Losartan Potassium (DuP 753)

Catalog No.S1359 Synonyms: MK 954

For research use only.

Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Losartan Potassium (DuP 753) Chemical Structure

CAS No. 124750-99-8

Selleck's Losartan Potassium (DuP 753) has been cited by 9 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
Features Losartan has a major active metabolite, EXP 3174.
Targets
AT1 receptor [1]
20 nM
In vivo Losartan (180 mg/d) causes significant increases in plasma angiotensin II and angiotensin-(1-7) in monkeys with diet-induced hypercholesterolemia. Losartan (180 mg/d) reduces the extent of fatty streak in the aorta, the coronary arteries, and the carotid arteries by approximately 50% in monkeys with diet-induced hypercholesterolemia. Losartan reduces the susceptibility of LDL to in vitro oxidation, serum levels of monocyte chemoattractant protein-1, and circulating monocyte CD11b expression in monkeys with diet-induced hypercholesterolemia. [2] Losartan (0.6 g/L in their drinking water) prevents elastic fiber fragmentation and blunted TGF-β signaling in the aortic media in pregnant Fbn1C1039G/+ mice, as evidenced by reduced nuclear accumulation of pSmad2. Losartan (0.6 g/L in their drinking water) shows a reduction in distal airspace caliber in pregnant Fbn1C1039G/+ mice. Losartan (0.6 g/L in their drinking water) improves disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics in pregnant Fbn1C1039G/+ mice. [3] Losartan (5 mg/kg/d) leads to a significant decrease in the development of atherosclerotic lesions in the apo E deficient mice. Losartan (5 mg/kg/d) significantly reduces the susceptibility of the mice LDL to lipid oxidation following its incubation with CuSO4 in the apo E deficient mice. [4] Losartan (10 mg/kg) administration increases blood angiotensin levels four fold to six fold, blood BK levels are unchanged in male Sprague Dawley rats. Losartan (10 mg/kg) increases plasma renin levels 100-fold, plasma angiotensinogen levels decreases to 24% of control and plasma aldosterone levels are unchanged in male Sprague Dawley rats. [5]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Male cynomolgus monkeys fed a diet containing 0.067 mg cholesterol/kJ
  • Dosages: 180 mg/d
  • Administration: Dietary

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 462.01
Formula

C22H23ClKN6O

CAS No. 124750-99-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00880386 Withdrawn Drug: Losartan Dyspnea|Lung Cancer|Pulmonary Complications|Radiation Fibrosis University of South Florida|National Cancer Institute (NCI) March 2009 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Losartan Potassium (DuP 753) | Losartan Potassium (DuP 753) ic50 | Losartan Potassium (DuP 753) price | Losartan Potassium (DuP 753) cost | Losartan Potassium (DuP 753) solubility dmso | Losartan Potassium (DuP 753) purchase | Losartan Potassium (DuP 753) manufacturer | Losartan Potassium (DuP 753) research buy | Losartan Potassium (DuP 753) order | Losartan Potassium (DuP 753) mouse | Losartan Potassium (DuP 753) chemical structure | Losartan Potassium (DuP 753) mw | Losartan Potassium (DuP 753) molecular weight | Losartan Potassium (DuP 753) datasheet | Losartan Potassium (DuP 753) supplier | Losartan Potassium (DuP 753) in vitro | Losartan Potassium (DuP 753) cell line | Losartan Potassium (DuP 753) concentration | Losartan Potassium (DuP 753) nmr