Prednisone

Catalog No.S1622

Prednisone  Chemical Structure

Molecular Weight(MW): 358.43

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 67 In stock
USD 97 In stock
USD 147 In stock
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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Targets
Glucocorticoid receptor [1]
()
In vitro

Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes. [1]

In vivo Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. [2] Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. [3] Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. [4] Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 71 mg/mL (198.08 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 358.43
Formula

C21H26O5

CAS No. 53-03-2
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01553188 Active, not recruiting Prostatic Neoplams|Prostate Cancer|Neoplasm, Prostate|Neoplasm,Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) February 7, 2012 Phase 2
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT01331018 Recruiting Fanconi Anemia Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) February 22, 2012 Phase 1
NCT02403505 Not yet recruiting Stage, Prostate Cancer|Surgery Dr. Han Xu, President/CEO / PD / PI / Monitor / IRB Chair|PPD|Medicine Invention Design, Inc August 2020 Phase 3
NCT02899026 Not yet recruiting Polymyalgia Rheumatica GlaxoSmithKline June 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID