Catalog No.S1679

Flurbiprofen  Chemical Structure

Molecular Weight(MW): 244.26

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
In vitro

Flurbiprofen effectively inhibits the growth of various tumor cells in a dose-dependent manner and causes a noticeable change in the progression of cells through cell cycle stages in tumor cell lines derived from medulloblastoma and glioblastoma multiforme. Flurbiprofen reduces the number of cells in G1 and G2, and significantly increases their numbers in S phase, suggesting that, Flurbiprofen accelerates G1/S entry, and/or delays cell exit from S to G2/M stages. Flurbiprofen causes a minor change in the RNA level of different cyclins, there is a significant decrease in the level of cyclin B protein upon flurbiprofen treatment. [1]

In vivo Flurbiprofen affords significant neuroprotection from ischemic injury as evidenced by reduction in cerebral infarct volume and neurobehavioral deficit. Flurbiprofen significantly reduces an early calcium dependent rise in levels of nitrite and MDA in ischemic brain regions of rats. Flurbiprofen also reduces the proteolytic products (SBDPs) caused by ischemic activation of calcium dependent protease calpain. [2] Flurbiprofen (5 mg/kg and 10mg/kg) significantly attenuates brain ischemia/reperfusion injury in rats, as shown by a reduction in the infarct volume, neurological deficit scores and cell apoptosis. Flurbiprofen not only inhibits the expression of Bax protein and p-GSK-3β, but also increases the expression of Bcl-2 protein, the ratio of Bcl-2/Bax as well as the P-Akt level in rats. [3]


Solubility (25°C)

In vitro DMSO 49 mg/mL (200.6 mM)
Ethanol 49 mg/mL (200.6 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.26


CAS No. 5104-49-4
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03562611 Recruiting Surgery|Anesthesia|Pain Sun Yat-sen University June 8 2018 Not Applicable
NCT00964106 Completed Drug Interactions GlaxoSmithKline August 26 2009 Phase 1
NCT03090009 Not yet recruiting Peri-implant Mucositis Polak David|Hadassah Medical Organization April 2017 Early Phase 1
NCT03165929 Completed Surgery Oral Gazi University May 2016 Early Phase 1
NCT02762123 Completed Rheumatoid Arthritis Bristol-Myers Squibb May 2016 Phase 1
NCT02674737 Unknown status Postoperative SedationGastrectomy Enhanced Recovery After Surgery Chinese Medical Association January 2016 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID