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Technical Data
| Formula | C34H63N5O9 |
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| Molecular Weight | 685.89 | CAS No. | 26305-03-3 | |
| Solubility (25°C)* | In vitro | DMSO | 50 mg/mL (72.89 mM) | |
| Ethanol | 3 mg/mL (4.37 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. | |||
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| In vitro | Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. [1] Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression. [2] |
Protocol (from reference)
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References
Selleck's Pepstatin A has been cited by 28 publications
| Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets [ Anim Nutr, 2024, 20:16:409-421.] | PubMed: 38371474 |
| ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury [ Int J Mol Sci, 2023, 24(2)1667] | PubMed: 36675183 |
| A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19 [ Biosensors (Basel), 2023, 13(7)682] | PubMed: 37504081 |
| Mannose ameliorates experimental colitis by protecting intestinal barrier integrity [ Nat Commun, 2022, 13(1):4804] | PubMed: 35974017 |
| Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals [ Proc Natl Acad Sci U S A, 2022, 119(39):e2117105119] | PubMed: 36122205 |
| Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis [ J Immunother Cancer, 2022, 10(3)e004129] | PubMed: 35288467 |
| Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy [ PLoS Pathog, 2022, 18(1):e1010204] | PubMed: 35030230 |
| SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling [ Mol Cell Biochem, 2022, 10.1007/s11010-022-04470-9] | PubMed: 35639235 |
| Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts [ Diagnostics (Basel), 2022, 12(6)1343] | PubMed: 35741154 |
| In situ assessment of statins' effect on autophagic activity in zebrafish larvae cardiomyocytes [ Front Cardiovasc Med, 2022, 9:921829] | PubMed: 36465443 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.