Tempol

Catalog No.S2910 Synonyms: 4-Hydroxy-TEMPO

Tempol Chemical Structure

Molecular Weight(MW): 172.24

Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.

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In DMSO USD 50 In stock
USD 40 In stock
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Biological Activity

Description Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In vitro

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]

In vivo Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: HL60
  • Concentrations: 0.05–1.6 mM
  • Incubation Time: 96 h
  • Method: The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Male Wistar rats
  • Formulation: Saline
  • Dosages: 30 mg/kg
  • Administration: bolus injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 34 mg/mL (197.39 mM)
Water 34 mg/mL (197.39 mM)
Ethanol 34 mg/mL (197.39 mM)
In vivo Add solvents individually and in order:
Saline
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 172.24
Formula

C9H18NO2

CAS No. 2226-96-2
Storage powder
Synonyms 4-Hydroxy-TEMPO

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00801086 Unknown status Alopecia Mitos Pharmaceuticals November 2008 Phase 2
NCT01324141 Terminated Anal Cancer National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 18, 2011 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID