Diclofenac Potassium

Catalog No.S3062 Synonyms: CGP-45840B

Diclofenac Potassium Chemical Structure

Molecular Weight(MW): 334.24

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
In vitro

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Protocol

Solubility (25°C)

In vitro DMSO 69 mg/mL (206.43 mM)
Water 10 mg/mL (29.91 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 334.24
Formula

C14H10Cl2KNO2

CAS No. 15307-81-0
Storage powder
Synonyms CGP-45840B

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02985671 Not yet recruiting Postural Low Back Pain|Mechanical Low Back Pain Ache Laboratorios Farmaceuticos S.A. June 2017 Phase 3
NCT03020368 Recruiting Rhizarthrosis Charite University, Berlin, Germany January 2017 --
NCT02952898 Recruiting Actinic Keratosis Gage Development Company, LLC October 2016 Phase 3
NCT02918812 Recruiting Female Infertility of Tubal Origin Bayer University Kano, Nigeria September 2016 Phase 4
NCT02714699 Not yet recruiting Endoscopy Assiut University September 2016 Phase 2|Phase 3
NCT02837770 Completed Pain University Hospital of Patras July 2016 --

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