Home Immunology & Inflammation Immunology & Inflammation related chemical Benzydamine HCl

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Benzydamine HCl Immunology & Inflammation related chemical

Cat.No.S4165

Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
Benzydamine HCl Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 345.87

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S416501 DMSO]69 mg/mL]false]Water]69 mg/mL]false]Ethanol]69 mg/mL]false Purity: 99.46%
99.46

Chemical Information, Storage & Stability

Molecular Weight 345.87 Formula

C19H23N3O.HCl

 Storage (From the date of receipt)
CAS No. 132-69-4 Download SDF Storage of Stock Solutions

Synonyms AF864 Smiles CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3.Cl

Solubility

In vitro
Batch:

DMSO : 69 mg/mL (199.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 69 mg/mL

Ethanol : 69 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Benzydamine is structurally unrelated to the corticosteroids. The action of benzydamine may be mediated by the prostaglandin system. The drug may affect formation of thromboxanes and alter biosynthesis of prostaglandin, in doses that can be reached by topical application. Benzydamine displays a stabilizing effect on cell membranes, inhibits degranulation of human polymorphonuclear leukocytes, and inhibits platelet aggregation. Benzydamine may affect aspects of tissue biochemistry relevant to local mechanisms of inflammation and pain. [1]
In vivo
Benzydamine significantly lower the incidence of postoperative sore throat (POST). At 6 hours after extubation, the incidence of POST is 17.0%. Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST. [2]
References

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