Factor Xa

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S3002 Rivaroxaban <1 mg/mL 87 mg/mL <1 mg/mL
S1593 Apixaban <1 mg/mL 18 mg/mL <1 mg/mL
S7280 Edoxaban <1 mg/mL 100 mg/mL <1 mg/mL
S5708 Edoxaban tosylate Monohydrate <1 mg/mL 49 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations


Rivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).



Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.



Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.


Edoxaban tosylate Monohydrate

Edoxaban Tosylate is the tosylate salt form of edoxaban, an orally active inhibitor of factor Xa with anticoagulant activity.