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Sasapyrine Immunology & Inflammation related chemical

Name: Sasapyrine
Brand: Selleck Chemicals
SKU: S4188
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4188

Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.

Chemical Structure

Molecular Weight: 258.23

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Quality Control

Batch: S418801 DMSO]52 mg/mL]false]Ethanol]52 mg/mL]false]Water]Insoluble]false Purity: 99.2%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.2

Related Targets	PD-1/PD-L1 CXCR STING AhR CD markers Interleukins Anti-infection Antioxidant COX Histamine Receptor
Other Immunology & Inflammation related Inhibitors	Cl-amidine Bestatin (Ubenimex) Bindarit (AF 2838) Tranilast Tempol Sinomenine GI254023X (GI4023) ATP Geniposidic acid CORM-3

Solubility

In vitro
Batch:

DMSO : 52 mg/mL (201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 52 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	258.23	Formula	C₁₄H₁₀O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	552-94-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC-49171,Salsalate			Smiles	C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/21762100/ [2] https://pubmed.ncbi.nlm.nih.gov/22074422/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03482440	Unknown status	Preeclampsia	University of Iowa\|Penn State University	August 26 2018	Early Phase 1
NCT03277573	Unknown status	Alzheimer Disease	Adam Boxer\|University of California San Francisco	July 21 2017	Phase 1
NCT01977417	Terminated	Prediabetes\|Obese	Gary L. Pierce\|University of Iowa	November 2012	Phase 2
NCT01489319	Terminated	Polycystic Ovary Syndrome	Indiana University	February 2012	Phase 1
NCT01182727	Completed	Schizophrenia\|Insulin Resistance	University of Maryland Baltimore\|US Department of Veterans Affairs	August 2010	Not Applicable

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Handling Instructions

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