Catalog No.S3062 Synonyms: CGP-45840B
Molecular Weight(MW): 334.24
Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
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|Description||Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.|
The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
|In vitro||DMSO||69 mg/mL (206.43 mM)|
|Water||10 mg/mL (29.91 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02985671||Not yet recruiting||Postural Low Back Pain|Mechanical Low Back Pain||Ache Laboratorios Farmaceuticos S.A.||June 2017||Phase 3|
|NCT03020368||Recruiting||Rhizarthrosis||Charite University, Berlin, Germany||January 2017||--|
|NCT02952898||Recruiting||Actinic Keratosis||Gage Development Company, LLC||October 2016||Phase 3|
|NCT02918812||Recruiting||Female Infertility of Tubal Origin||Bayer University Kano, Nigeria||September 2016||Phase 4|
|NCT02714699||Not yet recruiting||Endoscopy||Assiut University||September 2016||Phase 2|Phase 3|
|NCT02837770||Completed||Pain||University Hospital of Patras||July 2016||--|
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