3SxeHnjbZR6KGG\|c3H5		M3LJZ\|czKGi{cx?=	M4DD[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO\|YYmsJGlEPTB;MD6wN\|Ay\|ryP	MlXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV\|MEWzN\|AoRjJ3M{C1N\|MxRC:jPh?=
BT474	MmK0R5l1d3SxeHnjbZR6KGG\|c3H5		NUfuUpE5PzJiaILz	MnzXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRnQ1PzRiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OD1yLkC2N\|nPxE1?	NF;tcZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
MDA-MB-453	MXfDfZRwfG:6aXPpeJkh[XO\|YYm=		NEDSVGM4OiCqcoO=	M4nFb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20OVMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0xNjF7zszN	NVLkUXRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N\|A2OzNyPD;hQi=>
Calu3	NH7BcHlEgXSxdH;4bYNqfHliYYPzZZk>		MUS3NkBpenN?	NG[1VWtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[Wy3MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5MEBKSzVyPUCuNlPPxE1?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNyNUOzNEc,OjV\|MEWzN\|A9N2F-
SKOV3	Ml3KR5l1d3SxeHnjbZR6KGG\|c3H5		M2PoUlczKGi{cx?=	M{TmOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO\|YYmsJGlEPTB;MD61Pe69VQ>?	M{jLelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N\|MxLz5{NUOwOVM{ODxxYU6=
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A673	M2K1O5FJXFNiYYPzZZk>			NHT5[XZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQU[3N{Bk\Wyucx?=	M4nBZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	NUfLUop{eUiWUzDhd5NigQ>?			MmrUdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	NXu1V5htRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-37	MUHxTHRUKGG\|c3H5			MXjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	NXrVS243RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB-EBc1	MUjxTHRUKGG\|c3H5			MlTIdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ\|Eh[2WubIO=	MkS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
U-2 OS	MW\xTHRUKGG\|c3H5			NXfUSmExeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGWtNkBQWyClZXzsdy=>	NH\5XpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Saos-2	NIrle3pyUFSVIHHzd4F6			NUX1Snc3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-SH	NG[3W\|VyUFSVIHHzd4F6			MknQdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tV2gh[2WubIO=	M3ywbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5	Mo[4dWhVWyCjc4PhfS=>			M37kbpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
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RD	NGDPVWJyUFSVIHHzd4F6			M3;wRZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCURDDj[Yxtew>?	NF2yWpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
MG 63 (6-TG R)	MWDxTHRUKGG\|c3H5			MmTHdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy\|	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
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U-2 OS	MUHxTHRUKGG\|c3H5			NYfISZcyeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXS1{IF;TJINmdGy\|	Mkf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh41	NVzhTFJneUiWUzDhd5NigQ>?			MkDvdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog1OSClZXzsdy=>	M3zVclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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SK-N-SH	M2fK[JFJXFNiYYPzZZk>			MX;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNVOKIHPlcIx{	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
MCF7	NVzNcINvSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnTRO\|IhcHK\|	M1fXTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTZwON88US=>	NV;aZYVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
HCT116	NHfUPHlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MUe3NkBpenN?	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFyLkGy{txO	M1LNbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nki0O\|A5Lz5{OU[4OFcxQDxxYU6=
A2780	NHzkXmhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		Mmr2O\|IhcHK\|	MoC4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDMke4NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFyLkVOwG0>	MorNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OES3NFgoRjJ7Nki0O\|A5RC:jPh?=
SKBR3	NFXZb\|JEgXSxdH;4bYNqfHliYYPzZZk>		NXnSN3BpPzJiaILz	M1fXZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ\|IHPlcIx{KG:4ZYKg[ZhxemW\|c3nu[{BJTVJ{IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0xNjF5zszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyMkexPUc,Ojl7MEK3NVk9N2F-
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NCI-H1975	M{jKeWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NHTueYg4OiCqcoO=	MlrpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzOUe1JINmdGy\|IHjhdoJwemmwZzDFS2ZTKFR5OUDNJI12fGGwdDDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:OTFwNEdOwG0>	NVnaOYRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFI4OTlpPkK5PVAzPzF7PD;hQi=>
