Catalog No.S4165 Synonyms: AF864
Molecular Weight(MW): 345.87
Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
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|Description||Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.|
Benzydamine is structurally unrelated to the corticosteroids. The action of benzydamine may be mediated by the prostaglandin system. The drug may affect formation of thromboxanes and alter biosynthesis of prostaglandin, in doses that can be reached by topical application. Benzydamine displays a stabilizing effect on cell membranes, inhibits degranulation of human polymorphonuclear leukocytes, and inhibits platelet aggregation. Benzydamine may affect aspects of tissue biochemistry relevant to local mechanisms of inflammation and pain. 
|In vivo||Benzydamine significantly lower the incidence of postoperative sore throat (POST). At 6 hours after extubation, the incidence of POST is 17.0%. Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST. |
|In vitro||DMSO||69 mg/mL (199.49 mM)|
|Water||69 mg/mL (199.49 mM)|
|Ethanol||69 mg/mL (199.49 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02720783||Completed||Healthy Women||Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A.||March 4, 2016||Phase 1|
|NCT02713893||Recruiting||Healthy||Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A.||September 2015||Phase 1|
|NCT01637883||Unknown status||For Intervention||Prince of Songkla University||January 2011||Phase 3|
|NCT00814359||Completed||Head and Neck Cancer|Mucositis||Juravinski Cancer Centre Foundation||May 2009||Phase 3|
|NCT00051441||Completed||Stomatitis|Radiation Effects||McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.|Angelini||null||Phase 3|
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