Catalog No.S9887

For research use only.

P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.

P110 Chemical Structure

CAS No. Unknown

Purity & Quality Control

Choose Selective Dynamin Inhibitors

Biological Activity

Description P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.
Drp1 [1]
In vitro

P110 is a Drp1-specific inhibitor that binds directly to Drp1. In some cases, this binding inhibits translocation to the mitochondria or prevents mitochondrial docking.[2]

In vivo

P110 treatment inhibits the interaction of fission proteins Fis1/Drp1, decreases mitochondrial fission, and improves bioenergetics in three different rat models of IR, including primary cardiomyocytes, ex vivo heart model, and an in vivo myocardial infarction model.[2]

Protocol (from reference)

Cell Research:


  • Cell lines: Primary cardiac myocytes
  • Concentrations: 1 μmol/L
  • Incubation Time: 2h + 2 to 60 min
  • Method:

    Cells culture on chamber slides are treated with P110 and subjected to 2 hour of ischemia followed by 2 to 60 minutes of reoxygenation. At the end of the incubation the cells are washed with cold PBS, fixed in 4% formaldehyde then blocked for 2 hours with 2% normal goat serum in PBS containing 0.1% Triton‐X (blocking buffer). The cells are then incubated overnight at 4°C with antibodies against Tom-20 (1:500). Cells are washed with blocking buffer and incubated for 2 hours with Alexa546-labeled goat antirabbit antibody (1:500). Slides are mounted and imaged by SP5 multiphoton/confocal Laser Scanning Microscope using a ×63 oil immersion objective.

Animal Research:


  • Animal Models: Male Wistar rats (270-300 g)
  • Dosages: 0.5 mg/kg
  • Administration: IP

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(41.46 mM)
Water 100 mg/mL
(41.46 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 2411.78


CAS No. Unknown
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy P110 | P110 supplier | purchase P110 | P110 cost | P110 manufacturer | order P110 | P110 distributor