MDA-MB-361	NVqzbVJlS3m2b4TvfIlkcXS7IHHzd4F6		NES5ZYg4OiCqcoO=	MknJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUO2NUBk\WyuczDveoVzKGW6cILld5NqdmdiSFXSNkBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO\|YYmsJGlEPTB;MUOuO\|PPxE1?	Mof2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MEK3NVkoRjJ7OUCyO\|E6RC:jPh?=
HepG2	NImzeJpHfW6ldHnvckBie3OjeR?=			NIrte4pKdmirYnn0bY9vKG:oIFXHSnIhcW5iaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVA:OC5yMkex{txO	MonMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
insect cells	MnvxSpVv[3Srb36gZZN{[Xl?		NGfaNIw2KG2rboO=	M{CwVWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iRVfGVkBNQDV6UjDteZRidnRiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEWgcYlveyCob3zsc5dm\CCkeTDBWHAh[WSmaYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliSGTSSkBie3OjeTygTWM2OD1yLkCzO\|U2\|ryP	MkTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
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MCF7	MV;DfZRwfG:6aXPpeJkh[XO\|YYm=		MkPVNlQhcHK\|	NIHCSGtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OU4xOs7:TR?=	MmTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
HCT116	MUXDfZRwfG:6aXPpeJkh[XO\|YYm=		NUPtdmFZOjRiaILz	M1;sR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVUvQTMQvF2=	NX2x[GtyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVY2QDBpPkOwNFk3PThyPD;hQi=>
HepG2	Mmf6R5l1d3SxeHnjbZR6KGG\|c3H5		MoTNNlQhcHK\|	NWfhcGVIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0yOS55Md88US=>	NHfVU\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
Caco	MXzDfZRwfG:6aXPpeJkh[XO\|YYm=		NELkSVQzPCCqcoO=	MoHJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR4FkdyClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUGyMlEy\|ryP	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7NkW4NEc,OzByOU[1PFA9N2F-
HepG2	NX;KWYNPS3m2b4TvfIlkcXS7IHHzd4F6			Mn\pR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMtKFSFNUC9Ok4{\|ryP	Mo\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|NES5NFYoRjNyM{S0PVA3RC:jPh?=
L929	MlXHR5l1d3SxeHnjbZR6KGG\|c3H5		MVq3NkBpenN?	Mn3DR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFkzQSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Mj6wOe69VQ>?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODVyOEO3PUc,OzB3MEizO\|k9N2F-
A431	NVzGWlJLSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2GyTVczKGi{cx?=	NHznfJpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N\|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Lk[2{txO	NYjFNnpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C1NFg{PzlpPkOwOVA5Ozd7PD;hQi=>
A549	Ml3mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NUHGN5YyPzJiaILz	NWHMd\|ZGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Mz62OO69VQ>?	Ml2zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEizO\|koRjNyNUC4N\|c6RC:jPh?=
A549	M{G5TmN6fG:2b4jpZ4l1gSCjc4PhfS=>	M{nUTlYhfU1?	Mn7aNlQhcHK\|	MlzuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCnZn\lZ5Qhd25iaX70doFk\WyudXzhdkBCXFBibHX2[Yx{KGG2IE[geW0h[W[2ZYKgNlQhcHK\|IHL5JIx2[2moZYLhd4UudHWlaX\ldolvKGKjc3XkJIF{e2G7	NIe0Z2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwPFM4QSd-M{C1NFg{Pzl:L3G+
HN5	MkHlSpVv[3Srb36gZZN{[Xl?		MmDDNlQhcHK\|	NHzuOZVKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9vKGG2IGT5dk1z\XOrZIXlJIlvKGi3bXHuJGhPPSClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFI1KGi{czDmc4xtd3enZDDifUBGT0Zvc4TpcZVt[XSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|LDDJR\|UxRTBwMEJOwG0>	M4rUT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkCwNVQ6Lz5\|ME[wNFE1QTxxYU6=
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MDA231	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NF\Gc\|U4OiCqcoO=	M3r2eWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;ND62PVHPxE1?	NEjJW2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEe5NlExOSd-M{C3PVIyODF:L3G+
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JeKo1	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUi3NkBpenN?	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEqnS3:xJINmdGy\|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcoNmKGG\|c3H5MEBIUTVyPUZOwG0>	Ml7ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
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U87MG	NELzOYdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M3nVZ\|czKGi{cx?=	NXzIdoloSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiR1m1NF0yOM7:TR?=	NFfOOYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
MV4-11	NYHYfnBtSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoTEO\|IhcHK\|	Mk\TRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPVkStNVEh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9NVDPxE1?	NF7Z[2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
DU145	NYmyOmhSSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NF\W[pg4OiCqcoO=	MofERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCGVUG0OUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME2yNO69VQ>?	Mk\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
