Methylprednisolone
Licensed by Pfizer Catalog No.S1733 Synonyms: NSC-19987
Molecular Weight(MW): 374.47
Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.
Cited by 1 Publication
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Biological Activity
| Description | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. | ||||||||||||||||
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| In vitro |
Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages. [1] |
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| Cell Data |
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| In vivo | Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. [2] Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. [3] Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes. [4] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 75 mg/mL (200.28 mM) |
|---|---|---|
| Ethanol | 2 mg/mL (5.34 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 374.47 |
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| Formula | C22H30O5 |
| CAS No. | 83-43-2 |
| Storage | powder |
| Synonyms | NSC-19987 |
Bio Calculators
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02960555 | Recruiting | Myeloma | M.D. Anderson Cancer Center|Sanofi | February 8, 2017 | Phase 2 |
| NCT02798523 | Recruiting | Normal Physiology | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | June 7, 2016 | Phase 1 |
| NCT01875237 | Active, not recruiting | Leukemia|Myeloma|Myeloproliferative Diseases | M.D. Anderson Cancer Center|Bellicum Pharmaceuticals | December 27, 2013 | Phase 1|Phase 2 |
| NCT01331018 | Recruiting | Fanconi Anemia | Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) | February 22, 2012 | Phase 1 |
| NCT02867904 | Not yet recruiting | Arthroscopic Shoulder Surgery|Intra-articular Debridement|Subacromial Decompression|Acromioplasty|Acromioclavicular Joint Resection | Peter Chang|University of South Dakota | August 2017 | Phase 4 |
| NCT03007147 | Not yet recruiting | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia | Childrens Oncology Group|National Cancer Institute (NCI) | July 2017 | Phase 3 |
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