Pidotimod Chemical Structure

Pidotimod Chemical Structure
Molecular Weight: 244.27

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Pidotimod is an immunostimulant.
In vitro Pidotimod is a synthetic dipeptide molecule with biological and immunological activity on both the adaptive and the innate immune responses. In vitro studies, both from animal and human specimens, have documented a good activity on innate and adaptive immune responses and have been confirmed by in vivo studies. These activities have been applied in clinical studies demonstrating the efficacy of pidotimod in reducing the rate of recurrent infections of the upper respiratory and urinary tracts in children. The same results are obtained in recurrent respiratory tract infections in adults.
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Clemente E, et al. Arzneimittelforschung, 1994, 44(12A), 1490-1494.

[2] Riboldi P, et al. Int J Immunopathol Pharmacol, 2009, 22(2), 255-262.

Chemical Information

Download Pidotimod SDF
Molecular Weight (MW) 244.27
Formula

C9H12N2O4S

CAS No. 121808-62-6
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 49 mg/mL (200.59 mM)
Water 10 mg/mL (40.93 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (R)-3-((S)-2-oxopyrrolidine-5-carbonyl)thiazolidine-4-carboxylic acid

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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