HCT116	NXnoTZBGSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NVWweYlsPzJiaILz	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME2yNO69VQ>?	Mmn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
MDA-MB-231	MonlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXnpfWkyPzJiaILz	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFfJOVA:OjEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
T47D	Mlq4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYe3NkBpenN?	M2HVb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME20NO69VQ>?	NHv5NHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
A431	Mk\0SpVv[3Srb36gZZN{[Xl?		NY\yS\|JKQTBibXnudy=>	M3HNeGlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25icILlbY5kfWGkdHXkJIZweiB7MDDtbY5{KG[xbHzve4VlKGK7IFXHSk1{fGmvdXzheIlwdiCkeTDzZY5lf2mlaD3FUGlUSSxiSVO1NF0xNjB{Md88US=>	M2n2cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUezO\|M2Lz5\|MEm3N\|c{PTxxYU6=
UCH1	NYfQS3FOSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlLMO\|IhcHK\|	NHXj[\|VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGXDTFEh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7LDDJR\|UxRTNwMt88US=>	NUXFd3VFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
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UCH7	MmTnRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVW3NkBpenN?	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFWFSEegZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwQVI3\|ryP	NGLzTIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEm3N\|c{PSd-M{C5O\|M4OzV:L3G+
UCH12	NYXFUIoySW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUD5e5BtPzJiaILz	M2juTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVVPINVIh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7LDDJR\|UxRTN\|zszN	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl5M{ezOUc,OzB7N{O3N\|U9N2F-
A549	NIG5fGNHfW6ldHnvckBie3OjeR?=	M4XiWFg3KG2PL3vn	NXTOSG9IOjdiZHH5dy=>	M{K0fmRzfWdiY3;uZ4VvfHKjdHnvckBqdiCQT1SvV2NKTCCvb4Xz[UBjdG:xZDD4[Y5w\3KjZoTl[EB4cXSqIHj1cYFvKEF3NEmgZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDheEA5PiCvaXPyc41wdC:tZzygdI8h[WSvaX7pd5RmemWmIH;uZ4Uh\GGrbImg[o9zKDJ5IHThfZMh[W6mIH3lZZN2emWmIHH0JIRigSB{NzDheEAzKGi{czDh[pRmeiCuYYP0JIFldWmwaYP0[ZJm\CCmb4PlJIJ6KEyFLV3TM21UKGGwYXz5d4l{NCCFdE2yMlgy\|ryP	NUDKOFd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlU5QTRpPkOxNVI2QDl2PD;hQi=>
HCC1954	NF7BbHhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFjVe204OiCqcoO=	NUXV[ZVXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2MyQTV2IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhGWjJiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13zszN	M2ToUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
NCI-H1975	NGLF[JVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MlO1O\|IhcHK\|	NVjTfWJISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD17zszN	NWjpcld4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlU5QTRpPkOxNVI2QDl2PD;hQi=>
A549	NFXKWFlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWnLdWI6PzJiaILz	MkPFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNUS5JINmdGy\|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNe69VQ>?	NUTpZXFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlU5QTRpPkOxNVI2QDl2PD;hQi=>
Sf9	MXfGeY5kfGmxbjDhd5NigQ>?	MljhNUB1dyBzMDD1US=>	Mn7qOlAhdWmwcx?=	NUnKV\|VTUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDHV3QufGGpZ3XkJGVITlJiKHPheIFtgXSrYzDkc41icW5iNkm1JJRwKGWwZDDy[ZNq\HWnczmgZZV1d3Cqb4PwbI9zgWyjdHnvckBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4Y6KGOnbHzzJJV{cW6pIIDvcJkpKEeudTzUfZIqKDR8MTDhd{B{fWK\|dILheIUh[XRiMTD0c{AyOCC3TTDpcoN2[mG2ZXSg[o9zKDZyIH3pcpMh[nliRVzJV2E>	M2TuZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
HCC1954	M3XITGZ2dmO2aX;uJIF{e2G7	M1P6[\|AvODJidH:gNkB2VQ>?	NF;VcXgyKGi{	MYDJcohq[mm2aX;uJI9nKEiHUkKgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBJS0NzOUW0JINmdGy\|IH;2[ZJmgHC{ZYPzbY5oKEiHUkKgZZQhOC5yMjD0c{AzKHWPIHnuZ5Vj[XSnZDDmc5IhOSCqcjDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MkHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkW4PVQoRjNzMUK1PFk1RC:jPh?=
HCC827	NFPRdmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1GwVVczKGi{cx?=	MmjiRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ1O4Nlch[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwNt88US=>	NIDSZ4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUKwNlk6OCd-M{GyNFI6QTB:L3G+
A431	MnXpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MXu3NkBpenN?	M2jIfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PC56zszN	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMkm5NEc,OzF{MEK5PVA9N2F-
SW480	Mn;BRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MV23NkBpenN?	NHzYVmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMj61PO69VQ>?	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMkm5NEc,OzF{MEK5PVA9N2F-
