Imiquimod Chemical Structure

Imiquimod Chemical Structure
Molecular Weight: 240.3

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Imiquimod is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Imiquimod(Aldara) is a novel synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod’s proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. [1,2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from, updated on 2016-05-29)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02301494 Not yet recruiting Mycosis Fungoides Rochester General Hospital|Valeant Pharmaceuticals Intern  ...more Rochester General Hospital|Valeant Pharmaceuticals International, Inc.|Rochester Skin Lymphoma Medical Group, PLLC June 2017 --
NCT02669459 Not yet recruiting Cervical Intraepithelial Neoplasia Erasmus Medical Center|Maastricht University Medical Cent  ...more Erasmus Medical Center|Maastricht University Medical Center|meander medisch centrum Amersfoort|Albert Schweitzer Hospital|Sint Franciscus Gasthuis|Catharina Ziekenhuis Eindhoven March 2016 Phase 3
NCT02242929 Recruiting Nodular Basal Cell Carcinoma Maastricht University Medical Center January 2016 Phase 3
NCT02621112 Recruiting Renal Failure The University of Hong Kong January 2016 Phase 2|Phase 3
NCT02059499 Recruiting Anal Intraepithelial Neoplasia|High-grade Squamous Intraepithelial Lesion|HIV Infection AIDS Malignancy Consortium|National Cancer Institute (NCI  ...more AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation|University of Arkansas September 2015 Phase 3

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Chemical Information

Download Imiquimod SDF
Molecular Weight (MW) 240.3


CAS No. 99011-02-6
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms R-837, S-26308
Solubility (25°C) * In vitro DMSO 0.01 mg/mL (0.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

Tech Support

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