Home Metabolism Factor Xa inhibitor Edoxaban tosylate Monohydrate

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Edoxaban tosylate Monohydrate Factor Xa inhibitor

Cat.No.S7280

Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Edoxaban tosylate Monohydrate Factor Xa inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 738.27

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Quality Control

Batch: Purity: 99.95%
99.95

Solubility

In vitro
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Chemical Information, Storage & Stability

Molecular Weight 738.27 Formula

C24H30ClN7O4S.C7H8O3S.H2O

 Storage (From the date of receipt)
CAS No. 1229194-11-9 Download SDF Storage of Stock Solutions

Synonyms DU-176b Smiles CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O

Mechanism of Action

Targets/IC50/Ki
Factor Xa
(Cell-free assay)
0.561 nM(Ki)
In vitro
In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively.
In vivo
Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05339672 Recruiting
Drug-drug Interaction
Radboud University Medical Center|Astellas Pharma Inc
 July 1 2024 --
NCT06326138 Withdrawn
Bariatric Surgery Candidate
Institut universitaire de cardiologie et de pneumologie de Québec University Laval
 March 11 2024 Phase 1
NCT05869591 Recruiting
Liver Cirrhosis
Centre Hospitalier Universitaire Vaudois
 January 18 2024 Phase 2
NCT06149533 Not yet recruiting
Thrombosis Venous|Cancer|Catheter Complications
Cancer Institute and Hospital Chinese Academy of Medical Sciences
 November 30 2023 Phase 3
NCT05804747 Recruiting
Atrial Fibrillation
Daiichi Sankyo|Daiichi Sankyo Korea Co. Ltd.
 February 16 2023 --

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