Catalog No.S7515 Synonyms: GIT 27
Molecular Weight(MW): 205.21
VGX-1027 is an orally active immunomodulator. Phase 1.
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|Description||VGX-1027 is an orally active immunomodulator. Phase 1.|
VGX-1027 significantly inhibits both IL-1β/IFN-γ-induced TNF-α and nitrite accumulation, and causes a significant increase in cell survival by interfering with the cytotoxic effects of the cytokines.  VGX-1027 inhibits both proliferation of enterobacterial antigen-reactive CD4+CD25− T cells in vitro. 
|In vivo||VGX-1027 prevents development of spontaneous type 1 diabetes in NOD Mice and counteracts accelerated diabetogenesis induced by cyclophosphamide challenge or adoptive transfer of diabetogenic spleen cells in NOD Mice. VGX-1027 also reduces clinical signs of MLD-STZ-induced diabetes and suppresses pathohistological changes of pancreas.  VGX-1027 suppresses the development of clinical, histological and immunological signs of DNBS-induced colitis in CD1 mice.  In NZB/NZW F1 model of systemic lupus erythematosus (SLE), VGX-1027 ameliorates the course of the disease with higher percent survival and improved clinical and histopathological signs. |
|In vitro||DMSO||41 mg/mL (199.79 mM)|
|Ethanol||41 mg/mL (199.79 mM)|
|In vivo||Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00760396||Completed||Healthy||VGX Pharmaceuticals, LLC|GeneOne Life Science, Inc.||September 2008||Phase 1|
|NCT00627120||Completed||Healthy||VGX Pharmaceuticals, LLC|GeneOne Life Science, Inc.||February 2008||Phase 1|
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