cIAP Selective Inhibitors | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7015 Birinapant

Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2.

Selective cIAP1, Kd: <1 nM
S7010 GDC-0152

GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.

Pan cIAP2-BIR2, Ki: 9.6 μM; cIAP2-BIR3, Ki: 43 nM; cIAP1-BIR2, Ki: 14.5 μM; cIAP1-BIR3, Ki: 17 nM
S7597 BV-6

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

Pan
S7009 LCL161

LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.

Pan