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GSK3987 Liver X Receptor agonist

Name: GSK3987
Brand: Selleck Chemicals
SKU: E0099
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0099

GSK3987 is an agonist of pan LXRα/β with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. This compound increases the expression of ABCA1 and SREBP-1c and induces cellular cholesterol efflux and triglyceride accumulation.

Chemical Structure

Molecular Weight: 384.43

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Quality Control

Batch: E009901 DMSO]77 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.77%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.77

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Liver X Receptor Inhibitors	GW3965 Hydrochloride T0901317 LXR-623 (WAY-252623) SR9243 AZ876 Abequolixron (RGX-104) Desmosterol GSK2033

Solubility

In vitro
Batch:

DMSO : 77 mg/mL (200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Average weight of animals: g

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% DMSO

% Tween 80

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	384.43	Formula	C₂₄H₂₀N₂O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	264206-85-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	LXR-β 40 nM(EC50) LXR-α 50 nM(EC50)
References	[1] https://pubmed.ncbi.nlm.nih.gov/16107141/

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