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Angiotensin Receptor

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Angiotensin Receptor Products

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Angiotensin Receptor Inhibitor (1)
Angiotensin Receptor Antagonists (18)
New Angiotensin Receptor Products

Catalog No.	Product Name	Information	Product Use Citations
S7678	Sacubitril/valsartan (LCZ696)	Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	Cardiovasc Res, 2021, 117(5):1391-1401 Neurotox Res, 2021, 10.1007/s12640-021-00414-1 J Mol Cell Cardiol, 2017, 108:138-148
E0039^New	A-779	A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
S0326	Olodanrigan (EMA401)	Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
S1359	Losartan Potassium (DuP 753)	Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.	Front Cardiovasc Med, 2021, 8:692856 Biochem Biophys Res Commun, 2021, 544:1-7 Adv Healthc Mater, 2021, e2001856
S1507	Irbesartan	Irbesartan (BMS-186295, SR-47436) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.	Xenobiotica, 2020, 10.1080/00498254.2020.1745318 Front Physiol, 2019, 10:681 Antiviral Res, 2015, 120:140-6
S1578	Candesartan (CV-11974)	Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.	Hypertension, 2021, 77(5):1723-1736 Sci Rep, 2020, 8;10(1):6046 Neurosci Lett, 2020, 716:134684
S1604	Olmesartan Medoxomil	Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.	Sci Rep, 2015, 5:8116
S1738	Telmisartan	Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.	Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X Eur J Pharmacol, 2021, S0014-2999(21)00845-1 Sci Rep, 2019, 9(1):18177
S1894	Valsartan (CGP-48933)	Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.	Int J Mol Sci, 2021, 22(16)8598 Sci Rep, 2015, 5:8116 J Nat Med, 2014, 68(3):623-9
S2037	Candesartan Cilexetil	Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.	Exp Biol Med, 2015, 10.1177/1535370215576312 J Cardiovasc Pharmacol, 2015, 66(3):285-93 Sci Rep, 2015, 5:8116
S3046	Azilsartan	Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.	Front Pharmacol, 2021, 12:774709 bioRxiv, 2020, 10.1101/2020.10.13.337774 Sci Rep, 2015, 5:8116
S3057	Azilsartan Medoxomil	Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.	Sci Rep, 2015, 5:8116
S4102	Eprosartan Mesylate	Eprosartan is a nonpeptide angiotensin II receptor antagonist, [³H]-eprosartan binds to the AT1 receptor with K_D of 0.83 nM in rat vascular smooth muscle cells.	bioRxiv, 2020, 10.1101/2020.10.13.337774 Sci Rep, 2016, 10.1038/srep25694 Sci Rep, 2015, 5:8116
S4975	Fimasartan	Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.	Drug Metab Dispos, 2020, 48(12):1264-1270
S5067	Losartan	Losartan is a selective, orally administered, nonpeptide blocker of angiotensin II type 1 (AT1) receptor used to treat high blood pressure, diabetic kidney disease, heart failure, and left ventricular enlargement.	Xenobiotica, 2020, 10.1080/00498254.2020.1745318 Exp Ther Med, 2020, 20(2):818-829 Antioxid Redox Signal, 2020, 10.1089/ars.2019.7840
S5581	Olmesartan	Olmesartan (RNH-6270) is an an angiotensin 2 receptor antagonist with antihypertensive activity.	bioRxiv, 2020, 10.1101/2020.10.13.337774
S5980^New	Losartan Carboxylic Acid (EXP-3174)	Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.
S6665	Sparsentan (PS-433540, RE-021)	Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
S7098	PD123319	PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.	Cell Res, 2021, 10.1038/s41422-020-00464-8 Int J Biochem Cell Biol, 2020, 121:105703 Neurosci Lett, 2020, 716:134684
P1085	Angiotensin II human Acetate	Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.
S7678	Sacubitril/valsartan (LCZ696)	Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	Cardiovasc Res, 2021, 117(5):1391-1401 Neurotox Res, 2021, 10.1007/s12640-021-00414-1 J Mol Cell Cardiol, 2017, 108:138-148
E0039^New	A-779	A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
S0326	Olodanrigan (EMA401)	Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
S1359	Losartan Potassium (DuP 753)	Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.	Front Cardiovasc Med, 2021, 8:692856 Biochem Biophys Res Commun, 2021, 544:1-7 Adv Healthc Mater, 2021, e2001856
S1507	Irbesartan	Irbesartan (BMS-186295, SR-47436) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.	Xenobiotica, 2020, 10.1080/00498254.2020.1745318 Front Physiol, 2019, 10:681 Antiviral Res, 2015, 120:140-6
S1578	Candesartan (CV-11974)	Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.	Hypertension, 2021, 77(5):1723-1736 Sci Rep, 2020, 8;10(1):6046 Neurosci Lett, 2020, 716:134684
S1604	Olmesartan Medoxomil	Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.	Sci Rep, 2015, 5:8116
S1738	Telmisartan	Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.	Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X Eur J Pharmacol, 2021, S0014-2999(21)00845-1 Sci Rep, 2019, 9(1):18177
S1894	Valsartan (CGP-48933)	Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.	Int J Mol Sci, 2021, 22(16)8598 Sci Rep, 2015, 5:8116 J Nat Med, 2014, 68(3):623-9
S2037	Candesartan Cilexetil	Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.	Exp Biol Med, 2015, 10.1177/1535370215576312 J Cardiovasc Pharmacol, 2015, 66(3):285-93 Sci Rep, 2015, 5:8116
S3046	Azilsartan	Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.	Front Pharmacol, 2021, 12:774709 bioRxiv, 2020, 10.1101/2020.10.13.337774 Sci Rep, 2015, 5:8116
S3057	Azilsartan Medoxomil	Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.	Sci Rep, 2015, 5:8116
S4102	Eprosartan Mesylate	Eprosartan is a nonpeptide angiotensin II receptor antagonist, [³H]-eprosartan binds to the AT1 receptor with K_D of 0.83 nM in rat vascular smooth muscle cells.	bioRxiv, 2020, 10.1101/2020.10.13.337774 Sci Rep, 2016, 10.1038/srep25694 Sci Rep, 2015, 5:8116
S4975	Fimasartan	Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.	Drug Metab Dispos, 2020, 48(12):1264-1270
S5067	Losartan	Losartan is a selective, orally administered, nonpeptide blocker of angiotensin II type 1 (AT1) receptor used to treat high blood pressure, diabetic kidney disease, heart failure, and left ventricular enlargement.	Xenobiotica, 2020, 10.1080/00498254.2020.1745318 Exp Ther Med, 2020, 20(2):818-829 Antioxid Redox Signal, 2020, 10.1089/ars.2019.7840
S5581	Olmesartan	Olmesartan (RNH-6270) is an an angiotensin 2 receptor antagonist with antihypertensive activity.	bioRxiv, 2020, 10.1101/2020.10.13.337774
S5980^New	Losartan Carboxylic Acid (EXP-3174)	Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.
S6665	Sparsentan (PS-433540, RE-021)	Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
S7098	PD123319	PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.	Cell Res, 2021, 10.1038/s41422-020-00464-8 Int J Biochem Cell Biol, 2020, 121:105703 Neurosci Lett, 2020, 716:134684
E0039^New	A-779	A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
S5980^New	Losartan Carboxylic Acid (EXP-3174)	Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.