Cyclosporin A

Catalog No.S2286 Synonyms: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

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In DMSO USD 130 In stock
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  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

    Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

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Biological Activity

Description Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Targets
calcineurin [1]
(Cell-free assay)
7 nM
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells M2nVR2Z2dmO2aX;uJIF{e2G7 NYPH[WtnUW6qaXLpeIlwdiCxZjDsbZZmeiC|dHHn[UBRdGG|bX;kbZVuKGKncnfo[YkhcW6oZXP0bY9vKGmwIFjldGczKGOnbHzzMEBKSzVyPUGuOlUhdk1? NWrsOYZUOjJ3OE[xNlQ>
Jurkat cells MmP0SpVv[3Srb36gZZN{[Xl? M3XvNWludXWwb4P1dJBz\XO|aY\lJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCkeTDpcohq[mm2aX;uJI9nKHSqZTDJUE0zKHC{b3T1Z5Rqd25iaX6gTpVzc2G2IHPlcIx{NCCLQ{WwQVIhdk1? M3W0fFE1PjR|M{O3
human PBMC NHrtWZFHfW6ldHnvckBie3OjeR?= MYmxJIg> NIq5[lhCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJHBDVUNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjboTpMWNFOy:FREK4JIFvfGmkb3T5MYlv\HWlZXSgTWwuOiCycn;keYN1cW:wIITy[YF1\WRiZn;yJFEhcHJiYnXmc5JmKGGwdHmtR2Q{N0OGMkigZY51cWKxZImgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IE[gbJJ{KGK7IHntcZVvd3O3cIDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVMvOSCwTR?= NGjFR4gyQTl|M{e5OS=>
human Jurkat cells Ml;JSpVv[3Srb36gZZN{[Xl? NEWzS28yKGh? NXv6OWlESW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBLfXKtYYSgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjboTpMWNFOy:FREK4JIFvfGmkb3T5MYlv\HWlZXSgTWwuOiCycn;keYN1cW:wIITy[YF1\WRiZn;yJFEhcHJiYnXmc5JmKGGwdHmtR2Q{N0OGMkigZY51cWKxZImgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IE[gbJJ{KGK7IHntcZVvd3O3cIDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVUhdk1? NIDCPGcyQTl|M{e5OS=>
human T-cell M2Cz[mZ2dmO2aX;uJIF{e2G7 NGnxO25KdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWE1k\WyuIIDyc4R2[3Srb36gc4YhdHmvcHjvb4lv\SCLTD2yMEBKSzVyPUiuNUBvVQ>? M1XvSlc2Ozd|M{G=
human splenocytes NWTYOFdNTnWwY4Tpc44h[XO|YYm= MkiwOEBl[Xm| NXS2R3F3UW2vdX7vd5VxeHKnc4PpeoUh[WO2aY\peJkhcW5iaIXtZY4he3CuZX7vZ5l1\XNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlv[2:{cH;yZZRqd25iYX\0[ZIhPCCmYYnzJIJ6KGGubH;n[Y5q[yCvaYjl[EBtgW2yaH;jfZRmKHKnYXP0bY9vKGG|c3H5MEBKSzVyPUGwJI5O M4Dj[|E6QDJ5OEOx
mouse T cells M4\xW2Z2dmO2aX;uJIF{e2G7 MnroOEBl[Xm| MXXJcY12dm:|dYDwdoV{e2m4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDUJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIfvJJdigSCvaYjl[EBtgW2yaH;jfZRmKHKnYXP0bY9vKGGodHXyJFQh\GG7czDifUBOXFRiYYPzZZktKGmlNUC9NVEhdk1? M1\5UFIzQTh2OUi3
human PBMC MlPXVJJwdGmoZYLheIlwdiCjc4PhfS=> Mo[4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQl3DMEBKSzVyPUGyJI5O MXWxOVY4QTNyOR?=
human MDA435/LCC6MDR cells M1L6UWZ2dmO2aX;uJIF{e2G7 NIS2TXc2KGSjeYO= MWDNc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrbnegdIFkdGm2YYjlcEBz\XOrc4ThcoNmKG2nYYP1doVlKGG|IHPlcIwhe3W{dnn2ZYwh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlA{OiEQvF2u MWOyOVk5PTF7NR?=
HEK293 cells MYfGeY5kfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKE:DVGCxRlEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlbY4udWWmaXH0[YQheGm2YY\hd5RifGmwIIXweIFs\e,:jDDLbV0xNjJizszN MUCyNlU5Pzl6Nh?=
CK1 cells Ml;qSpVv[3Srb36gZZN{[Xl? MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOzNiaX7m[YN1\WRiaX6gR2syKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNzDkZZl{NCCWQ{WwQVAvOyEQvF2= MknoNVgzOTJzMEC=
mouse mammary carcinoma cell line EMT6/AR 1.0 NUHGV5g6TnWwY4Tpc44h[XO|YYm= NVy2TIxPWmW4ZYLzZYwh\W[oZXP0JI9vKHSqZTDhZ4N2dXWuYYTpc44hd2ZiW{PIYU0h\GG3bn;yeYJq[2mwIHnuJI1wfXOnIH3hcY1ienliY3HyZ4lvd22jIHPlcIwhdGmwZTDFUXQ3N0GUIEGuNEwhUUN3ME2wMlQ1KM7:TR?= MoH2NVAxQTh4N{G=
KB cell NVXXWJp4TnWwY4Tpc44h[XO|YYm= M4C2OWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBMSiClZXzsJIxqdmViYX\0[ZIhPzJiaDDv[kBlenWpIHX4dI9{fXKnLDDJR|UxRTBwNjFOwG0> MlPPNVU1QDF7OUG=
mouse L5178 cells NFK1UJdHfW6ldHnvckBie3OjeR?= MV2yNEBucW6| MoOyTY5pcWKrdHnvckBw\iCqdX3hckBCSkOEMT3t[YRq[XSnZDDybI9l[W2rbnWgNVI{KGWoZnz1fEBqdiCvb4Xz[UBNPTF5ODDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKE2GUkGgZYZ1\XJiMkCgcYlveyCkeTDGRWNUKGGwYXz5d4l{NCCLQ{WwQVAvPjVizszN NGfLOVAzOTN2MUe0OS=>
