Home Immunology & Inflammation Immunology & Inflammation related chemical - NF-κB modulator - HIF modulator - ROS modulator N-Acetylcysteine amide For research use only.

N-Acetylcysteine amide

N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.

N-Acetylcysteine amide Chemical Structure

N-Acetylcysteine amide Chemical Structure

CAS: 38520-57-9

Selleck's N-Acetylcysteine amide has been cited by 8 publications

Purity & Quality Control

Batch: Purity: 99.28%
99.28

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Biological Activity

Description N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
Targets
NF-κB [1] HIF-1α [1] ROS [1]
In vitro
In vitro

The antioxidant N-acetylcysteine (NAC) blocks erastin-induced or RSL3-induced cell death in Nupr1-/- mPDAC cells, an effect that is associated with decreased production or release of MDA, 8-OHdG, or HMGB1. NUPR1-knockdown PANC1 cells exhibits increased MDA, 8-OHdG, and HMGB1 release during ferroptotic cell death, which can be reversed by the addition of NAC.[2]
Cell Research Cell lines mPDAC cells
Concentrations 1 mM
Incubation Time 24 h
Method

Indicated mPDAC cells are treated with erastin (10 μM) or RSL3 (1 μM) in the absence or presence of DFO (100 M) or N-acetylcysteine (1 mM) for 24 h, and then intracellular MDA, intracellular 8-OHdG, extracellular HMGB1, and cell viability are assayed by a CCK8 kit.
In Vivo
In vivo

Combined n-acetylcysteine (NAC) and bone marrow-derived mesenchymal stem cells (BMSCs) therapy alleviates oxidative stress damage to the pancreas and inhibits the inflammatory response to a significantly greater extent than single therapy with either BMSCs or NAC.[3]

Chemical Information & Solubility

Molecular Weight 162.21 Formula

C5H10N2O2S
CAS No. 38520-57-9 SDF --
Smiles CC(=O)NC(CS)C(=O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 32 mg/mL ( (197.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : 16 mg/mL


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In vivo
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