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Technical Data
| Formula | C22H23ClKN6O |
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| Molecular Weight | 462.01 | CAS No. | 124750-99-8 | |
| Solubility (25°C)* | In vitro | DMSO | 92 mg/mL (199.12 mM) | |
| Water | 92 mg/mL (199.12 mM) | |||
| Ethanol | 92 mg/mL (199.12 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Losartan Potassium is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. | ||
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| Targets |
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| In vivo | Losartan (180 mg/d) causes significant increases in plasma angiotensin II and angiotensin-(1-7) in monkeys with diet-induced hypercholesterolemia. Losartan (180 mg/d) reduces the extent of fatty streak in the aorta, the coronary arteries, and the carotid arteries by approximately 50% in monkeys with diet-induced hypercholesterolemia. Losartan reduces the susceptibility of LDL to in vitro oxidation, serum levels of monocyte chemoattractant protein-1, and circulating monocyte CD11b expression in monkeys with diet-induced hypercholesterolemia. [2] Losartan (0.6 g/L in their drinking water) prevents elastic fiber fragmentation and blunted TGF-β signaling in the aortic media in pregnant Fbn1C1039G/+ mice, as evidenced by reduced nuclear accumulation of pSmad2. Losartan (0.6 g/L in their drinking water) shows a reduction in distal airspace caliber in pregnant Fbn1C1039G/+ mice. Losartan (0.6 g/L in their drinking water) improves disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics in pregnant Fbn1C1039G/+ mice. [3] Losartan (5 mg/kg/d) leads to a significant decrease in the development of atherosclerotic lesions in the apo E deficient mice. Losartan (5 mg/kg/d) significantly reduces the susceptibility of the mice LDL to lipid oxidation following its incubation with CuSO4 in the apo E deficient mice. [4] Losartan (10 mg/kg) administration increases blood angiotensin levels four fold to six fold, blood BK levels are unchanged in male Sprague Dawley rats. Losartan (10 mg/kg) increases plasma renin levels 100-fold, plasma angiotensinogen levels decreases to 24% of control and plasma aldosterone levels are unchanged in male Sprague Dawley rats. [5] | ||
| Features | Losartan has a major active metabolite, EXP 3174. |
Protocol (from reference)
| Animal Study:[2] |
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References
Customer Product Validation
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, , Sci Rep, 2015, 5:8116.
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Data from [Data independently produced by , , Neurotherapeutics, 2018, 15(2):500-510]
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Data from [Data independently produced by , , Sci Rep, 2018, 8(1):9302]
Selleck's Losartan Potassium has been cited by 11 publications
| Effects of Adjunct Antifibrotic Treatment within a Regenerative Rehabilitation Paradigm for Volumetric Muscle Loss [ Int J Mol Sci, 2023, 24(4)3564] | PubMed: 36834976 |
| Multitarget, multiagent PLGA nanoparticles for simultaneous tumor eradication and TME remodeling in a melanoma mouse model [ Drug Deliv Transl Res, 2023, 10.1007/s13346-023-01413-9] | PubMed: 37612575 |
| The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis [ Adv Healthc Mater, 2021, e2001856] | PubMed: 33511795 |
| The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection [ Front Cardiovasc Med, 2021, 8:692856] | PubMed: 34307505 |
| Anti-ATR001 monoclonal antibody ameliorates atherosclerosis through beta-arrestin2 pathway [ Biochem Biophys Res Commun, 2021, 544:1-7] | PubMed: 33516876 |
| Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens [ Biol Sex Differ, 2020, 11(1):48] | PubMed: 32843085 |
| Matrix Stiffness Controls Cardiac Fibroblast Activation Through Regulating YAP via AT 1 R [ J Cell Physiol, 2020, 2] | PubMed: 32239716 |
| Brain Renin–Angiotensin System Blockade Attenuates Methamphetamine-Induced Hyperlocomotion and Neurotoxicity [Jiang L Neurotherapeutics, 2018, 15(2):500-510] | PubMed: 29464572 |
| Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure [Jin L Sci Rep, 2018, 8(1):9302] | PubMed: 29915390 |
| Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na+-dependent taurocholate cotransporting polypeptide activity [Wang XJ, et al. Antiviral Res, 2015, 120:140-6] | PubMed: 26086883 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.