Catalog No.S4682 Synonyms: Koloxo, Loxoprofene, Loxoprofeno
Molecular Weight(MW): 246.30
Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
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|Description||Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.|
Loxoprofen sodium(LOX) does not affect the proliferation and viability of LLC cells in vitro. HUVECs treated with LOX results in the inhibition of the tubular formation. Treatment with 50 mg/ml LOX reveals a 33% decline in in vitro angiogenesis, compared with vehicle-treated HUVECs. This inhibition is presumably due to inhibition of VEGF activity.
|In vivo||Loxoprofen sodium (LOX), inhibits in vivo growth of implanted Lewis lung carcinoma (LLC). Intratumoral vessel density in LOX-treated mice is significantly lower than that of mice without treatment. Intratumoral expressions of vascular endothelial growth factor (VEGF) mRNA are attenuated by the LOX treatment. LOX suppresses both intratumoral and systemic VEGF protein in LLC-implanted mice. LOX also inhibits tubular formation of primary cultured human umbilical vein endothelial cells, presumably due to the inhibition of VEGF. In patients with advanced non-small cell lung cancer, LOX medication (120 mg/day) for a week significantly decreases the plasma VEGF level.|
|In vitro||DMSO||49 mg/mL (198.94 mM)|
|Ethanol||49 mg/mL (198.94 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Koloxo, Loxoprofene, Loxoprofeno|
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