For research use only.

Catalog No.S9887

P110 Chemical Structure

CAS No. Unknown

P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.

Purity & Quality Control

Choose Selective Dynamin Inhibitors

Biological Activity

Description P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.
Drp1 [1]
In vitro

P110 is a Drp1-specific inhibitor that binds directly to Drp1. In some cases, this binding inhibits translocation to the mitochondria or prevents mitochondrial docking.[2]

In vivo

P110 treatment inhibits the interaction of fission proteins Fis1/Drp1, decreases mitochondrial fission, and improves bioenergetics in three different rat models of IR, including primary cardiomyocytes, ex vivo heart model, and an in vivo myocardial infarction model.[2]


Cell Research:


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  • Cell lines: Primary cardiac myocytes
  • Concentrations: 1 μmol/L
  • Incubation Time: 2h + 2 to 60 min
  • Method:

    Cells culture on chamber slides are treated with P110 and subjected to 2 hour of ischemia followed by 2 to 60 minutes of reoxygenation. At the end of the incubation the cells are washed with cold PBS, fixed in 4% formaldehyde then blocked for 2 hours with 2% normal goat serum in PBS containing 0.1% Triton‐X (blocking buffer). The cells are then incubated overnight at 4°C with antibodies against Tom-20 (1:500). Cells are washed with blocking buffer and incubated for 2 hours with Alexa546-labeled goat antirabbit antibody (1:500). Slides are mounted and imaged by SP5 multiphoton/confocal Laser Scanning Microscope using a ×63 oil immersion objective.

    (Only for Reference)
Animal Research:


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  • Animal Models: Male Wistar rats (270-300 g)
  • Dosages: 0.5 mg/kg
  • Administration: IP
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (41.46 mM)
Water 100 mg/mL (41.46 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 2411.78


CAS No. Unknown
Storage powder
in solvent
Synonyms N/A

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID