Name: Edoxaban
Brand: Selleck Chemicals
SKU: S4429
Rating: 5 (4 reviews)

Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.

Edoxaban Chemical Structure

CAS: 480449-70-5

Selleck's Edoxaban has been cited by 4 publications

Purity & Quality Control

Batch: S442901 DMSO] 10 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.78%

99.78

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Signaling Pathway

Factor Xa Signaling Pathway

Choose Selective Factor Xa Inhibitors

Biological Activity

Description

Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.

Targets

Factor Xa ^[1] (Cell-free assay)	Prothrombinase ^[1] (Cell-free assay)
0.561 nM(Ki)	2.98 nM(Ki)

In vitro
In vitro	The dual split protein (DSP) assay using Calu-3 cells is performed in the presence of various anticoagulants, including edoxaban.^[2]
Cell Research	Cell lines	Calu-3 cells
	Concentrations	--
	Incubation Time	--
	Method	For the DSP assay using Calu-3 or H3255 cells, target cells were seeded in 384-well plates (2 × 10⁴ cells/50 μL) one day before the assay. Two hours before the DSP assay, cells were treated with 6 μM EnduRen. One microliter of each protease inhibitor or anticoagulant dissolved in DMSO was added to the 384-well plates with 9 μL of culture medium. Next, 40 μL of single cell suspension (effector cells) was added to the wells using a Multidrop dispenser. (Data sourced from selleck products)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05339672	Recruiting	Drug-drug Interaction	Radboud University Medical Center\|Astellas Pharma Inc	July 1 2024	--
NCT06149533	Not yet recruiting	Thrombosis Venous\|Cancer\|Catheter Complications	Cancer Institute and Hospital Chinese Academy of Medical Sciences	November 30 2023	Phase 3
NCT05869591	Not yet recruiting	Liver Cirrhosis	Centre Hospitalier Universitaire Vaudois	October 2023	Phase 2
NCT05804747	Recruiting	Atrial Fibrillation	Daiichi Sankyo Inc.\|Daiichi Sankyo Korea Co. Ltd.	February 16 2023	--
NCT05122455	Recruiting	SCAD\|AMI	University of Sao Paulo\|Daiichi Sankyo Inc.	September 14 2021	Phase 2\|Phase 3

References

Chemical Information & Solubility

Molecular Weight	548.06	Formula	C₂₄H₃₀ClN₇O₄S
CAS No.	480449-70-5	SDF	--
Smiles	CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(Cl)C=C4)C(=O)N(C)C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 10 mg/mL ( (18.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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