Immunology & Inflammation related
- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S2286||Cyclosporin A||<1 mg/mL||100 mg/mL||100 mg/mL|
|S5004||Pimecrolimus||<1 mg/mL||100 mg/mL||100 mg/mL|
|S1211||Imiquimod||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S3032||Bindarit||<1 mg/mL||64 mg/mL||64 mg/mL|
|S1407||Bimatoprost||<1 mg/mL||36 mg/mL||83 mg/mL|
|S3982||Batyl alcohol||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S3906||Astragalus polyphenols||-1 mg/mL||81 mg/mL||-1 mg/mL|
|S3877||Lysionotin||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S3881||Scopoletin||-1 mg/mL||38 mg/mL||-1 mg/mL|
|S3778||Patchouli alcohol||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S3790||Methyl gallate||-1 mg/mL||36 mg/mL||-1 mg/mL|
|S3799||Gentisic acid||-1 mg/mL||30 mg/mL||-1 mg/mL|
|S3765||Picroside II||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S3892||Isopsoralen||-1 mg/mL||14 mg/mL||-1 mg/mL|
|S3774||Dehydroandrographolide Succinate Potasium Salt||-1 mg/mL||10 mg/mL||-1 mg/mL|
|S3775||Ligustrazine hydrochloride||-1 mg/mL||34 mg/mL||-1 mg/mL|
|S3758||Sinomenine hydrochloride||-1 mg/mL||73 mg/mL||-1 mg/mL|
|S3932||Astilbin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S3837||Echinocystic acid||-1 mg/mL||94 mg/mL||-1 mg/mL|
|S3827||Royal jelly acid||-1 mg/mL||37 mg/mL||-1 mg/mL|
|S3841||Eleutheroside B||-1 mg/mL||74 mg/mL||-1 mg/mL|
|S3956||Tetramethylpyrazine||-1 mg/mL||27 mg/mL||-1 mg/mL|
|S3614||Lupeol||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S3685||4-Biphenylacetic acid||<1 mg/mL||42 mg/mL||42 mg/mL|
|S3680||NLRP3 Inflammasome Inhibitor I||<1 mg/mL||73 mg/mL||<1 mg/mL|
|S3745||Balsalazide disodium||87 mg/mL||87 mg/mL||<1 mg/mL|
|S3648||Amlexanox||<1 mg/mL||59 mg/mL||1 mg/mL|
|S3726||Selexipag||<1 mg/mL||99 mg/mL||49 mg/mL|
|S3668||Thymopentin||100 mg/mL||100 mg/mL||<1 mg/mL|
|S3622||Diammonium Glycyrrhizinate||100 mg/mL||100 mg/mL||<1 mg/mL|
|S3608||Demethylzeylasteral (T-96)||<1 mg/mL||96 mg/mL||33 mg/mL|
|S4753||Ganoderic acid A||<1 mg/mL||100 mg/mL||100 mg/mL|
|S8522||Compstatin||100 mg/mL||-1 mg/mL||-1 mg/mL|
|S8141||Cl-amidine||70 mg/mL||84 mg/mL||84 mg/mL|
|S1439||Tranilast||<1 mg/mL||66 mg/mL||<1 mg/mL|
|S1737||Prednisolone||<1 mg/mL||72 mg/mL||10 mg/mL|
|S1622||Prednisone||<1 mg/mL||71 mg/mL||<1 mg/mL|
|S4169||Teriflunomide||<1 mg/mL||32 mg/mL||,1 mg/mL|
|S2413||Geniposidic acid||<1 mg/mL||16 mg/mL||2 mg/mL|
|S1508||Alprostadil||<1 mg/mL||71 mg/mL||71 mg/mL|
|S1733||Methylprednisolone||<1 mg/mL||75 mg/mL||2 mg/mL|
|S1939||Levamisole hydrochloride||48 mg/mL||<1 mg/mL||<1 mg/mL|
|S2787||Laquinimod||<1 mg/mL||61 mg/mL||1 mg/mL|
|S1681||Mesalamine||<1 mg/mL||31 mg/mL||31 mg/mL|
|S2910||Tempol||34 mg/mL||34 mg/mL||34 mg/mL|
|S1679||Flurbiprofen||<1 mg/mL||49 mg/mL||49 mg/mL|
|S1829||Pranlukast||<1 mg/mL||11 mg/mL||<1 mg/mL|
|S1514||Cyclosporine||<1 mg/mL||100 mg/mL||100 mg/mL|
|S1576||Sulfasalazine||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S1654||Phenylbutazone||<1 mg/mL||62 mg/mL||62 mg/mL|
|S2512||Tenoxicam||<1 mg/mL||68 mg/mL||<1 mg/mL|
|S3062||Diclofenac Potassium||10 mg/mL||69 mg/mL||<1 mg/mL|