NCI-H1975	M3\FSWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MmrmO\|IhcHK\|	M4DPW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNk43QM7:TR?=	M3TLNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
A549	MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MXy3NkBpenN?	NH[0d5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF2LkpOwG0>	M3f1dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
A549	M4X1O2Z2dmO2aX;uJIF{e2G7	MkXxNVUhfU1?	MX20PEBpenN?	NV72S2d2UW6qaXLpeIlwdiCxZjDj[YxtKG2rZ4LheIlwdiCrbjDDUU1lcWxvbHHi[Yxt\WRiaIXtZY4hSTV2OTDj[YxteyC6ZX7v[5Ji\nSnZDDpckA1QCCqcoOgdI9{fC2oZYL0bYxqgmG2aX;uJJpm[nKjZnnzbEBmdWK{eX;zJIF1KDF3IIXNJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IHPvcoZw[2GuIH3pZ5Jwe2OxcHnjJI1mfGixZB?=	M2nD[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
WS1	M3zmV2N6fG:2b4jpZ4l1gSCjc4PhfS=>			MX3DfZRwfG:6aXPpeJkhcW5iaIXtZY4hX1NzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[pJwKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDkfYUh[mG\|ZXSgZZN{[XluIFnDOVA:OTQQvF2=	M1LSN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{e4OVcyLz5\|MUO3PFU4OTxxYU6=
SKBR3	NHLxfGpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MW[3NkBpenN?	NIPyRZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLRnI{KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPzcQvF2=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV2NkG5O{c,OzF3NE[xPVc9N2F-
SUM159	Mnn6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mn\nO\|IhcHK\|	NGK0WmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPVUVE2QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF06Njd4zszN	M134flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUS2NVk4Lz5\|MUW0OlE6PzxxYU6=
KG1a	M2TVcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFG3[o04OiCqcoO=	NVT3R3M4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLS\|FiKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPzcQvF2=	NWTtN5NmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1OFYyQTdpPkOxOVQ3OTl5PD;hQi=>
MCF7	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NXTJ[HVHPzJiaILz	MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjkQvF2=	NWrQS45MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G2OVU1OjlpPkOxOlU2PDJ7PD;hQi=>
A2780	M3HGT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MYK3NkBpenN?	MmPaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDMke4NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFyLkVOwG0>	NVP5[2puRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G2OVU1OjlpPkOxOlU2PDJ7PD;hQi=>
HT-29	MmTGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MWe3NkBpenN?	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTJwNkhOwG0>	M3TsXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNkW1OFI6Lz5\|MU[1OVQzQTxxYU6=
MRC5	MVfDfZRwfG:6aXPpeJkh[XO\|YYm=		M4jjN\|czKGi{cx?=	M3\WPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1TSzViY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xN{43Ps7:TR?=	NXTqXpZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G2OVU1OjlpPkOxOlU2PDJ7PD;hQi=>
NCI-H1648 cell	NYnpZ4xVT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MXHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODJ3NESg{txO	M4DTeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NMC-G1 cell	MnW5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3y1eGlvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PDVyMTFOwG0>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
NTERA-S-cl-D1 cell	NWHDT\|RVT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M3vLemlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPU[uNlY2PjFizszN	M1P1c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
OCUB-M cell	MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NW\SVYt2UW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB3N{Sg{txO	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OS-RC-2 cell	MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NF\5bXVKdmirYnn0bY9vKG:oIHj1cYFvKE:VLWLDMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7MUm5JO69VQ>?	NX\PZYRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
OVCAR-4 cell	Ml7oS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NGnUWYVKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjFzNke1JO69VQ>?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
RL95-2 cell	NWnV[oNMT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NWDRSndTUW6qaXLpeIlwdiCxZjDoeY1idiCUTEm1MVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjF3Nkeg{txO	NHHXdGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SW954 cell	MmC0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NGOwOmNKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4{QTJ2NTFOwG0>	NUPLVGJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
SW962 cell	NUTYXJdCT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MVjJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;NT6zPVI1PSEQvF2=	NFXwR2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-1 cell	NXjqfGRbT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NXmweWJtUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4xOjF3OTFOwG0>	NGnPcYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