LLC-PK1 epithelial cells MWnGeY5kfGmxbjDhd5NigQ>? MoXMTY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckwhdW:3c3WgUE1u\HJzYjDlfJBz\XO|ZXSgbY4hVEyFLWDLNUBmeGm2aHXsbYFtKGOnbHzzJJV{cW6pIHPhcINmcW5vQV2gdI9t[XKrc3H0bY9vKGG|c3H589yNKEmFNUC9NE44KM7:TR?= NEnUdWUyOjZ7OUO4PS=>
human K562/R7 cells MoHkSpVv[3Srb36gZZN{[Xl? NFrjeGQyKM7:TR?= MmjRO|IhcA>? NGnJNJlRd3SnboTpZZRqd25ib3[g[I95d3K3YnnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iS{W2Nk9TPyClZXzsd{Bie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGG2IEGgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlch|ryP MoHSNlU3OzRyNEG=
A2780/ADR cells MYLGeY5kfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4Pl[EBqdiCDMke4NE9CTFJiY3XscJMh[nliY3HsZ4VqdiCDTTDhd5Nige,:jDDJR|UxRTFwNEGyOVQh|ryP MoLQNVc5QTByOUS=
KB/MDR cell M4CyW2Z2dmO2aX;uJIF{e2G7 MUO3NkBp NYnObGp3UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEuEL13EVkBk\WyuIHzpcoUh[W[2ZYKgO|IhcHJib3[g[JJ2\yCneIDvd5Vz\SxiSVO1NF0yNjVizszN MWWxOVQ5OTl7MR?=
guinea pig ventricular myocytes MWjGeY5kfGmxbjDhd5NigQ>? NWe0dY5YUW6qaXLpeIlwdiCxZjDMMZR6eGViY3HsZ4l2dSClaHHucoVtKG2nYYP1doVlKHW|aX7nJJdpd2ynLXPlcIwheGG2Y3igZ4xidXBiaX6g[5VqdmWjIIDp[{B3\W62cnnjeYxieiCveX;jfZRmeyxiSVO1NF0zKM7:TR?= MXSyNlc3OTByMB?=
human MDA435/LCC6MDR cells NH;LTVREgXSxdH;4bYPDqGG|c3H5 MofPO|Jp MkLyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCPDN3L1zDR|ZOTFJiY3XscJMh\XiycnXzd4lv\yCPRGKgZYZ1\XJiN{KgbJJ{97zOIFnDOVA:Oi56IN88US=> NVvXW2FvOjJ|MkC0NFI>
human Caco2 cells M4\3O2Z2dmO2aX;uJIF{e2G7 NVzoZZhLdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hS2Glb{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGSrZ3;4bY4h\W[obIX4MEBKSzVyPUKuPUDPxE1? Mm\5NlM{QDJ2NUi=
leukemia CEM cells NYW4WnlMTnWwY4Tpc44h[XO|YYm= M1KzdGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDNSHIyKFBvR3z5Z49xem:2ZXnuJGFDSyCWcnHud5BwenSncjD1d4lv\yCuZYXr[Y1q[SCFRV2gZ4VtdHNuIFnDOVA:Oy52IN88US=> MXyxNlM3OTN6Nx?=
human HeLa cells M1rYemZ2dmO2aX;uJIF{e2G7 M1XNWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhRXi1zODDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNzDkZZl{97zOIGTDOVA:PC54IN88US=> MV6xPFIyOjFyMB?=
human 2008 cells MoXVSpVv[3Srb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiaX6gbJVu[W5iMkCwPEBk\WyuczygTWM2OD12Lke4JO69VQ>? NWCwOVRDOTh5MEe4PFQ>
human HuH7 cells M{T6dmN6fG:2b4jpZ:Kh[XO|YYm= Mn3zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXzlZZNmKG:oIHzhZ5RifGViZHXofYRzd2enbnHz[UwhUUN3ME21MlgyKM7:TR?= NWjOXG02OjB7NEOzPVA>
human Huh5-2 cells MYLDfZRwfG:6aXRCpIF{e2G7 M3PVeVMh\GG7cx?= MnXRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpPS1{IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZkhNCCFQ{WwQVYh|ryP MXSxPFYzPTd4Nh?=
human HuH6 cells MnjiR5l1d3SxeHnjxsBie3OjeR?= NHW4U5g{KGSjeYO= NUOxR3pxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNjDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCFQ{WwQVch|ryP MkXtNVg3OjV5Nk[=
human Huh-9-13 cells MknoR5l1d3SxeHnjxsBie3OjeR?= NV3HOnF2OyCmYYnz NHfkVnFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWhvOT2xN{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G778{MJGNEPTB;NzFOwG0> M{DROlE5PjJ3N{[2
african green monkey Vero cells NH7jRmhHfW6ldHnvckBie3OjeR?= M2LqWlI1KGh? MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDX[ZN1KE6rbHWgeolzfXNiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDDSUmEhe3mwdHjld4l{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:QCEQvF2= NVTrd4drOTl2NUGyPFY>
human HeLa cells NYr3cHdyS3m2b4TvfIlkyqCjc4PhfS=> MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzMEBVSzVyPUiuN{DPxE1? MX:xPFIyOjFyMB?=
human LCC-6 cells M4jMZmN6fG:2b4jpZ:Kh[XO|YYm= MX:3NkBp MnPMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUGNENTZiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxRThwMzFOwG0> NIXIUVQzOjN{MESwNi=>
MDCK cells M4TBNGN6fG:2b4jpZ:Kh[XO|YYm= Mn64R5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyxiVFO1NF06NjlizszN MWWxPFIyOjFyMB?=
human Huh-Mono cells NVPh[YFRS3m2b4TvfIlkyqCjc4PhfS=> M3nTNVMh\GG7cx?= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYguVW:wbzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F697zOIFPDOVA:OjRizszN NInlOpAyQDZ{NUe2Oi=>
mouse L929 cells M4TBSGN6fG:2b4jpZ:Kh[XO|YYm= NH\X[lM{KGSjeYO= M1X5b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGw6OjliY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VWyCjc4PhfUwhUUN3ME2zNEDPxE1? MWmyOVk5PTF7NR?=
rat H42E cells NEOwTJZEgXSxdH;4bYPDqGG|c3H5 M4rYW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDIOFJGKGOnbHzzJIF{e2W|c3XkJIF{KGmwdILhZ4VtdHWuYYKgRXRRKGyndnXsMEBVSzVyPUSyJO69VQ>? MV:xPVUxOjB3OB?=

... Click to View More Cell Line Experimental Data

In vivo Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7]

Protocol

Kinase Assay:[3]
+ Expand

Phosphatase Assay:

Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described.
Cell Research:[3]
+ Expand
  • Cell lines: Jurkat cells (clone J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1 hr
  • Method: Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 ml of complete medium in microcentrifuge tubes; 1 μl of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 ml of PBS on ice and lysed in 50μl of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per ml. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Rat
  • Formulation: 0.5% solution of tragacanth
  • Dosages: 45 mg/kg
  • Administration: orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+corn oil
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1202.61
Formula

C62H111N11O12

CAS No. 59865-13-3
Storage powder
Synonyms Cyclosporine A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01623167 Recruiting Aplastic Anemia|Neutropenia|Pancytopenia|Anemia|Thrombocytopenia National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) June 7, 2012 Phase 1|Phase 2
NCT02987257 Not yet recruiting Stevens-Johnson Syndrome|Toxic Epidermal Necrolyses Ottawa Hospital Research Institute|Canadian Dermatology Foundation|Vanderbilt University|Brooke Army Medical Center May 2017 Phase 3
NCT02887807 Not yet recruiting Shockable Out of Hospital Cardiac Arrest Hospices Civils de Lyon January 2017 Phase 3
NCT02876250 Not yet recruiting Lung Transplantation Hospices Civils de Lyon January 2017 Phase 3
NCT01962636 Not yet recruiting Acute Myeloid Leukemia (AML)|Acute Lymphocytic Leukemia (ALL)|Chronic Myelogenous Leukemia|Plasma Cell Leukemia|Myelofibrosis|Myelodysplasia|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Marginal Zone B-Cell Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Mantle-Cell Lymphoma|Prolymphocytic Leukemia|Diffuse Large B Cell Lymphoma|Lymphoblastic Lymphoma|Burkitts Lymphoma|Non-Hodgkin Lymphoma|Multiple Myeloma Masonic Cancer Center, University of Minnesota December 2016 --
NCT02907554 Not yet recruiting Brain Death|Kidney Transplantation University Hospital, Clermont-Ferrand|University Hospital, Estaing|Centre Hospitalier Universitaire de Nice|Groupe Hospitalier Pitie-Salpetriere|Centre Hospitalier Universitaire de Nīmes|University Hospital, Montpellier|Hôtel Dieu (Nantes)|Poitiers University Hospital|University Hospital, Toulouse|Hôpital de la Timone September 2016 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • Answer:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

Related Antibodies

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID