Ganoderic acid A

Catalog No.S4753

Ganoderic acid A Chemical Structure

Molecular Weight(MW): 516.67

Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.

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Biological Activity

Description Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
In vitro

GAA exhibits antitumor activity on human osteosarcoma, lymphoma, meningioma and breast cancer cells through suppressing growth and invasive behavior and/or inducing apoptosis of cancer cells. GAA could also enhance chemosensitivity of HepG2 cells to Cisplatin[1]. GA-A treatment induces caspase-dependent apoptotic cell death characterized by a dose-dependent increase in active caspases 9 and 3, up-regulation of pro-apoptotic BIM and BAX proteins, and a subsequent loss of mitochondrial membrane potential with release of cytochrome c. Lower doses of GA-A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma in vitro[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Bel7402 cells NX;MOYpVS3m2b4TvfIlkcXS7IHHzd4F6 MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{NCCLQ{WwQVcvOjVizszN NXzZUXA6OjNyOUKzPFk>
P388 cells MlHwR5l1d3SxeHnjbZR6KGG|c3H5 MkHMR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgVFM5QCClZXzsd{whUUN3ME23MlI2KM7:TR?= NYTZeoxIOjNyOUKzPFk>
SGC7901 cells M4TEcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUPjSZVTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczygTWM2OD15LkK1JO69VQ>? MWSyN|A6OjN6OR?=
HepG2 cells MWPGeY5kfGmxbjDhd5NigQ>? NWK2[HAzPDhiaB?= MYLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1|OD63JO69VQ>? MmXtNlQ6PzR|NEm=

... Click to View More Cell Line Experimental Data

In vivo GAA can significantly prolong the survival of EL4 syngeneic mice and decrease tumor metastasis to the liver, and enhance cell-mediated immune responses by attenuating myeloid-derived suppressor cells. GAA could undergo extensive metabolism, including reduction, oxidation, and hydroxylation phase I metabolism, and glucuronidation and sulfation phase II metabolism[1].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: Human pre-B acute lymphocytic leukemia (NALM-6), Burkitt lymphoma (Ramos, GA-10, CA-46 and Daudi) and non-Hodgkin's lymphoma (Toledo and DB) cell lines
  • Concentrations: 5, 10, 20, and 40μM
  • Incubation Time: 24 h
  • Method:

    Cells are seeded at 1×10<sup>4</sup> cells/well in 100μl of appropriate culture medium in a flat-bottom 96-well plate. GA-A is added to appropriate wells for final concentrations of 5, 10, 20, and 40μM. Following 24h of GA-A treatment, cell viability is measured using the CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS).


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Male Sprague-Dawley rats
  • Formulation: Dissolved in physiological saline containing 2% sodium carbonate and diluted with physiological saline
  • Dosages: 20 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (193.54 mM)
Ethanol 100 mg/mL warmed (193.54 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 516.67
Formula

C30H44O7

CAS No. 81907-62-2
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID