Licensed by Pfizer Catalog No.S1733 Synonyms: NSC-19987

Methylprednisolone Chemical Structure

Molecular Weight(MW): 374.47

Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.

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In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.

    Trop J Pharm Res, 2014, 13 (1): 53-59.. Methylprednisolone purchased from Selleck.

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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.
Glucocorticoid receptor [1]
In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells NEfEb29HfW6ldHnvckBie3OjeR?= NXvk[pY3OjRiaB?= MXvBZ5RqfmG2aX;uJI9nKHKjdDDQXHIh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[mG|ZXSgcJVucW6nc3PlcpQh[W6jbInzbZMtKEWFNUC9OEDPxE1? NVuzdVY{OjB7Nk[wOFM>

... Click to View More Cell Line Experimental Data

In vivo Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. [2] Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. [3] Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes. [4]


Solubility (25°C)

In vitro DMSO 75 mg/mL (200.28 mM)
Ethanol 2 mg/mL (5.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 374.47


CAS No. 83-43-2
Storage powder
in solvent
Synonyms NSC-19987

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02960555 Recruiting Myeloma M.D. Anderson Cancer Center|Sanofi February 8, 2017 Phase 2
NCT02798523 Recruiting Normal Physiology National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) June 7, 2016 Phase 1
NCT01875237 Active, not recruiting Leukemia|Myeloma|Myeloproliferative Diseases M.D. Anderson Cancer Center|Bellicum Pharmaceuticals December 27, 2013 Phase 1|Phase 2
NCT01331018 Recruiting Fanconi Anemia Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) February 22, 2012 Phase 1
NCT02867904 Not yet recruiting Arthroscopic Shoulder Surgery|Intra-articular Debridement|Subacromial Decompression|Acromioplasty|Acromioclavicular Joint Resection Peter Chang|University of South Dakota August 2017 Phase 4
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID