Coumarin

Catalog No.S4170

Coumarin Chemical Structure

Molecular Weight(MW): 146.14

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

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Biological Activity

Description Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
In vitro

Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. Coumarin is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. Coumarin is a member of a class of compounds called benzopyrones. Coumarin compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although coumarin itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.[1]

Protocol

Solubility (25°C)

In vitro DMSO 29 mg/mL (198.43 mM)
Ethanol 29 mg/mL (198.43 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C9H6O2

CAS No. 91-64-5
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01848210 Completed Chronic Venous Insufficiency Takeda May 2013 Phase 4
NCT00264277 Completed Deep Vein Thrombosis|Pulmonary Embolism St. Orsola Hospital September 2002 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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