Geniposidic acid

Catalog No.S2413

Geniposidic acid Chemical Structure

Molecular Weight(MW): 374.34

Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 90 In stock
USD 270 In stock
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Biological Activity

Description Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
In vivo Geniposidic acid shows a more remarkable inhibitory activity factor against implanted tumor growth when the doses of 500 mg/kg are given alone or combined with irradiation. [1] Geniposidic acid improves the plaque area, intima/media thickness ratio, and intimal foam cells number in rabbits. Geniposidic acid (100 μg/mL) results in relieving ECs shedding and improving aortic morphology disorders in rabbits. Geniposidic acid (100 μg/mL) performs significant inhibition on smooth muscle cells proliferation in rabbits. Geniposidic acid results in obvious inhibition on SMC migration from the upper chamber. [2] Geniposidic acid increases survival rate of rats with fulminant hepatic failure. Geniposidic acid attenuates the following effects: GalN/LPS increases serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreases hepatic glutathione content. Geniposidic acid augmentes increases in serum interleukin-6 level, heme oxygenase-1 and NF-E2-related factor 2 protein expression in rats with fulminant hepatic failure. Geniposidic acid decreases cleaved caspase-8 and caspase-3 protein expression and shows significantly fewer apoptotic cells in rats with fulminant hepatic failure. Geniposidic acid increases Bcl-xL protein expression and decreased Bax protein expression in rats with fulminant hepatic failure. Geniposidic acid treatment enhances phosphorylation of signal transducer and activator of transcription 3 in rats with fulminant hepatic failure. [3]

Protocol

Solubility (25°C)

In vitro DMSO 16 mg/mL (42.74 mM)
Ethanol 2 mg/mL (5.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 374.34
Formula

C16H22O10

CAS No. 27741-01-1
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID