- cIAP
- XIAP
cIAP Selective Inhibitors | Antagonists
| Catalog No. | Product Name | Information | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S7015 | Birinapant | Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2. |
Selective | cIAP1, Kd: <1 nM |
| S7010 | GDC-0152 | GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1. |
Pan | cIAP2-BIR2, Ki: 9.6 μM; cIAP2-BIR3, Ki: 43 nM; cIAP1-BIR2, Ki: 14.5 μM; cIAP1-BIR3, Ki: 17 nM |
| S7597 | BV-6 | BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. |
Pan | |
| S7009 | LCL161 | LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2. |
Pan |
