Catalog No.S4709 Synonyms: Xalatan, PhXA41, PHXA-41

Latanoprost Chemical Structure

Molecular Weight(MW): 432.59

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

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Description Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
retinoid X receptor α [2]
PGF-prostanoid receptor [3]
In vitro

Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].

In vivo Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].


Cell Research:[1]
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  • Cell lines: Human corneal stromal (HCS) cells
  • Concentrations: from 50 mg/l to 0.78125 mg/l
  • Incubation Time: 4, 8, 12 h
  • Method: HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: db/db or ob/ob mice
  • Formulation: 0.5% Tween 80
  • Dosages: 10 or 40 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 432.59


CAS No. 130209-82-4
Storage powder
in solvent
Synonyms Xalatan, PhXA41, PHXA-41

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03331770 Completed Primary Open-angle Glaucoma Laboratorios Poen January 6 2017 Phase 4
NCT02623738 Completed Primary Open Angle Glaucoma|Ocular Hypertension Santen Pharmaceutical Co. Ltd. December 6 2015 Phase 2|Phase 3
NCT03284853 Recruiting Open Angle Glaucoma|Ocular Hypertension Aerie Pharmaceuticals September 5 2017 Phase 3
NCT03067415 Recruiting Glaucoma Primary Open Angle|Ocular Hypertension Chong Kun Dang Pharmaceutical March 30 2017 Phase 2
NCT02622334 Completed Glaucoma Hoffmann-La Roche December 29 2015 Phase 1
NCT03419975 Recruiting Primary Open-angle Glaucoma|Ocular Hypertension Taejoon Pharmaceutical Co. Ltd. April 26 2016 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID