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Coumarin Immunology & Inflammation related chemical

Name: Coumarin
Brand: Selleck Chemicals
SKU: S4170
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S4170

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

Chemical Structure

Molecular Weight: 146.14

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S417001 DMSO]29 mg/mL]false]Ethanol]29 mg/mL]false]Water]Insoluble]false Purity: 99.97%

99.97

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Chemical Information, Storage & Stability

Molecular Weight	146.14	Formula	C₉H₆O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	91-64-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1=CC=C2C(=C1)C=CC(=O)O2

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. It is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. This compound is a member of a class of compounds called benzopyrones. These compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although this chemical itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.^[1]

References

[1] https://pubmed.ncbi.nlm.nih.gov/2078993/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04952792	Completed	Atrial Fibrillation\|Hemodialysis Complication	Hospital Universitari de Bellvitge\|Spanish Society of Nephrology\|Baxter Healthcare Corporation	May 20 2021	Phase 2
NCT01119300	Completed	Venous Thromboembolism\|Atrial Fibrillation	Utrecht Institute for Pharmaceutical Sciences\|Utrecht University\|Leiden University Medical Center\|Erasmus Medical Center\|University of Ulm\|Newcastle University\|University of Liverpool\|LGC Limited\|Uppsala University\|Democritus University of Thrace\|Elisabethinen Hospital	January 2011	Phase 4
NCT00157118	Completed	Protein C Deficiency	Baxalta now part of Shire\|Takeda	August 22 2003	Phase 2\|Phase 3

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