Benzydamine HCl

Catalog No.S4165 Synonyms: AF864

Benzydamine HCl Chemical Structure

Molecular Weight(MW): 345.87

Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.

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Biological Activity

Description Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
In vitro

Benzydamine is structurally unrelated to the corticosteroids. The action of benzydamine may be mediated by the prostaglandin system. The drug may affect formation of thromboxanes and alter biosynthesis of prostaglandin, in doses that can be reached by topical application. Benzydamine displays a stabilizing effect on cell membranes, inhibits degranulation of human polymorphonuclear leukocytes, and inhibits platelet aggregation. Benzydamine may affect aspects of tissue biochemistry relevant to local mechanisms of inflammation and pain. [1]

In vivo Benzydamine significantly lower the incidence of postoperative sore throat (POST). At 6 hours after extubation, the incidence of POST is 17.0%. Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST. [2]

Protocol

Solubility (25°C)

In vitro DMSO 69 mg/mL (199.49 mM)
Water 69 mg/mL (199.49 mM)
Ethanol 69 mg/mL (199.49 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 345.87
Formula

C19H23N3O.HCl

CAS No. 132-69-4
Storage powder
Synonyms AF864

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02720783 Completed Healthy Women Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. March 4, 2016 Phase 1
NCT02713893 Recruiting Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. September 2015 Phase 1
NCT01637883 Unknown status For Intervention Prince of Songkla University January 2011 Phase 3
NCT00814359 Completed Head and Neck Cancer|Mucositis Juravinski Cancer Centre Foundation May 2009 Phase 3
NCT00051441 Completed Stomatitis|Radiation Effects McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.|Angelini null Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID