Edoxaban tosylate Monohydrate

For research use only.

Catalog No.S7280 Synonyms: DU-176b

1 publication

Edoxaban tosylate Monohydrate Chemical Structure

Molecular Weight(MW): 738.27

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

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Selleck's Edoxaban tosylate Monohydrate has been cited by 1 publication

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Choose Selective Factor Xa Inhibitors

Biological Activity

Description Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Targets
Factor Xa [1]
(Cell-free assay)
0.561 nM(Ki)
In vitro

In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. [1]

In vivo Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. [1]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Venous stasis thrombosis model in rats and rabbits
  • Dosages: 0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (135.45 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 738.27
Formula

C24H30ClN7O4S.C7H8O3S.H2O

CAS No. 1229194-11-9
Storage powder
in solvent
Synonyms DU-176b
Smiles O.CN(C)C(=O)C1CCC(NC(=O)C(=O)NC2=CC=C(Cl)C=N2)C(C1)NC(=O)C3=NC4=C(CN(C)CC4)S3.CC5=CC=C(C=C5)[S](O)(=O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04072068 Recruiting Drug: Edoxaban Thromboembolism|Cancer Gruppo Oncologico Italiano di Ricerca Clinica June 27 2019 Phase 4
NCT03488420 Recruiting Drug: Edoxaban Pill Atrial Fibrillation and Flutter Montreal Heart Institute|Servier April 30 2019 --
NCT03666650 Completed Drug: Edoxaban 60 MG Blood Coagulation Disorder Turku University Hospital|Helsinki University Central Hospital November 26 2018 Phase 4
NCT03803579 Recruiting -- Atrial Fibrillation|Anticoagulant-induced Bleeding Arianna Anticoagulazione Foundation August 9 2018 --
NCT03777631 Recruiting Procedure: Catheter ablation Ischemic Stroke|Atrial Fibrillation Non-Rheumatic Nippon Medical School|Daiichi Sankyo Co. Ltd. April 1 2018 Phase 3
NCT03247569 Active not recruiting Drug: Edoxaban Atrial Fibrillation Daiichi Sankyo (Thailand) Ltd. a Daiichi Sankyo Company|Daiichi Sankyo Inc. October 18 2017 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID