Catalog No.S2910 Synonyms: 4-Hydroxy-TEMPO
Molecular Weight(MW): 172.24
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
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|Description||Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.|
Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage.  Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. 
|In vivo||Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat.  Tempol prevents cerebral vessel remodeling in hypertensive rats.  Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats.  Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. |
-  Mitchell JB, et al. Arch Biochem Biophys, 1991, 289(1), 62-70.
-  Gariboldi MB, et al. Free Radic Biol Med, 2000, 29(7), 633-641.
-  Chatterjee PK, et al. Kidney Int, 2000, 58(2), 658-673.
|In vitro||DMSO||34 mg/mL (197.39 mM)|
|Water||34 mg/mL (197.39 mM)|
|Ethanol||34 mg/mL (197.39 mM)|
|In vivo||Add solvents to the product individually and in order:
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00801086||Unknown status||Alopecia||Mitos Pharmaceuticals||November 2008||Phase 2|
|NCT01324141||Terminated||Anal Cancer||National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)||March 18, 2011||Phase 1|
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