Tomivosertib (eFT-508)

For research use only.

Catalog No.S8275

2 publications

Tomivosertib (eFT-508) Chemical Structure

Molecular Weight(MW): 340.38

Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth.

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Biological Activity

Description Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth.
MNK2 [1]
(Cell-free assay)
MNK1 [1]
(Cell-free assay)
1 nM 2.4 nM
In vitro

eFT508 has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. Treatment of tumor cell lines with eFT508 leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50 = 2-16 nM). In a panel of ~50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TMD8 M4XsNGZ2dmO2aX;uJIF{e2G7 M2noWFAvODFuIECuNUwhOSxiMzDhcoQhOTBizszN MnTiNkBp NEnFbXVxd3SnboSg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kBmUUZ2RTDT[ZIzODlicHjvd5Bpd3K7bHH0bY9v MYeyPVUzPjB7OB?=
TMD8 MmHKVJJwdGmoZYLheIlwdiCjc4PhfS=> MoLTNVIhcA>? Ml\0TWM2OD1{LkWzJO69VQ>? MoLpN|A5OjRzNke=
MV4-11 MUnQdo9tcW[ncnH0bY9vKGG|c3H5 M1zyTFEzKGh? MnTITWM2OD1zND60PUDPxE1? MXuzNFgzPDF4Nx?=
K562  M{LRNXBzd2yrZnXyZZRqd25iYYPzZZk> NFnLNGMyOiCq NYjlZYs1UUN3ME2xN{42PCEQvF2= NEnsc4o{ODh{NEG2Oy=>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot

PubMed: 30459229     

eFT508 significantly reduced the level of eIF4E phosphorylation at 0.1 and 1 μM after 1 hr, without affecting other signaling pathways in cultured mouse DRG neurons. 

Growth inhibition assay
Cell viability; 

PubMed: 30832411     

Head-to-head antiproliferative effects of VNLG-152R and eFT508 on MDA-MB-231 and MDA-MB-468 cells. The dose-response curves were generated from MTT assays after 6-day exposure to different concentrations of the compounds. Each point is a mean of replicates from three independent experiments.

In vivo

eFT508 is well-tolerated and shows efficacy against MyD88-mutant DLBCL models in vivo. Significant anti-tumor activity of eFT508 is observed in the TMD8 and HBL-1 ABC-DLBCL models(subcutaneous human lymphoma xenograft models), both of which harbor activating MyD88 mutations[1].


Cell Research:


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  • Cell lines: TMD8 cells
  • Concentrations: 0.01, 0.1, 1, 3, 10 μM
  • Incubation Time: 24 h
  • Method:

    TMD8 cells are treated with the indicated concentrations of eFT508 for 24 h. Cell lysates are subjected to m7-GTP Sepharose pull-down and bound proteins are analyzed by immunoblotting with the indicated antibodies.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 13 mg/mL (38.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.38


CAS No. 1849590-01-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C2N(C(=O)C(=C1)NC3=NC=NC(=C3)N)C4(CCCCC4)NC2=O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID