Name: Flurbiprofen
Brand: Selleck Chemicals
SKU: S1679
Rating: 5 (1 reviews)

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

Flurbiprofen Chemical Structure

CAS: 5104-49-4

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description	Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

In vitro
In vitro	Flurbiprofen effectively inhibits the growth of various tumor cells in a dose-dependent manner and causes a noticeable change in the progression of cells through cell cycle stages in tumor cell lines derived from medulloblastoma and glioblastoma multiforme. Flurbiprofen reduces the number of cells in G1 and G2, and significantly increases their numbers in S phase, suggesting that, Flurbiprofen accelerates G1/S entry, and/or delays cell exit from S to G2/M stages. Flurbiprofen causes a minor change in the RNA level of different cyclins, there is a significant decrease in the level of cyclin B protein upon flurbiprofen treatment. ^[1]

In Vivo
In vivo	Flurbiprofen affords significant neuroprotection from ischemic injury as evidenced by reduction in cerebral infarct volume and neurobehavioral deficit. Flurbiprofen significantly reduces an early calcium dependent rise in levels of nitrite and MDA in ischemic brain regions of rats. Flurbiprofen also reduces the proteolytic products (SBDPs) caused by ischemic activation of calcium dependent protease calpain. ^[2] Flurbiprofen (5 mg/kg and 10mg/kg) significantly attenuates brain ischemia/reperfusion injury in rats, as shown by a reduction in the infarct volume, neurological deficit scores and cell apoptosis. Flurbiprofen not only inhibits the expression of Bax protein and p-GSK-3β, but also increases the expression of Bcl-2 protein, the ratio of Bcl-2/Bax as well as the P-Akt level in rats. ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05901389	Not yet recruiting	Lidocaine\|Analgesia\|Pain Postoperative\|Thoracic Surgery	Qilu Hospital of Shandong University	June 2023	Not Applicable
NCT05622656	Recruiting	Pain Postoperative	First People''s Hospital of Chenzhou	December 1 2022	Phase 4
NCT05368831	Not yet recruiting	Healthy Volunteers	NorthSea Therapeutics B.V.	July 2022	Phase 1
NCT04805775	Completed	Desflurane\|Propofol\|Postoperative Sleep\|PSQI\|Breast Tumor	Zhongnan Hospital	October 21 2021	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	244.26	Formula	C₁₅H₁₃FO₂
CAS No.	5104-49-4	SDF	Download Flurbiprofen SDF
Smiles	CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 48 mg/mL ( (196.51 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 48 mg/mL

Water : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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