A253 cell	NUjZfY9HT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NWnxXFI{UW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDh\|IN88US=>	NYSzXm1MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
A388 cell	MlHMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC0PFMh\|ryP	MlrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
BB30-HNC cell	MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MljLTY5pcWKrdHnvckBw\iCqdX3hckBDSjNyLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTd\|M{Wg{txO	MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-12 cell	MorPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NVnjcnBuUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ{NUig{txO	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-5 cell	MnLPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NFnrXppKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1PjV2IN88US=>	NFnW[HI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-6 cell	M2jPfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M1:xSGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuOFkxPTdizszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-8 cell	NYjDNnpRT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NEPkd5dKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlA{PzNizszN	NHnN[mQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-9 cell	MkHyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M1nqUmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuOVUzODFizszN	MonZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TK10 cell	MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			Mkn6TY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;ND6xOlUzOiEQvF2=	M3GzO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
DSH1 cell	NFLlb2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NXnlPIhxUW6qaXLpeIlwdiCxZjDoeY1idiCGU1ixJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQTN7NjFOwG0>	NIH5RXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
ECC12 cell	MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NH7KOppKdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{GyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQTJ\|MTFOwG0>	MkfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
EKVX cell	NHXyZnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWDJcohq[mm2aX;uJI9nKGi3bXHuJGVMXlhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkS0PFc1KM7:TR?=	NFPxcYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
HCC2218 cell	M2HNfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NYHIO4lRUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNUOyOkDPxE1?	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LB2241-RCC cell	NVHW[\|JyT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGTB[3lKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1OFA{KM7:TR?=	MnfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LB996-RCC cell	MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NV7EbmdOUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkO2NlI5KM7:TR?=	NID1eZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LC-1F cell	M1TLO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M1f4S2lvcGmkaYTpc44hd2ZiaIXtZY4hVENvMV[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM5OjR2IN88US=>	M2P4NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
LS-513 cell	MkSzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			Mn\pTY5pcWKrdHnvckBw\iCqdX3hckBNWy13MUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxODRzIN88US=>	M4Ll[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ErbB2 / t-ErbB2 / p-Akt / t-Akt / p-Erk / t-Erk; PubMed: 25238247 PLoS One Dose response of lapatinib and PD168393 on phosphorylation of ErbB2, AKT and ERK in Calu3 and SkBr3 cells in response to EGF treatment. p-ErbB2: phosphorylated ErbB2; t-ErbB2: total-ErbB2; p-AKT: phosphorylated AKT; t-AKT: total AKT; p-ERK: phosphorylated ERK; t-ERK: total ERK. pEGFR / EGFR / p-mTOR / mTOR / PARP / c-PARP ; PubMed: 28938602 Oncotarget SKBR3 and 78617 cells were treated with lapatinib as in panel A, then the expression of phospho-ErbB2 (Tyr1221/1222), ErbB2, phospho-EGFR (Tyr1068), EGFR, phospho-Akt (Ser473), Akt, phospho-Erk1/2 (Thr202/Tyr204), Erk2, phospho-mTOR (Ser2448), and mTOR were analyzed using Western blotting. All values are presented as the mean ± standard error (S.E.) (**p < 0.01).	25238247 28938602
Growth inhibition assay	Cell viability ; PubMed: 24947784 Oncotarget Huh7 (A), HepG2 (B), or HA22T (C) HCC cells were left untreated or treated with 0.1% DMSO (vehicle, D) or with DMSO containing various concentrations of lapatinib (1.25, 2.5, 5, or 10 μM) for 3 days. Relative amounts of viable cells were detected by MTS assay. O.D. values from DMSO-treated control cells were designated 100%.	24947784

