VGX-1027

Catalog No.S7515 Synonyms: GIT 27

VGX-1027 Chemical Structure

Molecular Weight(MW): 205.21

VGX-1027 is an orally active immunomodulator. Phase 1.

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Biological Activity

Description VGX-1027 is an orally active immunomodulator. Phase 1.
In vitro

VGX-1027 significantly inhibits both IL-1β/IFN-γ-induced TNF-α and nitrite accumulation, and causes a significant increase in cell survival by interfering with the cytotoxic effects of the cytokines. [1] VGX-1027 inhibits both proliferation of enterobacterial antigen-reactive CD4+CD25− T cells in vitro. [2]

In vivo VGX-1027 prevents development of spontaneous type 1 diabetes in NOD Mice and counteracts accelerated diabetogenesis induced by cyclophosphamide challenge or adoptive transfer of diabetogenic spleen cells in NOD Mice. VGX-1027 also reduces clinical signs of MLD-STZ-induced diabetes and suppresses pathohistological changes of pancreas. [1] VGX-1027 suppresses the development of clinical, histological and immunological signs of DNBS-induced colitis in CD1 mice. [2] In NZB/NZW F1 model of systemic lupus erythematosus (SLE), VGX-1027 ameliorates the course of the disease with higher percent survival and improved clinical and histopathological signs. [3]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: NOD Mice with MLD-STZ-induced diabetes.
  • Formulation: 500 mM Na2HPO4
  • Dosages: 20 mg/kg b.wt. i.p. and 100 mg/kg b.wt. p.o.
  • Administration: i.p. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (199.79 mM)
Ethanol 41 mg/mL (199.79 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 205.21
Formula

C11H11NO3

CAS No. 6501-72-0
Storage powder
Synonyms GIT 27

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00760396 Completed Healthy VGX Pharmaceuticals, LLC|GeneOne Life Science, Inc. September 2008 Phase 1
NCT00627120 Completed Healthy VGX Pharmaceuticals, LLC|GeneOne Life Science, Inc. February 2008 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID