Edoxaban

Catalog No.S7280 Synonyms: DU-176b

Edoxaban Chemical Structure

Molecular Weight(MW): 738.27

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

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Biological Activity

Description Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Targets
Factor Xa [1]
(Cell-free assay)
0.561 nM(Ki)
In vitro

In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. [1]

In vivo Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. [1]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Venous stasis thrombosis model in rats and rabbits
  • Formulation: 0.5% methylcellulose
  • Dosages: 0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (135.45 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 738.27
Formula

C24H30ClN7O4S.C7H8O3S.H2O

CAS No. 1229194-11-9
Storage powder
in solvent
Synonyms DU-176b

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03524924 Recruiting Atrial Fibrillation University of Padova January 7 2018 --
NCT01802775 Completed Peripheral Arterial Disease Daiichi Sankyo Inc.|UMC Utrecht February 6 2013 Phase 2
NCT03489395 Recruiting Atrial Fibrillation Raffaele De Caterina|Hippocrates Research|G. d''Annunzio University January 30 2018 Phase 2
NCT02952599 Recruiting Venous Thromboembolism Daiichi Sankyo Inc. March 27 2017 --
NCT02866175 Recruiting Atrial Fibrillation Daiichi Sankyo Inc. February 24 2017 Phase 3
NCT02964949 Active not recruiting Atrial Fibrillation Daiichi Sankyo Inc.|Quintiles Inc. January 24 2017 Not Applicable

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Factor Xa Signaling Pathway Map

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