In vivo

Oral administration of Lapatinib Ditosylate (~100 mg/kg) twice daily significantly inhibits the growth of BT474 and HN5 xenografts in a dose-dependent manner. ^[1]

Protocol

Kinase Assay:^[1]	- Collapse In vitro kinase assays: The IC50 values for inhibition of enzyme activity are generated by measuring inhibition of phosphorylation of a peptide substrate. The intracellular kinase domains of EGFR and ErbB2 are purified from a baculovirus expression system. EGFR and ErbB2 reactions are performed in 96-well polystyrene round-bottomed plates in a final volume of 45 μL. Reaction mixtures contain 50 mM 4-morpholinepropanesulfonic acid (pH 7.5), 2 mM MnCl₂, 10 μM ATP, 1 μCi of [γ³³P] ATP/reaction, 50 μM Peptide A [Biotin-(amino hexonoic acid)-EEEEYFELVAKKK-CONH2], 1 mM dithiothreitol, and 1 μL of DMSO containing serial dilutions of Lapatinib beginning at 10 μM. The reaction is initiated by adding the indicated purified type-1 receptor intracellular domain. The amount of enzyme added is 1 pmol/reaction (20 nM). Reactions are terminated after 10 minutes at 23°C by adding 45 μL of 0.5% phosphoric acid in water. The terminated reaction mix (75 μL) is transferred to phosphocellulose filter plates. The plates are filtered and washed three times with 200 μL of 0.5% phosphoric acid. Scintillation cocktail (50 μL) is added to each well, and the assay is quantified by counting in a Packard Topcount. IC50 values are generated from 10-point dose-response curves.
Cell Research:^[1]	- Collapse Cell lines: HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, and HB4a c5.2 Concentrations: Dissolved in DMSO, final concentrations ~100 μM Incubation Time: 72 hours Method: Cells are exposed to various concentrations of Lapatinib for 72 hours. Relative cell number is estimated using methylene blue staining. The absorbance at 620 nm is read in a Spectra microplate reader. Cell death and cell cycle analysis are assessed by propidium iodide staining and antibody detection of incorporated BrdUrd and staining with propidium iodide. (Only for Reference)
Animal Research:^[1]	- Collapse Animal Models: CD-1 nude female mice implanted s.c. with HN5 cells, and C.B-17 SCID female mice implanted s.c. with BT474 cells Dosages: ~100 mg/kg Administration: Orally twice daily (Only for Reference)

References

[1] Rusnak DW, et al. Mol Cancer Ther, 2001, 1(2), 85-94.

Solubility (25°C)

In vitro	DMSO	100 mg/mL (108.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+40% PEG 300+5% Tween 80+53% ddH2O For best results, use promptly after mixing.	1.25 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Lapatinib (GW-572016) Ditosylate SDF

Molecular Weight	925.46
Formula	C₂₉H₂₆ClFN₄O₄S.2C₇H₈O₃S
CAS No.	388082-77-7
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04608409	Recruiting	Drug: Lapatinib and Paclitaxel	Ovarian Cancer	Frederick R. Ueland M.D.\|University of Kentucky	November 16 2020	Phase 1
NCT03075995	Unknown status	Other: hight-fat breakfast	Breast Cancer	Sun Yat-sen University	April 12 2017	Not Applicable
NCT02338245	Completed	Drug: ASLAN001\|Drug: Lapatinib\|Drug: Capecitabine	Metastatic Breast Cancer	Aslan Pharmaceuticals	December 29 2014	Phase 2
NCT02294786	Terminated	Drug: Lapatinib\|Drug: Capecitabine\|Drug: Octreotide	Cancer	Novartis Pharmaceuticals\|Novartis	December 17 2014	Phase 2
NCT02158507	Active not recruiting	Drug: Combination of Veliparib + Lapatinib	Metastatic Triple Negative Breast Cancer	University of Alabama at Birmingham\|Scariot Foundation\|GlaxoSmithKline\|AbbVie	July 2014	Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
If I need to use S1028 for treating tumor-bearing mice with injection, how could I prepare the solution?
Answer:
S1028 Lapatinib Ditosylate can be dissolved in 2% DMSO/30% PEG 300/ddH2O at 10 mg/ml as clear solution.

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

Selective EGFR Inhibitor

Erlotinib HCl (OSI-744) : EGFR-selective, IC50=2 nM.
Most Potent EGFR Inhibitor

Afatinib (BIBW2992) : EGFR(wt), IC50=0.5 nM; EGFR(L858R), IC50=0.4 nM; EGFR(L858R/T790M), IC50=10 nM; HER2, IC50=14 nM.
FDA-approved EGFR Inhibitor

Lapatinib : Approved by FDA for breast cancer.
Newest EGFR Inhibitor

CO-1686 (AVL-301) ^New : Irreversible, mutant-selective EGFR inhibitor with K_i of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively.

Related HER2 Products

Erlotinib (OSI-774) ^New

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
Bemcentinib (R428) ^New

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
Pexidartinib (PLX3397) ^New

Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.
AC480 (BMS-599626)

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
CP-724714

CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.
Neratinib (HKI-272)

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
Sapitinib (AZD8931)

Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
Mubritinib (TAK 165)

Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1.
Tyrphostin AG 879

Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

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Lapatinib (GW-572016) Ditosylate