|S7515||VGX-1027||<1 mg/mL||41 mg/mL||41 mg/mL|
|S4098||Halcinonide||<1 mg/mL||90 mg/mL||4 mg/mL|
|S1823||Fenoprofen Calcium||<1 mg/mL||105 mg/mL||10 mg/mL|
|S8301||AS101||<1 mg/mL||62 mg/mL||<1 mg/mL|
|S4268||Flufenamic acid||<1 mg/mL||56 mg/mL||56 mg/mL|
|S4529||Idramantone||33 mg/mL||33 mg/mL||33 mg/mL|
|S7211||PF-04418948||<1 mg/mL||81 mg/mL||<1 mg/mL|
|S4152||Ethamsylate||53 mg/mL||53 mg/mL||<1 mg/mL|
|S4165||Benzydamine HCl||69 mg/mL||69 mg/mL||69 mg/mL|
|S4170||Coumarin||<1 mg/mL||29 mg/mL||29 mg/mL|
|S7809||MCC950(CP-456773)||85 mg/mL||<1 mg/mL||40 mg/mL|
|S2400||Rheic Acid||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S4188||Sasapyrine||<1 mg/mL||52 mg/mL||52 mg/mL|
|S7448||CORM-3||<1 mg/mL||38 mg/mL||<1 mg/mL|
|S4682||Loxoprofen||<1 mg/mL||49 mg/mL||49 mg/mL|
|S8291||Atractylenolide I||<1 mg/mL||46 mg/mL||46 mg/mL|
|S7516||Y-320||<1 mg/mL||11 mg/mL||<1 mg/mL|
|S3027||Fenoprofen calcium hydrate||<1 mg/mL||48 mg/mL||18 mg/mL|
|S8097||C-DIM12||<1 mg/mL||71 mg/mL||71 mg/mL|
|S2350||Rutin||<1 mg/mL||100 mg/mL||2 mg/mL|
|S7434||TAPI-1||60 mg/mL||99 mg/mL||99 mg/mL|
|S4690||Escin||<1 mg/mL||66 mg/mL||<1 mg/mL|
- Immunology & Inflammation related Inhibitors (85)
- New Immunology & Inflammation related Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.
Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
Imiquimod is a novel synthetic agent with immune response modifying activity.
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.
5-Acetylsalicylic acid, also known as Mesalazine or Mesalamine, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease.
Batyl alcohol, isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.
Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.
Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.
Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.
Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.
4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine.
Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
Thymopentin has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.
Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Cells were cultured in LD collagen gels ± vehicle control (V), 100 M DFOM (D) or tranilast (T) for 24h (E-H) and assessed for P450 enzyme production.
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from
Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.
Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
(-)-Tetramisole is an inhibitor of alkaline phosphatase, used as an anthelmintic.
Laquinimod is a potent immunomodulator. Phase 3.
Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.
Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
VGX-1027 is an orally active immunomodulator. Phase 1.
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
Idramantone is an immune agonist.
PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.
Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.
CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.
C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).
2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.