Catalog No.S1681 Synonyms: 5-Aminosalicylic acid

Mesalamine Chemical Structure

Molecular Weight(MW): 153.14

Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

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In DMSO USD 130 In stock
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Biological Activity

Description Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
IKK [1]
In vitro

Mesalamine inhibits the enzyme 3-hydroxysteroid dehydrogenase, involved in the reversible conversion between DHP and THP, and therefore may affect the local actions of DHP and THP in the brain. Mesalamine, an anti-inflammatory aminosalicylate, dose-dependently inhibits IL-1-stimulated NF-kappaB-dependent transcription without preventing IkappaB degradation or nuclear translocation and DNA binding of the transcriptionally active NF-kappaB proteins, RelA, c-Rel, or RelB. Mesalamine is found to inhibit IL-1-stimulated RelA phosphorylation. [1] Mesalamine increases cell adhesion which is measured by cell adhesion assay and transcellular-resistance measurement. Mesalamine treatment restores membranous expression of adhesion molecules E-cadherin and β-catenin. [2] Mesalamine or sulfasalazine (2 mM), but not sulfapyridine, significantly reduces the expression of the TC22 transcript and significantly reduces the expression of TC22 protein in a dose-dependent and reversible manner. [3] Mesalamine induces membranous expression of E-cadherin and increases intercellular adhesion. Mesalamine activity modulates E-cadherin glycosylation and increases both mRNA and protein levels of GnT-III and its activity as detected by increased E4-lectin reactivity. [4] Mesalamine (0.1-1 mM) shows considerable inhibition of peroxynitrite-mediated luminol chemiluminescence in a dose-dependent fashion, suggesting that Mesalamine is able to directly scavenge the peroxynitrite. Mesalamine only at higher concentration (1 mM) inhibits the hydroxyl radical adduct while shifting Electron paramagnetic resonance (EPR) spectra. [5]


Solubility (25°C)

In vitro DMSO 31 mg/mL (202.42 mM)
Ethanol 31 mg/mL (202.42 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 153.14


CAS No. 89-57-6
Storage powder
in solvent
Synonyms 5-Aminosalicylic acid

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00514982 Withdrawn Hermanski-Pudlak Syndrome|Colitis|Cytokines|Lymphocytes|Drug Evaluation National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) August 7 2007 Phase 2
NCT03415711 Recruiting Ulcerative Colitis VSL Pharmaceuticals|Actial Farmaceutica S.r.l. April 28 2017 Not Applicable
NCT03070574 Recruiting Colorectal Cancer Christoph Gasche|Prof. Dr. Gabriela Möslein Germany|Prof. Dr. Hans Vasen The Netherlands|Prof. Dr. med. Jan Lubinski Poland|Prof. Dr. med. Yaron Niv Israel|Univ. Prof. Dr. Judith Karner-Hanusch Austria|Ann-Sofie Backman MD PhD Sweden|Medical University of Vienna September 2017 Phase 2
NCT02910245 Recruiting Colitis Ulcerative Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|ZonMw: The Netherlands Organisation for Health Research and Development November 2016 Phase 3
NCT02522780 Active not recruiting Ulcerative Colitis Ferring Pharmaceuticals February 2016 Phase 3
NCT02683733 Unknown status Ulcerative Colitis Asian Institute of Gastroenterology India February 2016 Phase 3

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IκB/IKK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID