Catalog No.S1737

Prednisolone  Chemical Structure

Molecular Weight(MW): 360.44

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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2 Customer Reviews

  • Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from
    0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.

    PLoS One, 2014, 9(12):e111840.. Prednisolone purchased from Selleck.

    Inhibition of proliferation of CMV-specifi CD8+ T cells by everolimus. Isolated CD8+ T cells were labeled with CFSE and stimulated with CMVpp65 peptide in a MLPC in the presence of increasing doses of everolimus. After 6 days T cells were stained for CD8 expression and specifi city for the HLA-A2 restricted epitope pp65 (495-503) . The numbers show percentages of (B) tetramer-positive cells of total CD8+ T cells using fl ow cytometry. One representative histogram/dot blot out of six experiments is shown.

    Leuk Lymphoma, 2014, 55(5):1144-50. . Prednisolone purchased from Selleck.

Purity & Quality Control

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Glucocorticoid receptor [1]
In vitro

Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. [1] Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. [2] Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. [3]

In vivo Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. [4] Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. [5]


Solubility (25°C)

In vitro DMSO 72 mg/mL (199.75 mM)
Ethanol 10 mg/mL (27.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.44


CAS No. 50-24-8
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03407144 Recruiting Hodgkin Lymphoma Merck Sharp & Dohme Corp. April 9 2018 Phase 2
NCT01283009 Completed Community Acquired Respiratory Disease Syndrome VA Office of Research and Development January 9 2012 Phase 3
NCT01471340 Completed Asthma Merck Sharp & Dohme Corp. January 9 2012 Phase 4
NCT01260623 Completed Asthma Exacerbation Lawson Health Research Institute September 9 2009 --
NCT03324503 Recruiting Sarcoidosis Pulmonary Celgene December 8 2017 Not Applicable
NCT03342638 Recruiting Multiple Sclerosis Relapsing-Remitting Northwestern University November 8 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID